KR830008543A - Process for preparing platinum coordination compound - Google Patents

Process for preparing platinum coordination compound Download PDF

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Publication number
KR830008543A
KR830008543A KR1019810003274A KR810003274A KR830008543A KR 830008543 A KR830008543 A KR 830008543A KR 1019810003274 A KR1019810003274 A KR 1019810003274A KR 810003274 A KR810003274 A KR 810003274A KR 830008543 A KR830008543 A KR 830008543A
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KR
South Korea
Prior art keywords
dimethylacetamide
coordination compound
platinum coordination
platinum
product
Prior art date
Application number
KR1019810003274A
Other languages
Korean (ko)
Other versions
KR890000640B1 (en
Inventor
시.하이드스 파울
알. 헵변 디렉
Original Assignee
스탠리 프란시스 로빈슨
존슨 매티 퍼블릭 리미티드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 스탠리 프란시스 로빈슨, 존슨 매티 퍼블릭 리미티드 캄파니 filed Critical 스탠리 프란시스 로빈슨
Publication of KR830008543A publication Critical patent/KR830008543A/en
Application granted granted Critical
Publication of KR890000640B1 publication Critical patent/KR890000640B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

백금 배위 화합물의 제조방법Process for preparing platinum coordination compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제6도는 본 발명 화합물이 X-선 분말 회절 패턴.6 is an X-ray powder diffraction pattern of the compound of the present invention.

제7도는 각 화합물의 크로마토그램을 나타낸 도면.7 shows a chromatogram of each compound.

Claims (3)

시스-디클로로-디(이소프로필아민)백금(Ⅱ)을 과산화수소와 반응시키고, 생성물을 분리한후, 이 생성물을 N,N-디메틸아세트아미드에 용해하고, 상기 화합물의 N,N-디메틸아세트아미드와의 1 : 1-부가체를 함유하는 생성물을 분리한 다음, 상기 N,N-디메틸아세트아미드를 80℃이하의 온도에서 진공하에 제거시킴을 특징으로 하는, 기의 순수 형태의 백금 배위 화합물을 제조 방법.The cis-dichloro-di (isopropylamine) platinum (II) is reacted with hydrogen peroxide, the product is separated and the product is dissolved in N, N-dimethylacetamide and the N, N-dimethylacetamide of the compound A pure, platinum coordination compound of a group, characterized in that the product containing 1: 1-addition of the was separated, and then the N, N-dimethylacetamide was removed under vacuum at a temperature below 80 ° C. Manufacturing method. 제1항에 있어서, N,N-디메틸아세트아미드를 50℃이하의 온도에서 진공하에 제거시키는 방법.The method of claim 1, wherein the N, N-dimethylacetamide is removed under vacuum at a temperature of 50 ° C. or less. 시스-디클로로-트랜스-디하이드록시-비스(이소프로필아민)백금(Ⅳ)과 디메틸아세트 아미드와의 1 : 1 부가체를 함유함을 특징으로 하는 물질의 조성물.A composition of matter, characterized by containing 1: 1 adduct of cis-dichloro-trans-dihydroxy-bis (isopropylamine) platinum (IV) with dimethylacetamide. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810003274A 1980-09-03 1981-09-02 Co-ordination compoune of platinum KR890000640B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8028484 1980-09-03
GB8028484 1980-09-03
GB8115549 1981-05-20
GB8115549 1981-05-20

Publications (2)

Publication Number Publication Date
KR830008543A true KR830008543A (en) 1983-12-10
KR890000640B1 KR890000640B1 (en) 1989-03-22

Family

ID=10515824

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003274A KR890000640B1 (en) 1980-09-03 1981-09-02 Co-ordination compoune of platinum

Country Status (5)

Country Link
JP (1) JPS5777694A (en)
KR (1) KR890000640B1 (en)
BE (1) BE890209A (en)
SU (2) SU1256698A3 (en)
ZA (1) ZA815852B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71804A (en) * 1983-05-10 1989-06-30 Andrulis Res Corp Bis-(platinum diamine)complexes and antitumor pharmaceutical compositions containing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578323A (en) * 1976-02-26 1980-11-05 Rustenburg Platinum Mines Ltd Compositions containing platinum

Also Published As

Publication number Publication date
BE890209A (en) 1982-01-04
JPS5777694A (en) 1982-05-15
ZA815852B (en) 1982-08-25
KR890000640B1 (en) 1989-03-22
JPH0349916B2 (en) 1991-07-31
SU1188179A1 (en) 1985-10-30
SU1256698A3 (en) 1986-09-07

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