KR840004753A - 3-아미노-6-아릴-1,2,4-트리아졸로[4,3-b] 피리다진의 제조방법 - Google Patents
3-아미노-6-아릴-1,2,4-트리아졸로[4,3-b] 피리다진의 제조방법 Download PDFInfo
- Publication number
- KR840004753A KR840004753A KR1019830001924A KR830001924A KR840004753A KR 840004753 A KR840004753 A KR 840004753A KR 1019830001924 A KR1019830001924 A KR 1019830001924A KR 830001924 A KR830001924 A KR 830001924A KR 840004753 A KR840004753 A KR 840004753A
- Authority
- KR
- South Korea
- Prior art keywords
- groups
- carbon atoms
- compound
- alkyl
- phenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- -1 biphenylyl Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010029216 Nervousness Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 208000005392 Spasm Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 하기 일반식(Ⅱ)의 아일히드라지노피리다진을 a) 폐환제와 반응시키거나, 또는 b) N―CR3―옥시)카보닐―0―메틸이소우레아와 반응시켜 하기 일반식(Ⅲ)의 화합물을 수득한 다음 가수분해시키거나, 또는 c) 하기 일반식(Ⅳ)의 화합물을 암모니아와 반응시키거나, 또는 d) 하기 일반식(Ⅴ)의 화합물을 필요에 따라서는 축합체를 첨가하여 가열에 의해 환화시키고, 얻어지는 하기 일반식(Ⅰ)의 화합물을 필요에 따라서는, 약학적으로 허용되는 산에 의해 그의 염의로 제조함을 특징으로 하는 3―아미미―6―아릴―1,2,4―트리아졸로〔4,3―6〕피리다진 및 약학적으로 허용되는 그의 염을 제조하는 방법.상기 식들에 있어서, R1과 R2는 동일 또는 상이한 것으로서, 수소, 탄소원자수 1 내지 6의 알킬기, 페닐기 또는 염소원자를 나타내고, Ar는 페닐, 비페닐릴, 톡녹시페닐, 페닐티오페닐, 페닐술피닐페닐, 페닐수포닐페닐, 1―또는 2―나프틸, 2―또는 3―티에닐, 2―푸릴, 2―피롤릴, 1―메틸―2―피롤릴, 2―, 3―또는 4―피리딜과 같은 방향족기 (이들 방향족기들은 플루오루, 염소, 브롬, 요오ㄷ, 탄소원자수 1 내지 6의 알킬기, 탄소원자수 3 내지 8의 시클로알킬기, 알킬 부위의 탄소원자수가 1 내지 4개인 페닐알킬기, 알킬부위의 탄소원자수가 각각 1 내지 6개인 알콕시 또는 알킬티오기, 히드록시기, 니트로기, 시아노기, 트리플루오로메틸기, 카복실기, 카복실기와 탄소원자수 1내지 6의 알콜과의 에스테르, 아미노카보닐, 아미노, 아세트아미도 또는 알킬부위의 탄소원자수가 1 내지 6개인 알콜시카보닐 아미노기와 같은 1,2,3 또는 4개의 원자(들) 또는 기(들)에 의해 임의로 치환될 수 있으며, R3는 탄소우너자수 1 내지 10의 알킬, 벤질 또는 페닐을 나타내며, R4는 염소, 브롬 또는 메틸티오를 나타내며, Z는 0,S는 NH를 나타낸다.
- 제1항에 있어서 일반식(Ⅰ)의 화합물을 함유하는 신경안정작용과 경련치료 작용을 갖는 약학조성물.
