KR840008364A - Method for preparing cynoline derivative - Google Patents

Method for preparing cynoline derivative Download PDF

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Publication number
KR840008364A
KR840008364A KR1019830001731A KR830001731A KR840008364A KR 840008364 A KR840008364 A KR 840008364A KR 1019830001731 A KR1019830001731 A KR 1019830001731A KR 830001731 A KR830001731 A KR 830001731A KR 840008364 A KR840008364 A KR 840008364A
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KR
South Korea
Prior art keywords
structural formula
following structural
prepare
derivative
cynoline
Prior art date
Application number
KR1019830001731A
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Korean (ko)
Other versions
KR860000037B1 (en
Inventor
김승호
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김승호
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Publication date
Application filed by 김승호 filed Critical 김승호
Priority to KR1019830001731A priority Critical patent/KR860000037B1/en
Publication of KR840008364A publication Critical patent/KR840008364A/en
Application granted granted Critical
Publication of KR860000037B1 publication Critical patent/KR860000037B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

시놀린 유도체의 제조방법Method for preparing cynoline derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

본문에 상술한 바와같이 다음 구조식(II)와 같은 3,4-메틸렌디옥시아닐린을 출발물질로하여 0℃와 10℃사이에서 소디움 나이트라이트와 염산으로 디자조늄염을 제조하고 60℃와 180℃사이에서 소디움설파이트를 사용하여 다음 구조식(III)과 같은 3,4-디메틸렌디옥시 페닐히다라진을 제조한다음 80℃와 110℃사이에서 디에틸케토말로 네티이트를 사용하여 다음 구조식(VI)를 제조하고 200℃와 260℃사이에서 1시간내지 5시간동안 반응시켜 다음구조식(V)를 제조한 다음 알킬하라이드 등과 염기를 극성유기용매중에서 8시간내지 10시간 동안 80℃와 100℃사이에서 반응하여 다음 구조식(VI)을 제조하고 강염기로 가수분해하여 다음 구조식(I)과 같은 시놀린 유도체를 제조하는 방법.As described above in the main body, a diazonium salt was prepared with sodium nitrite and hydrochloric acid at 0 ° C. and 10 ° C. using 3,4-methylenedioxyaniline as the following structural formula (II), and 60 ° C and 180 ° C. Sodium sulfite was used to prepare 3,4-dimethylenedioxy phenylhydrazine as shown in the following structural formula (III), and then diethylketomalonetite was used between 80 ° C and 110 ° C. VI) was prepared and reacted between 200 ° C. and 260 ° C. for 1 hour to 5 hours to prepare the following Structural Formula (V). Reacting between to prepare the following Structural Formula (VI) and to hydrolyze with a strong base to produce a sinoline derivative as the following Structural Formula (I). 상기구조식에서, R은 메틸, 에틸, n-푸로필, 이소푸로필, n-부틸, 비닐, 아릴 등 등의 탄소수가 적은 알킬기 혹은 알케닐기이다.In the above structural formula, R is an alkyl group or alkenyl group having a low carbon number such as methyl, ethyl, n-furophyll, isopurophyll, n-butyl, vinyl, aryl and the like. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830001731A 1983-04-23 1983-04-23 Process for preparing cinnoline derivatives KR860000037B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019830001731A KR860000037B1 (en) 1983-04-23 1983-04-23 Process for preparing cinnoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019830001731A KR860000037B1 (en) 1983-04-23 1983-04-23 Process for preparing cinnoline derivatives

Publications (2)

Publication Number Publication Date
KR840008364A true KR840008364A (en) 1984-12-14
KR860000037B1 KR860000037B1 (en) 1986-01-30

Family

ID=19228749

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001731A KR860000037B1 (en) 1983-04-23 1983-04-23 Process for preparing cinnoline derivatives

Country Status (1)

Country Link
KR (1) KR860000037B1 (en)

Also Published As

Publication number Publication date
KR860000037B1 (en) 1986-01-30

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