KR870005000A - 4- (1-Pyrrolidinyl) -1- (2,4,6-trimethoxyphenyl) -1-butanone 3-hydroxy-5- (hydroxymethyl) -2-methylisonicotinaldehyde-5 -Method of preparing phosphate - Google Patents

4- (1-Pyrrolidinyl) -1- (2,4,6-trimethoxyphenyl) -1-butanone 3-hydroxy-5- (hydroxymethyl) -2-methylisonicotinaldehyde-5 -Method of preparing phosphate Download PDF

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Publication number
KR870005000A
KR870005000A KR1019850008765A KR850008765A KR870005000A KR 870005000 A KR870005000 A KR 870005000A KR 1019850008765 A KR1019850008765 A KR 1019850008765A KR 850008765 A KR850008765 A KR 850008765A KR 870005000 A KR870005000 A KR 870005000A
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South Korea
Prior art keywords
trimethoxyphenyl
butanone
pyrrolidinyl
hydroxymethyl
hydroxy
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KR1019850008765A
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Korean (ko)
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KR900003456B1 (en
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자그놀리 기오르기오
콘테 우발도
콘테 파올로
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기안니 자그놀리
레보라토리오 이탈리아노 바이오키미코 파마쉬티코 리사파마 스파
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

4-(1-피롤리디닐)-1-(2,4,6-트리메톡시페닐)-1-부타논 3-하이드록시-5-(하이드록시메틸)-2-메틸이소니코틴알데하이드-5-포스페이트의 제조방법.4- (1-Pyrrolidinyl) -1- (2,4,6-trimethoxyphenyl) -1-butanone 3-hydroxy-5- (hydroxymethyl) -2-methylisonicotinaldehyde-5 Preparation of phosphates.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

3-하이드록시-5-(하이드록시메틸)-2-메틸-이소니코틴알데하이드-포스포르산을 염 유도체(I)가 고도로 용해되는 유기용매로 구성된 반응 매질에서 4-(1-피롤리디닐)-1-(2,4,6-트리메톡시페닐)-1-부타논과 반응시키고, 반응 생성물(I)를 반응 생성물(I)의 용해도가 낮은 유기용매로 결정화함을 특징으로하여, 하기 구조식(I)의 4-(1-피롤리디닐)-1-(2,4,6-트리메톡시페닐)-1-부타논 3-하이드록시-5-(하이드록시메틸)-2-메틸이소니코틴알데하이드-5-포스페이트로 구성된 약리학적으로 활성인 염 유도체의 제조방법 .4- (1-pyrrolidinyl) in a reaction medium consisting of 3-hydroxy-5- (hydroxymethyl) -2-methyl-isonicotinaldehyde-phosphoric acid in an organic solvent in which the salt derivative (I) is highly dissolved Reacting with -1- (2,4,6-trimethoxyphenyl) -1-butanone and crystallizing the reaction product (I) with an organic solvent having low solubility of the reaction product (I) 4- (1-Pyrrolidinyl) -1- (2,4,6-trimethoxyphenyl) -1-butanone 3-hydroxy-5- (hydroxymethyl) -2-methyliso of (I) Method for preparing pharmacologically active salt derivative consisting of nicotinaldehyde-5-phosphate. 제 1 항에 있어서, 상기 반응이 40℃ 내지 용매의 환류 온도, 및 바람직하게는 45 내지 55℃의 온도에서 수행됨을 특징으로 하는 방법.2. The process according to claim 1, wherein the reaction is carried out at a reflux temperature of 40 ° C. to a solvent, and preferably at a temperature of 45 to 55 ° C. 3. 제 1 항에 있어서, 상기 반응 매질이 탄소수 1 내지 4의 지방족 알코올로 구성됨을 특징으로 하는 방법.A process according to claim 1, characterized in that the reaction medium consists of aliphatic alcohols having 1 to 4 carbon atoms. 제 1 항에 있어서, 반응물을 거의 화학량론 몰비율로 반응시킴을 특징으로 하는 방법.The method of claim 1, wherein the reactants are reacted at about stoichiometric molar ratios. 제 1 항에 있어서, 상기 결정화 용매가 지방족 알코올 및 에틸 에테르의 혼합물로 구성됨을 특징으로 하는 방법.A process according to claim 1, wherein the crystallization solvent consists of a mixture of aliphatic alcohol and ethyl ether. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850008765A 1985-11-23 1985-11-23 Process for the preparation of 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone 3-hydroxy-5-(hydroxy-methyl)-2-methy-lisonicotinaldehyde-5-phosphate KR900003456B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019850008765A KR900003456B1 (en) 1985-11-23 1985-11-23 Process for the preparation of 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone 3-hydroxy-5-(hydroxy-methyl)-2-methy-lisonicotinaldehyde-5-phosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850008765A KR900003456B1 (en) 1985-11-23 1985-11-23 Process for the preparation of 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone 3-hydroxy-5-(hydroxy-methyl)-2-methy-lisonicotinaldehyde-5-phosphate

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KR870005000A true KR870005000A (en) 1987-06-04
KR900003456B1 KR900003456B1 (en) 1990-05-19

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KR1019850008765A KR900003456B1 (en) 1985-11-23 1985-11-23 Process for the preparation of 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone 3-hydroxy-5-(hydroxy-methyl)-2-methy-lisonicotinaldehyde-5-phosphate

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