- 제1항에 있어서, 초조감, 불면증, 경련 및 이경이긴장증(裡經異緊張症)의 질병 치료를 위한 일반식(Ⅰ) 화합물의 사용.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3217325.3 | 1982-05-08 | ||
DE19823217325 DE3217325A1 (de) | 1982-05-08 | 1982-05-08 | 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840004753A true KR840004753A (ko) | 1984-10-24 |
Family
ID=6163075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830001924A KR840004753A (ko) | 1982-05-08 | 1983-05-06 | 3-아미노-6-아릴-1,2,4-트리아졸로[4,3-b] 피리다진의 제조방법 |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0094038B1 (ko) |
JP (1) | JPS58203992A (ko) |
KR (1) | KR840004753A (ko) |
AT (1) | ATE24728T1 (ko) |
AU (1) | AU1434383A (ko) |
CA (1) | CA1201122A (ko) |
DE (2) | DE3217325A1 (ko) |
DK (1) | DK204783A (ko) |
ES (4) | ES522144A0 (ko) |
FI (1) | FI831548L (ko) |
GR (1) | GR79281B (ko) |
HU (1) | HU189277B (ko) |
IE (1) | IE55096B1 (ko) |
IL (1) | IL68611A0 (ko) |
MA (1) | MA19791A1 (ko) |
NO (1) | NO831614L (ko) |
NZ (1) | NZ204153A (ko) |
PT (1) | PT76654B (ko) |
ZA (1) | ZA833239B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3311753A1 (de) * | 1983-03-31 | 1984-10-04 | Hoechst Ag, 6230 Frankfurt | Substituierte 6-aryl-1,2,4-triazolo(4,3-b)pyridazine - ihre herstellung und verwendung - |
FR2562071B1 (fr) * | 1984-03-30 | 1986-12-19 | Sanofi Sa | Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
WO2006050389A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds, compositions and methods |
WO2006050359A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
WO2007127375A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Formulations containing pyridazine compounds for treating neuroinflammatory diseases |
CA2650711A1 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
EP2131839A2 (en) * | 2007-03-02 | 2009-12-16 | Northwestern University | Compositions comprising derivatives of 3-phenylpyridazine for treating seizure-related disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL128809C (ko) * | 1966-06-18 | |||
US3708484A (en) * | 1970-10-16 | 1973-01-02 | Sandoz Ag | Amino and substituted amino-s-triazolo-(4,3-b)-pyridazines |
DE2113438A1 (de) * | 1971-03-19 | 1972-09-21 | Boehringer Mannheim Gmbh | Nitrofuryl-triazolo[4,3-b]pyridazinderivate |
CA1080712A (en) * | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
US4260756A (en) * | 1979-11-15 | 1981-04-07 | American Cyanamid Company | 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines |
-
1982
- 1982-05-08 DE DE19823217325 patent/DE3217325A1/de not_active Withdrawn
-
1983
- 1983-05-04 GR GR71294A patent/GR79281B/el unknown
- 1983-05-05 DE DE8383104427T patent/DE3368931D1/de not_active Expired
- 1983-05-05 AT AT83104427T patent/ATE24728T1/de not_active IP Right Cessation
- 1983-05-05 FI FI831548A patent/FI831548L/fi not_active Application Discontinuation
- 1983-05-05 EP EP83104427A patent/EP0094038B1/de not_active Expired
- 1983-05-06 JP JP58078423A patent/JPS58203992A/ja active Pending
- 1983-05-06 NZ NZ204153A patent/NZ204153A/en unknown
- 1983-05-06 NO NO831614A patent/NO831614L/no unknown
- 1983-05-06 DK DK204783A patent/DK204783A/da not_active Application Discontinuation
- 1983-05-06 PT PT76654A patent/PT76654B/pt unknown
- 1983-05-06 HU HU831579A patent/HU189277B/hu unknown
- 1983-05-06 AU AU14343/83A patent/AU1434383A/en not_active Abandoned
- 1983-05-06 CA CA000427630A patent/CA1201122A/en not_active Expired
- 1983-05-06 ZA ZA833239A patent/ZA833239B/xx unknown
- 1983-05-06 MA MA20012A patent/MA19791A1/fr unknown
- 1983-05-06 KR KR1019830001924A patent/KR840004753A/ko not_active Application Discontinuation
- 1983-05-06 ES ES522144A patent/ES522144A0/es active Granted
