KR830007625A - N-hydroxy-1-R'-1,2-dihydro-2-oxo-5-PY-6-R-nicotinimide amide or acid addition salt thereof - Google Patents

N-hydroxy-1-R'-1,2-dihydro-2-oxo-5-PY-6-R-nicotinimide amide or acid addition salt thereof Download PDF

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Publication number
KR830007625A
KR830007625A KR1019810004973A KR810004973A KR830007625A KR 830007625 A KR830007625 A KR 830007625A KR 1019810004973 A KR1019810004973 A KR 1019810004973A KR 810004973 A KR810004973 A KR 810004973A KR 830007625 A KR830007625 A KR 830007625A
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South Korea
Prior art keywords
acid addition
dihydro
oxo
hydrogen
lower alkyl
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KR1019810004973A
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Korean (ko)
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디이 그루엣트 몬테
요어 레셔어 죠오지
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제이므즈 에이취 루우서
스터어링 드럭그 인코포레이팃드
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Publication of KR830007625A publication Critical patent/KR830007625A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음No content

Description

N-히드록시-1-R1-1,2-디하이드로-2-옥소-5-PY-6-니코틴이미드아마이드 또는 그의 산부가염의 제조방법Method for preparing N-hydroxy-1-R1-1,2-dihydro-2-oxo-5-PY-6-nicotinimide amide or acid addition salt thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

1-R1-1,2-디하이드로-2-옥소-5-PY-6-니코티노니트릴을 히드록실아민 또는 그의 산부가염과 반응시키고, 필요하다며, 얻어진 유리염기를 그의 산부가염으로 전환시키는 것을 특징으로 하는 구조식 I의 N-히드록시-1-R1-1,2-디하이드로-2-옥소-5-PY-6-니코틴이미드아마이드 또는 그의 산부가염을 제조하는 방법.Reacting 1-R 1 -1,2-dihydro-2-oxo-5-PY-6-nicotinonitrile with hydroxylamine or its acid addition salt and converting the free base obtained as necessary to its acid addition salt A process for preparing N-hydroxy-1-R 1 -1,2-dihydro-2-oxo-5-PY-6-nicotinimideamide or acid addition salts thereof of formula I, characterized in that: 상기식에서,In the above formula, R은 수소 또는 저급 알킬이고R is hydrogen or lower alkyl R1은 수소, 저급알킬 또는 저급히드록시알킬이며,R 1 is hydrogen, lower alkyl or lower hydroxyalkyl, PY는 4- 또는 3-피리디닐 또는 1 또는 2의 저급알킬 치환체를 갖는 4- 또는 3-피리디닐이다.PY is 4- or 3-pyridinyl with 4- or 3-pyridinyl or lower alkyl substituent of 1 or 2. 제1항에 있어서, PY가 4-또는 3-피리디닐인 것을 특징으로 하는 방법.The method of claim 1, wherein PY is 4- or 3-pyridinyl. 제1항 또는 2항에 있어서, R1이 수소이고 R이 수소, 메틸 또는 에틸인 것을 특징으로 하는 방법.The process according to claim 1 or 2, wherein R 1 is hydrogen and R is hydrogen, methyl or ethyl. 제1항에 있어서, N-히드록시-1,2-디하이드로-2-옥소-5-(4-피리디닐)니코틴이미드아마이드 또는 약리적으로 허용할 수 있는 그의 산부가염을 제조하는 것을 특징으로 하는 방법.The method according to claim 1, characterized in that N-hydroxy-1,2-dihydro-2-oxo-5- (4-pyridinyl) nicotinimideamide or a pharmacologically acceptable acid addition salt thereof is prepared. How to. 상기 청구범위중 어느하나에 따른 방법에 의해 제조된 구조식 I화합물을 다중인산과 반응시키는 것을 특징으로 하는 1-R1-3-아미노-5-PY-6-R-2(1H)-피리디논(여기서, R은 수소 또는 저급알킬이고; R1은 수소, 저급알킬 또는 저급히드록시알킬이며 PY는 4-또는 3-피미리닐 또는 1 또는 2의 저급알킬치환체를 갖는 4-또는 3-피리디닐임)의 제조방법.1-R 1-3 -amino-5-PY-6-R-2 (1H) -pyridinone, characterized by reacting a compound of formula I prepared by a method according to any one of the claims with polyphosphoric acid Wherein R is hydrogen or lower alkyl; R 1 is hydrogen, lower alkyl or lower hydroxyalkyl and PY is 4- or 3-pyrid having 4- or 3-pyrilinyl or 1 or 2 lower alkyl substituents Dinyne). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810004973A 1980-12-22 1981-12-17 N-hydroxy-1-R'-1,2-dihydro-2-oxo-5-PY-6-R-nicotinimide amide or acid addition salt thereof KR830007625A (en)

Applications Claiming Priority (2)

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US21891680A 1980-12-22 1980-12-22
US218,916 1980-12-22

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KR830007625A true KR830007625A (en) 1983-11-04

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KR1019810004973A KR830007625A (en) 1980-12-22 1981-12-17 N-hydroxy-1-R'-1,2-dihydro-2-oxo-5-PY-6-R-nicotinimide amide or acid addition salt thereof

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