KR860000689B1 - Method and device for pregnancy test of mammal - Google Patents

Abstract

This device is designed for testing the pregnancy possibility of a female mammal. The device comprises (a) an electro-probe for detecting the electro-chemical potential difference within the vagina according to the reduction and oxidation behavior of vaginal secretion which is affected by sexual hormones. And (b) a detector for amplifying the electric signals. An electro-probe having diameter, length, and shape suitable for insertion into vagina is made up of 2 electrodes, an anode and a cathode, consisting of metals which are different in electro-chemical potential. The 2 electrodes are insulated and are available in plastic bodies.

Description

Methods and apparatus for detecting fetuses likely to conceive

Figures exemplarily and schematically show the apparatus of the present invention.

* Explanation of symbols for main parts of the drawings

1: probe 2: detector

3: pillar electrode 4: peak electrode

5: ring-shaped zone 6: separation ring

7: connection cable 8: connection lead

9: differential voltage amplifier 10: indicator

A method of the kind described in the introduction (notice part) of Claim 1 of this invention.

Methods for determining the fecundity of cancers are very important. For example, in the case of gynecology, the issue of determining fertility exists for the purpose of contraception and raises the issues discussed recently in the chemical and mechanical practice of contraception. For female mammals such as, for example, cows and mares, there is a great economic interest in the precise time determination of the likelihood of conception, for example in the case of mare, just about 8 hours.

In the case of incorrect decisions, for example, significant mating costs are sometimes spent in vain.

Conventional methods for determining fertility, for example by long-term recording of basal temperature fluctuations, have always been found to be extremely inaccurate, especially considering periodic fluctuations in constitution and environmental conditions.

This has led to the need for a direct detection method. As a method of the kind mentioned at the outset, the measurement of the pH value of vaginal secretions is known. However, this kind of method presents several disadvantages. The pH measuring probes required are very complex and sensitive, and in particular complicated to operate. Moreover, the measurement results depend too much on various factors with marked individual dispersions.

Obvious measurement results can only be obtained with difficult and prolonged controlled measurements. This method was found to be inadequate for the purpose of obtaining measurement results that are obvious, rapid and independent of individual differences in the parent.

The object of the present invention is to create a method and apparatus of the kind described at the outset that enable more reliable and simple detection of fertility. This problem is solved according to the invention by the features of the characterizing part of claim 1.

The fertility period of female mammals, especially the monthly fertility period of a woman, is essentially consistent with ovulation.

Holmon's conceptional cycle is secreted by anterior pituitary gonadotropin that stimulates the ovary. In the first half of the menstrual cycle, follicular hormonal estrone continues, and in the middle of the cycle, luteal holmone progesterone is produced.

During the first half, estrone stimulates the development of follicles. Oocytes that develop in growing follicles finally grow. At this time, estrone is separated. In the middle of the menstrual cycle, the follicle drops the egg and then becomes the corpus luteum which is stimulated for the separation of progesterone through the progesterone. Progestron is thus predominant in the vagina in the middle of the menstrual cycle, while estrone is predominant in the early and late stages.

Thus, in the time range of ovulation, there is a sudden change in the state of sex and holiness, which affects different body tissues at different degrees. In particular, the mucous membrane of the cervix is sensitive. The secretions of the uterus and vagina that are encountered in the vagina are the cause of severe fluctuations in their chemical and in particular electrochemical properties based on this holmone variation.

The detection of this property variation of the secretions by measurement was found to be inadequate, as mentioned earlier. In many experiments, however, the secretion of secretions between oxidizing and reducing properties has been found to be consistent with the entry and exit thresholds at the time of conception, and in fact is essentially independent of other chemical variations in vaginal secretions. Determination of the intended to reduce properties was found to be extremely accurate for indications of fertility.

The method according to the invention makes it possible to apply very quickly, e.g. for a few seconds, through electrochemical preposition measurements and saves on costly chemical laboratory studies or long time measurement procedures.