- 1983-05-06 IE IE1043/83A patent/IE55096B1/en unknown
- 1983-05-06 IL IL68611A patent/IL68611A0/xx unknown
-
1984
- 1984-03-15 ES ES530639A patent/ES530639A0/es active Granted
- 1984-03-15 ES ES530640A patent/ES530640A0/es active Granted
- 1984-03-15 ES ES530638A patent/ES8501398A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ATE24728T1 (de) | 1987-01-15 |
AU1434383A (en) | 1983-11-10 |
NZ204153A (en) | 1985-04-30 |
ES8501399A1 (es) | 1984-11-16 |
NO831614L (no) | 1983-11-09 |
ES8405800A1 (es) | 1984-06-16 |
IL68611A0 (en) | 1983-09-30 |
ES530639A0 (es) | 1984-11-16 |
ES530638A0 (es) | 1984-11-16 |
DK204783D0 (da) | 1983-05-06 |
HU189277B (en) | 1986-06-30 |
JPS58203992A (ja) | 1983-11-28 |
IE831043L (en) | 1983-11-08 |
ES8501398A1 (es) | 1984-11-16 |
MA19791A1 (fr) | 1983-12-31 |
ES8501400A1 (es) | 1984-11-16 |
DE3368931D1 (en) | 1987-02-12 |
DE3217325A1 (de) | 1983-11-10 |
ES530640A0 (es) | 1984-11-16 |
PT76654A (de) | 1983-06-01 |
ZA833239B (en) | 1984-01-25 |
DK204783A (da) | 1983-11-09 |
FI831548A0 (fi) | 1983-05-05 |
FI831548L (fi) | 1983-11-09 |
PT76654B (de) | 1986-01-28 |
EP0094038B1 (de) | 1987-01-07 |
CA1201122A (en) | 1986-02-25 |
EP0094038A1 (de) | 1983-11-16 |
IE55096B1 (en) | 1990-05-23 |
GR79281B (ko) | 1984-10-22 |
ES522144A0 (es) | 1984-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR910011890A (ko) | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 | |
ES8300112A1 (es) | Un procedimiento para preparar compuestos de cefem . | |
AU528275B2 (en) | Imidazole derivatives | |
HU9600957D0 (en) | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases | |
IE832654L (en) | ß-LACTAM COMPOUNDS | |
IT1178154B (it) | Impiego in terapia di composti di trasferimento di metilolo, relative composizioni farmaceutiche e procedimento per preparare queste | |
ES8306160A1 (es) | "procedimiento para preparar un nuevo compuesto de cefem". | |
EA200100994A1 (ru) | 1-АМИНОТРИАЗОЛО[4,3-а]ХИНАЗОЛИН-5-ОНЫ И/ИЛИ -5-ТИОНЫ, ИНГИБИРУЮЩИЕ ФОСФОДИЭСТЕРАЗУ-IV | |
ES8101532A1 (es) | Un procedimiento para la preparacion de acetofenonas substi-tuidas | |
KR840004753A (ko) | 3-아미노-6-아릴-1,2,4-트리아졸로[4,3-b] 피리다진의 제조방법 | |
AT380471B (de) | Verfahren zur herstellung von neuen 2-oxoazetidin-derivate | |
ES8303427A1 (es) | "un procedimiento para preparar compuestos de cefem". | |
NZ333798A (en) | Arylcycloalkane carboxylic esters, their use for the treatment of urinary incontinence or irritable bowel syndrome, and method of manufacture. | |
ES8405006A1 (es) | Un procedimiento para la preparacion de derivados del acido tetrahidrofurancarboxilico. | |
KR920004387A (ko) | 진통제 및 피부질환 치료용 국소용 소염제로서의 4-치환된 디하이드로피리도[4,3-d]피리미딘 | |
AU579869B2 (en) | 4-amino-8-alkylthio-2-piperazino-pyrimido ``5,4-d`` pyrimidines | |
HUT37431A (en) | Process for the production of imidazo /1,2-c/pyrimidines and of their salts,as well as of therapeutic preparations containing these compounds as agent | |
AU539177B2 (en) | Amino alkoxy pyrazoles | |
IE820238L (en) | Carbapenem derivatives | |
KR850005435A (ko) | 3-알콕시-2-(n-피롤리디노)-n-피리미디닐-또는 n-피라지닐 프로필아민의 제조방법 | |
ES8403130A1 (es) | Procedimiento para la preparacion de tienobenzodiazepinonas sustituidas. | |
ES8602786A1 (es) | Derivados de pirimidoisoquinolina | |
ES8305319A1 (es) | "procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos" | |
KR830007684A (ko) | 세펨 화합물, 이것의 제조방법 및 제약학적 조성물 | |
GEP19981168B (en) | Benzimidazole derivatives and pharmaceutically acceptable salts thereof, intermediate compounds, method of their reception, stable crystals, a composition for inhibition of angiotensin ii |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |