KR850001299B1 - Process for preparing novel plasters - Google Patents

Abstract

Plasters for treatment of skin inflammations consist of a thermoplastic elastomer (100), an oil or higher fatty acid (25-370), an adhesive resin or rosin (25-200), and a medicinal component (0.09- 110 parts by wt.). The compsn. is spread onto a carrier and covered with a removable material. Thus, 100 parts isoprene-styrene block copolymer (Cariflex TR 1107), 125 parts liq. paraffin, and 125 parts of hydrogenated rosin acid ester were melted at 130-70≰C under N. The melt was cooled to < 150≰C and mixed with 0.3336 part flurandolenoride in 10 parts sorbitol trioleate. The plaster was effective in treatment of carrageenaninduced skin edema in rats.

Description

Manufacturing method of new patch

TECHNICAL FIELD The present invention relates to a method for producing a patch made of a thermoplastic elastomer made to be directly attached to a skin affected area. More specifically, the present invention relates to a method for producing a patch, characterized in that the drug substance is added to a mixture of a thermoplastic elastomer, a fat or oil or a higher fatty acid tackifying resin and applied to the support using an applicator. Conventionally, as a base of the patch, it is generally known to use a rubber used for a band-aid and an acrylic adhesive.

However, these patches are generally excellent in adhesiveness and adhesiveness at the time of application, but they are not desirable to pull the hair, physically hurt or pull the skin due to its adhesiveness at the time of peeling. In view of the poor phenomena, it has been desired to apply the attachment drug that can ease the qualification and easily peel off the hair and skin during peeling without any problem in adhesiveness and adhesiveness at the time of peeling.

MEANS TO SOLVE THE PROBLEM The present inventors made many experiments after the various research in order to provide the manufacturing method of the patch which satisfy | fills the above demands, and as a result of many experiments, a thermoplastic elastomer is melt | dissolved in a fatty acid or a higher fatty acid, and a tackifying resin and an active ingredient are prepared. By blending and spreading this on a support, the electrical requirements can be completely satisfied, and the present invention has been completed.

In addition, as an example of using a thermoplastic elastomer as a gas, as disclosed in Japanese Patent Application Publication No. 44-17037, an adhesive composition using a block copolymer of only ABA type has been publicly disclosed. Pressure-sensitive tapes, such as masking tapes, adhesive thin plates, other coatings for adhesives, adhesive tapes, repair tapes, electrical insulating tapes, laminates, hot melt adhesives, lime plaster, cement, high kin compounds, binders, sealants, etc. It relates only to adhesive compositions useful only in applications such as pressure sensitive adhesives, slow release adhesives, adhesive latexes, sole adhesives, rug backings, etc., and this has never been disclosed for use in medicine or as a patch. There was no description suggesting this.

Next, the electric thermoplastic elastomer and other components will be described in more detail.

The thermoplastic elastomer, which is the main base component of the patch obtained according to the present invention, is a block copolymer as general ABA or (AB) nX (wherein A is substantially a monovinyl substituted aromatic compound block, B is a substantially conjugated diolefin polymer block, n represents an integer of 3 to 7, X represents a residue derived from a multifunctional compound to which n polymer chains AB are bound], and a tere block copolymer and a lady tereblock copolymer and a mixture thereof do.

Styrene, O- or P-vinyl toloene, methyl styrene, ethyl styrene etc. are mentioned as said monovinyl substituted aromatic compound. Moreover, 1, 3- butadiene, 1, 3- pentadiene, isoprene etc. are mentioned as conjugated diolefin. Particularly preferred combinations are styrene and 1,3-butadiene, styrene and isoprene.

Block A, a polymer of styrene, is an inelastic thermoplastic hard polymer with a glass transition temperature above room temperature, and block B, a polymer of isoprene or butadiene, is an elastomer with glass transition temperature below room temperature.

Terminal block A of the block copolymer is generally 10 to 50% of the total weight.

Next, the fats and oils and fatty acids used as a component of the patch obtained by this invention are demonstrated.

Fatty or higher fatty acids useful in the practice of the present invention should be the solvent of the elastic block B of the polymer, but not the solvent of the block A. Examples of the solvent of the block B include tonsil oil, olive oil, camellia oil, bark oil, peanut oil, sesame oil, soybean oil, mink oil, cottonseed oil, corn oil, sunflower oil, palm oil, pimaji oil, oleic acid, liquid paraffin, and the like. However, it is preferable to use tonsil oil, olive oil, camellia oil, via oil, peanut oil, oleic oil, liquid paraffin, and the like.

The patch obtained by the present invention has the ideal characteristics as a patch as described above, but in order to do so, it is necessary to add a tackifying resin in addition to the electrical component. As a tackifier, rosin, dehydrogen rosin, glycerin esters of dehydrogen rosin, glycerin esters of gum rosin, hydrogenated rosin, glycerin esters of hydrogenated rosin, pentaerythrates of hydrogenated rosin, esters, methyl esters of hydrogenated rosin, Polymerized rosin, glycerin esters of polymerization loins, coumarin indene resins, hydrogenated petroleum resins, maleic anhydride modified rosin, rosin derivatives, C ₅ petroleum resins, partial esters of styrene-maleic acid copolymers, and the like. About the adhesive force of the desired adhesive force by a sticking part, it is used suitably by single or a combination with them.

Next, as a compounding agent which is an active ingredient of the patch, methyl salicylate, salicylic acid glycol, salicylic acid, mentorol, peppermint oil, camphor, thymol, acriol, belladonnax, maleic acid chloroperniamine, diphenhydramine, nicotinic acid benzyl ester , Red pepper extract, nonylic acid vanillylamide, capsaicin or ippropene, indomesacin, alcoholofenac, ketoprofen, probiprofen, phenofene, flafenamic acid, nipric acid, indopropene, formic acid Darren, naproquicene, glycanak, tolumethine, sprophene, benzadak and their esters, corticosteroids and the like are used alone or in combination with them. In addition, as steroids, cortisone acetate, hard gortiszoan, hydrocortisone acetate, gaproic acid hydrocortisone, prednisolone, prednisolone, prednisolone, methyl prednisolone, methyl prednisolone acetate, triamcinolone acetide, texa Meta-joint, texacetajoin, texasetajoin, sodium phosphate, beta-meta-join, beta-metajounic acid disodium, valeric acid-beta-join, flandrenolone acetide, fluosinolone acetide, propionate beclomethazoon, phi Divergent plemethazone, harsinoid, beta meta 17,21-dipropionate, beta metazoun 17-benzoate, clobetasol propionate, 17α-desoxymethazone, difluorotolone and the like.

