KR850007797A - N- (3-phenylbemelthio-1-oxopropyl) amino acetic acid derivative, its preparation and pharmaceutical composition comprising the same - Google Patents

N- (3-phenylbemelthio-1-oxopropyl) amino acetic acid derivative, its preparation and pharmaceutical composition comprising the same Download PDF

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Publication number
KR850007797A
KR850007797A KR1019850002634A KR850002634A KR850007797A KR 850007797 A KR850007797 A KR 850007797A KR 1019850002634 A KR1019850002634 A KR 1019850002634A KR 850002634 A KR850002634 A KR 850002634A KR 850007797 A KR850007797 A KR 850007797A
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KR
South Korea
Prior art keywords
group
compound
acid
formula
acid derivative
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Application number
KR1019850002634A
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Korean (ko)
Inventor
코마몬드 작크 (외 2)
Original Assignee
에 뚜레-레메뜨르
신 떼라보
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Application filed by 에 뚜레-레메뜨르, 신 떼라보 filed Critical 에 뚜레-레메뜨르
Publication of KR850007797A publication Critical patent/KR850007797A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

내용 없음No content

Description

N-(3-페닐베멜티오-1-옥소프로필) 아미노 아세트산 유도체, 그의 제법 및 그를 포함하는 의약조성물N- (3-phenylbemelthio-1-oxopropyl) amino acetic acid derivative, its preparation and pharmaceutical composition comprising the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

일반식(II)Formula (II) 의 할로겐화 유도체를 메르캅토프로피온산과 반응시키는 단계와, 일반식(III)Reacting the halogenated derivative of mercaptopropionic acid with the general formula (III) 의 얻어진 산을 염화티오닐과 반응시켜 일반식(IV)The acid obtained is reacted with thionyl chloride to give the general formula (IV) 의 산염화물을 얻는 단계, 그리고 산염화물(IV)을 일반식의 아미노산과 반응시키는 단계,Obtaining an acid chloride, and converting acid chloride (IV) Reacting with an amino acid of, 이어서, 원한다면 이와 같이 얻은 일반식(I)Then, if desired, the general formula (I) thus obtained 의 화합물을 치환기 R1을 변경시킴으로써 다른 화합물(I)로 전환시키는 단계, 그리고 선택적으로 화합물(I)을 염기와의 반응에 의해서 염으로 또한 전환시키는 단계로 이루어지는 것을 특징으로 하는 일반식(I)의 화합물인 아미노아세트산 유도체 또는 약리학상 허용되는 그의 염의 제조방법.Formula (I), which comprises converting a compound of to a different compound (I) by changing the substituent R 1 and optionally converting the compound (I) to a salt by reaction with a base. A method for producing an aminoacetic acid derivative or a pharmacologically acceptable salt thereof, which is a compound of. 상기 (I), (II) 및 (III)식에서 R1은 하나 또는 두 개의 할로겐원자, 하나 또는 2개의 메틸기, 트리플루오로메틸, 메톡시, 시아노, 니트로, 카바모일, 또는 벤조일기, 축합된 벤조핵을 나타내고 또는 R2가 (3-인돌릴)메틸 또는 2-메틸티오에틸기일때는 R1은 또한 수소원자일 수 있으며, R2는 수소원자 또는 직쇄 또는 분기상 C1-4알킬기, 카바모일매틸 또는 2-카바모일에틸기, 2-메틸티오에틸기, 선택적으로 히드록실화된 벤질기 또는 (3-인돌릴)메틸기를 나타낸다.In formulas (I), (II) and (III), R 1 is one or two halogen atoms, one or two methyl groups, trifluoromethyl, methoxy, cyano, nitro, carbamoyl, or benzoyl group, condensation R 1 may also be a hydrogen atom when R 2 represents a (3-indolyl) methyl or 2-methylthioethyl group, R 2 may be a hydrogen atom or a straight or branched C 1-4 alkyl group, Carbamoylmethyl or 2-carbamoylethyl group, 2-methylthioethyl group, optionally hydroxylated benzyl group or (3-indolyl) methyl group. 제1항에 있어서, R1은 2위치의 염소원자를 나타내거나 또는 4-위치의 시아노 또는 카바모일기를 나타내는 것을 특징으로 하는 아미노아세트산 유도체의 제조방법.The method for producing an aminoacetic acid derivative according to claim 1, wherein R 1 represents a chlorine atom at 2-position or a cyano or carbamoyl group at 4-position. 제1항 또는 제2항에 있어서, R2는 수소원자 또는 1-메틸프로필기를 나타내는 것을 특징으로 하는 아미노아세트산 유도체의 제조방법.The method for producing an aminoacetic acid derivative according to claim 1 or 2, wherein R 2 represents a hydrogen atom or a 1-methylpropyl group. 제1항, 제2항 또는 제3항에 있어서, 수성염기매제내에서 식(II)의 화합물을 메르캅토프로피온산과 반응시키고 식(IV)의 화합물을 아미노산과 반응시키는 것을 특징으로 하는 아미노아세트산 유도체의 제조방법.The aminoacetic acid derivative according to claim 1, 2 or 3, wherein the compound of formula (II) is reacted with mercaptopropionic acid and the compound of formula (IV) is reacted with an amino acid in an aqueous base. Manufacturing method. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850002634A 1984-04-19 1985-04-18 N- (3-phenylbemelthio-1-oxopropyl) amino acetic acid derivative, its preparation and pharmaceutical composition comprising the same KR850007797A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8406200A FR2563218B1 (en) 1984-04-19 1984-04-19 N - ((CHLORO-2 PHENYL) METHYLTHIO-3 OXO-1 PROPYL) -AMINOACETIC ACID DERIVATIVES SUBSTITUTED IN A, THEIR PREPARATION AND THERAPEUTIC APPLICATION
FR84/6200 1984-04-19

Publications (1)

Publication Number Publication Date
KR850007797A true KR850007797A (en) 1985-12-09

Family

ID=9303310

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850002634A KR850007797A (en) 1984-04-19 1985-04-18 N- (3-phenylbemelthio-1-oxopropyl) amino acetic acid derivative, its preparation and pharmaceutical composition comprising the same

Country Status (4)

Country Link
JP (1) JPS60233053A (en)
KR (1) KR850007797A (en)
FR (1) FR2563218B1 (en)
ZA (1) ZA852923B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS535112A (en) * 1976-03-08 1978-01-18 Santen Pharmaceutical Co Ltd New cysteine derivatives
IT1111384B (en) * 1978-12-21 1986-01-13 Sigma Tau Ind Farmaceuti GUAIACYL ESTERS OF MERCAPTOPROPIONIC ACID DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND THERAPEUTIC USE

Also Published As

Publication number Publication date
JPS60233053A (en) 1985-11-19
ZA852923B (en) 1985-11-27
FR2563218B1 (en) 1986-06-20
FR2563218A1 (en) 1985-10-25

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