KR830007684A - Cefem compound, preparation method thereof and pharmaceutical composition - Google Patents

Cefem compound, preparation method thereof and pharmaceutical composition Download PDF

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Publication number
KR830007684A
KR830007684A KR1019810003607A KR810003607A KR830007684A KR 830007684 A KR830007684 A KR 830007684A KR 1019810003607 A KR1019810003607 A KR 1019810003607A KR 810003607 A KR810003607 A KR 810003607A KR 830007684 A KR830007684 A KR 830007684A
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KR
South Korea
Prior art keywords
compound
salt
formula
carboxy
amino
Prior art date
Application number
KR1019810003607A
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Korean (ko)
Inventor
타까오 타까다니
히사시 타까스기
토시유끼 찌바
기요시 쓰지
Original Assignee
후지사와 토모키찌로오
후지사와 야꾸힝 코오교오 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 후지사와 토모키찌로오, 후지사와 야꾸힝 코오교오 가부시기 가이샤 filed Critical 후지사와 토모키찌로오
Priority to KR1019810003607A priority Critical patent/KR830007684A/en
Publication of KR830007684A publication Critical patent/KR830007684A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세펨 화합물, 이것의 제조방법 및 제약학적 조성물Cefem compound, preparation method thereof and pharmaceutical composition

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

(1) 하기 구조식(Ⅱ)의 7-아미노-3-세펨화합물 아미노기에서 이것의 반응성 유도체 혹은 이것의 염과 하기 구조식(Ⅲ)의 카르복실산 혹은 카르복실기에서 이것의 반응성 유도체 혹은 이것의 염과 반응시키고, 혹은(1) Reaction with a reactive derivative thereof or a salt thereof with a 7-amino-3-cefe compound amino group of the following structural formula (II) and a carboxylic acid or carboxyl group of the following structural formula Or (2) 하기 구조식(Ia)의 화합물 혹은 이것의 염을 R1 a상의 카르복시기의 제거반응에 가하여 하기 구조식(Ib)의 화합물 혹은 이것의 염을 제조하고, 혹은 (3) 하기 구조식(Ic)의 화합물 혹은 이것을 염을 R1 a상의 아미노-보호기의 제거반응에 가하여 하기 구조식(Id)의 화합물 혹은 이것의 염을 제조하고, 혹은 (4) 하기 구조식(Ie)의 화합물 혹은 이것을 염을 R4 a상의 카르복시 보호기의 제거반응에 가하여 하기 구조식(If)의 화합물 혹은 이것의 염을 제조하고, 혹은 (5) 하기 구조식(If)의 화합물 혹은 이것의 염을 카르복시 보호기의 삽입반응에 가하여 하기 구조식(Ie)의 화합물 혹은 이것의 염을 제조하는 하기 구조식(I)의 화합물을 제조하는 방법.(2) The compound of the following formula (Ia) or a salt thereof is added to the removal reaction of a carboxyl group on R 1 a to prepare a compound of the following formula (Ib) or a salt thereof, or (3) of the following formula (Ic) The compound or a salt thereof is added to the removal reaction of the amino-protecting group on R 1 a to prepare a compound of formula (Id) or a salt thereof, or (4) a compound of formula (Ie) or a salt thereof as R 4 a The compound of formula (If) or a salt thereof is prepared by addition of a carboxy protecting group on a phase, or (5) The compound of formula (If) or a salt thereof is added to an insertion reaction of a carboxy protecting group to form a compound of formula (Ie). Method for producing a compound of formula (I) to produce a compound of) or a salt thereof. 윗식에서 R1은 혹은 보호된 아미노이고,Where R 1 is or protected amino, R2는 카르복시(저급)알킬 혹은 보호된 카르복시(저급)알킬이고,R 2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl, R3는 할로겐 혹은 저급알콕시이고,R 3 is halogen or lower alkoxy, R4는 카르복시 혹은 보호된 카르복시이고,R 4 is carboxy or protected carboxy, R2 a는 보호된 카르복시(저급)알킬이고,R 2 a is protected carboxy (lower) alkyl, R2 b는 카르복시(저급)알킬이고,R 2 b is carboxy (lower) alkyl, R1 a는 보호된 아미노이고,R 1 a is protected amino, R4 a는 보호된 카르복시임.R 4 a is protected carboxy. 청구범위 1에 따르는 화합물 혹은 제약적으로 알맞는 이것의 염과 제약적으로 알맞는 무독성 매개물 혹은 부형제와 함께 구성되는 제약학적 조성물.A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically suitable nontoxic vehicle or excipient. 세균성 질병환자 혹은 동물에 청구범위 1의 화합물을 복용시키는 것으로 구성되는 병원성 미생물로 인한 질병치료방법.A method for treating a disease caused by a pathogenic microorganism comprising a compound of claim 1 in a bacterial disease patient or animal. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810003607A 1981-09-26 1981-09-26 Cefem compound, preparation method thereof and pharmaceutical composition KR830007684A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019810003607A KR830007684A (en) 1981-09-26 1981-09-26 Cefem compound, preparation method thereof and pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019810003607A KR830007684A (en) 1981-09-26 1981-09-26 Cefem compound, preparation method thereof and pharmaceutical composition

Publications (1)

Publication Number Publication Date
KR830007684A true KR830007684A (en) 1983-11-04

Family

ID=54149265

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003607A KR830007684A (en) 1981-09-26 1981-09-26 Cefem compound, preparation method thereof and pharmaceutical composition

Country Status (1)

Country Link
KR (1) KR830007684A (en)

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