To the patch obtained by the present invention, additives, fillers, for example, antioxidants and antioxidant reinforcing fillers can be added as necessary without destroying the gel properties of the base.

Next, the compounding quantity of the base component and the compounding agent required for the patch obtained by this invention is demonstrated. The amount of the thermoplastic elastomer and the fat or oil or higher fatty acid may be blended with 25 to 370 parts by weight of the fat or fat or higher fatty acid based on 100 parts by weight of the thermoplastic elastomer. If the added amount of fat or oil or higher fatty acid is 370 parts by weight or more, it is difficult to support the gel-like property of the base and the stability is also bad. Alternatively, if the added amount is 50% by weight or less, the gel-like nature of the base is very large, and even if it is pasted, there is a high risk of falling off, which is not preferable. Therefore, the amount of fat or oil added is preferably 50 to 250 parts by weight, and more preferably 75 to 200 parts by weight.

Next, the tackifying resin can be blended with 25 to 200 parts by weight, but the addition amount of the resin is less than 200 parts by weight of the gel-like properties of the base, giving a severe pain when peeling the patch, 25 parts by weight or less It's hard to stick and it's not good to miss the goal. Therefore, the addition amount of the tackifying resin is preferably 50 to 175 parts by weight, more preferably 50 to 150 parts by weight. Next, the amount of the active ingredient added is preferably 0.09 to 110 parts by weight, preferably 0.1 to 90 parts by weight.

As is apparent from the foregoing, the present invention adds 0.09 to 110 parts by weight of the active ingredient to a mixture of 100 parts by weight of a thermoplastic elastomer, 25 to 370 parts by weight of fatty or fatty fatty acids, and 25 to 200 parts by weight of a tackifier resin. It relates to a method for producing a new patch, characterized in that it is used to extend to the support.

More specifically, in the present invention, a mixture of a thermoplastic elastomer, a fat or fatty acid, and a predetermined ratio of a tackifying resin is first heated and stirred in a stream of nitrogen gas to prepare a melt. The temperature at the time of stirring is 120-200 degreeC, and stirring time is about 30 to 60 minutes.

Next, the temperature of the electric melt is cooled to 130 ° C. or lower to add the active ingredient and mixed for 10 to 20 minutes to obtain a uniform melt. Next, this melt is applied to the leading edge as a support using an applicator such as a duck roller, a pilor roller, a throat dynapcoater or the like. For the support, it is appropriately used to select a paper, a nonwoven fabric, a nonwoven paper, or a synthetic resin film.

After apply | coating the melt | dissolution to a support body completely, the peeling coating material is bonded together on it, but can be suitably selected from a peeling paper, a cellophane, or plastic films, such as polyethylene and a polypropylene. However, when the support is inferior in heat resistance and dimensional stability, it is applied to a stable support, for example, a release paper subjected to peeling treatment, and then the desired support is pressed and transferred thereon.

The method mentioned above is the most ideal method of this invention, but the patch obtained by this invention can be manufactured also by the manufacturing method according to the electric method using the compounding component like a natural electric manufacturing method.

In addition, examples of representative examples of other manufacturing methods of the present invention include a method of dissolving the base and the active ingredient in an organic solvent and applying it on a support, followed by removing the organic solvent through a drying furnace, or applying the base to a pressure-sensitive adhesive tape by applying only the base in advance. After apply | coating the organic solvent which melt | dissolved, the method of removing an organic solvent similarly, etc. are mentioned.

Although the patch obtained by this invention can adjust the thickness at the time of electrical coating as little as possible, normally, it is apply | coated to the leading edge in thickness of 30 micrometers-1 mm.

Hereinafter, the pharmacological action of the patch obtained by the present invention will be described. Comparison test with drug of other dosage form by 1karakeninrat dissemination edema method in experiment.

; 파스코·인터내숀날·캄파니 제〕생리식염액을 0.1㎖/site, 다른 측에 같은 량의 생리식염액을 각각 1개소씩 주사하고, 곧 실시예 14의 첩부약 (1.5㎝×1.5㎝) 및 실시예 14의 첩부약과 같은 약물을 같은 배합비로 처방된 하기 처방의 겔제를 도포한 비닐시이트(1.5㎝×1.5㎝)를 각각 주사부위 상에 첩부하였다. 2.5시간후에 1%폰다민스카이블루-6B〔요메야마 약품공업(주) 제〕용액을 0.5㎖/100g 체중, 정맥내 주사하고, 다시 30분 후에 방혈 치사시켜서 피부를 박리하고 카라케닌 주사 부위의 두께를 두께측정기〔다이알·쇽크내스케이지 40g압·피이콕크 희사제〕로 측정하고, 다음 식에 의하여 부종률을 구하였다. 그리고 색소 침출 부위의 장지름과 단지름을 곱함으로서 색소 침출 면적(㎠)을 산출하였다. 또 하라다에트 올〔HARADA et al(J. Pharmaceut. Pharmacol., 23, 218, 1971 M. Harada et al.)〕의 방법으로 이 부위의 폰다민스카이 블루-B6를 추출하여 침출 색소량(μg)을 구하였다.Hair loss was performed using Ebacrem (trade name: manufactured by Tokyo Tanabe Pharmaceutical Co., Ltd.). After 24 hours, 1% carrageenin (picnin A)

