KR870007200A - Process for preparing peptidyl aminodiol - Google Patents

Process for preparing peptidyl aminodiol Download PDF

Info

Publication number
KR870007200A
KR870007200A KR1019860004143A KR860004143A KR870007200A KR 870007200 A KR870007200 A KR 870007200A KR 1019860004143 A KR1019860004143 A KR 1019860004143A KR 860004143 A KR860004143 A KR 860004143A KR 870007200 A KR870007200 A KR 870007200A
Authority
KR
South Korea
Prior art keywords
hydrogen
methyl
lower alkyl
compound
benzyl
Prior art date
Application number
KR1019860004143A
Other languages
Korean (ko)
Other versions
KR910000405B1 (en
Inventor
리차드 룰리 제이
하워드 로젠버그 소울
제이콥 플래트너 존
케이엘 풍 안토니
Original Assignee
애보트 래보러토리스
조셉 엠·버니크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/818,714 external-priority patent/US4680284A/en
Application filed by 애보트 래보러토리스, 조셉 엠·버니크 filed Critical 애보트 래보러토리스
Publication of KR870007200A publication Critical patent/KR870007200A/en
Application granted granted Critical
Publication of KR910000405B1 publication Critical patent/KR910000405B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

펩티딜 아미노디올의 제조방법Process for preparing peptidyl aminodiol

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (11)

하기 일반식의 펩티딜 아미노디올 및 약제학적으로 무독한 이의 염.Peptidyl aminodiol of the general formula and pharmaceutically toxic salts thereof. 상기식에서,In the above formula, R10은 R 10 is 이며And A는 수소 또는 N-보호기이고,A is hydrogen or an N-protecting group, W는 0 또는 1이며,W is 0 or 1, B는 수소, 히드록시, NH, N-알킬, 저급알킬 또는 아릴알킬이고, 단, W가 1인경우, B는 NH이며,B is hydrogen, hydroxy, NH, N-alkyl, lower alkyl or arylalkyl, provided that when W is 1, B is NH, W가 0인 경우, B는 수소, 히드록시, 저급 알킬 또는 아릴알킬이고,When W is 0, B is hydrogen, hydroxy, lower alkyl or arylalkyl, R1은 저급알킬이거나, 친지방성 또는 방향족 또는 친수성 아미노산 측쇄이며,R 1 is lower alkyl, lipophilic or aromatic or hydrophilic amino acid side chain, m은 1내지 3이고,m is 1 to 3, n은 1내지 3이며,n is 1 to 3, p는 1내지 3이고,p is 1 to 3, q는 1내지 3이며,q is 1 to 3, s는 1내지 3이고,s is 1 to 3, t는 0내지 2이며,t is 0 to 2, R2는 수소 또는 저급 알킬이고,R 2 is hydrogen or lower alkyl, R3및 R4는 서로 무관하게 저급 알킬이거나 친지방성 또는 방향족 아미노산 측쇄이며,R 3 and R 4 , independently of one another, are lower alkyl or lipophilic or aromatic amino acid side chains, R5및 R7은 서로 무관하게 수소 또는 저급알킬이고,R 5 and R 7 are independently of each other hydrogen or lower alkyl, R6는 수소, 저급 알킬, 비닐, 아릴알킬 또는R 6 is hydrogen, lower alkyl, vinyl, arylalkyl or 이며, Is, R8은 수소 또는 저급 알킬이고,R 8 is hydrogen or lower alkyl, X는 산소, NH 또는 황이며,X is oxygen, NH or sulfur, R9는 수소, 저급 알킬 또는 알카노일이거나, XR9는 함께 저급알킬 술포닐, N3또는 Cl일 수 있다.R 9 may be hydrogen, lower alkyl or alkanoyl, or XR 9 together may be lower alkyl sulfonyl, N 3 or Cl. 제1항에 있어서, R10이이며, R7은 수소이고, R6이인 화합물.The compound of claim 1, wherein R 10 is R 7 is hydrogen and R 6 is Phosphorus compounds. 제2항에 있어서, W가 1이고, B는 NH이며, R1은 벤질, 4-메톡시벤질 또는 이소부틸이고, R2는 수소이며, R3은 저급알킬, (4-이미다졸)메틸 또는 (3-피라졸일)메틸이고, R4는 저급알킬 또는 시클로알킬메틸이며, R5가 수소인 화합물.The compound of claim 2, wherein W is 1, B is NH, R 1 is benzyl, 4-methoxybenzyl or isobutyl, R 2 is hydrogen, R 3 is lower alkyl, (4-imidazole) methyl Or (3-pyrazolyl) methyl, R 4 is loweralkyl or cycloalkylmethyl, and R 5 is hydrogen. 제1항에 있어서, R10이이며, R6은 수소, 저급 알킬, 비닐 또는 아릴알킬인 화합물.The compound of claim 1, wherein R 10 is And R 6 is hydrogen, lower alkyl, vinyl or arylalkyl. 제4항에 있어서, A가 t-부틸옥시카보닐. t-부틸아세틸 또는 에톡시카보닐이며, W는 1이고, B는 NH이며, R1은 벤질, 시클로헥실메틸, (4-메톡시)벤질 ; (1-나프틸)메틸 또는 이소부틸이고, R2는 수소 또는 메틸이며, R3는 메틸, (4-이미다졸일)메틸, 벤질, (3-피라졸일)메틸, (메틸 메캅토)메틸 또는 이소부틸이고, R4는 이소부틸 또는 시클로헥실메틸이며, R5는 수소 또는 이소펜틸이며, R6는 수소, 저급 알킬, 비닐 또는 벤질이고, R7이 수소 또는 에틸인 화합물.The method of claim 4, wherein A is t-butyloxycarbonyl. t-butylacetyl or ethoxycarbonyl, W is 1, B is NH, R 1 is benzyl, cyclohexylmethyl, (4-methoxy) benzyl; (1-naphthyl) methyl or isobutyl, R 2 is hydrogen or methyl, R 3 is methyl, (4-imidazolyl) methyl, benzyl, (3-pyrazolyl) methyl, (methyl mecapto) methyl Or isobutyl, R 4 is isobutyl or cyclohexylmethyl, R 5 is hydrogen or isopentyl, R 6 is hydrogen, lower alkyl, vinyl or benzyl, and R 7 is hydrogen or ethyl. 제5항에 있어서, A가 에톡시카보닐이고, R1은(4-메톡시)벤질이며, R2는 수소이고, R3은(4-이미다졸일)메틸이며, R4는 시클로헥실메틸이고, R5및 R7은 수소이며, R6이 이부틸인 화합물.The compound of claim 5, wherein A is ethoxycarbonyl, R 1 is (4-methoxy) benzyl, R 2 is hydrogen, R 3 is (4-imidazolyl) methyl, and R 4 is cyclohexyl Methyl, R 5 and R 7 are hydrogen, and R 6 is ibutyl. 제5항에 있어서, A가 에톡시카보닐이며, R1은 벤질이고, R2,R5및 R7은 수소이며, R3는 (4-이미다졸일)메틸이고, R4는 시클로헥실메틸이며, R6이 이소부틸인 화합물.The compound of claim 5, wherein A is ethoxycarbonyl, R 1 is benzyl, R 2 , R 5 and R 7 are hydrogen, R 3 is (4-imidazolyl) methyl, and R 4 is cyclohexyl Methyl and R 6 is isobutyl. 제5항에 있어서, A가 에톡시카보닐이며, R1은 벤질이고, R2, R5및 R7은 수소이며, R3및 R6은 이소부틸이고, R4가 시콜로헥실메틸인 화합물.6. A compound according to claim 5, wherein A is ethoxycarbonyl, R 1 is benzyl, R 2 , R 5 and R 7 are hydrogen, R 3 and R 6 are isobutyl and R 4 is cyclohexylmethyl compound. 제1항에 있어서, R10이The compound of claim 1, wherein R 10 is 이며, R4는 시클로헥실메틸이고, R5및 R7은 수소이며, R6가 저급 알킬인 화합물.R 4 is cyclohexylmethyl, R 5 and R 7 are hydrogen, and R 6 is lower alkyl. 제9항에 있어서, R10이 The compound of claim 9, wherein R 10 is 이며, A는 에톡시카보닐이고, n은 1이며 m이 2인 화합물.And A is ethoxycarbonyl, n is 1 and m is 2. 제9항에 있어서, R10이 The compound of claim 9, wherein R 10 is 이며, A는 수소이고, R1이 메틸인 화합물.And A is hydrogen and R 1 is methyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860004143A 1986-01-16 1986-05-27 Peptidyl aminodiol KR910000405B1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US81873486A 1986-01-16 1986-01-16
US81871586A 1986-01-16 1986-01-16
US818734 1986-01-16
US818714~5 1986-01-16
US817,715 1986-01-16
US818,734 1986-01-16
US06/818,714 US4680284A (en) 1985-01-23 1986-01-16 Modified phenylalanine peptidylaminodiols
US819,714 1986-01-16

