KR840006216A - Method for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine - Google Patents

Abstract

No content

Description

Method for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine

As this is a public information case, the full text was not included.

Claims (14)

A process for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine characterized by catalyzing 2-alkyl-4-amino-5-formylpyrimidine with hydrogen and ammonia in the presence of a reducing catalyst. The method according to claim 1, wherein a salt of divalent nickel is added to the reaction system in addition to a reduction catalyst. The process according to claim 2, wherein a salt of divalent nickel is used at 0.1 to 5 moles per mole of 2-alkyl-4-amino-5-formylpyrimidine. The process of claim 1 or 2, wherein the reaction product is reacted with ammonia in an inert solvent and the reaction product is reduced from the reaction mixture to reduce the reaction product thus obtained. A process for producing a non-isolated, inert solvent containing ammonia, hydrogen and a reducing catalyst. The process according to claim 1 or 2, wherein 5 to 400 moles of hydrogen are used per mole of 2-alkyl-4-amino-5-formylpyrimidine. The catalyst according to claim 1 or 2, wherein the reduction catalyst contains a metal atom selected from the group consisting of palladium, rhodium, platinum, ruthenium, nickel, cobalt, iron, copper and chromium, and 2-alkyl-4-amino- A method according to claim 1, wherein the metal is used per mole of 5-formylpyrimidine in an amount of 0.001 to 3 gram atoms. The process according to claim 1 or 2, wherein the reaction is carried out at a temperature of 0 to 200 캜. 3. Ammonia according to claim 1 or 2, characterized in that ammonia is used in the form of liquid ammonia, ammonia gas and ammonia water in an amount of 4 to 500 moles per mole of 2-alkyl-4-amino-5-formylpyrimidine. Manufacturing method. The amount of 4 to 500 moles per mole of 2-alkyl-4-amino-5-formylpyrimidine according to claim 4, wherein the ammonia for reaction with 2-alkyl-4-amino-5-formylpyrimidine is added. To a liquid ammonia, ammonia gas or ammonia water. The solvent for reaction of 2-alkyl-4-amino-5-formylpyrimidine with ammonia is 3 to 30 per 1 part by weight of 2-alkyl-4-amino-5-formylpyrimidine. A production method characterized by the use of the amount by weight. The production process according to claim 4, wherein the reaction between 2-alkyl-4-amino-5-formylpyrimidine and ammonia is performed at an ammonia partial pressure of 1 to 100 kg / cm 2 G at a temperature of 0 to 130 ° C. The production process according to claim 1 or 2, wherein the catalytic reaction is carried out at a temperature of 0 to 200 캜. Ammonia for catalysis is used in the form of liquid ammonia, ammonia gas and ammonia water in an amount of 4 to 300 moles per mole of 2-alkyl-4-amino-5-formylpyrimidine. The manufacturing method to make. The process according to claim 4, wherein the catalyst for catalysis is used in an amount of 2 to 20 parts by weight per 1 part by weight of 2-alkyl-4-amino-5-formylpyrimidine. ※ Note: The disclosure is based on the initial application.