KR840001997A - Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole - Google Patents

Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole Download PDF

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Publication number
KR840001997A
KR840001997A KR1019820004815A KR820004815A KR840001997A KR 840001997 A KR840001997 A KR 840001997A KR 1019820004815 A KR1019820004815 A KR 1019820004815A KR 820004815 A KR820004815 A KR 820004815A KR 840001997 A KR840001997 A KR 840001997A
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KR
South Korea
Prior art keywords
phenyl
hydrogen
lower alkyl
halogen
formula
Prior art date
Application number
KR1019820004815A
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Korean (ko)
Inventor
데이비스 래리 (외 1)
Original Assignee
마크 에드워드 로가트
훽스트-러셀 파마슈티칼 인코포레이티드
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Application filed by 마크 에드워드 로가트, 훽스트-러셀 파마슈티칼 인코포레이티드 filed Critical 마크 에드워드 로가트
Priority to KR1019820004815A priority Critical patent/KR840001997A/en
Publication of KR840001997A publication Critical patent/KR840001997A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

6-플루오로-3-[3-(1-헤테로사이클로)프로필]-1,2-벤즈이속사졸의 제조방법Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음 일반식(Ⅱ)의 화합물을 다음 일반식(Ⅲ)의 화합물과 반응시킴을 특징으로 하는, 다음 일반식(Ⅰ)의 화합물, 이의 광학적 대장체 또는 이의 약학적으로 허용되는 산부가염의 제조방법.A process for the preparation of a compound of formula (I), an optical colon or a pharmaceutically acceptable acid addition salt thereof, characterized by reacting a compound of formula (II) with a compound of formula (III) . 상기식에서 X는 O; C=O; 일반식의 그룹(여기서 m은 2 또는 3이다); CR1R2(여기서 R1은 수소, 저급알킬, 페닐 또는 저급알킬이고 R2는 수소, 시아노, 저급알킬카보닐, 페닐그룹이 할로겐으로 치환된 페닐 카보닐 또는 일반식의 그룹이며, R3는 저급알킬이다); CHZR4(여기서 Z는 O 또는 S이고 R4는 수소, 또는 트리플루오로메틸 또는 1 또는 2개의 할로겐그룹으로 치환된 페닐이다); CHNR5R6(여기서 R5는 수소 또는 페닐이고 R6는 페닐 카보닐 또는 저급알킬 카보닐이다); 또는 일반식의 그룹(여기서 R7은 할로겐이다)이고, Y는 CH2이며, X 및 Y는 함께 페닐핵을 형성하고, 점선은 X가 일반식의 그룹(여기서 R7은 할로겐이다)인 경우에 탄소 결합에 대해 부가적인 탄소를 나타내며, n은 1,2 또는 3이다.Wherein X is O; C = O; General formula A group of where m is 2 or 3; CR 1 R 2 , wherein R 1 is hydrogen, lower alkyl, phenyl or lower alkyl and R 2 is hydrogen, cyano, lower alkylcarbonyl, phenyl carbonyl or phenyl group substituted by halogen R 3 is lower alkyl; CHZR 4 , wherein Z is O or S and R 4 is hydrogen or phenyl substituted with trifluoromethyl or one or two halogen groups; CHNR 5 R 6 , wherein R 5 is hydrogen or phenyl and R 6 is phenyl carbonyl or lower alkyl carbonyl; Or general formula , Where R 7 is halogen, Y is CH 2 , X and Y together form a phenyl nucleus, and the dashed lines indicate that X is a general formula In the case of the group of where R 7 is halogen, it represents additional carbon to the carbon bond, n is 1,2 or 3; 제1항에 있어서, 반응을 50내지 130℃에서 산수용체치, 촉환 진제 및 적합한 용매 존재하에 진행시키는 방법.The process of claim 1 wherein the reaction proceeds at 50 to 130 ° C. in the presence of an acid acceptor value, catalyzing agent and a suitable solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820004815A 1982-10-26 1982-10-26 Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole KR840001997A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019820004815A KR840001997A (en) 1982-10-26 1982-10-26 Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019820004815A KR840001997A (en) 1982-10-26 1982-10-26 Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole

Publications (1)

Publication Number Publication Date
KR840001997A true KR840001997A (en) 1984-06-11

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ID=55026137

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820004815A KR840001997A (en) 1982-10-26 1982-10-26 Method for preparing 6-fluoro-3- [3- (1-heterocyclo) propyl] -1,2-benzisoxazole

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