KR840002769A - Method for preparing metopeto - Google Patents

Method for preparing metopeto Download PDF

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Publication number
KR840002769A
KR840002769A KR1019820005677A KR820005677A KR840002769A KR 840002769 A KR840002769 A KR 840002769A KR 1019820005677 A KR1019820005677 A KR 1019820005677A KR 820005677 A KR820005677 A KR 820005677A KR 840002769 A KR840002769 A KR 840002769A
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KR
South Korea
Prior art keywords
methoxyethyl
phenoxy
reaction
metopeto
preparing
Prior art date
Application number
KR1019820005677A
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Korean (ko)
Other versions
KR880002619B1 (en
Inventor
혼카넨(외4) 에르키
Original Assignee
안티 케레넨 파시 살로캉가스
오리온 위티머 오위
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Application filed by 안티 케레넨 파시 살로캉가스, 오리온 위티머 오위 filed Critical 안티 케레넨 파시 살로캉가스
Priority to KR8205677A priority Critical patent/KR880002619B1/en
Publication of KR840002769A publication Critical patent/KR840002769A/en
Application granted granted Critical
Publication of KR880002619B1 publication Critical patent/KR880002619B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

메토프토를의 제조방법Method for preparing metopeto

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

다음구조식(IV)의 3-[4-(2-메톡시에틸)페녹시]-1,2-프로판디올을 당량의 트리알킬아민 존재하에 디클로로메탄중에서 티오닐클로라이드와 반응시켜서 다음구조식(V)의 4-[4-[(2-메톡시에틸]페녹시]메틸]-1,3,2-디옥사티올린-2-옥사이드를 제조한 후, 이 구조식(V)의 화합물을 아세토니트릴중에서 이소프로필아민과 반응시켜서 다음구조식(I)의 1-이소프로필아미노-3-[4-(2-메톡시에틸)페녹시]-2-프로파놀을 제조하는 방법.3- [4- (2-methoxyethyl) phenoxy] -1,2-propanediol of formula (IV) is reacted with thionyl chloride in dichloromethane in the presence of an equivalent of trialkylamine 4- [4-[(2-methoxyethyl] phenoxy] methyl] -1,3,2-dioxathiolin-2-oxide was prepared and then the compound of formula (V) was dissolved in acetonitrile. Reacting with isopropylamine to prepare 1-isopropylamino-3- [4- (2-methoxyethyl) phenoxy] -2-propanol of the following formula (I). 제1항에서, 3-[4-(2-메톡시에틸)페녹시]-1,2-프로판디올과 티오닐클로라이드와의 반응을 0-5℃에서 약 15분간 반응시킴을 특징으로 하는 방법.The method of claim 1, wherein the reaction of 3- [4- (2-methoxyethyl) phenoxy] -1,2-propanediol with thionyl chloride is carried out at 0-5 ° C. for about 15 minutes. . 제1 또는 2항에서, 4-[4-[(2-메톡시에틸]페녹시]메틸]-1,3,2-디옥사티올린-2-옥사이드와 이소프로필아민과의 반응을 약 80℃에서 약 20시간 행함을 특징으로 하는 방법.The reaction according to claim 1 or 2, wherein the reaction of 4- [4-[(2-methoxyethyl] phenoxy] methyl] -1,3,2-dioxathiolin-2-oxide with isopropylamine is carried out at about 80 And about 20 hours at < RTI ID = 0.0 > 제1-3항에서, 트리알킬아민이 트리에틸아민임을 특징으로 하는 방법.The method of claim 1-3 wherein the trialkylamine is triethylamine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR8205677A 1982-12-18 1982-12-18 Process for the preparation of metoprolol KR880002619B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR8205677A KR880002619B1 (en) 1982-12-18 1982-12-18 Process for the preparation of metoprolol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR8205677A KR880002619B1 (en) 1982-12-18 1982-12-18 Process for the preparation of metoprolol

Publications (2)

Publication Number Publication Date
KR840002769A true KR840002769A (en) 1984-07-16
KR880002619B1 KR880002619B1 (en) 1988-12-07

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ID=19226307

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205677A KR880002619B1 (en) 1982-12-18 1982-12-18 Process for the preparation of metoprolol

Country Status (1)

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KR (1) KR880002619B1 (en)

Also Published As

Publication number Publication date
KR880002619B1 (en) 1988-12-07

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