; Pasco International Co., Ltd.] 0.1 ml / site of physiological saline solution, the same amount of physiological saline solution was injected into the other side, respectively, and the patch of Example 14 (1.5 cm x 1.5 cm) and A vinyl sheet (1.5 cm x 1.5 cm) coated with the gel of the following formulation prescribed in the same compounding ratio as the patch of Example 14 was affixed on the injection site, respectively. After 2.5 hours, 0.5% / 100 g of body weight and intravenous injection of 1% Fondaminsky Blue-6B (manufactured by Yomeyama Pharmaceutical Co., Ltd.) were injected intravenously. The thickness was measured with a thickness gauge [diag shank 40 g pressure picock coke diluent], and the seeding rate was calculated | required by the following formula. And the pigment leaching area (cm <2>) was computed by multiplying the long diameter and jar diameter of a pigment leaching site | part. In addition, the amount of leaching pigment (μg) by extracting Fondaminsky Blue-B6 at this site by the method of Harada et al. (HARADA et al (J. Pharmaceut. Pharmacol., 23, 218, 1971 M. Harada et al.)). Was obtained.

In any experimental system, the untreated group was compared by t test.

×100Edema rate (%) =

× 100

Prescription gel preparation

Etphenamate 5 parts by weight

Propylene Glycol 27 〃

Jeong Jae-soo 25.42 〃

Isopropyl alcohol 40 〃

Carboxy vinyl polymer 1 〃

Hydroxylpropylcellulose 1.5 〃

Triethanolamine 0.08 〃

The test results are shown in Table 1.

TABLE 1

(): Inhibition rate for no treatment group

*: P <0.05, ^** : P <0.01 indicates that there are significant differences (意 有 差), respectively.

As apparent from the above results, the patch obtained by the present invention exhibited the same effect as that of the gel under the same conditions and showed a significant inhibitory effect. Experimental Example 2 Comparative test with a patch only for a base by the Karakenin rat dissemination edema method and another patch.

In accordance with the method of Experimental Example 1, the same amount of each sample was immediately affixed on the injection site immediately after the injection of the physiological saline solution. Hereinafter, the pigment leaching area (cm 2) and the leaching pigment amount (μg) were determined in the same manner according to the method of Experimental Example 1. In any experimental system, the t test was compared with respect to the group to which only the base was attached, respectively. The test results are shown in Tables 2-4. Table 2 (Comparison of Base Only and Patch of Example 7).

TABLE 2

(): Inhibition rate for the group attached only to the substrate

^** : P <0.01 shows significant differences.

However, each sample affixed 1.5 square * 1.5 cm square thing.

As is apparent from the above results, the patch obtained by the present invention showed a significant (P <0.01) inhibitory effect in any of the edema rate, pigment leaching area and amount of leaching pigment.

The active ingredient is released from the base.

Table 3 (comparison with the patch of Example 17 and a commercial analog drug Sekul [trade name: Udok Pharmaceutical Co., Ltd. product))

TABLE 3

(): Inhibition rate for no treatment group

^** : Indicates that there is significant difference as P <0.01.

However, each sample affixed 1.5 square * 1.5 cm square thing.

As apparent from the above results, the patch obtained by the present invention exhibited an effect equivalent to that of cekul, and showed a significant inhibitory effect in any of them.

Table 4 (Comparison of the patch of Example 24 and the drenisone tape)

TABLE 4

(): Inhibition rate for no treatment group

^** : Indicates that there is significant difference as P <0.01.

However, each sample affixed the circular thing of 1.6 cm in diameter. Moreover, in the patch of Example 24 and drenisone tef, content of each sample was 8g.

As is apparent from the above results, the patch of the present invention showed an effect equivalent to that of drenissonte, and showed a significant inhibitory effect in any of them.

Experimental Example 3 Intensity test of the effect by UV-induced morphologic skin erythema method.

This method is a method that has conventionally been used as an evaluation method of oral anti-inflammatory agents. According to this law, the strength of the effects of the patch of the present invention and the existing patch was compared. A group of Haatei male mortars with a body weight of 300-500 g were depilated with Ever Cream and used for one night. Thick ultraviolet protective hoppers with circular holes of 3 diameters of 5 mm were irradiated to mortar hair loss distribution skin for 20 seconds with a UV irradiation device (500W × 2, etc.) at a distance of about 25 cm from each skin. Each sample of a predetermined amount was affixed on.

After 2 hours and 55 minutes, the tape was removed from this, the residue was removed, and the degree of erythema was evaluated after 3 hours and 24 hours, and the efficacy was evaluated as a total of three points. Score is 0: no change. 1: erythema with mild erythema, 2: borderline unclear, erythema with relatively clear border; 4: erythema with edema with clear border; 0.5 sker was evaluated and one peak was 12.

The test results are shown in Tables 5-6.

Table 5 (Comparison of Patches and Examples of Examples 17)

TABLE 5

(): Inhibition rate for no treatment group

^** : P <0.01 indicates significant difference.

However, each sample affixed 1.5 square * 1.5 cm square thing.

As is evident from the above results, the patch obtained by the present invention showed a significant edema inhibitory effect, showing an effect almost equivalent to that of cekul.

Table 6 (Comparison of the patch of Example 24 and the drenisone tape)

TABLE 6

(): Inhibition rate for no treatment group

^** : P <0.01 indicates significant differences, respectively.

However, each sample affixed the circular thing of 1.6 cm in diameter. Moreover, in the patch of Example 24 and the drenisone tape, content of each sample is 8 micrograms.

As apparent from the above results, the patch obtained by the present invention exhibited a significant edema inhibitory effect, which showed an effect equivalent to that of drenisone tape.

Experimental Example 4 Anti-rat Rabbit Serum-induced Rat Skin Edema Inhibitory Action Test.

Weyster male rats (4 weeks old) of 100g body weight were dehydrated with ever cream with 8-9 rats per group, and used at midnight. In other words, injection of anti-rat rabbit serum 0,1ml / site on the one side and the same amount of physiological saline solution on the other side to make the median symmetry in the dorsal skin. The original patch of Example 24 (containing 8 μg of the drug) and the drenisone tape (containing 8 μg of the drug) were affixed on the injection site. At the time of injection, 0.5 ml / 100 g of 1% Vontaminsky Blue-B6 solution was injected intravenously, intravenously injected, and 30 minutes later, the skin was separated by bleeding, and carrageenan-induced rat skin edema was injected against the injection site of anti-rat rabbit serum. As in the case, the edema rate, the pigment leaching area, and the leaching pigment amount were determined, and compared with the t test for each group.

The results are shown in Table 7. The patch of Example 24 also showed a significant (P <0.01) inhibitory effect equivalent to that of drenisone tape in the present experimental system.

Table 7 (Comparison of the patch of Example 24 and the drenisone tape)

TABLE 7

(): Inhibition rate for untreated group

^** : P <0.01 indicates that there are significant differences.

Experimental Example 5 Picryl chloride-induced mouse delayed contact dermatitis inhibitory effect.

The experiment was conducted in accordance with the method reported by Natsu Ume (梅). This model is thought to be the type IV allergic reaction claimed by Gell et al. The abdomen of an ICR male mouse (4 weeks old) at around 30 g body weight was cut about 2.5 cm x 1.5 cm, and after 24 hours, a 7% picryl chloride solution (for acetone 4, for olive oil 1) was felt with a diameter of 1.3 cm and a width of 1.7 cm. It was squeezed by reciprocating with a roller (Sens.itization). After 7 days, a 0.5 cm x 1.0 cm flat felt paper-fixed creep moistened with 1% picryl chloride solution (olive oil) was used to stiffen the 0.5 cm tip of both ears, causing a skin challenge (first challenge) and only 1 hour before and 16 hours. The thickness of the algae was measured using a thickness gauge, and 10 to 11 mice in the selected group were selected to generate sufficient edema. Two days later, induction was performed in the same manner as the first challenge. (second challenge).

After 1 hour, the patch of Example 24 (containing 4 μg of the drug) and the drenisone tape (containing 4 μg of the drug) of 0.7 mm × 1.45 mm were folded on both ears and stuck from both sides so as not to leave. The effect was measured by the thickness layer measuring the increase in thickness after 16 hours from the thickness of 1 hour before the second challenge, and compared with the t test for the untreated group. The results are shown in Table 8. The patch of Example 24 significantly inhibited (P <0.01) pigyl chloride-induced dermatitis almost identically to drenisone tape.

Table 8 (Comparison of the patch of Example 24 and the drenisone tape)

TABLE 8

(): Inhibition rate for no treatment group

^** : Indicates that there is significant difference as P <0.01.

Examples are described next, but in the following description "parts" means parts by weight.

Example 1

Styrene-isoprene-styrene tere block copolymer (Garipurex TR 1107, made by Schiel Chemical Co., Ltd.) 100 parts, liquid paraffin (chemical light agent) 150 parts, rosin-modified maleic acid resin (Marukid No. 2-N, Aragawa Chemical) First) 50 parts are melted by heating to 140-150 degreeC in nitrogen gas stream.

After cooling this melt | dissolution (about 150 degreeC) to about 120 degreeC, 30 parts of methyl salicylates and 21 parts of L-menthols were added and mixed, and it was made uniform. This was rolled around about 1 mm in thickness on the support of the nonwoven fabric using a rolling machine.

After cooling to around room temperature, the surface was covered with a polyethylene film and cut to a desired size to produce a product. As a result of affixing to the human body and testing the feeling of use, it was found that there is a skin qualification by the active ingredient, and there is an adhesive feeling due to the flexibility and proper adhesion, but it has the advantage as an external preparation, which has been difficult to combine with the conventional patch which is easy to peel off. Could know.

Example 2

100 parts of styrene-isoprene-styrene radical tere block copolymers (Solprene 418, a product made by Philips Betrory Amsa), 150 parts of liquid paraffin (Crystal 355, an Exos Daned oil company), rosin modified maleic acid resin (floor 40 parts of Kid 2-N, manufactured by Aragawa Chemical Co., Ltd., and 10 parts of hydrogenated rosin ester (ester gum H, Aragawa compound) are dissolved in a stream of nitrogen gas. After cooling to ° C, 30 parts of methyl salicylate and 21 parts of L-menthol are added and mixed to make it uniform. When this was rolled up to about 200 μm on a brushed cloth, the surface was covered with a polypropylene film, cut to a desired size, and affixed to the human body. As a result, it was found to have almost the same advantages as in Example 1. .

Example 3

75 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR 1107, made by Schiel Chemical), 25 parts of styrene-butadiene-styrene tere block copolymers (Garipurex TR 1101, made by Schiel Chemical), liquid paraffin Pure agent) 250 parts, rosin-modified maleic acid resin (Marukid No. 2-N, Aragawa Chemical) 75 parts, hydrogenated rosin ester (ester gum H, Aragawa Chemical) 25 parts dissolved in a nitrogen gas stream And after cooling this melt | dissolution (about 150 degreeC) to about 120 degreeC, 0.45 part of capsaicin and 13.5 part of sarocool were added, mixed, and it was made uniform. This was rolled on a rolling machine and then rolled on a nonwoven fabric with a thickness of about 1 mm, and then the surface was covered with a cellophane film and cut to a desired size to produce a product. The usability attached to the human body was the same as in Example 1.

Example 4

100 parts of styrene-isoprene styrene terblock copolymers (Garipurex TR 1107, made by Schiel Chemicals), 210 parts of liquid paraffin (chemical light agent), rosin modified maleic acid resin (Marukid No. 2-N, Aragawa Chemical) 1) 100 parts were dissolved in a stream of nitrogen gas and the melt (about 150 ° C.) was cooled to about 120 ° C., 16.4 parts of sarocool and 4.1 parts of red pepper extract were added and mixed to make them uniform. This was rolled to an induction machine on a non-aerated fabric, about 150μ thick, and then the surface was covered with a polyethylene film and cut to a desired size to produce a product. The usability attached to the human body was the same as in Example 1.

Example 5

100 parts of styrene-isoprene-styrene radial tereblock copolymers (Solprene 418, the product made by phylipps Bettriarm Co., Ltd.), 250 parts of liquid paraffin (a light pure chemical agent), rosin modified maleic acid resin (marukid No. 2-N, Ara) 90 parts of Kagawa Chemicals) and 10 parts of hydrogenated rosin esters (ester gum H, manufactured by Aragawa Chemical) were dissolved in a stream of nitrogen gas, and the melt (about 150 ° C) was cooled to about 120 ° C. 22.5 parts of lene is added and mixed, and it is uniform. It was found to have the same advantages as in Example 1 as a result of attaching this to the insulator on the brushed fabric with a thickness of about 300 mu and then covering the surface with a polypropylene film and cutting it to a desired size.

Example 6

90 parts of styrene-isoprene-styrene radial tere block copolymers (Solprene 418, a Philips betoroli company), styrene-butadiene-styrene radial tere block copolymer (Solrene T-414, Japan Elastoma company make) 10 parts, liquid paraffin (Crystal 70, 300 parts of Exosdan Darth Petroleum Co., Ltd.), and 150 parts of rosin modified maleic acid resin (Marukide No. 2-N, manufactured by Aragawa Chemical) are dissolved in a nitrogen gas stream. After cooling (about 150 degreeC) to about 120 degreeC, 16.5 parts of sarocool, 16.5 parts of L-menthol, and 5 parts of d- camphor were added and mixed, and it was made uniform. This was rolled up to a thickness of about 200 mu on a brushed cloth using an electric rolling machine, and then the surface was covered with a cellophane film and cut to a desired size to obtain a product. The feeling attached to the human body was the same as in Example 1.

Example 7

100 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR 1107, made by Schiel Chemical Co., Ltd.), 193 parts of a liquid paraffin (fluorescent pure chemical), 125 parts of hydrogenated rosin esters (ester gum H, Aragawa Chemical) After dissolving in a stream of nitrogen gas and cooling the dissolved product (about 150 ° C.) to about 120 ° C., 22 parts of 2- (para-isobutylphenyl) propionic acid-2-pyridine methyl ester were added and mixed to make it uniform. This was rolled around the support of the non-napping fabric with a thickness of about 50 mu using a rolling machine, and then covered with a polyethylene film to obtain a cut product to a desired size. As a result of sticking to the human body and testing the feeling of use, it was found that there was a feeling of adhesion to the skin, the peeling was easy, and there was an advantage as a patch.

Example 8

100 parts of styrene-isoprene-styrene radial tere block copolymers (isoprene 418, a liprips betorolith company), 135 parts of liquid paraffin (Crystal 355, the product made by Exo-Sdandade Petroleum), hydrogenated rosin ester (ester gum H, 80 parts of Aragawa Chemicals) and 20 parts of rosin-modified maleic acid resin (Marukide No.-N, Aragawa Chemicals) are dissolved in a stream of nitrogen gas, and the dissolved substance (about 150 ° C) is heated to about 120 ° C. After cooling, 17.6 parts of esters of ketoprofen were added and mixed to make it uniform. This was rolled on a rolling machine, and then rolled on a nonwoven fabric with a thickness of about 50μ, covered with a polypropylene film, and cut into a desired size to produce a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 9

Styrene-isoprene-styrene tereblock copolymer (Garipurex TR 1170, made by Schiel Chemical) 75 parts, Styrene-butadiene-styrene tere block copolymer (Garipurex TR 1102, made by Schiel Chem. Part 25, liquid paraffin Drug) 145 parts, hydrogenated rosin ester (ester gum H, Aragawa Chemical) 100 parts, rosin-modified maleic acid resin (Marukid No. 2-N, Aragawa Chemical) is dissolved in a nitrogen stream, After cooling the melt (about 150 DEG C) to about 120 DEG C, 20.8 parts of Krydanak was added and mixed to make it uniform. The mold was treated with a release paper treated with a release paper, cut into a desired size to obtain a product, and the result was affixed to the human body, whereby the same result as in Example 7 was obtained.

Example 10

100 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR 1107, made by Schiel Chemical Co., Ltd.), 185 parts of liquid paraffin (Moresco white P-350, product made in Japan), hydrogenated rosin ester (ester gum H, ara) 50 parts of Kawa Chemical Co., Ltd. were dissolved in a stream of nitrogen gas, and the melt (about 150 ° C.) was cooled to about 120 ° C., followed by addition and mixing of 10.4 parts of ketoprofen to make it uniform. This was rolled to about 50μ thick on a nonwoven fabric using a rolling mill, and then covered with a polypropylene film subjected to a release treatment to cut into desired sizes to obtain a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 11

90 parts of styrene-isoprene-styrene radial tere block copolymers (sol-prene 418, the Philips betorori cancer company), styrene-butadiene-styrene radial tere block copolymer (sol-prene T-431, the product made by Asahi Kasei) 10 Part, 310 parts of liquid paraffin (Crystal 70, Exosdandar oil company), 110 parts of hydrogenated rosin ester (ester gum H, Aragawa Chemical), rosin modified maleic acid resin (Marukid No. 2-N, Ara) 65 parts of Kawa Chemical Co., Ltd. was dissolved in a stream of nitrogen gas, and the melt (about 150 ° C.) was cooled to about 120 ° C., and then 5.9 parts of alcoholofenac was added and mixed to make it uniform. This was rolled up to a thickness of about 90 mu on a brushed cloth using an electric rolling machine, and then covered with a polyethylene film and cut into a desired size to obtain a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 12

60 parts of styrene-isoprene-styrene tereblock copolymer (Garipurex TR 1107, made by Schiel Chemistry), 40 parts of styrene-isoprene-styrene radial tereblock copolymer (solprene 418, manufactured by Philips. 60 parts of rosin esters (ester gum H, Aragawa Chemical), 15 parts of rosin-modified maleic acid resin (Marukit No.-N, Aragawa Chemical), liquid paraffin (Crystal 355, Exos Dandade Petroleum) ) 300 parts were dissolved in a stream of nitrogen gas, the used water (about 150 ° C.) was cooled to about 120 ° C., and indomesacin 25 was added and mixed to make it uniform. This was rolled to a thickness of about 50 mu on a nonwoven fabric using a rolling mill, and then covered with a release treated release paper to cut into a desired size to obtain a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 13

