KR830009083A - Method for preparing pyridinone derivative - Google Patents

Method for preparing pyridinone derivative Download PDF

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Publication number
KR830009083A
KR830009083A KR1019820000802A KR820000802A KR830009083A KR 830009083 A KR830009083 A KR 830009083A KR 1019820000802 A KR1019820000802 A KR 1019820000802A KR 820000802 A KR820000802 A KR 820000802A KR 830009083 A KR830009083 A KR 830009083A
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KR
South Korea
Prior art keywords
formula
compound
following compound
preparing
benzyl
Prior art date
Application number
KR1019820000802A
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Korean (ko)
Inventor
장민선
강정진
Original Assignee
원본미기재
동아제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 원본미기재, 동아제약 주식회사 filed Critical 원본미기재
Priority to KR1019820000802A priority Critical patent/KR830009083A/en
Publication of KR830009083A publication Critical patent/KR830009083A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음No content

Description

피리디논 유도체의 제조방법Method for preparing pyridinone derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

다음 구조식(II)의 4-피리딘 아세토니트릴과 다음구조식(III)의 α-아미노 아크릴산의 에스테르를 반응시켜 제조되는 다음 구조식(IV) 화합물을 환원시켜 다음구조식(V) 화합물을 만들고 다시 환화 반응을 시켜 다음 구조식(IV) 화합물을 만든후, 이 구조식(VI) 화합물을 탈수소화시키고 가수분해시켜 다음 구조식(I) 화합물 및 그의 약리학상 허용되는 산부가염을 제조하는 방법.Next, the following compound of formula (IV) prepared by reacting 4-pyridine acetonitrile of formula (II) and the ester of α-amino acrylic acid of formula (III) is reduced to form the following compound of formula (V), and further cyclization reaction is carried out. To make the following compound of formula (IV), followed by dehydrogenation and hydrolysis of the compound of formula (VI) to produce the next compound of formula (I) and pharmacologically acceptable acid addition salts thereof. 상기식에서 R은 메칠, 에칠, 이소프로필 등의 저급알킬, 또는 페닐, 저급알킬페닐등의 아랄킬이며, A는 아미노 보호기로서, =CH2, 엔아민유도체,(여기서 R1은 에칠, 벤질, 또는 벤질유도체를 나타낸다.) 등이다.In the formula, R is lower alkyl such as methyl, ethyl, isopropyl, or aralkyl such as phenyl, lower alkylphenyl, A is an amino protecting group, = CH 2 , enamine derivative, (Wherein R 1 represents ethyl, benzyl or benzyl derivatives). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820000802A 1982-02-23 1982-02-23 Method for preparing pyridinone derivative KR830009083A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019820000802A KR830009083A (en) 1982-02-23 1982-02-23 Method for preparing pyridinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019820000802A KR830009083A (en) 1982-02-23 1982-02-23 Method for preparing pyridinone derivative

Publications (1)

Publication Number Publication Date
KR830009083A true KR830009083A (en) 1983-12-17

Family

ID=55025573

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820000802A KR830009083A (en) 1982-02-23 1982-02-23 Method for preparing pyridinone derivative

Country Status (1)

Country Link
KR (1) KR830009083A (en)

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