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Alkylergolines (I ; R = CH2-CN or CH2CONH2), prolactin inhibitors, were prepd. by two methods. Thus, D-6-methyl-8-substituted ergolin (II) was treated with methylformate and ethanethiol, and the resulting dithioacetal of ergolin converted to I by desulfurization; or D-6-methyl-8-halomethyl ergolin converted to 2-formyl substituted dithioacetal by formylization in the presence of ethanedithiol and 2-methyl substituted dithioacetal by desulfurization, and the resulting compd. reacted with an inorg. cyanide in an inactive solvent followed by hydrolysis to give I.
KR7403798A1974-10-111974-10-11Process for producing d-2,6-dimethyl-8-substituted ergolines
KR790000122B1
(en)
Procedure for the preparation of urea inclusion compounds based on perdicarboxylic acids (Machine-translation by Google Translate, not legally binding)
Procedure for the purification of insulin from an aqueous extract of pancreas with insulin content or other aqueous solutions with insulin content. (Machine-translation by Google Translate, not legally binding)