100 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR 1107, made by Schiel Chem), 250 parts of liquid paraffin (Crystal 355, manufactured by Exos Dandad), hydrogenated rosin ester (ester gum H, Aragawa) Chemical) 60 parts, rosin-modified maleic acid resin (Marukid No. 2-N, Aragawa Chemical) 90 is dissolved in a stream of nitrogen gas, and the dissolved product (about 150 ° C) is cooled to about 120 ° C. 5.1 parts of probiprofen was added and mixed, and it was made uniform. This was rolled to a thickness of about 90 mu on a staple using an electric rolling machine, and then covered with a release polypropylene film and cut into a desired size to obtain a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 14

100 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR 1107, a Cheel Chemical company), 150 parts of liquid paraffin (Crystal 355, Exosdandard company), hydrogenated rosin ester (ester gum H, Aragawa) Chemicals) 150 parts were dissolved in a nitrogen gas stream, and the melt (about 150 ° C.) was cooled to about 120 ° C., followed by addition and mixing of 21.05 parts of etophenamate to be uniform. This was rolled onto a release paper with a thickness of 90 on a release paper, and after cooling, a polyethylene film having a thickness of 60 µ was pressed, transferred onto the film, and cut into desired sizes to obtain a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 15

60 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR 1107, made by Schiel Chemical Co., Ltd.), 40 parts of styrene-isoprene-styrene radial tereblock copolymers (solfurene 418, manufactured by Philips Vetoroli Amsa), flow 300 parts of paraffin (Crystal 355, Exos dandade petroleum), 60 parts of hydrogenated rosin ester (ester gum H, Aragawa Chemical), rosin modified maleic acid resin (Marukide No. 2-N, Aragawa Chemical) 15) 15 parts were melt | dissolved in nitrogen gas stream, this melt | dissolution (about 150 degreeC) was cooled to about 120 degreeC, and 25 parts of carboxyl methyl esters of indo mesacin were added and mixed, and it was made uniform. This was rolled onto a release paper using a rolling machine, 50μ thick on a release paper, and after cooling, a polyethylene film having a thickness of 60μ was pressed, transferred onto the film, and cut into a desired size to produce a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 16

90 parts of styrene-isoprene-styrene radial tereblock copolymers (solprene 418, a philipse, betoroliarm company), styrene-butadiene-styrene radial tereblock copolymer (solprene T-431, the Asahi Kasei) 10 Part, 308,99 parts of liquid paraffin (Crystal 70, Exosdand petroleum), 110 parts of hydrogenated rosin ester (ester gum H, Aragawa Chemical), rosin modified maleic acid resin (Makid No. 2-N) And 65 parts of Aragawa Chemical Co., Ltd. were dissolved in a stream of nitrogen gas, and the used water (about 150 ° C) was cooled to about 120 ° C, followed by addition and mixing of 5.90 parts of n-butyl ester of fulfenamic acid to make it uniform. After the leading edge and cooling, the soft vinyl chloride film having a thickness of 80 mu was pressed and then transferred onto the film, cut into a desired size, and commercialized. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Example 17

100 parts of styrene-isoprene-styrene tereblock copolymers (Garipurex TR-1107, made by Schiel Chemical Co., Ltd.), 150 parts of liquid paraffin (made by Hwagwang Pure Chemical Co., Ltd.), 60 parts of rosin modified maleic acid resin, hydrogenated furnace 90 parts of gin esters (ester gum H, manufactured by Aragawa Chemical Co., Ltd.) were melted by heating to 130 to 150 ° C in a nitrogen gas stream, and the melt (about 150 ° C) was cooled to about 120 ° C, followed by salicylic acid glycol 25 To 25 parts of L-menthol was added and mixed to make it uniform. This was applied to a release paper with a thickness of about 90 mu on a release paper and cooled, and then a polyethylene film having a thickness of about 60 mu was transferred onto the pressed film on it, and cut into a desired size to obtain a product. It is attached to the human body and tested for its use, it has skin qualification by the active ingredient, and it has a feeling of adhesion to the skin with flexibility and moderate adhesion, and when peeling, it can be easily peeled off with little pain. It has been found that there is an advantage as a patch having the above characteristics not found in the patch.

Example 18

Styrene-isoprene-styreneradial tereblock copolymer [Solphrene-418 phillips. 100 parts of Vetorori Arm Co., Ltd., 100 parts of liquid paraffin (Crystal-355 Exosdandade Petroleum Co., Ltd. product), 100 parts of hydrogenated rosin ester [Ester gum H, Aragawa Chemical Co., Ltd. product] It melt | dissolved in nitrogen gas stream, and this melt (about 150 degreeC) was cooled to about 120 degreeC, and 20 parts of salicylic acid glycol and 20 parts of L-menthols were added and mixed, and it was made uniform. This was rolled up to about 90μ in thickness on a nonwoven fabric using a rolling machine, and then covered with a release paper treated with a release treatment to cut to a desired size to obtain a product. The same result as in Example 17 was also obtained.

Example 19

75 parts of styrene-isoprene-styrene tereblock copolymers (manufactured by Garipurex 1107 Schiel Chemical Co., Ltd.), 25 parts of styrene-butadiene-styrene tereblock copolymer [manufactured by Garipurex TR-1102 Schiel Chemical Co., Ltd.], 200 parts of liquid paraffin (made by Hakwang Pure Chemical Co., Ltd.), rosin-modified maleic acid resin [Marukide No. 2-N, Aragawa Chemical Co., Ltd. product] 50 parts, hydrogenated rosin ester [ester gum H, Aragawa 75 parts of Chemical Co., Ltd. was melt | dissolved in air stream of nitrogen gas, this melt (about 150 degreeC) was cooled to about 120 degreeC, and 27 parts of salicylic acid glycol and 27 parts of L-menthol were added and mixed, and it was made uniform. This was applied to a release paper with a thickness of about 90 mu using a rolling machine. After cooling, a soft vinyl chloride sheet having a thickness of about 120 µ was pressed and cut to a desired size on the sheet, and affixed to the human body, and the same results as in Example 17 were obtained.

