KR850006195A - 4- (5-Chloro-2-oxobenzimidazolin-1-yl) -1- [3- (2-oxobenzimidazolin-1-yl) propyl] -piperidine and its salt - Google Patents

4- (5-Chloro-2-oxobenzimidazolin-1-yl) -1- [3- (2-oxobenzimidazolin-1-yl) propyl] -piperidine and its salt Download PDF

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Publication number
KR850006195A
KR850006195A KR1019840001162A KR840001162A KR850006195A KR 850006195 A KR850006195 A KR 850006195A KR 1019840001162 A KR1019840001162 A KR 1019840001162A KR 840001162 A KR840001162 A KR 840001162A KR 850006195 A KR850006195 A KR 850006195A
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KR
South Korea
Prior art keywords
oxobenzimidazolin
chloro
piperidine
propyl
following structural
Prior art date
Application number
KR1019840001162A
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Korean (ko)
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KR860000590B1 (en
Inventor
원용인
Original Assignee
김덕기
근화제약 주식회사
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Priority to KR1019840001162A priority Critical patent/KR860000590B1/en
Publication of KR850006195A publication Critical patent/KR850006195A/en
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Publication of KR860000590B1 publication Critical patent/KR860000590B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

내용 없음No content

Description

4-(5-클로로-2-옥소벤즈이미다졸린-1-일)-1-[3-(2-옥소벤즈이미다졸린-1-일)프로필]-피페리딘 및 그 염의 제조방법4- (5-Chloro-2-oxobenzimidazolin-1-yl) -1- [3- (2-oxobenzimidazolin-1-yl) propyl] -piperidine and its salt

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

다음 구조식(Ⅱ)의 4-(5-클로로-2-옥소벤즈이미다졸린-1-)일피페리딘을 다음 구조식(Ⅲ)의 에피클로로하이드린과 반응시켜서 얻어진 다음 구조식(Ⅳ)의 4-(5-클로로-2-옥소벤즈이미다졸린-1-일)-1-(2-하이드록시-3-클로로프로필)-피페리딘을 산수용체의 존재하에 다음 구조식(Ⅴ)의 2-옥소벤즈이미다졸린과 반응시키고, 얻어진 다음 구조식(Ⅳ)의 4-(5-클로로-2-옥소벤즈이미다졸린-1-일)-1-[2-하이드록시-3-(2-옥소벤즈이미다졸린-1-일)프로필]피페리딘을 탈수제의 존재하에 탈수시킨 중간체를 접촉 환원시켜서 다음 구조식(I)의 4-(5-클로로-2-옥소벤즈이미다졸린-1-일)-1-[3-(2-옥소벤즈이미다졸린-1-일)프로필]피페리딘을 제조하는 방법.4- (5-chloro-2-oxobenzimidazolin-1-) ylpiperidine of the following structural formula (II) is reacted with epichlorohydrin of the following structural formula (III) to obtain 4- of the following structural formula (IV) 2- (5-chloro-2-oxobenzimidazolin-1-yl) -1- (2-hydroxy-3-chloropropyl) -piperidine in the presence of an acid acceptor Reacted with benzimidazolin and obtained 4- (5-chloro-2-oxobenzimidazolin-1-yl) -1- [2-hydroxy-3- (2-oxobenz) of the following structural formula (IV): 4- (5-chloro-2-oxobenzimidazol-1-yl) of the formula (I) by contact reduction of an imidazolin-1-yl) propyl] piperidine dehydrated in the presence of a dehydrating agent A process for preparing -1- [3- (2-oxobenzimidazolin-1-yl) propyl] piperidine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840001162A 1984-03-08 1984-03-08 Process for preparing 4-(5-chloro-2-oxobenzimidazolin-1-yl)-1-(3-(2-oxobenzimidazolin-1-yl)propyl)-piperidine and salts thereof KR860000590B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840001162A KR860000590B1 (en) 1984-03-08 1984-03-08 Process for preparing 4-(5-chloro-2-oxobenzimidazolin-1-yl)-1-(3-(2-oxobenzimidazolin-1-yl)propyl)-piperidine and salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840001162A KR860000590B1 (en) 1984-03-08 1984-03-08 Process for preparing 4-(5-chloro-2-oxobenzimidazolin-1-yl)-1-(3-(2-oxobenzimidazolin-1-yl)propyl)-piperidine and salts thereof

Publications (2)

Publication Number Publication Date
KR850006195A true KR850006195A (en) 1985-10-02
KR860000590B1 KR860000590B1 (en) 1986-05-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001162A KR860000590B1 (en) 1984-03-08 1984-03-08 Process for preparing 4-(5-chloro-2-oxobenzimidazolin-1-yl)-1-(3-(2-oxobenzimidazolin-1-yl)propyl)-piperidine and salts thereof

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KR (1) KR860000590B1 (en)

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Publication number Publication date
KR860000590B1 (en) 1986-05-17

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Free format text: OPPOSITION NUMBER: 001986001231; OPPOSITION DATE: 19860716