KR20240064226A - Method for providing customized diet menu of infant based on height-related gene and intestinal microbiological examination - Google Patents
Method for providing customized diet menu of infant based on height-related gene and intestinal microbiological examination Download PDFInfo
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- KR20240064226A KR20240064226A KR1020220146001A KR20220146001A KR20240064226A KR 20240064226 A KR20240064226 A KR 20240064226A KR 1020220146001 A KR1020220146001 A KR 1020220146001A KR 20220146001 A KR20220146001 A KR 20220146001A KR 20240064226 A KR20240064226 A KR 20240064226A
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- 238000000034 method Methods 0.000 title claims abstract description 31
- 230000002906 microbiologic effect Effects 0.000 title 1
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- 238000012360 testing method Methods 0.000 claims abstract description 38
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Abstract
본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명은 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법에 관한 것으로, 영유아의 유전자형 및 장내 미생물 환경에 따른 식단을 제공함으로써 키성장을 촉진시킬 수 있을 뿐만 아니라, 웹 또는 앱을 이용한 실시간으로 자동 영유아용 맞춤형 식단을 제공함으로써, 편리하게 키성장용 식단을 제공할 수 있다.The present invention was developed in response to the above-mentioned needs. The present invention relates to a method of providing a customized diet for infants and young children for height growth based on height growth-related genes and intestinal microorganism tests, according to the infant's genotype and intestinal microbial environment. Not only can height growth be promoted by providing a diet, but it is also possible to conveniently provide a diet for height growth by automatically providing customized diets for infants and toddlers in real time using the web or app.
Description
본 발명은 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법에 관한 것이다.The present invention relates to a method of providing a customized diet for infants and young children for height growth based on height growth-related genes and intestinal microorganism tests.
최근 들어 체형의 서구화 및 평균 신장의 상승으로 인하여 키 성장에 대한 관심이 높아지고 있다. 사람의 키성장은 유아기에서 사춘기까지의 시기에 대부분이 일어나며, 이 시기에 적절한 영양섭취가 이루어지지 않으면 성장이 제대로 이루어지지 않게 된다. 성장기 어린이들의 뼈는 성인과는 달리 성장판이 열려있으며, 이 시기에 각종 영양성분의 섭취와 적절한 운동을 통하여 성장판의 부위가 성장하여 전체적으로 키가 커지게 된다. 이러한 이유로, 영유기부터 키성장에 대한 관심은 급증하고 있는 상황이다. Recently, interest in height growth is increasing due to the westernization of body types and the increase in average height. Most of a person's height growth occurs from infancy to puberty, and if proper nutritional intake is not provided during this period, growth will not occur properly. Unlike adults, growing children's bones have an open growth plate. During this period, through intake of various nutrients and appropriate exercise, the growth plate area grows and the overall height increases. For this reason, interest in height growth from infancy is rapidly increasing.
성장을 광의의 개념으로 정의하면 신장의 증가뿐 아니라 신체 각 기관의 크기와 기능의 증대를 포함하는 것이라 할 것이나, 이를 협의의 개념으로 정의하자면 신장의 증가를 의미하는 것으로 볼 수 있다. 이러한 신장의 증가는 영양과 성장 호르몬 등의 여러 요인에 의한 결과물일 것이다.If growth is defined in a broad sense, it will include not only an increase in height, but also an increase in the size and function of each organ in the body. However, if it is defined as a narrow concept, it can be seen as meaning an increase in height. This increase in height may be the result of several factors such as nutrition and growth hormones.
