KR840004758A - Preparation method of new cefem compound - Google Patents

Preparation method of new cefem compound Download PDF

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Publication number
KR840004758A
KR840004758A KR1019840000135A KR840000135A KR840004758A KR 840004758 A KR840004758 A KR 840004758A KR 1019840000135 A KR1019840000135 A KR 1019840000135A KR 840000135 A KR840000135 A KR 840000135A KR 840004758 A KR840004758 A KR 840004758A
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KR
South Korea
Prior art keywords
alkyl
amino
protected
hydroxy
carboxy
Prior art date
Application number
KR1019840000135A
Other languages
Korean (ko)
Other versions
KR850000322B1 (en
Inventor
히사시(외3) 다까스기
Original Assignee
후지사와 도모기찌로오
후지사와 야꾸힌 고오교오 가부시기 가이샤
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Application filed by 후지사와 도모기찌로오, 후지사와 야꾸힌 고오교오 가부시기 가이샤 filed Critical 후지사와 도모기찌로오
Priority to KR1019840000135A priority Critical patent/KR850000322B1/en
Publication of KR840004758A publication Critical patent/KR840004758A/en
Application granted granted Critical
Publication of KR850000322B1 publication Critical patent/KR850000322B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

새로운 세펨화합물의 제조방법Preparation method of new cefem compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

하기식(IV)의 화합물이나 그의 염을 다음식(V)인 티올화합물이나 그의 염과 반응시켜 하기식(I)화합물이나 제약상 허용되는 그의 염을 제조하는 방법.A method for producing a compound of formula (I) or a pharmaceutically acceptable salt thereof by reacting a compound of formula (IV) or a salt thereof with a thiol compound of formula (V) or a salt thereof. 상기식들에서, R1은 아미노 또는 보호된 아미노이며, R2는 저급알킬, 아미노(저급)알킬, 보호된 아미노(저급)알킬, 하이드록시(저급)알킬, 보호된 하이드록시(저급)알킬, 저급 알킬티오(저급)알킬, 카복시(저급)알킬, 에스테르화된 카르복시(저급)알킬, (C3-C8)싸이클로알킬, 저급알케닐 또는 저급알키닐이며, R3는 아미노(저급)알킬, 보호된 아미노(저급)알킬, 하이드록시(저급)알킬 또는 아미노 및 저급알킬로 치환된 복소환기이고, R4는 카르복시 또는 보호된 카르복시이며, 다만 R2가 저급알킬일때 R3는 하이드록시(저급)알킬이나 아미노 및 저급알킬로 치환된 복소환기이다. R5는 아실.Wherein R 1 is amino or protected amino, and R 2 is lower alkyl, amino (lower) alkyl, protected amino (lower) alkyl, hydroxy (lower) alkyl, protected hydroxy (lower) alkyl , Lower alkylthio (lower) alkyl, carboxy (lower) alkyl, esterified carboxy (lower) alkyl, (C 3 -C 8 ) cycloalkyl, lower alkenyl or lower alkynyl, R 3 is amino (lower) Alkyl, protected amino (lower) alkyl, hydroxy (lower) alkyl or a heterocyclic group substituted with amino and loweralkyl, R 4 is carboxy or protected carboxy, provided that R 3 is hydroxy when R 2 is loweralkyl It is a heterocyclic group substituted with (lower) alkyl, amino, and lower alkyl. R 5 is acyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840000135A 1979-09-11 1984-01-13 Process for preparing new cephem compounds KR850000322B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840000135A KR850000322B1 (en) 1979-09-11 1984-01-13 Process for preparing new cephem compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR7903114A KR840001616B1 (en) 1979-09-11 1979-09-11 Process for preparing nobel cephem compound
KR1019840000135A KR850000322B1 (en) 1979-09-11 1984-01-13 Process for preparing new cephem compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR7903114A Division KR840001616B1 (en) 1979-09-11 1979-09-11 Process for preparing nobel cephem compound

Publications (2)

Publication Number Publication Date
KR840004758A true KR840004758A (en) 1984-10-24
KR850000322B1 KR850000322B1 (en) 1985-03-20

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR7903114A KR840001616B1 (en) 1979-09-11 1979-09-11 Process for preparing nobel cephem compound
KR1019840000135A KR850000322B1 (en) 1979-09-11 1984-01-13 Process for preparing new cephem compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR7903114A KR840001616B1 (en) 1979-09-11 1979-09-11 Process for preparing nobel cephem compound

Country Status (1)

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KR (2) KR840001616B1 (en)

Also Published As

Publication number Publication date
KR850000322B1 (en) 1985-03-20
KR840001616B1 (en) 1984-10-11

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