KR830007563A - remedy - Google Patents

remedy Download PDF

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Publication number
KR830007563A
KR830007563A KR1019810003592A KR810003592A KR830007563A KR 830007563 A KR830007563 A KR 830007563A KR 1019810003592 A KR1019810003592 A KR 1019810003592A KR 810003592 A KR810003592 A KR 810003592A KR 830007563 A KR830007563 A KR 830007563A
Authority
KR
South Korea
Prior art keywords
compound
formula
anion
prepare
preparing
Prior art date
Application number
KR1019810003592A
Other languages
Korean (ko)
Other versions
KR860000650B1 (en
Inventor
빅터 데이비스 로이
Original Assignee
로버트 노만군, 드렉 노만 에드먼드슨
더 부츠 캄파니 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 로버트 노만군, 드렉 노만 에드먼드슨, 더 부츠 캄파니 리미티드 filed Critical 로버트 노만군, 드렉 노만 에드먼드슨
Publication of KR830007563A publication Critical patent/KR830007563A/en
Application granted granted Critical
Publication of KR860000650B1 publication Critical patent/KR860000650B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음No content

Description

치료제remedy

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

(a) 다음 일반식(II)의 화합물을 메틸티올레이트 음이온 CH3S또는 메탄설피네이트 음이온 CH3SO2 와 반응시켜 n이 0 또는 2인 다음 일반식(I)의 화합물을 제조하거나,(a) Methyl thiolate anion CH 3 S Or methanesulfinate anion CH 3 SO 2 React with to form a compound of formula (I) wherein n is 0 or 2, or (b) n 이 0 또는 1인 일반식(I)의화합물을 산화시켜 n인 2인 일반식(I)의 화합물을 제조하거나,(b) oxidizing a compound of formula (I) wherein n is 0 or 1 to prepare a compound of formula (I) wherein n is 2; or (c) 다음 일반식(III)의 퀴놀리늄염을 가수분해하여 n이 2인 일반식(I)의화합물을 제조하거나,(c) hydrolyzing the quinolinium salt of formula (III) to prepare a compound of formula (I) wherein n is 2, or (d) 다음 일반식(V)의 화합물을 가열 전위시켜 n 이 2인 일반식(I)의 화합물을 제조하거나,(d) preparing a compound of formula (I) wherein n is 2 by subjecting the compound of formula (V) to heating potential; (e) n이 1 또는 2인 다음 일반식(Ⅵ)의 화합물을 알킬화시켜 n이 1 또는 2인 일반식(I)의 화합물을 제조함을 특징으로하여 다음 일반식(I)의 화합물을 제조하는 방법.(e) preparing a compound of formula (I) wherein alkylation of a compound of formula (VI) wherein n is 1 or 2 yields a compound of formula (I) How to. 상기식에서In the above formula n은 0,1 또는 2;n is 0, 1 or 2; R1은 저급알킬;R 1 is lower alkyl; R3는 수소, 저급알킬, 메톡시, 메틸티오, 할로 또는 트리플로오로메틸;R 3 is hydrogen, lower alkyl, methoxy, methylthio, halo or trifluoromethyl; X는 이탈기;X is a leaving group; Z는 이탈기;Z is a leaving group; 는 음이온을 나타낸다. Represents an anion. 제1항에 있어서 제조된 화합물이 1-메틸-3-메틸설포닐메틸-4-퀴놀론인 화합물.The compound of claim 1, wherein the compound prepared is 1-methyl-3-methylsulfonylmethyl-4-quinolone. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810003592A 1980-09-26 1981-09-25 Process for the preparation of quinolone compounds KR860000650B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB8031106 1980-09-26
GB8031162 1980-09-26
GB8031106 1980-09-26
GB8031162 1980-09-26
GB8118879 1981-06-19
GB8119062 1981-06-19
GB8118879 1981-06-19

Publications (2)

Publication Number Publication Date
KR830007563A true KR830007563A (en) 1983-10-21
KR860000650B1 KR860000650B1 (en) 1986-05-28

Family

ID=27261015

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003592A KR860000650B1 (en) 1980-09-26 1981-09-25 Process for the preparation of quinolone compounds

Country Status (2)

Country Link
KR (1) KR860000650B1 (en)
ZW (1) ZW22481A1 (en)

Also Published As

Publication number Publication date
ZW22481A1 (en) 1982-04-28
KR860000650B1 (en) 1986-05-28

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