KR830003427A - Method for preparing decahydroquinolinol derivatives - Google Patents

Method for preparing decahydroquinolinol derivatives

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Publication number
KR830003427A
KR830003427A KR1019800003669A KR800003669A KR830003427A KR 830003427 A KR830003427 A KR 830003427A KR 1019800003669 A KR1019800003669 A KR 1019800003669A KR 800003669 A KR800003669 A KR 800003669A KR 830003427 A KR830003427 A KR 830003427A
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KR
South Korea
Prior art keywords
decahydroquinoline
acid addition
trans
phenoxy
good acid
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Application number
KR1019800003669A
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Korean (ko)
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KR840001357B1 (en
Inventor
프로스트 모리스
크라비에레 미셀드
Original Assignee
베르날드 레일러
옴니엄 피난시에 아퀴테느 푸르 라 이젠 에 라산테(사노피) 주식회사
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Priority to KR1019800003669A priority Critical patent/KR840001357B1/en
Publication of KR830003427A publication Critical patent/KR830003427A/en
Application granted granted Critical
Publication of KR840001357B1 publication Critical patent/KR840001357B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

데카하이드로퀴놀린올 유도체의 제조방법Method for preparing decahydroquinolinol derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (28)

약학적으로 좋은 산첨가 염이 염산염 혹을 메탄설포네이트인 특허청구범위 제3항∼제15항중 어느 한항에 따른 데카하이드로 퀴놀린올 유도체의 제조방법.A method for producing a decahydroquinolinol derivative according to any one of claims 3 to 15, wherein the pharmaceutically good acid addition salt is hydrochloride or methanesulfonate. 다음과 같은 일반적 구조식의 N-치환된 4-하이드록시-트란스-데타하이드로퀴놀린을 제조하기 위하여To prepare N-substituted 4-hydroxy-trans-detahydroquinoline of the general structure 여기에서 n,X 및 Ar은 다음과 같은 일반적인 구조식의 화합물과 함께 실온의 불활성 유기용제 내에서 반응되고 :Where n, X and Ar are reacted in an inert organic solvent at room temperature with a compound of the general structure: 여기에서 R2은 다음과 같은 일반적 구조식의 카르보옥시 유도체를 얻기 위하여 염소원자 또는 페녹시기를 나타내고 :Wherein R 2 represents a chlorine atom or a phenoxy group to obtain a carbooxy derivative of the general structure: 여기에서, n,X,R2및 Ar은 상기에서와 똑같은 의미를 갖고, 상기 카보닐옥시 유도체는 다음과 같은 일반적 구조식의 암모니아 또는 주요 아민과 함께 종속적으로 농축되며 :Herein, n, X, R 2 and Ar have the same meaning as above, and the carbonyloxy derivative is dependently concentrated with ammonia or main amine of the general structure of: 여기에서 R'은 상기에서와 똑같은 의미를 갖고, 만일 원한다면 약학적으로 좋은 산첨가염을 제공하기 위하여 유기산 혹은 무기산과 함께 자유로운 염기 형태에서 대응하는 데카하이드로퀴놀린을 카바미크 에스터를 형성하기 위하여 실온에서, 특히 불활성 용제가 있는 곳에서 반응이 이루어지는 데카하이드로퀴놀린올 유도체의 제조방법.Where R 'has the same meaning as above and, if desired, at room temperature to form a carbamic ester of the corresponding decahydroquinoline in free base form with an organic or inorganic acid to provide a pharmaceutically good acid addition salt. In particular, a method for producing a decahydroquinolinol derivative in which a reaction occurs in the presence of an inert solvent. 4-카르바모이록시-1-[3-(4-플루오르-페녹시)-프로필]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.A process for preparing 4-carbamohydroxy-1- [3- (4-fluoro-phenoxy) -propyl] -trans-decahydroquinoline (axial alignment) and a pharmaceutically good acid addition salt according to the above. 1-[3-(4-브로모-페녹시)-프로필]-4-카르바모이록시-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.1- [3- (4-Bromo-phenoxy) -propyl] -4-carbamooxy-trans-decahydroquinoline (axial alignment) and a method for producing a pharmaceutically good acid addition salt according to the above. 4-카르바모이록시-1-[3-(4-시아노-페녹시)-프로필]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산 첨가염의 제조방법.A process for preparing 4-carbamohydroxy-1- [3- (4-cyano-phenoxy) -propyl] -trans-decahydroquinoline (axial alignment) and a pharmaceutically good acid addition salt according to the above. 