KR820000269B1 - Capsule body for a pharmaceutical preparation - Google Patents

Capsule body for a pharmaceutical preparation Download PDF

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Publication number
KR820000269B1
KR820000269B1 KR7801519A KR780001519A KR820000269B1 KR 820000269 B1 KR820000269 B1 KR 820000269B1 KR 7801519 A KR7801519 A KR 7801519A KR 780001519 A KR780001519 A KR 780001519A KR 820000269 B1 KR820000269 B1 KR 820000269B1
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South Korea
Prior art keywords
capsule
capsule body
immersion
pref
cap
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KR7801519A
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Korean (ko)
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울리히 보데만 한스
필립 반 헤리 루이스
마텐스 위넨트
Original Assignee
에이치. 유. 보덴만
캡슈겔 에이지
지·지그만
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Priority to KR7801519A priority Critical patent/KR820000269B1/en
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Publication of KR820000269B1 publication Critical patent/KR820000269B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The body has a narrow longitudinal zone of reduced dia. immediately adjacent the open end to be capped. Such a body is pref. produced by first forming a body which is longer than required for the final casing. Near the open end of the overlength body there is a narrow zone of reduced dia. produced by forming an annular channel in the outer surface. The body is cut to the required length transversely through the annular channel, pref. at the smallest possible dia. of a tapered or radiused channel. The overlength body is pref. moulded around a forming mandrel having an annular groove to form the channel. The mandrel is dipped into a liq. which will set, e.g. gelatin, to form a casing.

Description

약학적 캅셀체의 제조방법Manufacturing method of pharmaceutical capsule

제 1 도- 5 도는 캅셀체를 제조하는 각 단계도.1 to 5 are each step of producing a capsule body.

본 발명은 캅셀체에 캅셀캡이 끼워진 캅셀로서 특히 약학적 제제용으로 적합한 한쪽 끝이 폐쇄된 원주형 형태의 약학적 캅셀체의 제조방법에 관한 것이다. 또한 본 발명은 상기 캅셀체를 제조하는 방법과 고체화되어 캅셀체의 벽을 형성하는 상기 방법을 실시하는 침액조에 침액핀이 장치된 기구에 관한 것이다.The present invention relates to a method for producing a pharmaceutical capsule body in the form of a columnar form in which one end is closed, which is particularly suitable for pharmaceutical preparations, as a capsule in which a capsule cap is inserted in the capsule body. The present invention also relates to a mechanism in which a immersion pin is provided in a immersion tank for carrying out the method for producing the capsule body and the method of solidifying to form a wall of the capsule body.

최근에 몸체부분이 캡을 끼운 결합된 캅셀에 대한 요구가 증가하였다. 이러한 종류의 결합된 캅셀은 약학제제를 쉽게수용할 수 있으며 또한 기타 조심스레 저장해야할 물질도 수용가능하다. 재래식 결합된 캅셀에서는 몸체와 캡을 끼웠을때 아주 꼭맞게 제조하였다. 그러나 몸체와 캡의 측면에 물결 무늬등을 삽입하므로써 이들이 단단히 결합하게 할수도 있다.Recently, there has been an increasing demand for combined capsules in which body parts are capped. This type of bound capsule can easily accommodate pharmaceutical formulations and other substances that should be stored carefully. In conventional combined capsules, the body and the cap fit perfectly when fitted. However, by inserting a wave pattern on the side of the body and cap, they can be firmly combined.

이러한 형태의 결합된 캅셀은 주로 몸체의 상단 구멍에서 저장물질을 채운후 캡으로 상기 몸체를 끼우는 방법을 사용한다. 이러한 저장 작업은 양이 많으면 간단한 주기간격 실시 한다. 몸체의 캡의 배열이 항상 완전하지 못하므로 충진기에 관한 관용도 및 몸체내의 충진 물질중 잔여부분으로 인하여 캡과 몸체를 끼울 경우 캡의 끝이 몸체의 끝과 서로 닿아 캡이나 몸체를 손상시킬 수도 있으며 충진기의 가동을 중단시킬 수도 있다.This type of combined capsule mainly uses a method of filling the body with a cap after filling the storage material in the upper hole of the body. If this storage is large, a simple main period is carried out. Since the arrangement of the cap of the body is not always perfect, when the cap and the body are fitted due to the latitude of the filler and the remaining part of the filling material in the body, the cap ends may come into contact with the ends of the body and damage the cap or the body. It is also possible to shut down the filling machine.

본 발명은 캅셀체와 캡을 끼웠을때 끝이 접착하는 위험을 줄이고자 함에 그 목적이 있다.An object of the present invention is to reduce the risk of tip adhesion when the capsule body and the cap are fitted.