Example 20

90 parts of styrene-isoprene-styrene radial tereblock copolymer [isoprene 418, product made by phylipus betoroliam], styrene-butadiene-styrene radial tere copolymer [solprene T-431 Asahi Kasei Co., Ltd. 10 parts], liquid paraffin (Morasco white P-350 Nippon Petroleum Co., Ltd.) 250 parts, rosin modified maleic acid resin (Marukide No. 2-N, Aragawa Chemical Co., Ltd.) 175 parts Nitrogen gas After melt | dissolving in air stream and this melt (about 150 degreeC) was cooled to about 120 degreeC, 33 parts of salicylic acid glycol and 33 parts of L-menthols were added and mixed, and it was made uniform. This was affixed on the human body with the same conditions and the same method as Example 17 using the electric rolling machine, and the same result as Example 17 was obtained.

Example 21

Styrene-isoprene-styrene radial tere block copolymer [Solprene-418 phillips betoroliarm Co., Ltd. product] 80 parts, styrene-butadiene-styrene tere block copolymer [Garipurex T-1102 Siel Chemical Co., Ltd. ) Agent] 20 parts, liquid paraffin (Crystal-70, Exos Dandade Co., Ltd.) 250 parts, hydrogenated rosin ester [ester gum H, Aragawa Chemical Co., Ltd.] 100 parts melt in a nitrogen gas stream And after cooling this melt (about 150 degreeC) to about 120 degreeC, 28 parts of salicylic acid glycol and 28 parts of L-menthols were added and mixed, and it was made uniform. The same conditions and methods as in Example 17 were applied and cut to a desired size on the human body, and the same results as in Example 17 were obtained.

Example 22

100 parts of styrene-isoprene-styrene tereblock copolymers (manufactured by Garipurex TR-1107 Schiel Chemical Co., Ltd.), 150 parts of liquid paraffin (Crystal-355, manufactured by Exos Dandade Co., Ltd.), hydrogenated rosin ester [ 75 parts of ester gum H, manufactured by Aragawa Chemical Co., Ltd. are melted in a nitrogen gas stream, and after cooling the melt (about 150 ° C.) to about 120 ° C., 6 parts of methyl salicylate, 15 parts of salicylic acid glycol, and L 20 parts of menthol were added and mixed to make it uniform. As a result of applying the same to the human body by applying the same conditions and methods as in Example 17 and cutting it to a desired size, the same results as in Example 17 were obtained.

Example 23

100 parts of styrene-isoprene-styrene tereblock copolymers (manufactured by Garipurex TR-1107 Schiel Chemical Co., Ltd.), 100 parts of liquid paraffin (manufactured by Crystal-355 Exos Dandard Co., Ltd.), hydrogenated rosin ester [ester Gum H, Aragawa Chemical Co., Ltd.] 50 parts were melted in a nitrogen gas stream, and the melt (about 150 ° C.) was cooled to about 120 ° C., then 10 parts of peppermint oil, 6 parts of salicylate glycol, and L-menthol 10 parts, 5 parts of d-camphor and 1 part of thymol were added and mixed, and it was made uniform. This was applied to a thickness of about 90μ on a 25μ polyester film using an electric roll. Then, it was covered with a release paper treated with a release treatment and cut into a desired size to produce a product.

The result attached to the human body was the same as that of Example 17.

Example 24

100 parts of styrene-isoprene-styrene tereblock copolymers (manufactured by Garipurex TR-1107 Cheel Chemical Co., Ltd.), liquid paraffin (manufactured by Hwagwang Pure Chemical Co., Ltd.) 182 parts, hydrogenated rosin ester [ester gum H, araga] 125 parts of WA Chemical Co., Ltd.] were melted by heating to 130-170 ° C in a nitrogen gas stream. After cooling this melt to about 150 degreeC or less, the thing which melt | dissolved 0.3336 parts of Poland lenoids in 10 parts of sorbitan trioleate (made by SO-30 Nigo Chemical Co., Ltd.) was added to the said melt, and it was made uniform. This was applied to a release paper with a thickness of about 50μ using a rolling mill, and after cooling, a polyethylene film having a thickness of 60μ was pressed and transferred onto the support to be cut into a desired size. As a result of affixing it to a human body and testing its usability, it has the softness of the patch and the adhesiveness to the skin which has moderate adhesiveness, and it can peel easily easily without feeling a little pain at the time of peeling, and it is ever a patch Could recognize the advantage as a medicinal agent with ideal characteristics that he had not seen.

Example 25

100 parts of styrene-isoprene-styrene radial tereblock copolymers (made by Solprene-418 phillips betorori cancer company), 80 parts of hydrogenated rosin esters (ester gum H, Aragawa Chemical Corporation make), rosin modification 20 parts of maleic acid resin (Marukide No. 2-N Aragawa Co., Ltd. product), and 123.4 parts of liquid paraffin (Crystal-355 Exosdandade Co., Ltd. product) are heat-melted in a nitrogen gas stream, and this melt is made into about After cooling to 150 degrees C or less, the thing which melt | dissolved 0.2669 parts of fluoro goldide in 10 parts of sorbitan sesquioleate (made by SO-15 Nikgo Chemical Co., Ltd.) was added to the said melt, and it was made uniform. This was applied in the same manner as in Example 24, cut to a desired size, and affixed to a pregnant body, and the same result as in Example 24 was obtained.

