KR830000198A - Preparation of [1-oxo-2-aryl or thienyl-2-substituted-5-indayloxy (or thio)]alkanoic acid - Google Patents

Preparation of [1-oxo-2-aryl or thienyl-2-substituted-5-indayloxy (or thio)]alkanoic acid Download PDF

Info

Publication number
KR830000198A
KR830000198A KR1019740003765A KR740003765A KR830000198A KR 830000198 A KR830000198 A KR 830000198A KR 1019740003765 A KR1019740003765 A KR 1019740003765A KR 740003765 A KR740003765 A KR 740003765A KR 830000198 A KR830000198 A KR 830000198A
Authority
KR
South Korea
Prior art keywords
lower alkyl
represents hydrogen
thienyl
aryl
halo
Prior art date
Application number
KR1019740003765A
Other languages
Korean (ko)
Other versions
KR870000034B1 (en
Inventor
제이아르 에드워드 제트로 크라고
제이아르 옷토 윌리암 월터스도르프
Original Assignee
스테펜 지, 젤레즈나크
맬크앤드 캄파니, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스테펜 지, 젤레즈나크, 맬크앤드 캄파니, 인코포레이티드 filed Critical 스테펜 지, 젤레즈나크
Publication of KR830000198A publication Critical patent/KR830000198A/en
Application granted granted Critical
Publication of KR870000034B1 publication Critical patent/KR870000034B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/42—Polycyclic acids with carboxyl groups bound to condensed ring systems containing three or more condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음No content

Description

[1-옥소-2-아릴 또는 티에닐-2-치환-5-인다닐옥시(또는 티오)]알카노익 애시드의 제법Preparation of [1-oxo-2-aryl or thienyl-2-substituted-5-indayloxy (or thio)]alkanoic acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음This content is subject to disclosure, so the full text is not included.

Claims (19)

본문에 상술한 바와 같이, 다음 일반식(4)의 2-아릴 또는 2-티에닐-2-치환-5-하이드록시(또는 메르캅토)-1-인다논을 염기의 존재하에서 다음 일반식(가)의 할로알카노익 애시드 또는 그 에스테르와 반응시켜 다음 일반식(1)의 [1-옥소-1-아릴 또는 티에닐-2-치환-5-인다닐옥시(또는 티오)]알카노익애시드를 제조하는 방법.As described above in the text, 2-aryl or 2-thienyl-2-substituted-5-hydroxy (or mercapto)-1-indaone of the following general formula (4) in the presence of a base is given by the following general formula ( [1-oxo-1-aryl or thienyl-2-substituted-5-danyloxy (or thio)] alkanoic of the following general formula (1) by reacting with a) haloalkanoic acid or ester A method of making acid. 식중,Food, 을 표시하고And A는 산소 또는 유황을 표시하며,A denotes oxygen or sulfur, R은 저급알킬, 저급알케닐, 페닐저급알킬, 티에닐, 페닐저급알케닐, 페닐, 싸이클로알킬 또는 싸이클로알킬저급알킬을 표시하고,R represents lower alkyl, lower alkenyl, phenyl lower alkyl, thienyl, phenyl lower alkenyl, phenyl, cycloalkyl or cycloalkyl lower alkyl, R1은 수소, 저급알킬 또는 아릴을 표시하며, 또는R 1 represents hydrogen, lower alkyl or aryl, or R1과 R은 함께 결합하여 싸이클로 알켄을 형성하고,R 1 and R combine together to form a cycloalkene, Y은 1-약 4개의 탄소원자를 함유하는 알킬렌 또는 할로알킬렌을 표시하며,Y represents an alkylene or haloalkylene containing 1 to about 4 carbon atoms, X3는 수소, 니트로, 저급알킬, 저급알콕시, 싸이클로알킬, 할로, 아미노, 시아노, 설파모일 또는 메탄설포닐을 표시하고,X 3 represents hydrogen, nitro, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl or methanesulfonyl, X7은 수소, 저급알킬 또는 할로겐을 표시하며,X 7 represents hydrogen, lower alkyl or halogen, X8은 수소 또는 저급알킬을 표시하고,X 8 represents hydrogen or lower alkyl, X1은 수소 할로 또는 메틸을 표시하며,X 1 represents hydrogen halo or methyl, X2은 할로, 메틸 또는 트리할로메틸을 표시하며, 또는X 2 represents halo, methyl or trihalomethyl, or X1과 X2는 함께 결합하여 3-약 4개의 탄소원자를 함유하는 하이드로카르빌 렌체인을 형성하고,X 1 and X 2 are bonded together to form a hydrocarbylene chain containing 3 to about 4 carbon atoms, Z는 할로를 표시하며,Z denotes halo, R3는 수소 또는 저급알킬을 표시한다.R 3 represents hydrogen or lower alkyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed according to the contents of the initial application.
KR7403765A 1973-10-11 1974-10-08 The process for preparing (1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy) alkanoic acids KR870000034B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40573673A 1973-10-11 1973-10-11
US405736 1973-10-11
US49265174A 1974-07-30 1974-07-30
US492651 1990-03-13

Publications (2)

Publication Number Publication Date
KR830000198A true KR830000198A (en) 1983-03-30
KR870000034B1 KR870000034B1 (en) 1987-02-07

Family

ID=27019215

Family Applications (1)

Application Number Title Priority Date Filing Date
KR7403765A KR870000034B1 (en) 1973-10-11 1974-10-08 The process for preparing (1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy) alkanoic acids

Country Status (27)