캅셀체나 캅셀캡의 제조시 부정확성, 혹은 상기를 서로 끼웠을 경우 잘못된 배열, 충진 물질중 잔여부분은 몸체와 캡이 끼움을 좀더 사전 준비함으로 캅셀체와 캡이 서로 접합하는 것을 방지할 수 있다.Inaccuracies in the manufacture of the capsule body or capsule cap, or in the case of the interfitting, the misalignment, the remaining part of the filling material can prevent the capsule body and the cap from bonding to each other by preparing the body and the cap in advance.

본 발명에 따라서 캅셀체는 하기 언급한 방법으로 우수하게 제조한다. 캅셀체는 우선 홈을 두고 제조하여 그 입구를 압축하고 압축 부분을 절단하여 제조한다.According to the present invention, the capsule body is excellently prepared by the method mentioned below. The capsule body is first manufactured by making a groove, compressing the inlet, and cutting the compressed part.

캅셀체는 압축부분의 최소직경에서 절단하는 것이 유리하다. 이로서 생성캅셀체의 직경은 압축부가 깊이가 있을 경우 각 끝에서 가장 적게 제조한다.The capsule body is advantageously cut at the minimum diameter of the compressed portion. As a result, the diameter of the resulting capsule body is the smallest at each end when the compression part is deep.

장치에 관한 본 발명에 있는 문제는 본 발명에 따른 상기 언급한 장치로 침액핀을 침액옥조로부터 간격을 둔 연속적 홈으로 제조한 방법에 의해 해결된다. 상기 방법에서, 침액핀을 욕조에서 꺼낼때 캅셀체를 홈에 상당하는 압축부가 있는 침액핀으로 제조한다.The problem in the present invention with respect to the device is solved by the method in which the immersion pins are produced in a continuous groove spaced from the immersion ox with the abovementioned device according to the invention. In the above method, the capsule body is made of the immersion pin having a compression portion corresponding to the groove when the immersion pin is taken out of the bath.

홈의 축 넓이는 깊이의 10-20배가 유리하다. 이 칫수는 침액핀에서 굳은 캅셀체를 침액핀을 꺼낼때 홈부근에서 기계적 강도로 인해 찢어지지 않고 침액핀을 꺼낼수 있게 한다.The axial width of the groove is advantageously 10-20 times the depth. This dimension makes it possible to remove the immersion pin from the immersion pin without pulling the immersion pin from the immersion pin due to the mechanical strength near the groove.

본 발명에 따라 캅셀체는 결합된 캅셀 즉 상응하는 캅셀 캡을 끼우므로 유용할 뿐 아니라 캅셀에 우선 분말이나 액체물질로 채우고 호정으로 봉입한 후 캅셀체 물질로 결합된 조성물의 봉입부를 굳게한 캅셀로도 유용하다. 발명된 캅셀체 끝부분의 압축부분은 봉입조성물로 형성된 표피층은 캅셀체의 압축부분 때문에 캅셀체와 꼭 결합하므로 상기 연결에서 봉입조성물을 특히 안전하게 지지한다. 캅셀체를 젤라틴으로 만들경우 사용된 봉입조성물은 특히 안전한 결합이 젤라틴 봉입 캅셀체와 캅셀체 양벽 사이에서 이루어지므로 젤라틴이 역시 좋다.According to the present invention, the capsule body is not only useful because it fits the combined capsule, that is, the corresponding capsule cap, but also fills the capsule with powder or liquid material first, and then encapsulates the capsule, and then encapsulates the encapsulation part of the composition combined with the capsule material. Also useful. The compressive portion of the end of the capsule body invented is formed of an encapsulation composition, so that the epidermal layer is tightly coupled with the capsule body because of the compressive portion of the capsule body, so that the encapsulation composition is particularly securely supported in the connection. The encapsulation composition used when making the capsule body gelatin is particularly good because the safe bond is made between the gelatin encapsulation capsule body and both capsule body walls.

본 발명을 하기한 도면에 관해서 보다 상세히 설명할 것이다.DETAILED DESCRIPTION OF THE INVENTION The present invention will be described in more detail with reference to the following drawings.

제 1 도는 고체화되는 액체 즉 젤라틴 욕조 10, 및 하단이 둥글게 되어있고 환형으로 홈 14가 파져있는 침액 핀 14를 도시하고 있다.FIG. 1 shows a liquid to be solidified, ie a gelatin bath 10, and a immersion pin 14 with a rounded bottom and an annular groove 14.

침액핀은 우선 재래식 기구(도시되지 않았음)로 여러변 기름을 바른후 욕조 10에 홈 14가 닿지 않게 침액한다.The immersion pin is first lubricated with conventional oils (not shown) and then immersed in the tub 10 so that the grooves 14 do not touch the tub 10.

