KR800001939Y1 - Device for the inhalation of medicaments - Google Patents

Abstract

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Description

Pharmaceutical Inhalation Device

1 is a side view of Embodiment 1. FIG.

2 is a plan view of the medical container of Figure 1 removed.

3 is a cross-sectional view at cross section 1-1 of FIG.

4 is a view from the bottom to separate only the medical container of FIG.

5 is a side view of the medicine receiving plate 20 of FIG.

6 is a rear view of the medicine receiving plate 20 of FIG.

7 is a side view of Example 2. FIG.

8 is a side view of Example 3. FIG.

9 is a side view of only the medical container of Example 3.

10 is a side view of Example 4. FIG.

11 is a plan view of Example 4 with the medical container removed.

12 is a side view of Example 5. FIG.

13 is a longitudinal sectional view of the sixth embodiment;

14 is a longitudinal sectional view of the seventh embodiment;

15 is a longitudinal sectional view of the eighth embodiment;

16 is a longitudinal sectional view of Embodiment 9;

The present invention relates to a powder medicine or a liquid medicine inhalation device.

Usually, powdered or liquid medicine is known to be used for diseases of the respiratory system such as bronchial asthma and rhinitis.

These medicines are made by miniaturizing the medicine by blowing compressed air, superheated steam or gas, and then inhaling these medicines in an aerosol state. However, this method has the disadvantage that most of the medicine is not inhaled in the respiratory tract. Therefore, it is difficult to take the correct amount of medication. Moreover, this method can cause a significant amount of medication to enter the stomach and be absorbed, often causing unexpected side effects. And because the gas must be blown during the inhalation of the patient to put a burden on the stomach. To compensate for these drawbacks, powdered medicine inhalation devices have been developed. A feature of this device is that the powdered drug is dispersed and sucked only when the air is sucked through the opening containing the drug (Belgium Patent Number: 804,645, US Patent No. 3,795,244).

This known device has a generally propeller-shaped flow portion device operated by inhalation air to disperse powder medicine. The use of such devices allows a significant amount of powdered medicine to be inhaled into organs of the respiratory system, but there are also some disadvantages to this device.

First, since the medication is dispersed only when the patient inhales a significant amount of air, a fairly deep breathing can be very painful for the patient.

Second, it is inevitable that some of the powdered drug will stick to the flow section of the device during inhalation.

Third, the device with a floating part is relatively expensive for a large number of patients with respiratory disease to buy and use.

Finally, the existing device can only be used in powder medicines in needle-sized capsules, and the device is limited in size to the drug particles for proper drug dispersion.

This existing device is unsuitable for micron-sized powdered or liquid medicines.

The present invention seeks to provide a device which compensates for the disadvantages of existing devices.

These shortcomings were solved by the medical inhalation device. Looking at the structure of the drug inhalation device as follows.

In other words, there is a venturi tube-shaped housing 1 and a suction aid 2 therein and a container 3 for receiving medicine, and the opening 5 for discharging the medicine is a diffusion part of the venturi tube-shaped housing 1. Pierced up to

In the apparatus of the present invention, the venturi tube-shaped housing to be handled is made such that the air flow in the interior thereof is the same as the gas flow in the venturi tube.

The shape of the housing is venturi tube shape, and the discharge opening 5 of the medicine container 3 is disposed in front of the diffusion part of the housing, which causes optimum dispersion and atomization of the medicine suitable for inhalation use.

Moreover, the device of the present invention can be used not only in any small particle sized medicine but also in micron sized powder medicine or liquid medicine.

The structure of the device allows it to be used in medicines that are in capsules or not.

The basic structure of the device is as follows. That is, the venturi tube-shaped housing has a small chamber (6) in which the front end is open, and the rear end is connected to the annular or tubular constriction part (7), which is in turn connected to the suction aid (2). have. Immediately next to the constriction 7 is an opening 5 of the container 3 which is drilled to the diffusion of the housing.

The vane 6 with the shear open may be in various shapes such as circumference, ellipse, spherical or funnel. The open front end of this chamber may have one to two openings, which are 1 to 100 times the minimum area of the entire constriction of the chamber. The disappearance itself has a maximum inner diameter of 2 to 10 times the minimum inner diameter of the tightening portion.

