KR860002514A - Process for preparing cefem compound - Google Patents

Process for preparing cefem compound Download PDF

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Publication number
KR860002514A
KR860002514A KR1019840005388A KR840005388A KR860002514A KR 860002514 A KR860002514 A KR 860002514A KR 1019840005388 A KR1019840005388 A KR 1019840005388A KR 840005388 A KR840005388 A KR 840005388A KR 860002514 A KR860002514 A KR 860002514A
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KR
South Korea
Prior art keywords
compound
hydrogen
formula
carbon atoms
halogen
Prior art date
Application number
KR1019840005388A
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Korean (ko)
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KR870000725B1 (en
Inventor
2) 백원영(외
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이우용
동화약품공업 주식회사
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Application filed by 이우용, 동화약품공업 주식회사 filed Critical 이우용
Priority to KR1019840005388A priority Critical patent/KR870000725B1/en
Publication of KR860002514A publication Critical patent/KR860002514A/en
Application granted granted Critical
Publication of KR870000725B1 publication Critical patent/KR870000725B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세펨화합물의 제조방법Process for preparing cefem compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

구조식(Ⅳ)화합물의 존재하에 구조식(Ⅱ) 화합물과 구조식(Ⅲ)화합물을 반응시키고 통상의 방법으로 아미노보호기를 제거하여 구조식(Ⅰ)화합물을 제조하는 방법.A method for preparing a compound of formula (I) by reacting a compound of formula (II) with a compound of formula (III) in the presence of a compound of formula (IV) and removing an amino protecting group in a conventional manner. 상기식에서,R은 수소 또는 알카리금속이며, R1은 수소 또는 실릴기,R2는 탄소수 1-4의 저급알킬, R3은 수소 또는 중성조건하에 쉽게 제거될 수 있는 아미노보호기, X는 수소, 할로겐, 니트로, 탄소수 1-4의 저급알킬 또는 알콕시,Y는 할로겐, 또는(여기에서 X1은 할로겐 니트로, 탄소수 1-4의 저급알킬 또는 알콕시기이다)이다.Wherein R is hydrogen or an alkali metal, R 1 is hydrogen or silyl group, R 2 is lower alkyl of 1-4 carbon atoms, R 3 is hydrogen or aminoprotecting group which can be easily removed under neutral conditions, X is hydrogen, Halogen, nitro, lower alkyl or alkoxy of 1-4 carbon atoms, Y is halogen, or Wherein X 1 is halogen nitro, a lower alkyl or alkoxy group having 1 to 4 carbon atoms. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840005388A 1984-09-03 1984-09-03 Process for preparing cephem derivatives KR870000725B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840005388A KR870000725B1 (en) 1984-09-03 1984-09-03 Process for preparing cephem derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840005388A KR870000725B1 (en) 1984-09-03 1984-09-03 Process for preparing cephem derivatives

Publications (2)

Publication Number Publication Date
KR860002514A true KR860002514A (en) 1986-04-26
KR870000725B1 KR870000725B1 (en) 1987-04-09

Family

ID=19235278

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005388A KR870000725B1 (en) 1984-09-03 1984-09-03 Process for preparing cephem derivatives

Country Status (1)

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KR (1) KR870000725B1 (en)

Also Published As

Publication number Publication date
KR870000725B1 (en) 1987-04-09

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Date Code Title Description
G160 Decision to publish patent application
O035 Opposition [patent]: request for opposition

Free format text: OPPOSITION NUMBER: 001987000350001987000768; OPPOSITION DATE: 22111120