침액핀 12를 욕조밖으로 꺼낼경우 이때 고체화 되는 액체층 16은 침액핀 표면에 피복된다. 상기 층의 두께를 균일하게 유지하기 위하여 액체의 유동성이 없어질 정도로 고체화되기전에 침액핀 12를 제 2 도에서 처럼 하단이 둥근 재래식 기구를 사용하여 때로는 위로 때로는 아래로 횡축으로 회전시킨다.When the immersion pin 12 is taken out of the bath, the solidified liquid layer 16 is then coated on the immersion pin surface. In order to keep the thickness of the layer uniform, the immersion pin 12 is sometimes rotated transversely up and down sometimes using a conventional rounded bottom as shown in FIG.

박피 16이 굳으면 침액핀 12를 2-3부품 즉 20,22등으로 이루어진 틀속에 집어넣고 굳은 박피 16을 양면에 꽉 조인다.When the peeling 16 is hardened, put the immersion pin 12 into a frame composed of 2-3 parts, that is, 20 and 22, and tighten the firm peeling 16 firmly on both sides.

제 4 도에서 예시한 것처럼 침액핀 12를 틀 18의 위쪽으로 뽑아내면 박피 16은 홈 26이 있는 몸체 24로서 틀 18안에 남아있게 된다. 침액핀내의 홈 14는 침액핀 12를 박피 16밖으로 꺼낼수 있고 몸체 24에 이러한 운동을 방해하는 홈 14로 인해 형성된 압축부 26이 양적으로 관련되지 않을 정도로 넓다. 각종 칫수 범위가 몸체 24 물질의 탄성에 따라 가능하다. 직경 약 6.7mm의 침액핀 12의 홈 14는 예컨데 1.5mm의 축길이와 약 0.9mm의 깊이를 갖는다.As illustrated in FIG. 4, when the immersion pin 12 is pulled out of the frame 18, the peeling 16 remains in the frame 18 as the body 24 having the groove 26. The grooves 14 in the immersion pins are wide enough that the immersion pins 12 can be pulled out of the peeling 16 and the compression portion 26 formed by the grooves 14 in the body 24 which interferes with this movement is not quantitatively related. Various ranges of dimensions are possible depending on the elasticity of the body 24 material. The groove 14 of the immersion pin 12 having a diameter of about 6.7 mm has an axis length of 1.5 mm and a depth of about 0.9 mm, for example.

틀 18의 하단면은 평면이며 압축부 26의 가장 깊은 위치로 배열되어 있다. 침액핀 12를 꺼낸후 몸체 24를 틀 18을 종축으로 몸부분 24와 함께 회전시키며 칼날 18로 압축부 26의 가장 깊은 부분을 절단한다.The bottom face of the framework 18 is planar and arranged in the deepest position of the compression section 26. Take out the immersion pin 12 and rotate the body 24 to the frame 18 along the body 24 along the longitudinal axis, and cut the deepest part of the compression section 26 with the blade 18.

생성된 몸체 30은 틀 18의 부품 20과 22를 풀어 꺼내며 입구부분의 32의 직경은 줄어진 형태로 제조되었다.The resulting body 30 unscrews parts 20 and 22 of the frame 18 and the diameter of the inlet 32 is reduced.

침액핀을 제 1 도에 따른 침액핀 12로 대체하여 제 1 도- 5 도에서의 방법은 재래식 기구를 사용하여서도 가능하다.The method in FIGS. 1-5 is also possible using a conventional instrument by submerging the immersion pins with the immersion pins 12 according to FIG. 1.

Claims (1)

캅셀체(30)를 우선 홈이 파지게 제조한 후 입구부위(32)의 직경이 줄어지게하고 압축부(26)을 최소직경에서 절단하는 것을 특징으로하는 캅셀체와 캅셀캡을 서로 끼운 결합된 캅셀로서 특히 약학적 제제용으로 적합한 한쪽끝이 폐쇄된 원주형 형태의 캅셀체의 제조방법.The capsule body 30 is first manufactured to be grooved, and then the diameter of the inlet portion 32 is reduced, and the compression body 26 is cut at the minimum diameter. A method for producing a capsule body in the form of a cylinder in which one end is closed, which is particularly suitable as a capsule, for pharmaceutical preparations.
KR7801519A 1978-05-20 1978-05-20 Capsule body for a pharmaceutical preparation KR820000269B1 (en)

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KR7801519A KR820000269B1 (en) 1978-05-20 1978-05-20 Capsule body for a pharmaceutical preparation

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Application Number Priority Date Filing Date Title
KR7801519A KR820000269B1 (en) 1978-05-20 1978-05-20 Capsule body for a pharmaceutical preparation

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KR820000269B1 true KR820000269B1 (en) 1982-03-15

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KR7801519A KR820000269B1 (en) 1978-05-20 1978-05-20 Capsule body for a pharmaceutical preparation

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