1-[3-(4-플루오르-페녹시)-프로필]-4-(N-메틸카르바모이록시)-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.Preparation of 1- [3- (4-Fluoro-phenoxy) -propyl] -4- (N-methylcarbamooxy) -trans-decahydroquinoline (axial alignment) and pharmaceutically good acid addition salts according to the above Way. 4-(N-에틸카르바모이록시)-1-[3-(4-플루오르-페녹시)-프로필]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.Preparation of 4- (N-ethylcarbamohydroxy) -1- [3- (4-fluoro-phenoxy) -propyl] -trans-decahydroquinoline (axial alignment) and pharmaceutically good acid addition salts according to the above Way. 1-[3-(4-플루오르-페녹시)-프로필]-4-(N-n-프로필카르바모이록시)-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.Preparation of 1- [3- (4-Fluoro-phenoxy) -propyl] -4- (Nn-propylcarbamooxy) -trans-decahydroquinoline (axial alignment) and pharmaceutically good acid addition salts according to the above Way. 4-(N-n-부틸카르바모이록시)-1-[3-(4-플루오르-페녹시)-프로필]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.Preparation of 4- (Nn-butylcarbamohydroxy) -1- [3- (4-fluoro-phenoxy) -propyl] -trans-decahydroquinoline (axial alignment) and pharmaceutically good acid addition salts according to the above Way. 4-카르바모이록시-1-[2-(2,6-디클로로-페녹시)-에틸]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산첨가염의 제조방법.A process for preparing 4-carbamohydroxy-1- [2- (2,6-dichloro-phenoxy) -ethyl] -trans-decahydroquinoline (axial alignment) and the pharmaceutically good acid addition salt according to the above. 4-카르바모이록시-1-[3-(4-플루오르-페녹시)-프로필]-트란스-데카하이드로퀴놀린(수평배열)과 상기에 따른 약학적으로 좋은 산 첨가염의 제조방법.A process for preparing 4-carbamohydroxy-1- [3- (4-fluoro-phenoxy) -propyl] -trans-decahydroquinoline (horizontal arrangement) and a pharmaceutically good acid addition salt according to the above. 4-[(3-클로로-4-메틸-페닐-)-카르바모이록시-1-3-(4-플루오르-페녹시)-프로필]-트란스-데카하이드로퀴놀린(수평배열)과 상기에 따른 약학적으로 좋은 산 첨가염의 제조방법.4-[(3-Chloro-4-methyl-phenyl-)-carbamohydroxy-1-3- (4-fluoro-phenoxy) -propyl] -trans-decahydroquinoline (horizontal arrangement) and accordingly Method for preparing pharmaceutically good acid addition salt. 1-[2-(4-브로모-페녹시)-에틸]-4-카르바모이록시-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산 첨가염의 제조방법.1- [2- (4-Bromo-phenoxy) -ethyl] -4-carbamooxy-trans-decahydroquinoline (axial alignment) and a process for preparing a pharmaceutically good acid addition salt according to the above. 4-카르바모이록시-1-[2-(1-나프티록시)-에틸]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산 첨가염의 제조방법.A process for preparing 4-carbamohydroxy-1- [2- (1-naphthyoxy) -ethyl] -trans-decahydroquinoline (axial alignment) and a pharmaceutically good acid addition salt according to the above. 4-카르바모이록시-1-[2-(2-나프티록시)-에틸]-트란스-데카하이드로퀴놀린(축배열)과 상기에 따른 약학적으로 좋은 산 첨가염의 제조방법.A process for preparing 4-carbamohydroxy-1- [2- (2-naphthyoxy) -ethyl] -trans-decahydroquinoline (axial alignment) and a pharmaceutically good acid addition salt according to the above. 중요한 필수성분은 약학적인 캐리어 혹은 부형제와 관련된 데카하이드로 퀴놀린 유도체중 하나로 약학적 혹은 가축병 치료에 쓰일 수 있는 성분비의 제조방법.An important essential ingredient is one of the decahydroquinoline derivatives associated with pharmaceutical carriers or excipients. 여러 가지 원인의 심장부정맥증, 특히 숙주에 의한 심근경맥증에 기인하는 부정맥증에 대하여 데카하이드로 퀴놀린올 유도체중 하나를 이용한 효과적인 투약량으로 구성되는 치료방법.A method of treatment comprising an effective dosage using one of the decahydroquinolinol derivatives against cardiac arrhythmias of various causes, particularly arrhythmia caused by host cardiomyopathy. 상기 효과적인 투약량은 구강 투약인 경우 60kg인 인간을 기준으로 할 때 100∼200mg인 특허청구범위 제17항에 따른 방법.The effective dosage is a method according to claim 17, wherein the effective dosage is 100-200 mg based on a 60 kg human for oral dosing. 특허청구범위 제1항에 따른 데카하이드로퀴놀린올 유도체중 적어도 하나를 이용한 상기 숙주에 대한 효과적인 투약량으로 구성되는 국소마취를 시키는 것을 포함하는 방법.A method comprising local anesthesia consisting of an effective dosage for said host using at least one of the decahydroquinolinol derivatives according to claim 1. * 참고사항 : 최초출원 내용에 의하여 공개하는 것임.* Note: The disclosure is based on the original application.
KR1019800003669A 1980-09-18 1980-09-18 Process for preparing decahydro quinolinol derivatives KR840001357B1 (en)

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KR1019800003669A KR840001357B1 (en) 1980-09-18 1980-09-18 Process for preparing decahydro quinolinol derivatives

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KR1019800003669A KR840001357B1 (en) 1980-09-18 1980-09-18 Process for preparing decahydro quinolinol derivatives

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KR830003427A true KR830003427A (en) 1983-06-20
KR840001357B1 KR840001357B1 (en) 1984-09-20

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