볼트 내지 볼트 범위)의 전압차이가 나타나며 이 전압차이는 용액의 산화 내지 환원거동에 의존한다. 차이전압 증폭장치와 연결된 지시 계기를 가지고 전압변동은 대단히 빨리 그리고 정확히 검출된다. 이 장치 비용이 대단히 작게 유지되어질 수 있으며 그 결과 이런 종류의 장치는 대단히 근소한 제조비용이 들 것이다. 여기서 분비물의 임계이상의 변동의 경우에는 전극 사이의 차이 전압의 극성의 역전이 일어나며 이 역전은 특히 간단한 방법으로 검출되어질 수 있다. 이 경우에 전극은 청구범위 제3항에 따라서 유리하게는 금 내지 크롬으로 구성된다. 이 금속들은 높고 우수한 검출 능력이 있는 전위차와 우수한 생리적인 융화성에 의하여 뛰어난 것이다.An apparatus having advantages for the practice of the method according to the invention is characterized by the features of claim 2. If two metals at different positions in the electrical voltage train, that is, with different standard potentials, are placed in an aqueous solution, there is an easily measurable degree of magnitude between them (

A voltage difference (volts to volts) is shown, which depends on the oxidation or reduction behavior of the solution. With an indicator instrument connected to the differential voltage amplifier, the voltage change is detected very quickly and accurately. The cost of this device can be kept very small, and as a result, this type of device will have very little manufacturing cost. Here, in the case of variation above the threshold of secretion, an inversion of the polarity of the difference voltage between the electrodes occurs, and this inversion can be detected in a particularly simple manner. In this case the electrode is advantageously composed of gold to chromium according to claim 3. These metals are distinguished by their high and excellent detection potential and their excellent physiological compatibility.

The device according to this invention is more advantageously characterized by the features of claim 4. This type of transducer can be provided with a simple and sturdy structure to enter the vagina. In this case, the electrode is advantageously arranged in accordance with claim 5 so that the secretion is in the immediate vicinity of the entrance of the uterus, ie the strongest hormonal fluctuations, e.g. least affected by external influences such as urine or washing and least disturbed In such areas are measured secretion.

According to claim 6 this device is advantageously formed. In this structure, one electrode is arranged at the end in a distant position in rounding the transducer tip to the physiological advantage. Substantially free from the electrodes, almost ring-shaped regions of the transducer surface formed of an insulating material serve as electrical insulation of the two electrodes. The remaining near position area of the transducer surface is formed by the second electrode. This arrangement has been shown to be excellent in excluding disturbances in the external vaginal region in several experiments.

Finally, the device according to the invention is advantageously characterized by the features of claim 7. In this way, the transducer's heat capacity is kept to a very small extent, which results in its body getting back quickly without removing the maternal thermal sensation.

In the figure, the transducer 1 is shown together with the connected detector 2. This transducer 1 is composed of a cylindrical body having a diameter and a length corresponding to a vaginal shape. The end of the distant position is rounded in a nearly hemispherical shape. The reference electrode 3 and the peak electrode 4 are arrange | positioned on the probe surface. The peak electrode 4 covers the tip region of the transducer almost in a hemispherical shape. The pillar electrode 3 covers the entire transducer column up to the end of the near position.

A ring-shaped range (5) is advantageous between the two electrodes, which is formed from a highly insulating material, under which both the transducer body is advantageously composed of the insulating material. In an advantageous way, the electrodes 3 and 4 are formed as a thin layer on the solid plastic body, which is exposed in the insulating region 5. If a plastic body or thin metal layer is used, the heat capacity of the transducer is small. So this takes body temperature very quickly.

A separating ring 6 is arranged above the transducer, which is not shown but is arranged to be displaceable on the transducer and fixed in any position, for example by any tightening means based on friction. This separation ring allows the insertion depth of the transducer to be given in advance, and as a result, the correct insertion depth is guaranteed even with rapid use.

The electrodes 3 and 4 are in contact with the connecting cable 7, in which case the pole electrode 3 is in contact with the end of the near position and the peak electrode 4 is passing through the inside of the transducer. It is connected to the connecting cable through the cable.

