KR830005147A - Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline - Google Patents

Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline Download PDF

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Publication number
KR830005147A
KR830005147A KR1019810001220A KR810001220A KR830005147A KR 830005147 A KR830005147 A KR 830005147A KR 1019810001220 A KR1019810001220 A KR 1019810001220A KR 810001220 A KR810001220 A KR 810001220A KR 830005147 A KR830005147 A KR 830005147A
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South Korea
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groups
group
carbon atoms
methoxy
morpholino
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KR1019810001220A
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Korean (ko)
Inventor
뢰셀 발테르
에세르 프란쯔
루스 오토
라이클 리차드
죠세프 쿤 프란쯔
트라우넥케르 베르네르
Original Assignee
오토 핀케 및 피터 베르호프
씨. 에취. 보링거죤
피터 베르호프
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Priority to KR1019810001220A priority Critical patent/KR830005147A/en
Publication of KR830005147A publication Critical patent/KR830005147A/en

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  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

치환 1-(α-아미노카보닐-벤질)-3,4-디하이드로이소퀴놀린의 제조방법Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

다음 일반식(Ⅱ)의 페닐말론산의 디아미드를 고리화반응시키고, 필요한 경우 제조된 염을 유리염기로 변화시키거나 또는 이 제조염기를 생리적으로 허용되는 산과 반응시켜 이의 염으로 변화시키는 것을 특징으로 하는 다음 일반식(Ⅰ)화합물의 제조방법.And then cyclizing the diamide of phenylmalonic acid of general formula (II), and if necessary, converting the prepared salt into a free base or reacting the prepared base with a physiologically acceptable acid to a salt thereof. The method for producing the following compound of formula (I). 상기 일반식에서In the above general formula R1,R2및 R3는 수소, 하이드록시 또는 메톡시기이거나 또는 합쳐서 메틸렌디옥시기이며R 1 , R 2 and R 3 are hydrogen, hydroxy or methoxy groups or combined are methylenedioxy groups X는 1개 내지 3개 탄소원자를 갖는 디알킬아미노기이거나 또는 아지리디닐, 아제티디닐 또는 피롤리디닐기, 몰포리노 또는 N'-메틸-또는 N'-벤질피페라지노기, N'-메톡시페닐피페리노와 같은 헤테로사이클기, 또는 NHR로서, 이때 R는 1개 내지 4개 탄소원자를 갖는 저급알킬기, 3개 탄소원자를 갖는 알케닐 또는 알키닐기, 3개 내지 6개 탄소원자를 갖는 사이클로알킬기, 몰포리노 또는 피리딜기 또는 하이드록시, 메톡시, 디메틸아미노, 페닐, 메톡시페닐, 디메톡시페닐, 메틸렌디옥시페닐, 몰포리노 또는 인돌릴기에 의해 치환된 디-또는 트리메틸렌기이다.X is a dialkylamino group having 1 to 3 carbon atoms or an aziridinyl, azetidinyl or pyrrolidinyl group, morpholino or N'-methyl- or N'-benzylpiperazino group, N'-methoxy Heterocycle groups, such as phenylpiperino, or NHR, wherein R is a lower alkyl group having 1 to 4 carbon atoms, an alkenyl or alkynyl group having 3 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, a molar Lino or pyridyl groups or di- or trimethylene groups substituted by hydroxy, methoxy, dimethylamino, phenyl, methoxyphenyl, dimethoxyphenyl, methylenedioxyphenyl, morpholino or indolyl groups. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810001220A 1981-04-10 1981-04-10 Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline KR830005147A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019810001220A KR830005147A (en) 1981-04-10 1981-04-10 Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019810001220A KR830005147A (en) 1981-04-10 1981-04-10 Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline

Publications (1)

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KR830005147A true KR830005147A (en) 1983-08-03

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KR1019810001220A KR830005147A (en) 1981-04-10 1981-04-10 Method for preparing substituted 1- (α-aminocarbonyl-benzyl) -3,4-dihydroisoquinoline

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