KR20240153588A - Glp-2 수용체 작용제 융합체를 암호화하는 바이러스 벡터 및 단장 증후군 치료에서의 이의 용도 - Google Patents

Glp-2 수용체 작용제 융합체를 암호화하는 바이러스 벡터 및 단장 증후군 치료에서의 이의 용도 Download PDF

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KR20240153588A
KR20240153588A KR1020247031780A KR20247031780A KR20240153588A KR 20240153588 A KR20240153588 A KR 20240153588A KR 1020247031780 A KR1020247031780 A KR 1020247031780A KR 20247031780 A KR20247031780 A KR 20247031780A KR 20240153588 A KR20240153588 A KR 20240153588A
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sequence
glp
seq
aav
protein
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Korean (ko)
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제임스 엠. 윌슨
크리스티안 힌더러
마코토 호리우치
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더 트러스티스 오브 더 유니버시티 오브 펜실베니아
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
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    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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KR1020247031780A 2022-03-03 2023-03-03 Glp-2 수용체 작용제 융합체를 암호화하는 바이러스 벡터 및 단장 증후군 치료에서의 이의 용도 Pending KR20240153588A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263316219P 2022-03-03 2022-03-03
US63/316,219 2022-03-03
PCT/US2023/063681 WO2023168405A2 (en) 2022-03-03 2023-03-03 Viral vectors encoding glp-2 receptor agonist fusions and uses thereof in treating short bowel syndrome

Publications (1)

Publication Number Publication Date
KR20240153588A true KR20240153588A (ko) 2024-10-23

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ID=87884276

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Application Number Title Priority Date Filing Date
KR1020247031780A Pending KR20240153588A (ko) 2022-03-03 2023-03-03 Glp-2 수용체 작용제 융합체를 암호화하는 바이러스 벡터 및 단장 증후군 치료에서의 이의 용도

Country Status (10)

Country Link
US (1) US20250186613A1 (https=)
EP (1) EP4486765A4 (https=)
JP (1) JP2025509193A (https=)
KR (1) KR20240153588A (https=)
CN (1) CN119522285A (https=)
AU (1) AU2023227587A1 (https=)
CA (1) CA3245162A1 (https=)
IL (1) IL315253A (https=)
MX (1) MX2024010774A (https=)
WO (1) WO2023168405A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025106930A1 (en) * 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007067828A2 (en) * 2005-10-24 2007-06-14 Centocor, Inc. Glp-2 mimetibodies, polypeptides, compositions, methods and uses
CA2833623A1 (en) * 2011-04-20 2012-10-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aav mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity
EP3332012A4 (en) * 2015-08-06 2019-01-16 The Trustees of The University of Pennsylvania GLP-1 AND USE THEREOF IN COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES
CN107987170B (zh) * 2016-10-27 2018-12-18 浙江道尔生物科技有限公司 一种用于治疗肠道疾病的融合蛋白
US20200199192A1 (en) * 2017-08-22 2020-06-25 Shire-Nps Pharmaceuticals, Inc. Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions

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WO2023168405A3 (en) 2023-10-12
US20250186613A1 (en) 2025-06-12
WO2023168405A2 (en) 2023-09-07
JP2025509193A (ja) 2025-04-11
EP4486765A2 (en) 2025-01-08
EP4486765A4 (en) 2026-04-15
CA3245162A1 (en) 2023-09-07
CN119522285A (zh) 2025-02-25
AU2023227587A1 (en) 2024-09-19
IL315253A (en) 2024-10-01
MX2024010774A (es) 2024-12-06

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