KR830003425A - Quinoline compound and preparation method thereof - Google Patents

Quinoline compound and preparation method thereof Download PDF

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Publication number
KR830003425A
KR830003425A KR1019800003739A KR800003739A KR830003425A KR 830003425 A KR830003425 A KR 830003425A KR 1019800003739 A KR1019800003739 A KR 1019800003739A KR 800003739 A KR800003739 A KR 800003739A KR 830003425 A KR830003425 A KR 830003425A
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KR
South Korea
Prior art keywords
alkyl
quinoline compound
preparation
dihydroquinoline
difluoro
Prior art date
Application number
KR1019800003739A
Other languages
Korean (ko)
Other versions
KR840000522B1 (en
Inventor
요시다까 무시까
쥰이찌 다니
도다로 야마구찌
사또시 오오시마
Original Assignee
마쯔바라 이찌로
다나베 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 마쯔바라 이찌로, 다나베 세이야꾸 가부시끼가이샤 filed Critical 마쯔바라 이찌로
Priority to KR1019800003739A priority Critical patent/KR840000522B1/en
Publication of KR830003425A publication Critical patent/KR830003425A/en
Application granted granted Critical
Publication of KR840000522B1 publication Critical patent/KR840000522B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

퀴놀린 화합물 및 그의 제조방법Quinoline compound and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

다음 구조식(II)의 알킬 6,8-디플루오로-7-메틸-4-옥소-1,4-디하이드로퀴놀린-3-카복실레이트를 다음 구조식(II)의 알킬할라이드와 축합시켜서 다음 구조식(IV)의 알킬 1-치환된-6,8-디플루오로-7-메틸-4-옥소-1,4-디하이드로퀴놀린-3-카복실레이트를 얻고 화합물(IV)를 가수분해 시키고 필요하다면 생성물을 그의 약제학적으로 무독한 염으로 전환시켜서 다음 구조식(I)의 퀴놀린 화합물 또는 그의 약제학적으로 무독한 염을 제조하는 방법.Alkyl 6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate of the following formula (II) is condensed with an alkyl halide of the following formula (II) To obtain alkyl 1-substituted-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate of IV) and hydrolyze compound (IV) and, if necessary, product To convert to a pharmaceutically nontoxic salt thereof to prepare a quinoline compound of formula (I) or a pharmaceutically nontoxic salt thereof. 상기 구조식에서In the above structural formula R1은 수소 또는 불소이고R 1 is hydrogen or fluorine R2는 탄소수 1 내지 5의 알킬이며,R 2 is alkyl having 1 to 5 carbon atoms, X는 할로겐이다.X is halogen. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019800003739A 1980-09-25 1980-09-25 Process for preparation of quinoline derivatives KR840000522B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019800003739A KR840000522B1 (en) 1980-09-25 1980-09-25 Process for preparation of quinoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019800003739A KR840000522B1 (en) 1980-09-25 1980-09-25 Process for preparation of quinoline derivatives

Publications (2)

Publication Number Publication Date
KR830003425A true KR830003425A (en) 1983-06-20
KR840000522B1 KR840000522B1 (en) 1984-04-17

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ID=19217808

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003739A KR840000522B1 (en) 1980-09-25 1980-09-25 Process for preparation of quinoline derivatives

Country Status (1)

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KR (1) KR840000522B1 (en)

Also Published As

Publication number Publication date
KR840000522B1 (en) 1984-04-17

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