KR830001193A - Pentapeptide with analgesic action - Google Patents

Pentapeptide with analgesic action Download PDF

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Publication number
KR830001193A
KR830001193A KR1019790002689A KR790002689A KR830001193A KR 830001193 A KR830001193 A KR 830001193A KR 1019790002689 A KR1019790002689 A KR 1019790002689A KR 790002689 A KR790002689 A KR 790002689A KR 830001193 A KR830001193 A KR 830001193A
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KR
South Korea
Prior art keywords
methyl
hydrogen
pentapeptide
involved
protected
Prior art date
Application number
KR1019790002689A
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Korean (ko)
Inventor
엠. 가르스키 빅터
Original Assignee
존 알. 스태포드
아메리칸 홈 프로닥트스 코포레이숀
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 존 알. 스태포드, 아메리칸 홈 프로닥트스 코포레이숀 filed Critical 존 알. 스태포드
Priority to KR1019790002689A priority Critical patent/KR830001193A/en
Publication of KR830001193A publication Critical patent/KR830001193A/en

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Abstract

내용 없음No content

Description

진통작용을 갖는 펜타펩타이드Pentapeptide with analgesic action

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음This content is subject to disclosure, so the full text is not included.

Claims (8)

펩타이드 형성에 필수적인 아미노산 또는 이의 활성 유도체를 반응에 관여되지 않는 반응성 그룹은 중간단계에서 보호 시키는 반면 목적한 순서대로 연속하여 형성되는 CO-NH-결합을 축합(여기에서 반응에 관여하지 않는 반응성 그룹은 중간 단계에서 보호됨)시킴을 특징으로하여 다음 구조식(A)를 갖는 펜타펩타이드 및 약학적으로 무독한 이의 염의 제조방법.Reactive groups that are not involved in the reaction of amino acids essential for peptide formation or active derivatives thereof are protected in an intermediate step, while condensation of CO-NH-bonds that are formed consecutively in the desired order (here, reactive groups not involved in the reaction are Protected in the intermediate step), characterized in that the method for producing a pentapeptide having the following structural formula (A) and a pharmaceutically non-toxic salt thereof. 상기 구조식에서In the above structural formula R1은 수소, 메틸, 에틸, 프로필, 2메틸-2-펜틸-2-메틸-1-펜테닐, 사이클로프로필메틸 또는 사이클로 부틸 메틸이고,R 1 is hydrogen, methyl, ethyl, propyl, 2methyl-2-pentyl-2-methyl-1-pentenyl, cyclopropylmethyl or cyclobutyl methyl, R2, R3및 R4는 각기 수소 또는 메틸이며,R 2 , R 3 and R 4 are each hydrogen or methyl, X는 -OH, -NH2, -NHCnH2n+1이며(여기에서 n은 1,2,3 또는 4임), -OR5또는 CH2OR5이다.X is -OH, -NH 2 , -NHCnH 2 n +1 (where n is 1,2,3 or 4), -OR 5 or CH 2 OR 5 . (여기에서 R5는 수소 또는 탄소수 1 내지 4의 저급 알킬임)(Wherein R 5 is hydrogen or lower alkyl having 1 to 4 carbon atoms) ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed according to the contents of the initial application.
KR1019790002689A 1979-08-07 1979-08-07 Pentapeptide with analgesic action KR830001193A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019790002689A KR830001193A (en) 1979-08-07 1979-08-07 Pentapeptide with analgesic action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019790002689A KR830001193A (en) 1979-08-07 1979-08-07 Pentapeptide with analgesic action

Publications (1)

Publication Number Publication Date
KR830001193A true KR830001193A (en) 1983-04-29

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ID=72896978

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019790002689A KR830001193A (en) 1979-08-07 1979-08-07 Pentapeptide with analgesic action

Country Status (1)

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KR (1) KR830001193A (en)

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