Example 26

75 parts of styrene-isoprene tereblock copolymers (manufactured by Garipurex TR-1107 Cheel Chemical Co., Ltd.), 25 parts of styrene-butadiene-styrene tereblock copolymer [Gaaripurex TR-1102 Cheel Chemical Co., Ltd. product] , 128 parts of liquid paraffin [Hwagwang Pure Chemical Co., Ltd. product], hydrogenated rosin ester [ester gum H, Aragawa Chemical Co., Ltd. product] 100 parts, rosin modified maleic acid resin [Marukid No. 2-N Aragawa] 50 parts of Chemicals Co., Ltd. is melt | dissolved in a nitrogen gas stream, and this melt is cooled to about 150 degrees C or less, and 10 parts of sorbitan monostearate (SO-10 Nigo Chemical Co., Ltd.) The melt | dissolution of 0.6228 parts of needs was added and mixed with the said melt, and it was made uniform. This was applied to a release paper with a thickness of 50 mu using a rolling mill, and after cooling, the nonwoven fabric was pressed, transferred onto the support, cut into desired sizes, and affixed to a human body. The same results as in Example 24 were obtained.

Example 27

100 parts of styrene-isoprene-styrene tere block copolymers (manufactured by Garipurex TR-1107 Cheel Chemical Co., Ltd.), 172 parts of liquid paraffin [moresco white P-350 Nippon Petroleum Co., Ltd.], hydrogenated rosin ester [ 50 parts of ester gum H, manufactured by Aragawa Chemical Co., Ltd. are melted in a nitrogen gas stream, and the melt is cooled to about 150 ° C. or lower, followed by tripolyoxyethylene alkyl etheric acid [TUP-2 Nikgo Chemical Co., Ltd.]. (2) The thing which melt | dissolved 2 parts of prednisolone in 10 parts was added and mixed with the said melt, and it was made uniform. This was applied to a release paper with a thickness of about 50μ on a release paper, and after cooling, a vinyl chloride sheet having a thickness of about 120μ was pressed, transferred onto the sheet, cut to a desired size, and affixed to a human body. Got.

Example 28

10 parts of styrene-isoprene-styrene radial tereblock copolymers (Solprene-413 Asahi Kasei Co., Ltd. product), 298.4 parts of light paraffin (Crystal-70, Exosdandade Co., Ltd. product), hydrogenated rosin ester [ Ester gum H, 105 parts of Aragawa Chemical Co., Ltd.], and 65 parts of rosin-modified maleic acid resin (Marukide No. 2-N Aragawa Chemical Co., Ltd.) are melted in a nitrogen gas stream, and the melt is weakened. After cooling to 150 degrees C or less, the thing which melt | dissolved 0.4671 parts of polenrenonide in 10 parts of dipolyoxyethylene alkyl ether ricins (DOP-2 Nigo Chemical Co., Ltd. product) 10 parts was added and mixed to the said melt, and it was made uniform. This was applied directly to a thickness of about 50μ on a polyester film having a thickness of 25μ using an electric rolling machine, and then covered with a release-treated paper, which was then cut to a desired size and commercialized. The result of affixing this to a human body obtained the same result as Example 24.

Example 29

60 parts of styrene-isoprene-styrene tereblock copolymers (manufactured by Garipurex TR-1107 Cheel Chemical Co., Ltd.), and styrene-isoprene-styrene radial tere block copolymers [Solphrene-418 phillips betoroliarm (note) ) 40 parts, liquid paraffin [Crystal-355 exoth dandard Co., Ltd. 287.3 parts, hydrogenated rosin ester [ester gum Aragawa Chemical Co., Ltd.] 60 parts, trijin modified maleic acid resin [marukide 2 Part 15 of Ho-Aragawa Chemical Co., Ltd. was melted in a nitrogen gas stream. After cooling this melt to about 150 degrees C or less, the thing which melt | dissolved 0.3781 parts of fluorogoldide in 10 parts of sorbitan trioleate (SO-30 Nigo Chemical Co., Ltd. product) was added to the said melt, and it was made uniform. This melt was applied under the same conditions and methods as in Example 24, cut to a desired size, and affixed to a human body. The same results as in Example 24 were obtained.

Example 30

100 parts of styrene-isoprene-styrene tereblock copolymers (manufactured by Garipurex TR-1107 Cheel Chemical Co., Ltd.), 240 parts of liquid paraffin (manufactured by Crystal-355 Exos Dandard Co., Ltd.), hydrogenated rosin ester [ester 60 parts of gum H, Aragawa Chemical Co., Ltd.], and 90 parts of rosin-modified maleic acid resin [Marukide No. 2-N Aragawa Chemical Co., Ltd.] are melted in a stream of nitrogen gas, and the melt is weakened. After cooling to 150 degrees C or less, the thing which melt | dissolved 0.4004 parts of polish lenolides in 10 parts of sorbitan monooleate (SO-10 Niggo Chemical Co., Ltd. product) was added to the said melt, it was made uniform. This was applied to a nonwoven fabric with a thickness of about 50μ using a rolling machine, and then covered with a release paper treated with a release treatment, and cut into a desired size to produce a product. As a result of affixing this to a human body, the same result as Example 24 was obtained.

Example 31

100 parts of styrene-isoprene-styrene terblock copolymers (manufactured by Garipurex TR-1107 Cheel Chemicals Co., Ltd.), 195 parts of liquid paraffin (Crystal 355, manufactured by Exos Danhakd), hydrogenated rosin ester [ester gum H, Aragawa Made by Chemical Co.] 125 parts were dissolved in a stream of nitrogen gas, the melt (about 150 ° C.) was cooled to about 120 ° C., and 17.5 parts of indopropene were added and mixed to make it uniform. This was rolled on a rolling machine, and a polyethylene film having a thickness of 50 µm was rolled on a release paper and then 60 µm thick after cooling, then transferred onto the film, and cut into a desired size to obtain a product. As a result of affixing this to a human body, the same result as Example 7 was obtained.

Claims (1)

The active ingredient in a mixture of 100 parts by weight of ABA block copolymer, A is a monovinyl substituted aromatic compound polymer block, and B is a conjugated diolefin polymer block, 25-370 parts by weight of fat or fatty acid, and 25-200 parts by weight of tackifying resin. A method for producing a patch, characterized in that 0.09-110 parts by weight is added, and this is rolled on a support using an applicator.