KR830007608A - Method for preparing 1,4-2 substituted piperazine derivatives - Google Patents

Method for preparing 1,4-2 substituted piperazine derivatives Download PDF

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Publication number
KR830007608A
KR830007608A KR1019810005097A KR810005097A KR830007608A KR 830007608 A KR830007608 A KR 830007608A KR 1019810005097 A KR1019810005097 A KR 1019810005097A KR 810005097 A KR810005097 A KR 810005097A KR 830007608 A KR830007608 A KR 830007608A
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KR
South Korea
Prior art keywords
formula
general formula
substituted
preparing
substituted piperazine
Prior art date
Application number
KR1019810005097A
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Korean (ko)
Inventor
쓰도무 이리꾸라
게이고 니시노
규우야 오까무라
다로오 다가후꾸
Original Assignee
하기하라 미노루
교린 세이야꾸 가부시기 가이샤
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Application filed by 하기하라 미노루, 교린 세이야꾸 가부시기 가이샤 filed Critical 하기하라 미노루
Publication of KR830007608A publication Critical patent/KR830007608A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음No content

Description

1,4-2치환 피페라진 유도체의 제조방법Method for preparing 1,4-2 substituted piperazine derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

일반식(Ⅱ)의 1-(4-카베톡시부틸)-4-치환 피페라진을 일반식(Ⅲ)의 0-페닐렌디아민과 반응시키고 생성된(Ⅳ)의 1-(4-(2-벤즈이미다졸릴)부틸)-4-치환 피페라진을 일반식(Ⅴ)의 알킬화제로 반응시켜 일반식(Ⅰa)의 화합물 또는 그 산부가염을 제조하는 방법.1- (4-carbetoxybutyl) -4-substituted piperazine of general formula (II) is reacted with 0-phenylenediamine of general formula (III) and 1- (4- (2- A method for preparing a compound of formula (Ia) or an acid addition salt thereof by reacting benzimidazolyl) butyl) -4-substituted piperazine with an alkylating agent of formula (V). 일반식(Ⅵ)의 1-[4-(0-하이드록시 페닐카바모일)부틸-4-치환 피페라진을 5산화인과 반응시켜 일반식(Ⅰb)의 1-[4-(2-벤즈옥사졸릴)부틸]-4-치환 피페라진 또는 그 산부가염을 제조하는 방법.1- [4- (0-hydroxyphenylcarbamoyl) butyl-4-substituted piperazine of general formula (VI) was reacted with phosphorus pentaoxide to form 1- [4- (2-benzoxa) of general formula (Ib) A method for producing zolyl) butyl] -4-substituted piperazine or acid addition salts thereof. 일반식(Ⅶ)의 1-(4-치환)부틸 피페라진을 일반식(Ⅷ)의 치환 벤조일 할로겐화물과 반응시켜(1)의 화합물을 제조하는 방법.A method of preparing the compound of (1) by reacting 1- (4-substituted) butyl piperazine of formula (VII) with a substituted benzoyl halide of formula (VII). 위 일반식에서In the above general formula R1은 1-메틸벤즈이미다졸, 1-벤질벤즈이미다졸 또는 벤즈옥사졸 그룹을R 1 represents a 1-methylbenzimidazole, 1-benzylbenzimidazole or benzoxazole group R2는 메틸 그룹을,R 2 represents a methyl group, R3는 메틸 또는 벤질 그룹을R 3 represents a methyl or benzyl group X는 할로겐 원자를 나타낸다.X represents a halogen atom. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810005097A 1980-12-23 1981-12-23 Method for preparing 1,4-2 substituted piperazine derivatives KR830007608A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55182632A JPS57106663A (en) 1980-12-23 1980-12-23 1,4-disubstituted piperazine derivative and its preparation
JP55-182632 1980-12-23

Publications (1)

Publication Number Publication Date
KR830007608A true KR830007608A (en) 1983-11-04

Family

ID=16121678

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810005097A KR830007608A (en) 1980-12-23 1981-12-23 Method for preparing 1,4-2 substituted piperazine derivatives

Country Status (10)

Country Link
JP (1) JPS57106663A (en)
KR (1) KR830007608A (en)
AU (1) AU7877481A (en)
BE (1) BE891580A (en)
DE (1) DE3151123A1 (en)
FR (1) FR2496661A1 (en)
GB (1) GB2091255A (en)
IT (1) IT1142620B (en)
SE (1) SE8107680L (en)
ZA (1) ZA818900B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US5149700A (en) * 1990-05-30 1992-09-22 American Home Products Corporation Substituted arylsulfonamides and benzamides
WO2000051614A1 (en) * 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2297045A1 (en) * 1975-01-10 1976-08-06 Delalande Sa NEW (AROYL-2 'ETH-1' YL) -1 (ACETAMIDO-4 '' PIPERAZIN-1 '' YL METHYL) -2 BENZIMIDAZOLES WITH GASTRIC AND ANTIULCEROUS ANTI-SECRETORY PROPERTIES
YU39992B (en) * 1976-04-02 1985-06-30 Janssen Pharmaceutica Nv Process for obtaining new piperazine and piperidine derivatives

Also Published As

Publication number Publication date
AU7877481A (en) 1982-07-01
IT1142620B (en) 1986-10-08
DE3151123A1 (en) 1982-08-12
SE8107680L (en) 1982-06-24
IT8125742A0 (en) 1981-12-21
JPS57106663A (en) 1982-07-02
FR2496661A1 (en) 1982-06-25
BE891580A (en) 1982-04-16
GB2091255A (en) 1982-07-28
ZA818900B (en) 1982-12-29

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