KR850002975A - Method for preparing imidazoline derivative - Google Patents

Method for preparing imidazoline derivative Download PDF

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Publication number
KR850002975A
KR850002975A KR1019840006390A KR840006390A KR850002975A KR 850002975 A KR850002975 A KR 850002975A KR 1019840006390 A KR1019840006390 A KR 1019840006390A KR 840006390 A KR840006390 A KR 840006390A KR 850002975 A KR850002975 A KR 850002975A
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KR
South Korea
Prior art keywords
formula
iii
ester
imidazoline derivative
alkyl
Prior art date
Application number
KR1019840006390A
Other languages
Korean (ko)
Inventor
빅 데니스 (외 2)
Original Assignee
에 뚜레-레메뜨르
신뜨라보
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8316474A external-priority patent/FR2553416B3/en
Priority claimed from FR8401997A external-priority patent/FR2559485B2/en
Application filed by 에 뚜레-레메뜨르, 신뜨라보 filed Critical 에 뚜레-레메뜨르
Publication of KR850002975A publication Critical patent/KR850002975A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

이미다졸린 유도체의 제조방법Method for preparing imidazoline derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음 일반식(Ⅱ)의 에스테르를 환원시켜 다음 일반식(Ⅲ)의 에스테르를 얻고, 다음에 R이 C1내지 C3알킬이나 알릴인 일반식(Ⅰ)의 이미다졸린 유도체를 얻고져하는 경우에는 일반식(Ⅲ)의 에스테르를 리튬디이소푸로필아미드와 일반식 RY의 화합물과 반응시킴으로서 에스테르(Ⅲ)를 알킬화하여 일반식(Ⅳ)의 화합물을 얻고, 최종적으로 일반식(Ⅲ) 또는 (Ⅳ)의 화합물을 트리메틸알루미늄의 존재하에 에틸렌디아민과 함께 반응시키고, 요구에 따라서는 생성되는 이미다졸린유도체(Ⅰ)을 약학적으로 유용한 산부가염으로 전환시킴을 특징으로 하는 다음 일반식(Ⅰ)의 이미다졸린유도체(Ⅱ)와 약학적으로 유용한 그의 산부가염을 대장체가 또는 그의 혼합물의 형태로 제조하는 방법.When the ester of the following general formula (II) is reduced to obtain an ester of the following general formula (III), and then an imidazoline derivative of the general formula (I) wherein R is C 1 to C 3 alkyl or allyl is obtained. In (III), the ester of formula (III) is reacted with lithium diisofurofilamide and a compound of formula RY to alkylate ester (III) to obtain a compound of formula (IV), and finally to formula (III) or ( The compound of formula IV) is reacted with ethylenediamine in the presence of trimethylaluminum, and if necessary, the resulting imidazoline derivative (I) is converted into a pharmaceutically useful acid addition salt. A method for preparing an imidazoline derivative (II) of pharmaceutically acceptable acid addition salt thereof in the form of a colon or mixture thereof. 상기식에서, n은 1 또는 2이고, R은 C1내지 C3알킬 또는 알릴이며, X는 수소, 할로겐, 메틸 또는 메톡시이고, R'는 C1내지 C4알킬이며, Y는 불안정한 기이다.Wherein n is 1 or 2, R is C 1 to C 3 alkyl or allyl, X is hydrogen, halogen, methyl or methoxy, R 'is C 1 to C 4 alkyl and Y is an unstable group . 제1항에 있어서, R은 수소이거나 메틸이고, X는 수소나 플루오르이며, 염이 생성되는 경우에는 푸마산염인것을 특징으로 하는 방법.The method of claim 1 wherein R is hydrogen or methyl, X is hydrogen or fluorine, and fumarate when a salt is produced. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840006390A 1983-10-17 1984-10-16 Method for preparing imidazoline derivative KR850002975A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR83/16474 1983-10-17
FR8316474A FR2553416B3 (en) 1983-10-17 1983-10-17 PYRROLO-QUINOLINE DERIVATIVE, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS
FR84/01997 1984-02-09
FR8401997A FR2559485B2 (en) 1984-02-09 1984-02-09 PYRROLO-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
KR850002975A true KR850002975A (en) 1985-05-28

Family

ID=55970581

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840006390A KR850002975A (en) 1983-10-17 1984-10-16 Method for preparing imidazoline derivative

Country Status (1)

Country Link
KR (1) KR850002975A (en)

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