한편, 이유식은 아기와 아동(이하 '영유아')에게 먹이는 반고형 음식이다. 생후 6개월이 지난 영유아는 우유만으로는 성장에 필요한 영양을 충분히 공급받지 못하기 때문에, 생후 2, 3개월부터 연하고 부드러운 음식으로 부족한 영양을 보충해야 한다. 또한, 점진적으로 고형식에 익숙해지도록 훈련해야 하는데 이유식은 이러한 영유아의 발달 과정을 돕는 음식이다. 이유식은 영유아 때 섭취하는 음식이므로 아동에게 필수적으로 공급되어야 하는 영양소를 갖추어야 하고, 소화되기 쉽고 영유아의 기호도 고려하여야 한다. 아울러 영유아의 월령과 성장 과정에 잘 맞아야 한다. 하지만, 이유식은 분유와는 달리 다양한 식자재를 이용해 조리해서 영유아에게 제공해야 하므로 이유식 조리는 일반 보호자의 입장에서 결코 쉬운 일이 아니다. 더욱이 이유식 조리를 위한 식자재는 영유아의 성장과 건강상태 등에 맞춰 선택해야 하므로, 영양학에 지식이 없는 보호자는 이유식의 메뉴 선택이 부담되어서 결코, 쉬운 일은 아니다. 그러므로 영양학적인 관점을 넘어 개인의 유전자형 또는 장내 미생물 분포 등과 같이 개인별 신체 특성과, 기호도 등을 고려하는 식단정보 등에 대한 기대가 점차 증가하고 있는 추세이다. Meanwhile, baby food is a semi-solid food fed to babies and children (hereinafter referred to as ‘infants’). Infants over 6 months old do not receive sufficient nutrients for growth through milk alone, so they must supplement their nutritional deficiency with soft, soft foods from 2 to 3 months of age. In addition, children must be gradually trained to become accustomed to solid foods, and baby food is food that helps infants and toddlers in their development process. Baby food is food consumed by infants and young children, so it must contain the nutrients that are essential for children, be easy to digest, and take into account the infants' preferences. In addition, it must be well suited to the infant's age and growth process. However, unlike powdered milk, baby food must be cooked using a variety of ingredients and provided to infants, so preparing baby food is not an easy task for the average guardian. Moreover, since food ingredients for preparing baby food must be selected according to the infant's growth and health status, guardians without knowledge of nutrition find it burdensome to choose a baby food menu, which is not an easy task. Therefore, expectations for dietary information that goes beyond nutritional perspectives and takes into account individual physical characteristics and preferences, such as an individual's genotype or distribution of intestinal microorganisms, are gradually increasing.
영유아기의 식단 관리 시스템 관련 기술로는 한국등록특허 제2387409호에 식재료와 건강 정보가 연동된 맞춤형 영유아 식단 관리 서비스 제공방법이 개시되어 있고, 한국등록특허 제-2429411호에 영유아의 영양 및 소화흡수 상태 모니터링에 의한 맞춤형 HMR 이유식 제공방법 및 제공시스템이 개시되어 있으나, 아직까지는 본 발명의 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법에 대해 개시된 바 없다.As technology related to the diet management system for infants and toddlers, Korea Patent No. 2387409 discloses a method of providing customized infant and toddler diet management services linked with food ingredients and health information, and Korea Patent No. -2429411 discloses nutrition, digestion and absorption of infants and young children. Although a method and provision system for providing customized HMR baby food through condition monitoring have been disclosed, a method for providing a customized diet for infants and young children for height growth based on the height growth-related genes and intestinal microorganism tests of the present invention has not yet been disclosed.
본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명은 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법을 제공하고, 유전자형 및 영양성분과의 상관관계 분석 및 장내미생물 분포와 영양성분의 상관관계를 데이터베이스로 구축함으로써, 본 발명을 완성하였다.The present invention was developed in response to the above-mentioned needs. The present invention provides a method of providing a customized diet for infants and young children for height growth based on height growth-related genes and intestinal microorganism tests, and analyzes the correlation between genotype and nutritional components and The present invention was completed by constructing a database of the correlation between the distribution of intestinal microorganisms and nutritional components.
상기 목적을 달성하기 위하여, 본 발명은 (1) 영유아용 맞춤형 식단을 제공하는 데이터베이스 시스템에, 맞춤형 식단을 제공받고자 하는 영유아의 개월수, 키, 체중, 부모 및 영유아의 식품 알러지에 대한 기본정보를 입력하는 단계;In order to achieve the above object, the present invention (1) provides basic information on the number of months, height, weight, and food allergies of parents and infants of infants who wish to receive customized diets in a database system that provides customized diets for infants and young children. Entering steps;
(2) 상기 단계 (1)에서, 기본정보를 입력한 영유아의 키성장 관련 유전자 GDF5(growth differentiation factor 5) 및 IGF1R(insulin-like growth factor 1 receptor) 돌연변이 유무에 대한 결과값과 장내미생물 검사 결과값을 입력하는 단계;(2) In step (1) above, results of mutations in the growth-related genes GDF5 (growth differentiation factor 5) and IGF1R (insulin-like growth factor 1 receptor) and intestinal microorganism test results for infants who entered basic information in step (1) above. Entering a value;
(3) 상기 단계 (2)에서 입력한 유전자 GDF5 및 IGF1R의 돌연변이 여부가 적용된 GDF5 및 IGF1R 단백질에 대한 영양성분의 결합능 및 장내 미생물 분포도 가중치를 적용하여 영유아에게 필요한 영양성분을 선별하는 단계; 및(3) selecting nutrients needed for infants and young children by applying weights to the binding ability of nutrients to the GDF5 and IGF1R proteins and the distribution of intestinal microorganisms based on the mutation of the genes GDF5 and IGF1R entered in step (2); and
(4) 상기 단계 (3)에서 선별한 영양성분을 포함하는 식품을 맵핑하여, 상기 단계 (1)에서 입력한 영유아의 개월수에 맞춰 식품의 양과 조리법을 선정하여 제공하는 단계;를 포함하는 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법을 제공한다.(4) mapping the food containing the nutritional ingredients selected in step (3), and selecting and providing the amount and recipe of the food according to the number of months of the infant entered in step (1). Provides a method of providing a customized diet for infants and young children for height growth based on growth-related genes and intestinal microorganism tests.