In order to obtain the optimum flow, the chamber 6 is formed in a funnel shape in the direction of the constriction 7.

The annular or tubular constriction portion 7 connected to the chamber 6 has a length of 1 mm to 20 mm and a minimum inner diameter of 1 mm to 5 mm.

The suction aids 2 located in the constriction 7 may be tubular and often widen outwardly in a funnel shape. When the device of the present invention is used to inhale medicine through the nose, the inhalation aid (2) is preferably extended outwardly like a funnel, and the dosing tube (8) bent upwards is added.

The dosing tube can be detached and attached, and at its end, a conical adduct 30 is added which can be detached and attached freely and shaped appropriately for inhalation through the nose.

When the device of the present invention inhales medicine through the mouth, the suction aid (2) is wider like a funnel, it is preferable to be narrowed in the shape of a truncated cone near the mouth, the upper and lower portions of the narrow conical portion of the suction aid (2) It is preferable to be flat so as to have an ellipse or quasi-rectangular opening. Because of the unusual shape of this opening, patients involuntarily push the tongue downward of the suction aid 2 to obtain optimal suction.

The container 3 containing the medicine may have a medication device 4 attached thereto, and the medicine release opening 5 of the medicine container 3 or the medication device 4 may be extended to the diffusion part of the venturi tube-shaped housing 1. Connected to the housing.

In principle, the device of the present invention allows the use of several kinds of containers 3 together with the application device 4, in which the discharge opening 5 is fixedly connected to the housing and drilled in front of the diffusion of the housing 1. The vessel holder 13 is added together. The container support 13, the medicine support 14, and the respective components of the dosage device are combined to form a container 3 containing the medicine, and in particular, their form depends on the powder or liquid of the medicine used in the device of the present invention. .

The medicament container 14 can thus be divided into dosage sections within 2 to 24, with each dosage section being filled with a certain amount of powdered medicament and then placed on the container support 13 by a commonly used device. Device. The medical container 14 is then rotated so that one of the sections of medication is placed over the opening 5 of the container holder 13 and the other dosage sections are blocked by the container holder 13 or (the container holder 13 It is closed by a cover plate (17) which is secured to and has a hole which can also be moved over the opening (5).

For example, the structure of the pharmaceutical container 3 which is good for accommodating powdered medicine is as follows.

The medicine container 14 is cylindrical, and cylindrical or conical two to twenty-four needle holes, which can be used as the dosage section, are located at the same distance from the center of the cylinder, and each of the dosage sections can release the medicine on the cylinder. It is positioned so that it is mutually symmetrical around the center of the cone. Each of these dose sections has a precisely defined dose to take the required individual dose of the medication to be taken. The medicine container 14 can be added with a rotatable and open cover plate 17 and can release the medicine through the opening of the cover plate. The reason is that the distance from the center of the cover plate opening is the same distance from the center of the other opening in the medical container. In this form of the medical container 14 and the cover plate 17, the medical container support 13 preferably has a cylindrical cavity, in which the medical container 14 together with the cover plate 17 It is inserted to rotate. A device is provided in the cover plate and the container support to enable the cover plate 17 to be coupled to the cavity of the container support 13. The opening 5 which is drilled into the container support penetrates into the inside of the housing 1 in the form of a venturi tube, and the cavity and the cavity 15 from the center of the medical container 14 to the needle hole 15 are rotated when the medical container 14 is rotated. Since the distance from the center is located equal, the medication is arranged to be released.

The device described above is suitable for the administration of powdered medications having a prescribed number of doses. After taking the medicine, the empty container 14 should be replaced with a new container filled with medicine, if necessary. Patients are given a fixed amount of medication, and taking more than that can be dangerous. Therefore, it is very convenient to use this device in this case.

In addition, when the apparatus of the present invention is used for individual doses of powdered medicines in a larger number of times without exchange of medical containers, the shape of the medical container 14 may be a bottle or a box.

The medication container 14 may be connected to the vessel holder 13, which is arranged upside down in a housing 1 similar to a venturi tube, and which has a movable dosage plate 17 having 1 to 20 dose sections and an opening portion of the vessel. Closing lid 18, the remaining dosing section is closed from the vessel holder 13, while moving over the opening 5 and under the lid 18 of the dosing container holder 13 by movement of the dosing plate 17. Is configured to be, is provided in the medicament container 14 or the support 13.

The apparatus described above may have the following structure. That is, the box-shaped container 14 is closed at the bottom of the cover plate 18, and the cover plate has an opening some distance from the center. The movable axis is through the center of the medicament container, on which side is fitted a handle and an agitator and is fixed to the dosage plate 17 under the cover plate. In the dosage plate 17, there are 1 to 20 dosage sections, which are arranged at the same distance from the center as the distance of the opening of the cover plate.

The vessel holder 13 is connected to a housing formed similarly to the venturi tube and has an upper portion in the shape of a plate. And also has the release opening 5 at the same distance as the distance from the center of the dosage plate. The container holder 13 or the medical container 14 also has an annular or nodal shape device, in which the dosage plate 17 is placed on the plate-shaped surface of the support 13, and the opening 5 of the support and the opening of the lid are relatively different. The medical container 14 can be installed in the container holder 13 so as to be replaced by the container.

The above-described apparatus may have the following structure.

That is, the medical container support 13 is connected to the venturi tube-shaped housing 1, and the upper part is shaped like a disk, is fixed to the center of this disk, and has a pin away from the discharge opening 5. The pin has a medication plate 17 with one to twenty dose sections and the distance to the center of these dose sections is equal to the distance to the center of the opening 5. The medication plate 17 is provided with a support ring, on which a box-shaped medical container 14 may be mounted. The cover plate is securely fixed to the pin, which is configured to close the dosage section above the opening 5 from the contents of the medical container.

The above-described device is provided with a receiving plate 20 which is located in the constriction 7 and located below the discharge opening 5. The plate is formed such that the drug from the opening 5 is retained in the plate 20 even when the device is inclined and during the rearward rotation of the diffusion while the preliminary turn takes place in the receiving plate by suction action. To this end, the receiving plate 20 has a groove in its longitudinal direction and has a front edge protruding beyond the surface of the plate, which is 30 ° to 120 ° with the bottom of the plate. In addition, the above-mentioned device is provided with a device which rotates the container 3 or the dosage plate 17 and is coupled to each other when the dosage section is located on the discharge opening 5.

The following structure is suitable for inhalation of liquid medicine.

A venturi tube-shaped housing 1 is connected to the vessel holder 13, which has a cylindrical cavity used as a dose section and a tubular discharge opening 5 for acting as a discharge. The medicament container 14, which is made of a bottle-shaped elastic material, can be mounted to the support 13 by supporting it with a support device, which, when placed in position, protrudes into a cavity in the support 13 It is closed by a plug that extends through the shaped opening.

On the other hand, the container 3 containing the medicine may be open on both sides, and the opening 5 for discharging the container is disposed so as to end just before the diffusion portion of the housing 1 in the form of a venturi tube.

The container 3 can be tubular, funnel-shaped, spherical or rounded in shape, with one or more openings at both ends. Inside the container there is an ideal post, knot or protrusion that is particularly ideal when inhaling the medicine contained in the capsule.

The container 3 containing the medicine may be placed between the chamber 6 and the constriction 7 and is directly related to the constriction 7.

When the container 3 is used to inhale a medicament contained in a capsule, its inner diameter is ideally 1 to 2 times the diameter of the capsule and its length is ideally 0.6 to 1.2 times the length of the capsule to be inserted.

Therefore, the container 3, which is open at both ends for receiving medicine, may consist of a funnel for receiving medicine, which funnel is provided as a capillary outlet in which the opening 5 ends in front of the constriction.

Ideally, the capillary release opening 5 of the container 3 has an opening 0.1 mm to 2 mm in diameter therein. It can stretch in a straight line, and the funnel (ideally provided at the front of the tubular) is placed in the middle of the chamber and is connected to the latter by a strut.

On the other hand, the capillary release opening 5 can be bent and the funnel can be laterally fixed to the vanishing wall so as to project into the vanishing wall from the outside.

