KR20250128304A - 올리고뉴클레오티드의 제조 방법 - Google Patents

올리고뉴클레오티드의 제조 방법

Info

Publication number
KR20250128304A
KR20250128304A KR1020257019981A KR20257019981A KR20250128304A KR 20250128304 A KR20250128304 A KR 20250128304A KR 1020257019981 A KR1020257019981 A KR 1020257019981A KR 20257019981 A KR20257019981 A KR 20257019981A KR 20250128304 A KR20250128304 A KR 20250128304A
Authority
KR
South Korea
Prior art keywords
oligonucleotide
group
less
flp
chain length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257019981A
Other languages
English (en)
Korean (ko)
Inventor
유키 다나카
Original Assignee
스미또모 가가꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스미또모 가가꾸 가부시끼가이샤 filed Critical 스미또모 가가꾸 가부시끼가이샤
Publication of KR20250128304A publication Critical patent/KR20250128304A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
KR1020257019981A 2022-12-26 2023-12-25 올리고뉴클레오티드의 제조 방법 Pending KR20250128304A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022208672 2022-12-26
JPJP-P-2022-208672 2022-12-26
PCT/JP2023/046424 WO2024143276A1 (ja) 2022-12-26 2023-12-25 オリゴヌクレオチドの製造方法

Publications (1)

Publication Number Publication Date
KR20250128304A true KR20250128304A (ko) 2025-08-27

Family

ID=91717985

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257019981A Pending KR20250128304A (ko) 2022-12-26 2023-12-25 올리고뉴클레오티드의 제조 방법

Country Status (5)

Country Link
EP (1) EP4644404A1 (https=)
JP (1) JPWO2024143276A1 (https=)
KR (1) KR20250128304A (https=)
CN (1) CN120418262A (https=)
WO (1) WO2024143276A1 (https=)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
MX370398B (es) 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
CN116063365A (zh) * 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
KR102670605B1 (ko) 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Org. Chem., 1970, 35, 3800-3803
Mass Spectrometry, Reviews 2021, 40, 75-109
Oligonucleotides 2006, 16, 181-185

Also Published As

Publication number Publication date
WO2024143276A1 (ja) 2024-07-04
CN120418262A (zh) 2025-08-01
EP4644404A1 (en) 2025-11-05
JPWO2024143276A1 (https=) 2024-07-04

Similar Documents

Publication Publication Date Title
JP7719788B2 (ja) 核酸オリゴマーの製造方法
JP7777452B2 (ja) 核酸オリゴマーの製造方法
JP7759323B2 (ja) 核酸オリゴマーの製造方法
JP7698631B2 (ja) 核酸オリゴマーの製造方法
JP7667788B2 (ja) 核酸オリゴマーの製造方法
KR20250046255A (ko) 티오화 용액
KR20250042734A (ko) 올리고뉴클레오티드의 제조 방법
EP4410770A1 (en) Production method for purified dichloroacetic acid
KR20250128304A (ko) 올리고뉴클레오티드의 제조 방법
JP7825064B2 (ja) オリゴヌクレオチドの製造方法
WO2026071145A1 (ja) 核酸オリゴマーの製造方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

Q12 Application published

Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-NAP-PG1501 (AS PROVIDED BY THE NATIONAL OFFICE)