또한, 본 발명은 제공하고자 하는 영유아의 기본정보 입력부; 사용자 기본정보를 저장하는 제1 저장부; 키성장 유전자 GDF5 및 IGF1R의 돌연변이 부위별 식품성분 결합능 계산값을 저장하는 제2 저장부; 장내 미생물 분포 및 키성장 점수화 값을 저장하는 제3 저장부; 연령별 열량 및 식품성분을 저장하는 제4 저장부; 식품 및 조리법을 저장하는 제5 저장부; 및 유용성분 또는 장내미생물 검사값과 식품과의 상관관계를 저장하는 제6 저장부; 상기 제1~6 저장부의 데이터로부터 개인별 맞춤형 식단을 계산하는 계산부; 및 키성장 촉진용 맞춤형 식단 출력부;를 포함하는 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단 제공용 데이터베이스 시스템을 제공한다.In addition, the present invention provides a basic information input unit for infants and young children; a first storage unit that stores basic user information; a second storage unit storing calculated food ingredient binding capacity values for each mutation site of the height growth genes GDF5 and IGF1R; a third storage unit that stores intestinal microorganism distribution and height growth scoring values; a fourth storage unit that stores calories and food ingredients for each age; A fifth storage unit for storing food and recipes; and a sixth storage unit that stores the correlation between useful ingredients or intestinal microorganism test values and food; a calculation unit that calculates a customized diet for each individual from the data of the first to sixth storage units; It provides a database system for providing a customized diet for infants and children for height growth based on height growth-related genes and intestinal microorganism tests, including a customized diet output unit for promoting height growth.
본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 본 발명은 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법에 관한 것으로, 영유아의 가족력, 알러지 또는 개월 수뿐만 아니라, 영유아의 유전자형과 장내 미생물 환경을 분석한 후, 식품 내 영양성분과의 상관관계를 맵핑하여 개인별 맞춤형 키성장 식단을 제공할 수 있으므로, 키성장을 촉진시킬 수 있다. The present invention was developed in response to the above-mentioned needs. The present invention relates to a method of providing a customized diet for infants and young children for height growth based on height growth-related genes and intestinal microorganism tests, and is based on the infant's family history, allergies, or number of months. In addition, after analyzing the infant's genotype and intestinal microbial environment, the correlation with nutrients in food can be mapped to provide a personalized height growth diet, thereby promoting height growth.
도 1은 본 발명의 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공 받기 위해 사용자가 입력해야 하는 기본정도를 나타낸 흐름도이다.
도 2는 본 발명의 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하기 위하여 필요한 영유아의 자료 입력 및 식단제공 알고리즘을 나타낸 개략도이다.
도 3은 본 발명의 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단 제공용 데이터베이스 시스템(서버)의 이용과정을 나타낸 개략도이다.
도 4는 본 발명의 맞춤형 식단에서 가중치로 적용하는 GDF5 유전자의 돌연변이가 발생하지 않은 경우, 영양성분의 GDF5 단백질에 대한 친화력을 분석한 결과로, 결합에너지(Kcal/mol)가 낮을수록 단백질의 활성은 증진되는 것을 의미한다.
도 5는 본 발명의 맞춤형 식단에서 가중치로 적용하는 GDF5 유전자의 돌연변이가 발생한 경우, 영양성분의 GDF5 단백질에 대한 친화력을 분석한 결과로, 결합에너지(Kcal/mol)가 낮을수록 단백질의 활성은 증진되는 것을 의미한다.
