KR830009000A - 2-benzoylamino-substituted benzylamine derivatives and preparation method thereof - Google Patents

2-benzoylamino-substituted benzylamine derivatives and preparation method thereof Download PDF

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Publication number
KR830009000A
KR830009000A KR1019820001086A KR820001086A KR830009000A KR 830009000 A KR830009000 A KR 830009000A KR 1019820001086 A KR1019820001086 A KR 1019820001086A KR 820001086 A KR820001086 A KR 820001086A KR 830009000 A KR830009000 A KR 830009000A
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KR
South Korea
Prior art keywords
benzoylamino
substituted benzylamine
hydroxyl group
following formula
acid addition
Prior art date
Application number
KR1019820001086A
Other languages
Korean (ko)
Inventor
히데오 가또오
노부오 오가와
사까에 구라다
가가리 야마기시
에이이찌 고시나까
Original Assignee
이또오 겐지
호꾸리꾸 세이야꾸 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3870681A external-priority patent/JPS57154154A/en
Priority claimed from JP14774681A external-priority patent/JPS5852261A/en
Application filed by 이또오 겐지, 호꾸리꾸 세이야꾸 가부시기 가이샤 filed Critical 이또오 겐지
Publication of KR830009000A publication Critical patent/KR830009000A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음No content

Description

2-벤조일아미노-치환벤질아민 유도체 및 그 제조방법2-benzoylamino-substituted benzylamine derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

아래식으로 표시되는 2-벤조일아미노-치환벤질아민유도체:2-benzoylamino-substituted benzylamine derivatives represented by the following formula: 다만, R은 수소원자 또는 수산기군 및 약학적으로 인정된 산첨가염이다.However, R is hydrogen atom or hydroxyl group and pharmaceutically acceptable acid addition salt. 상기 수산기군은 시클로헥산 핵의 3위치 위에 있는 것을 특징으로 하는 2-벤조일아미노-치환벤질아민유도체인 것을 특징으로 하는 특허청구의 범위 1항 기재의 2-벤조일아미노-치환벤질아민유도체.The hydroxyl group is 2-benzoylamino-substituted benzylamine derivative according to claim 1, characterized in that the 2-benzoylamino-substituted benzylamine derivative, characterized in that it is located at the 3-position of the cyclohexane nucleus. 상기 수산기군은 시클로헥산 핵의 4위치 위에 있는 것을 특징으로 하는 특허청구의 범위 1기재의 2-벤조일아미노-치환벤질아민 유도체.2-benzoylamino-substituted benzylamine derivative according to claim 1, wherein the hydroxyl group is on the 4-position of the cyclohexane nucleus. 2-(4-하이드록시-3-메톡시벤조일아미노)-3,5-디브로도-N-시클로헥실-N-메틸벤질아민.2- (4-hydroxy-3-methoxybenzoylamino) -3,5-dibrodo-N-cyclohexyl-N-methylbenzylamine. 아래식에 의하여 표시되는 2-벤조일아미노-치환벤질아민 유도체의 제조방법:Method for preparing 2-benzoylamino-substituted benzylamine derivatives represented by the following formula: 다만, R은 1개의 수소원자 또는 수산기군 및 약학적으로 인정된 산첨가염 그리고 이 산첨가염은 함수 매체중에서 아래식의 에스테르 화합물을 가수분해함으로써 이루어진다.However, R is one hydrogen atom or hydroxyl group and a pharmaceutically recognized acid addition salt, and this acid addition salt is formed by hydrolyzing an ester compound of the following formula in a hydrous medium. 다만, R은 상기와 같고, R1은 저알킬군 또는 저알콕시군이다.However, R is as described above, and R 1 is a low alkyl group or a low alkoxy group. 아래식에 의하여 표시되는 2-벤조일아미노-치환벤질아민 유도체의 제조방법:Method for preparing 2-benzoylamino-substituted benzylamine derivatives represented by the following formula: 다만, R은 1개의 수소원자 또는 수산기군 및 아래식의 2-아미노-치환벤질아민 유도체.However, R is one hydrogen atom or hydroxyl group and 2-amino-substituted benzylamine derivative of the formula below. (다만, R은 상기와 같다)(However, R is the same as above) 축합제의 존재하에 아래식의 바닐라산과 반응시켜 이루어지는 약학적으로 승인된 산첨가염:Pharmaceutically approved acid addition salts formed by reacting vanillaic acid in the presence of a condensing agent: ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820001086A 1981-03-19 1982-03-13 2-benzoylamino-substituted benzylamine derivatives and preparation method thereof KR830009000A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP38706 1981-03-19
JP3870681A JPS57154154A (en) 1981-03-19 1981-03-19 2-benzoylamino-substituted benzylamine derivative
JP147746 1981-09-21
JP14774681A JPS5852261A (en) 1981-09-21 1981-09-21 2-benzoylamino-substituted benzylamine derivative and its preparation

Publications (1)

Publication Number Publication Date
KR830009000A true KR830009000A (en) 1983-12-16

Family

ID=26377985

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820001086A KR830009000A (en) 1981-03-19 1982-03-13 2-benzoylamino-substituted benzylamine derivatives and preparation method thereof

Country Status (8)

Country Link
EP (1) EP0061157A1 (en)
KR (1) KR830009000A (en)
AU (1) AU8160582A (en)
BR (1) BR8201502A (en)
DE (1) DE3209970A1 (en)
DK (1) DK110582A (en)
ES (1) ES510608A0 (en)
FI (1) FI820876L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6272657A (en) * 1985-09-27 1987-04-03 Terumo Corp Amide derivative and 5-lipoxygenase action inhibitor containing said derivative
IT1248702B (en) * 1990-06-06 1995-01-26 Yason Srl ANTITUSSIVE AGENT AND MUCOREGULATOR, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2440546C2 (en) * 1974-08-23 1984-07-26 Johann Günter Wachswarenfabrik, 6968 Walldürn candle

Also Published As

Publication number Publication date
ES8305703A1 (en) 1983-04-16
DE3209970A1 (en) 1982-09-30
AU8160582A (en) 1982-09-23
DK110582A (en) 1982-09-20
EP0061157A1 (en) 1982-09-29
ES510608A0 (en) 1983-04-16
FI820876L (en) 1982-09-20
BR8201502A (en) 1983-02-01

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