KR850006179A - Method for preparing D-α- (4-hydroxy-6-methylnicotinamido) -4-hydroxyphenyl acetic acid - Google Patents

Method for preparing D-α- (4-hydroxy-6-methylnicotinamido) -4-hydroxyphenyl acetic acid Download PDF

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Publication number
KR850006179A
KR850006179A KR1019840001589A KR840001589A KR850006179A KR 850006179 A KR850006179 A KR 850006179A KR 1019840001589 A KR1019840001589 A KR 1019840001589A KR 840001589 A KR840001589 A KR 840001589A KR 850006179 A KR850006179 A KR 850006179A
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South Korea
Prior art keywords
hydroxy
formula
amine
methylnicotinamido
acylating agent
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KR1019840001589A
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Korean (ko)
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KR860001026B1 (en
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1) 김완주(외
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전학제
한국과학기술원
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Priority to KR1019840001589A priority Critical patent/KR860001026B1/en
Publication of KR850006179A publication Critical patent/KR850006179A/en
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Publication of KR860001026B1 publication Critical patent/KR860001026B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음No content

Description

D-α-(4-히드록시-6-메틸니코틴아미도)-4-히드록시페닐 초산의 제조방법Method for preparing D-α- (4-hydroxy-6-methylnicotinamido) -4-hydroxyphenyl acetic acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (10)

다음 구조식(Ⅵ)의 4-히드록시-6-메틸니코틴산과 다음 구조식(Ⅲ)의 4-히드록시 페닐글리신 및 그 유도체를 반응시킴에 있어서, 유기 용매중에서 아민 존재하에 구조식(Ⅶ)의 아실화제를 사용하여 아실화시키는 것을 특징으로 하는 다음 구조식(I)의 D-α-(4-히드록시-6-메틸니코틴아미도)-4-히드록시페닐 초산의 제조 방법.In reacting 4-hydroxy-6-methylnicotinic acid of formula (VI) with 4-hydroxy phenylglycine of formula (III) and derivatives thereof, acylating agent of formula (VIII) in the presence of an amine in an organic solvent A method for producing D-α- (4-hydroxy-6-methylnicotinamido) -4-hydroxyphenyl acetic acid of the following structural formula (I), characterized in that it is acylated by using: 상기 구조식 R는 벤조트리아졸릴기 및 피리딜기이고, R′는 수소, 메틸기, 또는 에틸기이며, n은 1 또는 2의 정수이다.R is a benzotriazolyl group and a pyridyl group, R 'is a hydrogen, a methyl group, or an ethyl group, n is an integer of 1 or 2. 제1항에 있어서, 용매가 N,N-디메틸아세트아미드, N-메틸-2-피롤리돈, 디클로로메탄, 클로로포름, 아세토니트릴 메트라히드로푸탄 및 디옥산 중에서 선택되는 것이 특징인 방법.The method of claim 1 wherein the solvent is selected from N, N-dimethylacetamide, N-methyl-2-pyrrolidone, dichloromethane, chloroform, acetonitrile methrahydroputane and dioxane. 제2항에 있어서, 용매가 N,N-디메틸포름아미드 또는 M-N,-디메틸아세트아미드인 것이 특징인 방법.The method according to claim 2, wherein the solvent is N, N-dimethylformamide or M-N, -dimethylacetamide. 제1항에 있어서, 아민이 피리딘, 트리에틸아민, 트리-n-부틸아민, N,N-디메틸아닐린 및 N,N-디메틸아미노피리딘 중에서 선택되는 것이 특징인 방법.The method of claim 1 wherein the amine is selected from pyridine, triethylamine, tri-n-butylamine, N, N-dimethylaniline and N, N-dimethylaminopyridine. 제4항에 있어서, 아민이 피리딘인 것이 특징인 방법.The method of claim 4 wherein the amine is pyridine. 제1항에 있어서, 아실화제가 1,1′-(카르보닐디옥시) 디벤조트리아졸, 1,1′-디벤조트리아졸로옥살레이트 및 디-2-피리딜카르보네이트 중에서 선택되는 것이 특징인 방법.The acylating agent of claim 1, wherein the acylating agent is selected from 1,1 '-(carbonyldioxy) dibenzotriazole, 1,1'-dibenzotriazolooxalate and di-2-pyridylcarbonate Characteristic method. 제1항에 있어서, 아실화 반응이 실온에서 2-5시간 진행되는 것이 특징인 방법.The method of claim 1, wherein the acylation reaction proceeds at room temperature for 2-5 hours. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840001589A 1984-03-27 1984-03-27 Process for preparation of d- -(4-hydroxy-6-methyl nicotinic amido)-4-hydroxy phenyl acetic acid KR860001026B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840001589A KR860001026B1 (en) 1984-03-27 1984-03-27 Process for preparation of d- -(4-hydroxy-6-methyl nicotinic amido)-4-hydroxy phenyl acetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840001589A KR860001026B1 (en) 1984-03-27 1984-03-27 Process for preparation of d- -(4-hydroxy-6-methyl nicotinic amido)-4-hydroxy phenyl acetic acid

Publications (2)

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KR850006179A true KR850006179A (en) 1985-10-02
KR860001026B1 KR860001026B1 (en) 1986-07-28

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Application Number Title Priority Date Filing Date
KR1019840001589A KR860001026B1 (en) 1984-03-27 1984-03-27 Process for preparation of d- -(4-hydroxy-6-methyl nicotinic amido)-4-hydroxy phenyl acetic acid

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KR860001026B1 (en) 1986-07-28

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