Publications (2)

Publication Number Publication Date
KR870007200A true KR870007200A (en) 1987-08-17
KR910000405B1 KR910000405B1 (en) 1991-01-25

Family

ID=27420128

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004143A KR910000405B1 (en) 1986-01-16 1986-05-27 Peptidyl aminodiol

Country Status (2)

Country Link
KR (1) KR910000405B1 (en)
GR (1) GR860286B (en)

Also Published As

Publication number Publication date
GR860286B (en) 1986-06-02
KR910000405B1 (en) 1991-01-25

Similar Documents

Publication Publication Date Title
KR920002596A (en) Azibicyclo derivatives
ES8800269A1 (en) Peptidylaminodiols.
AU8772691A (en) New compounds
AU4067195A (en) Morphinan derivative and medicinal use
DK189586A (en) DOUBLE HEART VALVE HOLDER / ROTATOR
KR920004338A (en) Substituted valineamide derivatives
KR860007207A (en) Method for preparing phenyl carbamate and its salts
LU90856I2 (en) Uprima - apomorphine hydrochloride and its pharmaceutically acceptable derivatives
EP0236140A3 (en) Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
AU7998291A (en) Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
MY131595A (en) Heterocyclically substituted phenyl-cyclohexane- carboxylic acid derivatives
ATE58292T1 (en) MEDICATION CONTAINING L-DOPA.
CA2038848A1 (en) Hydantoin derivatives
EP0775487A4 (en) Triazine derivative and medicine
GB2283016A (en) Scavenging of hydrogen sulphide
IS4165A (en) Process for the production of aminoalkyl guanidines
PL328789A1 (en) Novel heterocyclic compounds, method of obtaining them, their application in production of a pharmaceutic agent and pharmaceutic agent obtained thereby
AU4611589A (en) Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof.
KR840002773A (en) Manufacturing method of substituted urea and thiourea
BR9100221A (en) COMPOUND; METHOD FOR TREATING HYPERTENSION, CONGESTIVE HEART FAILURE OR GLAUCOMA IN A MAMMALIAN; AND PHARMACEUTICAL COMPOSITION
DK0775135T3 (en) N-Substituted 3-azabicyclo [3.2.0] heptane derivatives as neuroleptics
ATE30407T1 (en) ENZYMATIC REMOVAL OF AROMATIC HYDROXY COMPOUNDS AND AROMATIC AMINES FROM WASTE WATER.
KR870007200A (en) Process for preparing peptidyl aminodiol
KR970064396A (en) Stress Relief Feed
ATE55057T1 (en) CENTRALLY ACTING MUSCLE RELAXANTS.

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee