KR850008337A - Method for preparing (S) -alpha-ethyl-2-oxo-1-pyrrolidineacetamide - Google Patents

Method for preparing (S) -alpha-ethyl-2-oxo-1-pyrrolidineacetamide Download PDF

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KR850008337A
KR850008337A KR1019850003323A KR850003323A KR850008337A KR 850008337 A KR850008337 A KR 850008337A KR 1019850003323 A KR1019850003323 A KR 1019850003323A KR 850003323 A KR850003323 A KR 850003323A KR 850008337 A KR850008337 A KR 850008337A
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South Korea
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oxo
alpha
ethyl
group
formula
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KR1019850003323A
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Korean (ko)
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KR920003818B1 (en
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고버트(외 3) 쟝
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레이몬드 두셀도르프
유 시 비 에스. 에이
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Priority claimed from GB848412357A external-priority patent/GB8412357D0/en
Priority claimed from GB848412358A external-priority patent/GB8412358D0/en
Application filed by 레이몬드 두셀도르프, 유 시 비 에스. 에이 filed Critical 레이몬드 두셀도르프
Publication of KR850008337A publication Critical patent/KR850008337A/en
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Publication of KR920003818B1 publication Critical patent/KR920003818B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

내용 없음No content

Description

(S)-알파-에틸-2-옥소-1-피롤리딘 아세트 아미드의 제조방법Method for preparing (S) -alpha-ethyl-2-oxo-1-pyrrolidine acetamide

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (10)

(R)-알파-에틸-2-옥소-1-피롤리딘 아세트 아미드.(R) -alpha-ethyl-2-oxo-1-pyrrolidine acetamide. (R)-알파-에틸-2-옥소-1-피롤리딘 아세틱을 연속적으로 (1) Hal이 할로겐원자를 나타내고 2가 1에서 4의 탄소수를 가지는 알킬기를 나타내는 일반식 HalCOOZ의 알킬 할로포름 에이트와, (2) 암모니아와 반응시킴을 특징으로 하는 (R)-알파-에틸-2-옥소-1-피롤리딘 아세트 아미드의 제조방법.(R) -alpha-ethyl-2-oxo-1-pyrrolidine acetic acid in series (1) alkyl haloform of the general formula HalCOOZ in which Hal represents a halogen atom and an alkyl group having divalent 1 to 4 carbon atoms And (2) a method for producing (R) -alpha-ethyl-2-oxo-1-pyrrolidine acetamide. 일반식 (A)의 (R)-2-아미노-부탄아미드를 불활성 용매 중에서와 염기성 물질의 존재하에서 고리화시킴을 특징으로 하는 (R)-알파-에틸-2-옥소-1-피롤리딘 아세트 아미드의 제조방법 :(R) -alpha-ethyl-2-oxo-1-pyrrolidine, characterized by cyclization of (R) -2-amino-butanamide of formula (A) in an inert solvent and in the presence of a basic substance Process for the preparation of acetamide: X-CH2CH2-Y-NHCH(C2H5)CONH2(A)X-CH 2 CH 2 -Y-NHCH (C 2 H 5 ) CONH 2 (A) 상기식에서 X가 ZOOC-또는 HalCH2-기를 나타내며, Z가 1에서 4의 탄소수를 가지는 알킬기이고, Hal은 할로겐원자이며, 그리고 Y가 -CH2- 또는 -CO- 기를 나타내지만, 단 X가 ZOOC-기를 나타낼 때 Y는 -CO-기이며, X가 HalCH2-기를 나타낼 때 Y는 -CO-기를 나타내는 조건에서이다.Wherein X represents a ZOOC- or HalCH 2 -group, Z is an alkyl group having 1 to 4 carbon atoms, Hal is a halogen atom, and Y represents a -CH 2 -or -CO- group, provided that X represents ZOOC Y represents a -CO- group when representing a-group, and Y is under conditions representing a -CO- group when X represents a HalCH 2 -group. 상기 3항에 있어서, 일반식(A)의 화합물은 일반식 ZOOCCH2CH2NHCH (C2H5)CONH2의 알킬 (R)-4[[1-(아미노카르보닐)프로필]아미노]-부티레이트이고 (R)-2-아미노-부탄아미드를 일반식 ZOOCCH2CH2Hal의 알킬 4-할로부티레이트로서 응축하여 얻음을 특징으로 하는 상기의 화합물 및 제조방법. 여기서 2는 상기 3항과 같은 의미를 가지고 Hal은 할로겐원자이다.The compound of formula (A) according to claim 3, wherein the compound of formula (A) is alkyl (R) -4 [[1- (aminocarbonyl) propyl] amino]-of formula ZOOCCH 2 CH 2 NHCH (C 2 H 5 ) CONH 2 . And (R) -2-amino-butanamide, obtained by condensation as alkyl 4-halobutyrate of the general formula ZOOCCH 2 CH 2 Hal. Where 2 has the same meaning as in paragraph 3 above and Hal is a halogen atom. 상기 3항에 있어서, 일반식(A)의 화합물은 일반식 HalCH2CH2CH2CONHCH (C2H5)CONH의 (R)-N-[1-아미노카르보닐)프로필]-4-할로부탄아미드이고 (R)-2-아미노-부탄아미드를 일반식 HalCH2CH2CH2COHal의 4-할로부티릴 할라이드로서 응축하여 얻음을 특징으로 하는 상기의화합물 및 제조방법 : 여기서 Hal은 할로겐 원자이다.The compound of formula (A) is (R) -N- [1-aminocarbonyl) propyl] -4-halo of formula HalCH 2 CH 2 CH 2 CONHCH (C 2 H 5 ) CONH Wherein said compound is obtained by condensation of (R) -2-amino-butanamide as 4-halobutyryl halide of the general formula HalCH 2 CH 2 CH 2 COHal, wherein Hal is a halogen atom to be. 치료상으로 유효한 양의 (R)-알파-에틸-2-옥소-1-피롤리딘아세트아미드와 약제학적으로 수용 가능한 고체 또는 액체 희석제 또는 그 대신에 중량제를 포함하는 약제학적 조성물.A pharmaceutical composition comprising a therapeutically effective amount of (R) -alpha-ethyl-2-oxo-1-pyrrolidineacetamide and a pharmaceutically acceptable solid or liquid diluent or instead a weight agent. 기억력 손상의 치료를 필요로 하는 환자의 치료 방법에 있어서, 유효한 양의 (R)-알파-에틸-2-옥소-1-피롤리딘아세트 아미드를 상기 환자에게 투여함을 특징으로 하는 상기의 치료방법.A method of treatment of a patient in need of treatment of memory impairment, wherein the effective amount of (R) -alpha-ethyl-2-oxo-1-pyrrolidineacetamide is administered to the patient. Way. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850003323A 1984-05-15 1985-05-15 (r)-alpha-ethyle-2-oxo-1-pyrrolidineace KR920003818B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB84/12358 1984-05-15
GB848412357A GB8412357D0 (en) 1984-05-15 1984-05-15 Pharmaceutical composition
GB12358/84 1984-05-15
GB848412358A GB8412358D0 (en) 1984-05-15 1984-05-15 Pharmaceutical composition

Publications (2)

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KR850008337A true KR850008337A (en) 1985-12-16
KR920003818B1 KR920003818B1 (en) 1992-05-15

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