KR830006253A - Method for producing lactam having antihypertensive activity - Google Patents

Method for producing lactam having antihypertensive activity Download PDF

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Publication number
KR830006253A
KR830006253A KR1019810001803A KR810001803A KR830006253A KR 830006253 A KR830006253 A KR 830006253A KR 1019810001803 A KR1019810001803 A KR 1019810001803A KR 810001803 A KR810001803 A KR 810001803A KR 830006253 A KR830006253 A KR 830006253A
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KR
South Korea
Prior art keywords
heteroaryl
alkyl
heterocycloalkyl
aryl
carbon
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KR1019810001803A
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Korean (ko)
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KR850000573B1 (en
Inventor
리이·수우 죤
이·윌리암스 브루스
더블류 스킬즈 제리
뢰브 버나드
Original Assignee
모리스 이·실버슈트인
유우 에스 브이 파마슈티칼 코포레이션
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Priority to KR1019810001803A priority Critical patent/KR850000573B1/en
Publication of KR830006253A publication Critical patent/KR830006253A/en
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Publication of KR850000573B1 publication Critical patent/KR850000573B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음No content

Description

항고혈압 활성을 가지는 락탐의 제조방법Method for producing lactam having antihypertensive activity

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

상응하는 ω-메르캅토카복실산 또는 그의 유도체를 폐환시켜서 다음 일반식의 화합물을 제조하는 방법.A method for preparing a compound of the general formula 상기 식에서,Where n은 0 내지 2의 정수이다.n is an integer of 0-2. R1,R2,R3,R4,R5,R6및 R7은 따로 취해질때는 각각 수소, 알킬, 알케닐, 알키닐, 사이클로알킬, 사이클로알킬알킬, 폴리사이클로알킬, 폴리사이클로알킬알킬, 아릴, 아르알킬, 헤테로아릴, 헤테로아릴-알킬, 헤테로사이클로사이클로알킬, 헤테로사이클로알킬-알킬, 융합아릴사이클로알킬, 융합아릴사이클로알킬알킬, 융합헤테로아릴사이클로-알킬알킬, 치환된 알킬, 예를 들면 하이드록시알킬, 카복시알킬, 카브알콕시알킬, 알콕시알킬, 알킬티옹알킬, 알킬아미노알킬, 또는 디알킬아미노알킬등이며 함게 취해질때R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 when taken separately are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, polycycloalkyl, polycycloalkylalkyl , Aryl, aralkyl, heteroaryl, heteroaryl-alkyl, heterocyclocycloalkyl, heterocycloalkyl-alkyl, fused arylcycloalkyl, fused arylcycloalkylalkyl, fused heteroarylcyclo-alkylalkyl, substituted alkyl, e.g. For example hydroxyalkyl, carboxyalkyl, carboalkoxyalkyl, alkoxyalkyl, alkylthionalkyl, alkylaminoalkyl, or dialkylaminoalkyl, and when taken together R1및 R2와 이들이 결합된 탄소,R 1 and R 2 and the carbon to which they are bonded, R3및 R4와 이들이 결합된 탄소 및R 3 and R 4 and the carbon to which they are bonded and R5및 R6와 이들이 결합된 탄소는 함께 사이클로알킬, 헤테로사이클로알킬, 헤테로사이클로알케닐 또는 사이클로알케닐이며R 5 and R 6 and the carbon to which they are attached together are cycloalkyl, heterocycloalkyl, heterocycloalkenyl or cycloalkenyl R2가 R3및 이들이 결합된 탄소들과 함께 취해질때까지는 사이클로알킬, 헤테로사이클로알킬, 아릴 또는 헤테로아릴, 단 형성된 환이 아릴 또는 헤테로아릴일때Cycloalkyl, heterocycloalkyl, aryl or heteroaryl until R 2 is taken together with R 3 and the carbons to which they are attached, provided that the ring formed is aryl or heteroaryl R1및 R7이 R6가 결합된 탄소 및 R7이 결합된 질소와 함께 취해질땐헤테로사이클로환을 형성하며 이환은 알킬, 치환된 알킬, 알케닐, 하이드록시, 아미노, 니트로, 카복시, 카브알콕시, 아릴, 헤테로아릴, 헤테로사이클로알킬등의 치환체를 가질수도 있으며When R 1 and R 7 are taken together with R 6 bonded carbon and R 7 bonded nitrogen, they form a heterocyclo ring, which ring is alkyl, substituted alkyl, alkenyl, hydroxy, amino, nitro, carboxy, carb It may have a substituent such as alkoxy, aryl, heteroaryl, heterocycloalkyl, Y는 =0, =S, -NR1-, =NOR, 또는 =N-NH2이다.Y is = 0, = S, -NR 1- , = NOR, or = N-NH 2 . 상응하는 카복실산이 다음 일반식을 가지는 특허 청구범위 1에 따른 방법.The process according to claim 1, wherein the corresponding carboxylic acid has the general formula: 기설명은 전술된 바와 같음.Description is as described above. 상응하는 카복실산이 다음 일반식(Ⅱ) 또는 (Ⅱa)를 가지는 특허청구범위 1에 따르는 방법.The process according to claim 1, wherein the corresponding carboxylic acid has the following general formula (II) or (IIa). 상기 식에서 기설명은 전술된 바와 같다.The description in the above formula is as described above. 상응하는 카복실산이 다음 일반식을 가지는 특허청구범위 1에 따르는 방법.A process according to claim 1 wherein the corresponding carboxylic acid has the general formula 상기 식에서In the above formula R7은 전술된 바와 같다.R 7 is as described above. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810001803A 1981-05-23 1981-05-23 Process for preparing lactams KR850000573B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019810001803A KR850000573B1 (en) 1981-05-23 1981-05-23 Process for preparing lactams

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019810001803A KR850000573B1 (en) 1981-05-23 1981-05-23 Process for preparing lactams

Publications (2)

Publication Number Publication Date
KR830006253A true KR830006253A (en) 1983-09-20
KR850000573B1 KR850000573B1 (en) 1985-04-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810001803A KR850000573B1 (en) 1981-05-23 1981-05-23 Process for preparing lactams

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Publication number Publication date
KR850000573B1 (en) 1985-04-29

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