KR860001868B1 - Process for preparing 2'-deoxy-5-substituted uridine derivatives - Google Patents

Process for preparing 2'-deoxy-5-substituted uridine derivatives

Info

Publication number
KR860001868B1
KR860001868B1 KR8607839A KR860007839A KR860001868B1 KR 860001868 B1 KR860001868 B1 KR 860001868B1 KR 8607839 A KR8607839 A KR 8607839A KR 860007839 A KR860007839 A KR 860007839A KR 860001868 B1 KR860001868 B1 KR 860001868B1
Authority
KR
South Korea
Prior art keywords
deoxy
preparing
alkyl
uridine derivatives
methylbenzyl
Prior art date
Application number
KR8607839A
Other languages
Korean (ko)
Inventor
Setsuro Fujii
Setsuo Takeda
Tadahumi Terada
Junichi Yamashita
Hiroshi Matsumoto
Mitsugi Yasumoto
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58091190A external-priority patent/JPS59216899A/en
Priority claimed from JP58170149A external-priority patent/JPS6061593A/en
Priority claimed from JP58170147A external-priority patent/JPS6061591A/en
Priority claimed from KR1019840002789A external-priority patent/KR860001865B1/en
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to KR8607839A priority Critical patent/KR860001868B1/en
Application granted granted Critical
Publication of KR860001868B1 publication Critical patent/KR860001868B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uridine derivs. of formula (I) are new . In (I), R1 is H, PhCO or tetrahydrofuranyl; R2 is F or CF3; one of R3, R4 is H; and the other of R3, R4 is C1-10 alkyl, C2-6 alkenyl or benzyl opt. substd. by a halogen, C1-4 alkyl, C1-4 alkoxy or NO2, or C1-3 alkyl substd. by 1 or 2 Ph gps. 18 Compds. (I), including 2'-deoxy -5'-O-(2- methylbenzyl)-5-trifluoromethyluridine (Ia) and the corresp. 3- methylbenzyl compd. are claimed. (I) are antitumor agents with favourable therapeutic index valves. Dose is 0.1-2 g daily for an adult.
KR8607839A 1983-05-23 1986-09-17 Process for preparing 2'-deoxy-5-substituted uridine derivatives KR860001868B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR8607839A KR860001868B1 (en) 1983-05-23 1986-09-17 Process for preparing 2'-deoxy-5-substituted uridine derivatives

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP58091190A JPS59216899A (en) 1983-05-23 1983-05-23 2'-deoxy-5-trifluoromethyluridine derivative, its preparation, and antitumor agent containing it
JP58170149A JPS6061593A (en) 1983-09-14 1983-09-14 2'-deoxy-5-trifluoromethyluridine derivative and antitumor agent containing the same
JP58170147A JPS6061591A (en) 1983-09-14 1983-09-14 2'-deoxy-5-fluorouridine derivative, its preparation and antitumor agent containing the same
KR1019840002789A KR860001865B1 (en) 1983-05-23 1984-05-22 Process for preparing 2'-deoxy-5-substituted uridine derivatives
KR8607839A KR860001868B1 (en) 1983-05-23 1986-09-17 Process for preparing 2'-deoxy-5-substituted uridine derivatives

Publications (1)

Publication Number Publication Date
KR860001868B1 true KR860001868B1 (en) 1986-10-24

Family

ID=27525531

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8607839A KR860001868B1 (en) 1983-05-23 1986-09-17 Process for preparing 2'-deoxy-5-substituted uridine derivatives

Country Status (1)

Country Link
KR (1) KR860001868B1 (en)

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Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 19871224

Year of fee payment: 12

LAPS Lapse due to unpaid annual fee