KR790000220B1 - Process for preparing 5-(1-hydroxy-2-substituted-amino)alkyl-8-substituted-carbostyril (or-3,4-dihydro carbostril) derivatives - Google Patents

Process for preparing 5-(1-hydroxy-2-substituted-amino)alkyl-8-substituted-carbostyril (or-3,4-dihydro carbostril) derivatives

Info

Publication number
KR790000220B1
KR790000220B1 KR7404368A KR740004368A KR790000220B1 KR 790000220 B1 KR790000220 B1 KR 790000220B1 KR 7404368 A KR7404368 A KR 7404368A KR 740004368 A KR740004368 A KR 740004368A KR 790000220 B1 KR790000220 B1 KR 790000220B1
Authority
KR
South Korea
Prior art keywords
substituted
alkyl
carbostyril
carbostril
dihydro
Prior art date
Application number
KR7404368A
Other languages
Korean (ko)
Inventor
Kazuyuki Nakakawa
Shiro Yoshizaki
Kaozu Tanimura
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP744192A external-priority patent/JPS539227B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Priority to KR7404368A priority Critical patent/KR790000220B1/en
Application granted granted Critical
Publication of KR790000220B1 publication Critical patent/KR790000220B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril

Abstract

H, C1-4 alkyl, R2, R3 = H, C1-4 alkyl, straight or branched aralkyl(C1-4 alkyl). C4-6 cycloalkyl) were prepd. by treating carbostyril or 3,4-dihydrocarbostyril with alkanoic acid in the presence of Lewis acid, aminating with sec. amine, then reducing in the presence of catalyst. The derivs. have bronchodilating, or hypotensive actions.
KR7404368A 1973-12-26 1974-12-26 Process for preparing 5-(1-hydroxy-2-substituted-amino)alkyl-8-substituted-carbostyril (or-3,4-dihydro carbostril) derivatives KR790000220B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR7404368A KR790000220B1 (en) 1973-12-26 1974-12-26 Process for preparing 5-(1-hydroxy-2-substituted-amino)alkyl-8-substituted-carbostyril (or-3,4-dihydro carbostril) derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP744192A JPS539227B2 (en) 1973-12-26 1973-12-26
KR7404368A KR790000220B1 (en) 1973-12-26 1974-12-26 Process for preparing 5-(1-hydroxy-2-substituted-amino)alkyl-8-substituted-carbostyril (or-3,4-dihydro carbostril) derivatives

Publications (1)

Publication Number Publication Date
KR790000220B1 true KR790000220B1 (en) 1979-04-06

Family

ID=26337923

Family Applications (1)

Application Number Title Priority Date Filing Date
KR7404368A KR790000220B1 (en) 1973-12-26 1974-12-26 Process for preparing 5-(1-hydroxy-2-substituted-amino)alkyl-8-substituted-carbostyril (or-3,4-dihydro carbostril) derivatives

Country Status (1)

Country Link
KR (1) KR790000220B1 (en)

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