Containers of this kind are suitable for accommodating pharmaceutical capsules and for accommodating 1 mg to 1000 mg of powder or liquid medicine.

The material of manufacture of the device can be made of glass, porcelain, synthetic resin or metal without any particular limitation, but synthetic resins which are easy to process are ideal.

The device is a clear, light colored synthetic resin that allows the patient to control inhalation.

In order to prevent the device from being electrostatically charged, the housing can be made of synthetic resin, if necessary, coated with a conductive material or synthesized with conductive tissue.

The device according to the invention can, if necessary, add a device that can make the use of the device more convenient. In other words, for example, a blower gas, or a device capable of allowing suction as superheated steam or compressed air, may be attached to the chamber 6. On the other hand, a needle or knife-like member which is arranged to penetrate the inserted medical capsule of the device may also be provided.

Each of the following examples illustrate the device and method of use of the present invention.

Example 1

The present invention will be described in detail below with reference to FIGS. 1 to 6.

The device consists of a venturi tube-shaped housing (1) provided with a suction aid (2), a container support (13), a receiving plate (20), a dosage plate (17), and a medicine container (14), each of which is heated. It is a plastic material and made of transparent, light green synthetic resin.

The venturi tube-shaped housing 1 consists of two truncated cones, and the ends of the truncated cones are connected to each other to form the vanishing chamber 6 and the funnel-shaped vanishing chamber 10. Between these two chambers, there is a constriction 7 having an inner diameter of 4 mm. The funnel-shaped chamber 10 has a suction aid 2. This suction aid consists of a truncated cone casing (11), which is in contact with the top and bottom of the arch-like cover plate (12), thus forming a quasi-rectangular inlet of 6 mm in height and 20 mm in length.

A wedge-shaped receiving plate 20 having a thickness of 2 mm and a depth of 17 mm is arranged to protrude 12 mm into the chamber 6 from the venturi tubular housing horizontally symmetrical surface and close at the same height as the side wall. This receiving plate has a bang on its base and has a groove on its upper surface.

The vessel holder 13 above the chamber 6 is formed to lie flush with the upper half of the chamber 6 and ends at the top of the cylindrical plate provided with an annular rim. The vessel holder has an opening 5 with a diameter of 3.5 mm and its center is at a distance of 6 mm from the center of the cylindrical plate. This opening reaches the chamber 6 through the container 13 and extends to the constriction 7. This opening is on the opposite side of the hole 21 for receiving the support plate of the dosage plate 17.

The medical container 14 is cylindrical and the upper half of the container is an annular rim with grooves on the side. The medical container has a cylindrical cavity at the bottom. There are five conical holes 15 in this cavity, located at intervals of 60 ° from each other, a distance of 6 mm from the center, and a dosage section having an underside 8 mm high and 3.5 mm in diameter.

In the cavity of the vessel holder is placed loosely a dosage plate 17 3.5 mm in diameter, 6 mm from the center, with a support pin 22 on the opposite side away from the hole. How to use this device is as follows. That is, the medication plate and the container 14 filled with 20 mm ³ of powder medicine in each of the five cone holes are inserted into the vessel holder 13 so that the support pins 22 of the medication plate 17 come into contact with the holes 21. do. By rotating the container 14 by 60 °, 20 mm ³ of medicine can be discharged and aspirated.

Example 2

A side view of the apparatus described in this embodiment is shown enlarged twice in FIG. 7.

The device consists of a suction aid (2), a container support (13), a venturi tube-shaped housing (1) provided with a receiving plate (20) and a container (3) provided with a dosage device (4) made of polycarbonate. .

The venturi tubular housing 1, the suction aid 2, and the receiving plate 20 have the same shape and size as the same parts of the apparatus described in the embodiment 1.

The vessel holder 13 of this apparatus differs from that described in Example 1 only in that there are annular grooves and center holes, respectively, instead of the annular rims and holes 21.

The container 3 of the device provided with the dosage device 4 comprises a medicine container 14, a shaft 26 with an agitator 24, a dosage plate 17, a handle 25, and a cover plate 18. It is.

