KR860007241A - Process for preparing 2-oxa-or-aza-pregnan compound - Google Patents

Process for preparing 2-oxa-or-aza-pregnan compound Download PDF

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KR860007241A
KR860007241A KR1019860001625A KR860001625A KR860007241A KR 860007241 A KR860007241 A KR 860007241A KR 1019860001625 A KR1019860001625 A KR 1019860001625A KR 860001625 A KR860001625 A KR 860001625A KR 860007241 A KR860007241 A KR 860007241A
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South Korea
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compound
formula
hydrogen atom
general formula
atom
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KR1019860001625A
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Korean (ko)
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KR900006219B1 (en
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겡유 시바다
노부야끼 야마고시
나오유기 고이쓰미
시께히로 다게까와
에이이지로우 시마사와
마모루 미에따
Original Assignee
데이꼬꾸조오끼세이야꾸 가부시끼가이샤
야마구찌 에이이찌
데이꼬꾸조오끼세이야꾸 가부시끼 가이샤
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Publication of KR860007241A publication Critical patent/KR860007241A/en
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Publication of KR900006219B1 publication Critical patent/KR900006219B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

2-옥사-또는-아자-프레그난 화합의 제조방법Process for preparing 2-oxa-or-aza-pregnan compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

하기 일반식(Ⅶ)의 화합물을 탈수시킴을 특징으로하는 하기 일반식(Ⅰ)의 화합물의 제조방법.A method for producing a compound of formula (I), wherein the compound of formula (iii) is dehydrated. [상기 식중,[In the above meal, A는 수소원자 또는 저급알카노일기를 나타내고,A represents a hydrogen atom or a lower alkanoyl group, Z는 산소원자 또는 일반식(R은 수소원자 또는 저급알킬기를 나타낸다)의 기를 나타내고,Z is oxygen atom or general formula (R represents a hydrogen atom or a lower alkyl group), X는 할로겐원자를 나타낸다.]X represents a halogen atom.] 하기 일반식(Ⅸ)의 화합물을 환원시킴을 특징으로하는 하기 일반식(Ⅰ)의 화합물의 제조방법.A method for producing a compound of formula (I), wherein the compound of formula (VII) is reduced. [상기 식중,[In the above meal, A는 수소원자 또는 저급알카노일기를 나타내고,A represents a hydrogen atom or a lower alkanoyl group, Z는 산소원자 또는 일반식(R은 수소원자 또는 저급알킬기를 나타낸다)의 기를 나타내고,Z is oxygen atom or general formula (R represents a hydrogen atom or a lower alkyl group), X는 할로겐원자를 나타낸다.]X represents a halogen atom.] 하기 일반식(Ⅸ)의 화합물을 포름산의 존재하에 일반식 R-NH2의 화합물과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 제조방법.A method for producing a compound of formula (I), wherein the compound of formula (VII) is reacted with a compound of formula R-NH 2 in the presence of formic acid. [상기 식중,[In the above meal, A는 수소원자 또는 저급알카노일기를 나타내고,A represents a hydrogen atom or a lower alkanoyl group, Z는 산소원자 또는 일반식의 기를 나타내고,Z is oxygen atom or general formula Represents a group of R은 수소원자 또는 저급알킬기를 나타내고,R represents a hydrogen atom or a lower alkyl group, X는 할로겐원자를 나타낸다.]X represents a halogen atom.] 하기 일반식(Ⅹ)의 화합물을 일반식 R-NH2의 화합물의 존재하에 또는 부재하에 환원시키거나 또는 포름산의 존재하에 일반식 R-NH2의 화합물과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 제조방법.Order characterized by the general formula (Ⅹ) compound to Sikkim general formula R-NH to reduction under or without the presence of a compound of 2, or the general formula R-NH 2 compound in the presence of formic acid and reaction of the formula ( Process for the preparation of the compound of I). [상기 식중,[In the above meal, A는 수소원자 또는 저급알카노일기를 나타내고,A represents a hydrogen atom or a lower alkanoyl group, Z는 산소원자 또는 일반식의 기를 나타내고,Z is oxygen atom or general formula Represents a group of R은 수소원자 또는 저급알킬기를 나타내고,R represents a hydrogen atom or a lower alkyl group, X는 할로겐원자를 나타내고,X represents a halogen atom, R1은 저급알킬기를 나타낸다.]R 1 represents a lower alkyl group.] 식중 A가 수소원자인 하기 일반식(Ⅰ)의 화합물을 저급알카노일화 시킴을 특징으로하는 식중 A가 저급알카노일인 하기 일반식(Ⅰ)의 제조방법.A process for preparing general formula (I) below, wherein A is lower alkanoyl, characterized by lower alkanoylation of a compound of formula (I) wherein A is a hydrogen atom. [상기 식중,[In the above meal, A는 수소원자 또는 저급알카노일기를 나타내고,A represents a hydrogen atom or a lower alkanoyl group, Z는 산소원자 또는 일반식(R은 수소원자 또는 저급알킬기를 나타낸다)의 기를 나타내고,Z is oxygen atom or general formula (R represents a hydrogen atom or a lower alkyl group), X는 할로겐원자를 나타낸다.]X represents a halogen atom.] ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860001625A 1985-03-07 1986-03-07 Process for preparing 2-oxa or aza-pregmane compounds KR900006219B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP43732 1985-03-07
JP60043731A JPS61204198A (en) 1985-03-07 1985-03-07 2-oxa-pregnane compound
JP43731 1985-03-07
JP43731/85 1985-03-07

Publications (2)

Publication Number Publication Date
KR860007241A true KR860007241A (en) 1986-10-10
KR900006219B1 KR900006219B1 (en) 1990-08-25

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KR1019860001625A KR900006219B1 (en) 1985-03-07 1986-03-07 Process for preparing 2-oxa or aza-pregmane compounds

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JP (1) JPS61204198A (en)
KR (1) KR900006219B1 (en)

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* Cited by examiner, † Cited by third party
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EP3456729B1 (en) * 2016-05-11 2020-09-02 ASKA Pharmaceutical Co., Ltd. CRYSTALLINE POLYMORPH OF 15ß-HYDROXY-OSATERONE ACETATE
CN118286233A (en) 2019-10-02 2024-07-05 Aska制药株式会社 Urination disorder improving agent
WO2021065027A1 (en) 2019-10-02 2021-04-08 あすか製薬株式会社 Dysuria-alleviating agent
US20240041899A1 (en) 2020-12-18 2024-02-08 Aska Pharmaceutical Co., Ltd. Solid preparation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5421329A (en) * 1977-07-18 1979-02-17 Hitachi Ltd Control system for cameras

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KR900006219B1 (en) 1990-08-25
JPS61204198A (en) 1986-09-10
JPH0149358B2 (en) 1989-10-24

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