The transducers 3 and 4 are made of different metals and these metals differ in terms of standard potential differences, that is, in terms of their position in the electrochemical potential sequence. Gold and chromium are particularly suitable, as detailed later on, which are suitable in terms of standard potential differences and do not need to be considered physiologically as well, i.e. harmful to tissue as may be the case with eg equally usable brass alloys. Does not cause.

The electrodes 3 and 4 are connected to the detector 2 via a connecting cable 7. Here they are coupled to the inlet of the differential voltage amplifier 9 and to the outlet of which the indicator 10 is connected. This may be configured as an analogue indicating indicator or as a digital display, for example, as shown. In the simplest case, two lamps with different colors may be provided, eg with a yes / no indication.

The appropriate choice of electrode material, for example the use of gold and chromium, is in the oxidative range in the case of chemical changes of vaginal discharge at this point in time of interest here at the beginning and end of the menstrual cycle. The change in properties occurs from the reducing range to the reversal of the polarity of the electrode, ie the sign fluctuation of the measured voltage. For this reason, the indicator 10 can advantageously set a zero point at the center of the scale as an indicator, whereby a state of positive or negative fertility is indicated through the amplitude from left to right in a particularly simple manner. .

This device according to the invention can thus be used with advantage for the measurement of advantageous time points for pregnancy and also for contraception. In the fluctuation of secretion from oxidative behavior to reducing behavior, it was measured that the holmone relationship, which acts for about 4 to 5 days, appeared about 15 days after pregnancy in the vagina. This instruction differs significantly from normal ovulation so that the resulting pregnancy can be measured. Since studies have shown that the precise temporal determination of fertilization in relation to the ovulation shape over time affects the likelihood of fertilization as a male sperm or female egg, a very accurate measure according to the invention of this time course is Will affect the probability of the baby's production.

In a manner not represented, the device according to the invention can be modified in relation to the electrode arrangement. A unique measurement result that can be detected very well is obtained as such an electrode arrangement in which one of the electrodes is provided at a remarkable distance from the electrode in which the electrodes are arranged only in the electrode arrangement. In this type of batch, chemical or electrochemical differences in vaginal secretions between the internal and external vagina are detected and this difference gives information about the likelihood of pregnancy in a characteristic way.

Complex electrode arrangements are also possible here.

In the far-end region of the transducer, two electrodes from different metals, such as gold and chromium, are arranged insulated from each other on the surface of the transducer, but the inside of the transducer is such that the electrodes are electrically connected to each other and coupled to the inlet of the measuring amplifier. This study was found to be particularly advantageous. This is again the same material, apart from the electrode array, through a larger insulating area, again with another double-electrode array consisting of gold and chromium, which are insulated from each other in a corresponding way and electrically connected to each other and to the other amplifier inlet. have.

Claims (7)

In a device for detecting fertility of a female mammal by measuring the oxidation and reduction behavior of vaginal secretions, the probe having a probe having two electrodes connected to a measurement amplifier, wherein both electrodes (3, 4) are remote from the probe. And the electrode is constructed from a metal which is arranged at an end region of the position and whose position in the electrochemical voltage train differs from the metal of the other electrode. 2. Device according to claim 1, characterized in that one of the electrodes is arranged at a position close to the other electrode to form a surface area (3) of the entire close position of the transducer. The device according to claim 1 or 2, wherein one of the electrodes covers the tip region of the far position of the transducer and is separated by an insulating region (5) into an electrode (3) of a close position. The transducer according to claim 3, wherein the remote electrode (4) forms a hemispherical surface of the transducer in a substantially hemispherical shape. Apparatus according to any one of the preceding claims, wherein both electrodes consist of gold and chromium. The transducer according to any one of the preceding claims, characterized in that the transducer (1) consists of an insulator which extends long and the electrodes (3, 4) are arranged at a distance (5) from each other on the surface of the transducer. Device according to claim 6, characterized in that the electrodes (3, 4) consist of a thin layer on the plastic body.

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