The medicine container 14 is a hollow cylinder whose top is blocked and has a center hole at the bottom. In this central opening there is a shaft 26 provided with a handle 25 and a stirrer 24 which is twisted in the form of a screw. Under the stirrer is a cover plate fixed to the medical container with a central hole and a 6mm wide rim under the cover plate. There is a hole of 3.5 mm in diameter at a position 6 mm from the center of the cover plate. Underneath the cover plate, a 2.6 mm thick dosage plate 17 having two holes 15 with a diameter of 3.5 mm, 6 mm away from the center of the dosage plate, is arranged on the opposite side and fixed to the shaft 26. do.

For use of the device, the container filled with powdered medicine 3 is placed on the container holder 13 so that the hole in the cover plate 18 is placed away from the outlet opening 5 of the container holder 13. By rotating the handle 180 °, medicine at 25 mm ³ can be aspirated through the opening.

Example 3

Side views of scale 2 of the device to be performed are shown in figures 8 and 9. The figure 8 shows a venturi tube-shaped housing 1, a suction aid 2 and a container support 13 attached to the housing, the material being polycarbonate. The shape and size of the housing 1 and the suction aid 2 are the same as those in the embodiment 1.

The vessel holder 13 is composed of a hollow cylinder having a height of 9 mm and an inner diameter of 12 mm, and is covered by a bottom placed on the housing 1 so that the center of the hollow cylinder lies on the constriction portion 7 of the venturi tubular housing 1. Through the bottom and the chamber 6, a metal tube 5 with an inner diameter of 1 mm and 4 mm from the center of the hollow cylinder is disposed, which projects 3.5 mm into the hollow cylinder and extends through the center of the elongate portion 7 and tightens. It is bent inside the chamber so as to end at 1 mm of the part 7.

9 shows the container 3 removed from the device. It consists of a medicament bottle 14 made of polyethylene and has a cavity of 10 ml volume. The neck of the medicament bottle 14 is inserted with a plug 27 made of polyethylene and protrudes 5 mm above the rim of the bottle. A metal tube 28 having an internal diameter of 1 mm away from the center of the plug extends through the plug and projects 3.5 mm above the plug.

On the neck of the bottle is provided a welcoming support 29 made of elastic synthetic resin and provided with eight grooves.

For use the venturi tubular housing is mounted on the vertical container 3 and the hollow interior is filled with liquid medicine by the pressure of the medical container. The medicine container is released and the medicine inside is inhaled.

Example 4

The apparatus described in this embodiment is shown in FIGS. 10 and 11 on a scale 2. FIG. 10 is a side view of the device, and FIG. 11 is a plan view of the device from which the medical container is removed.

The device is connected to a suction aid (2), a dosage device (4), and a medical container (14), each composed of a venturi tube-shaped housing (1) made of thermoplastic transparent synthetic resin.

The venturi tubular housing 1 is narrower and there is a building 7 having a diameter of 2 mm at a place of 22 mm. The dosing tube 8 connected to it bends upwards as shown in FIG. 10. The end of the dosing tube 8 is chamfered and fitted with a conical cap 30 with a hole. The disc-shaped support 13 is arranged on the housing 1 by the basic principle so that the central axis of the support 13 is 4 mm in front of the constriction 7. At the center of the vessel holder 13 is pin 31 which extends up to the cover plate. At a distance of 6 mm from the center of the vessel holder there is an opening 5 having a diameter of 3.5 mm and opening up to the enlarged part 10 of the housing 1. Opposite this opening is a cavity 32 in which is a helical spring with a stop pin. The dosage plate 17 is rotatably mounted on the support, and the dosage plate has a diameter of 3.5 mm with a center hole and a shape of the center hole shown in FIGS. 10 and 11, respectively, and is rotated by 120 ° 6 mm away from the center. It has three holes 15 as shown. There are three hemispherical grooves 34 on the bottom of the medication plate, each 9 mm from the center, opposite each of the openings 15 and with the stop pin 33 inserted.

A lid 18 (on the opening 5) is secured to the medication plate and secured to the pin 31 and covering the opening 15 to close the medical container 14.

The medical container 14 itself is a box-shaped member and can be placed on the dosage plate 17. This device is used to inhale 20 mm ³ of powdered medicine every time.