Country Link
JP (1) JPS5939415B2 (en)
KR (1) KR870000034B1 (en)
AR (4) AR213065A1 (en)
AT (1) AT342036B (en)
BG (1) BG28255A3 (en)
CA (1) CA1063125A (en)
CH (2) CH613933A5 (en)
CS (1) CS190439B2 (en)
CY (1) CY1074A (en)
DD (1) DD118075A5 (en)
DE (2) DE2463215C2 (en)
EG (1) EG11741A (en)
ES (2) ES430900A1 (en)
FR (1) FR2247218B1 (en)
GB (2) GB1474460A (en)
HK (1) HK47680A (en)
HU (1) HU169587B (en)
IE (1) IE39927B1 (en)
IL (1) IL45779A (en)
KE (1) KE3068A (en)
LU (1) LU71078A1 (en)
MY (1) MY8100163A (en)
NL (2) NL187854C (en)
PH (2) PH22225A (en)
RO (2) RO71480A (en)
SU (1) SU738509A3 (en)
YU (1) YU39727B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51535B1 (en) * 1980-09-02 1987-01-07 Merck & Co Inc Pharmaceutical compositions containing 4-((6,7-dihalogen-2,3-dihydro-1-oxo-1h-inden-5-yl)-oxy)butanoic acid compounds
US5489712A (en) * 1994-11-04 1996-02-06 Hoechst Celanese Corporation Process for preparing cyclic ketones
CN109748785A (en) * 2019-01-14 2019-05-14 山东大学 Two aromatic hydrocarbon substituted propenone class compounds of one kind and preparation method and application

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3704314A (en) * 1968-11-25 1972-11-28 Merck & Co Inc (1-oxo-2-alkylideneindanyloxy) and (1-oxo - 2 - alkylideneindanylthio) alkanoic acids
US3668241A (en) * 1968-11-25 1972-06-06 Merck & Co Inc Substituted 1-oxoinden-5-yloxy alkanoic acids

Also Published As

Publication number Publication date
IE39927L (en) 1975-04-11
PH22017A (en) 1988-05-13
ES449917A1 (en) 1977-11-16
JPS5939415B2 (en) 1984-09-22
HK47680A (en) 1980-09-05
YU39727B (en) 1985-04-30
KE3068A (en) 1980-08-08
ES430900A1 (en) 1977-01-01
RO64568A (en) 1979-03-15
PH22225A (en) 1988-07-01
JPS5076058A (en) 1975-06-21
NL187854B (en) 1991-09-02
LU71078A1 (en) 1975-06-24
FR2247218B1 (en) 1978-02-03
AR213620A1 (en) 1979-02-28
KR870000034B1 (en) 1987-02-07
ATA807874A (en) 1977-07-15
AT342036B (en) 1978-03-10
IL45779A0 (en) 1974-12-31
AR213170A1 (en) 1978-12-29
NL7412829A (en) 1975-04-15
RO71480B (en) 1983-07-30
AR213840A1 (en) 1979-03-30
AR213065A1 (en) 1978-12-15
DE2448454C2 (en) 1985-08-29
GB1474460A (en) 1977-05-25
CH613933A5 (en) 1979-10-31
SU738509A3 (en) 1980-05-30
DE2463215C2 (en) 1986-03-13
GB1474459A (en) 1977-05-25
NL187854C (en) 1992-02-03
AU7391674A (en) 1976-04-08
BG28255A3 (en) 1980-03-25
CH610290A5 (en) 1979-04-12
FR2247218A1 (en) 1975-05-09
IE39927B1 (en) 1979-01-31
EG11741A (en) 1977-12-31
DE2448454A1 (en) 1975-04-24
HU169587B (en) 1976-12-28
MY8100163A (en) 1981-12-31
CA1063125A (en) 1979-09-25
YU272774A (en) 1983-06-30
NL9100396A (en) 1991-06-03
DD118075A5 (en) 1976-02-12
IL45779A (en) 1978-06-15
RO71480A (en) 1983-08-03
CS190439B2 (en) 1979-05-31
CY1074A (en) 1980-10-24

Similar Documents

Publication Publication Date Title
ES2020981B3 (en) SUBSTITUTED PHENYLSULPHONAMIDES.
KR850006386A (en) Preparation method of azoles
KR830009064A (en) Method for preparing compound containing sulfur compound in cyclodextrin
KR900016190A (en) 2-phenylpyridine
KR840006324A (en) Method for preparing 2-nitro-1,1-enediamine
KR830000198A (en) Preparation of [1-oxo-2-aryl or thienyl-2-substituted-5-indayloxy (or thio)]alkanoic acid
KR830004300A (en) Method for preparing benzodiazepine compound
KR840006128A (en) Animal growth promoter
IT1115063B (en) STABILIZED ANAEROBIC COMPOSITIONS CONTAINING ACIDS
KR830010106A (en) Method for preparing piperazine derivatives
SE7908994L (en) TIAZOLIDINE AND PYRROLIDINE DERIVATIVES
KR830007539A (en) Method for preparing intramolecular or intermolecular disulfide in cysteine fluid
KR830007655A (en) Process for preparing benzodiazepine compound
KR870006024A (en) How to prepare nizatidine
GB1302823A (en)
KR840007656A (en) Insecticide composition
KR830009090A (en) Method for preparing 1-benzyl-4- [4- (2-pyrimidinylamino) benzyl] -2,3-dioxopiperazin derivative
KR840009099A (en) Method for preparing cyclic dithiodiacetamide
KR830009044A (en) Method for preparing 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compound
ES377689A1 (en) A procedure for the preparation of an aciloxialquilheterociclico compound. (Machine-translation by Google Translate, not legally binding)
KR830010075A (en) Method for preparing compound having peripheral vasodilating action
KR890011901A (en) Animal growth promoters
KR830001264A (en) Benzothiazepine derivatives
KR830006266A (en) Method for preparing carbamate derivative
KR830006379A (en) Olefin Polymer Composition