KR20240172228A - Nlrp3을 억제하기 위한 옥소인돌리닐 아미드 유도체 및 이의 용도 - Google Patents

Nlrp3을 억제하기 위한 옥소인돌리닐 아미드 유도체 및 이의 용도 Download PDF

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KR20240172228A
KR20240172228A KR1020247038886A KR20247038886A KR20240172228A KR 20240172228 A KR20240172228 A KR 20240172228A KR 1020247038886 A KR1020247038886 A KR 1020247038886A KR 20247038886 A KR20247038886 A KR 20247038886A KR 20240172228 A KR20240172228 A KR 20240172228A
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alkyl
compound
cycloalkyl
halo
haloalkyl
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Korean (ko)
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패트릭 시어
스테판 시블랫
제이슨 버치
스테판 도리치
미구엘 세인트-온지
램지 베버리지
알렉산드르 코테
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벤투스 테라퓨틱스 유에스 인코포레이티드
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Publication of KR20240172228A publication Critical patent/KR20240172228A/ko
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020247038886A 2022-05-13 2023-05-12 Nlrp3을 억제하기 위한 옥소인돌리닐 아미드 유도체 및 이의 용도 Pending KR20240172228A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263341614P 2022-05-13 2022-05-13
US63/341,614 2022-05-13
PCT/US2023/066934 WO2023220715A1 (en) 2022-05-13 2023-05-12 Oxoindolinyl amide derivatives for inhibiting nlrp3 and uses thereof

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KR20240172228A true KR20240172228A (ko) 2024-12-09

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KR1020247038886A Pending KR20240172228A (ko) 2022-05-13 2023-05-12 Nlrp3을 억제하기 위한 옥소인돌리닐 아미드 유도체 및 이의 용도

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US (1) US20240368131A1 (cg-RX-API-DMAC7.html)
EP (1) EP4522591A1 (cg-RX-API-DMAC7.html)
JP (1) JP2025516719A (cg-RX-API-DMAC7.html)
KR (1) KR20240172228A (cg-RX-API-DMAC7.html)
CN (1) CN119212978A (cg-RX-API-DMAC7.html)
AU (1) AU2023268557A1 (cg-RX-API-DMAC7.html)
CA (1) CA3251062A1 (cg-RX-API-DMAC7.html)
CL (1) CL2024003460A1 (cg-RX-API-DMAC7.html)
CO (1) CO2024015371A2 (cg-RX-API-DMAC7.html)
IL (1) IL316674A (cg-RX-API-DMAC7.html)
JO (2) JOP20240258A1 (cg-RX-API-DMAC7.html)
MX (1) MX2024013978A (cg-RX-API-DMAC7.html)
PE (1) PE20251252A1 (cg-RX-API-DMAC7.html)
TW (1) TW202409013A (cg-RX-API-DMAC7.html)
WO (1) WO2023220715A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20252770A1 (es) * 2023-03-17 2025-12-22 Ventus Therapeutics U S Inc Derivados de amida para inhibir nlrp3 y usos de estos
CN122206665A (zh) * 2023-11-15 2026-06-12 万特斯治疗美国公司 用于抑制nlrp3的内酰胺衍生物及其用途
TW202545527A (zh) 2024-01-16 2025-12-01 英商諾得瑟拉公司 Ｎｌｒｐ３及ｇｌｐ－１ａ組合療法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
AR119731A1 (es) * 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3

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Publication number Publication date
WO2023220715A1 (en) 2023-11-16
US20240368131A1 (en) 2024-11-07
CO2024015371A2 (es) 2024-12-30
PE20251252A1 (es) 2025-05-06
EP4522591A1 (en) 2025-03-19
CA3251062A1 (en) 2023-11-16
TW202409013A (zh) 2024-03-01
JOP20240257A1 (ar) 2024-11-12
JP2025516719A (ja) 2025-05-30
IL316674A (en) 2024-12-01
MX2024013978A (es) 2024-12-06
CN119212978A (zh) 2024-12-27
CL2024003460A1 (es) 2025-04-11
AU2023268557A1 (en) 2024-11-14
JOP20240258A1 (ar) 2024-11-12

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