KR840006993A - Pyridine derivatives - Google Patents

Abstract

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Description

Pyridine derivatives

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Claims (9)

A process for preparing the compound of formula (1) and its salt which can be accepted chemically. Wherein R ¹ and R ² may be the same or different, and are hydrogen, C _1-6 alkyl, C _1-6 alkoxy or halogen, R ³ is optionally substituted phenyl or pyridyl, and any substituent thereof Examples thereof include one or several C _1-6 alkyl, C _1-6 alkoxy or hydroxy groups or halogen atoms. R ³ may also be optionally substituted furanyl or thienyl, optionally substituted with one or several C _1-6 alkyl or C _1-6 alkoxy groups or halogen atoms. a is a number from 1 to 6, b is a number from 2 to 4, and R ⁴ is a group of formula (2) or a group of formula (3) or a group of formula (4) or a group of formula (5). Wherein R ⁵ is hydrogen, C _1-6 alkyl or (CH ₂ ) _d R ⁶ , where d is a number from 1 to 6 and R ⁶ is optionally substituted phenyl or pyridyl, with one optional substituent Or several C _1-6 alkyl, C _1-6 alkoxy, hydroxy groups or halogen atoms. R ⁶ may also be optionally substituted thiadiazole, furanyl, thienyl, optionally substituted with one or several C _1-6 alkyl or C _1-6 alkoxy groups or halogen atoms. r is a number from 0 to 2. The compound of formula (1) is produced by reacting the compound of formula (6) as shown below. In the above formula, R ¹ , R ² , R ³ , a and b are as defined in formula (1). (A) When R ⁴ is a compound of formula (2) or (3) as defined in formula (1), the preparation of the compound of formula (1) may be carried out by the compound of formula (6) By reacting with the compound of 8). X is a group which may be substituted with an amine. (B) When R ⁴ is a group of the formula (4) or (5), the compound of formula (1) is prepared by reacting the compound of formula (6) with the compound of formula (9) or (10). In the above formula, X is a group which may be substituted with an amine, and X ¹ is a group which may be substituted with an amine, or a group having a formula of NHR ⁵ , wherein R ⁵ is as defined with respect to formula (1). When X ¹ is a group which may be substituted with an amine, it is reacted with an amine of formula (12). Where R ⁵ is as defined in equation (1). The compound of formula (1) obtained as above is optionally converted to a pharmaceutically acceptable salt. The treatment method as claimed in claim 1, wherein R ¹ and R ² are both hydrogen. the same method as claimed in claim 1 or 2 where a is 1. The processing method as claimed in claims 1 to 3 when b is 3. The process as claimed in claims 1 to 3 when is phenyl, 4-fluorophenyl, 2-thienyl or 3-thienyl. The treatment method as claimed in claims 1 to 5 when R ⁴ and R ⁵ are a group of formula (4) wherein hydrogen is a group. R ⁴ is a group of formula (5), R ⁵ is hydrogen, methyl or d is 1 and R ⁶ is 2-pyridyl, 3-pyridyl, or 4-pyridyl- (CH ₂ ) _d R ⁶ the same method as claimed in claims 1 to 6 where r is 1 or 2. The treatment method as claimed in claim 1, wherein X of the compound of formula (7) is nitroamino or QS- wherein Q is methyl. The treatment method as claimed in claim 1, wherein X and X ¹ of the compound of formula (9) or (10) are QO- wherein Q is methyl. ※ Note: It is to be disclosed based on the initial application.