Example 5

The device shown in FIG. 12 consists of a venturi tube-shaped housing 1, a suction aid 2, a receiving plate of the type described in embodiment 1, in which the dosing device described in embodiment 4 In addition to (4), the medical container 14 is installed by the basic principle.

Example 6

A longitudinal sectional view of the apparatus described in this embodiment is shown in FIG.

The device is made of transparent glass plates and is 90mm long. The apparatus consists of a spherical suction aid 2 having a maximum internal diameter of 25 mm and a diameter of a circular hole of 20 mm. Adjacent to this inhalation aid, there is a constriction 7 with an inner diameter of 5 mm, and a tubular container 3 containing powder medicine and having a length of 20 mm and a minimum inner diameter of 6 mm has three welcoming ridges to fix the capsule.

A ship-shaped chamber 6 having a length of 40 mm and a minimum inner diameter of 25 mm is connected to this part, and there is a circular hole 4 at the front end.

The described apparatus may be configured to have a suction aid having the form described in the embodiments (1) to (4) instead of the suction aid (2) described above.

The device is used to inhale powdered medicine in a perforated capsule of 6 mm in diameter and 18 mm in length, which is inserted into the container 3 for inhalation purposes.

Example 7

The longitudinal cross-sectional view described in this embodiment is shown in FIG. The device is made of glass and the housing is made of a funnel-shaped suction aid (2) with a length of 25 mm and a maximum inner diameter of 25 mm, a constriction (7) with a minimum inner diameter of 5 mm, and a funnel-shaped chamber with a length of 35 mm and a maximum diameter of 38 mm (6). It is composed.

The second glass tube with an internal diameter of 6 mm becomes a container 3 for containing medicine. It extends up to 13mm of this tube and becomes narrower in the shape of funnel from then on, forming a capillary tube 25mm in length and 1mm in inner diameter, which is bent at about 120 °.

This part is inserted into a hole in the housing and the capillary hole is fused to the housing such that it is axisymmetric to the constriction.

The described device may be configured to have a suction aid of the type described in embodiment (1) or (4) instead of the suction aid described above.

This device is used for inhalation of powder or liquid medicine contained in a reservoir provided with a dosage device.

Example 8

A longitudinal sectional view of the apparatus described in this embodiment is shown in FIG.

The device is made of plastic glass.

The device consists of a funnel-type suction aid 2 having a length of 20 mm and a maximum inner diameter of 13 mm, which is connected to a tubular constriction 7 having a length of 4 mm and an inner diameter of 4 mm.

This constriction is also connected to a ship-shaped chamber 6 having a length of 30 mm and a maximum inner diameter of 25 mm. At the anterior end, this vane has a 23 mm circular hole, which is intercepted by two struts 9 each extending symmetrically to the center of the hole. A 41 mm long, 6 mm inner tubular vessel (3), which holds the medicine and lies on the axis of symmetry of the device, is secured to these posts, which has a funnel-shaped constriction that terminates at a posterior end with a capillary tube with an inner diameter of 1 mm, which protrudes into the center of the constriction. do.

The device is suitable for inhaling powdered medicine in perforated capsules 18 mm long and 6 mm in diameter.

Example 9

A longitudinal cross-sectional view of the apparatus described in this embodiment is shown in FIG. 16 and is made of P.V.C. The device consists of a tube 16 having a length of 60 mm, an outer diameter of 21 mm, and an inner diameter of 19 mm, which is 25 mm apart from one end of the tube and is 25 mm long and 13 mm deep and 8 mm in diameter. There is a circular member 35 having a funnel-shaped hole located on the other side of the central hole.

A 6 mm diameter medical capsule is inserted into the large hole of the circular member 35. After the funnel-shaped capsule support 36 is inserted, the device is closed on both sides in each case by a plug carrying a needle 37 with an inner diameter of 2 mm, which needle has a length that passes through the capsule when the plug is inserted.

After removal of the plug, medication in the device may be inhaled and the device discarded after use.

Claims (1)

A device for inhaling medicine in the form of a powder or liquid, comprising a venturi tube, a housing (1) provided with an inhalation aid (2) and a container in which the discharge opening (5) ends in front of the diffusion of the housing (1) Pharmaceutical inhalation device characterized by (3).