도 6은 본 발명의 맞춤형 식단에서 가중치로 적용하는 IGF1R 유전자의 돌연변이가 발생하지 않은 경우, 영양성분의 IGF1R 단백질에 대한 친화력을 분석한 결과로, 결합에너지(Kcal/mol)가 낮을수록 단백질의 활성은 증진되는 것을 의미한다.
도 7은 본 발명의 맞춤형 식단에서 가중치로 적용하는 IGF1R 유전자의 돌연변이가 발생한 경우, 영양성분의 IGF1R단백질에 대한 친화력을 분석한 결과로, 결합에너지(Kcal/mol)가 낮을수록 단백질의 활성은 증진되는 것을 의미한다.
도 8은 ET-E 장형의 (Family) 수준(A) 및 속(Genus) 수준(B)에서 정상인과 왜소증인의 장내미생물 분포도를 비교한 결과이다.
도 9는 ET-P 장형의 (Family) 수준(A) 및 속(Genus) 수준(B)에서 정상인과 왜소증인의 장내미생물 분포도를 비교한 결과이다.
도 10은 균의 성장 촉진/저해 식품, 한약재의 예시를 나타낸 것으로, 가로축의 값이 1보다 작으면 각 균의 성장을 저해시키는 소재이고, 1보다 크면 균의 성장을 촉진시키는 것을 의미한다.
도 11은 ET-E 장형(A) 및 ET-P 장형(B)에서 정상 키 어린이와 왜소증 어린이의 주요 장내미생물 균 분포를 나타낸 것이다.
도 12는 ET-E 장형(A) 및 ET-P 장형(B)에서 정상 키 어린이와 왜소증 어린이의 장내미생물의 균 기능(신호전달)과의 관계를 확인한 결과이다.Figure 1 is a flowchart showing the basic level that a user must input in order to receive a customized diet for infants and children for height growth based on height growth-related genes and intestinal microorganism tests of the present invention.
Figure 2 is a schematic diagram showing the data input and diet provision algorithm for infants and young children required to provide a customized diet for infants and young children for height growth based on height growth-related genes and intestinal microorganism tests of the present invention.
Figure 3 is a schematic diagram showing the process of using the database system (server) for providing customized diet for infants and children for height growth based on height growth-related genes and intestinal microorganism tests of the present invention.
Figure 4 shows the results of analyzing the affinity of nutrients to the GDF5 protein when no mutation in the GDF5 gene, which is applied as a weight in the customized diet of the present invention, has occurred. The lower the binding energy (Kcal/mol), the higher the activity of the protein. means to be promoted.
Figure 5 shows the results of analyzing the affinity of nutrients to the GDF5 protein when a mutation in the GDF5 gene, which is applied as a weight in the customized diet of the present invention, occurs. The lower the binding energy (Kcal/mol), the higher the activity of the protein. It means becoming.
Figure 6 shows the results of analyzing the affinity of nutrients for the IGF1R protein when no mutation in the IGF1R gene, which is applied as a weight in the customized diet of the present invention, occurs. The lower the binding energy (Kcal/mol), the higher the activity of the protein. means to be promoted.
Figure 7 shows the results of analyzing the affinity of nutrients to the IGF1R protein when a mutation in the IGF1R gene, which is applied as a weight in the customized diet of the present invention, occurs. The lower the binding energy (Kcal/mol), the higher the activity of the protein. It means becoming.
Figure 8 shows the results of comparing the distribution of intestinal microorganisms between normal people and people with dwarfism at the ET-E intestinal type (Family) level (A) and genus level (B).
Figure 9 shows the results of comparing the distribution of intestinal microorganisms between normal people and people with dwarfism at the ET-P intestinal type (Family) level (A) and genus level (B).
Figure 10 shows examples of foods and herbal medicines that promote/inhibit the growth of bacteria. If the value on the horizontal axis is less than 1, the material inhibits the growth of each bacteria, and if it is greater than 1, it means that it promotes the growth of bacteria.
Figure 11 shows the distribution of major intestinal microorganisms in children of normal height and children with dwarfism in the ET-E long type (A) and ET-P long type (B).
Figure 12 shows the results of confirming the relationship between the bacterial function (signal transduction) of intestinal microorganisms in children of normal height and children with dwarfism in ET-E long type (A) and ET-P long type (B).
본 발명은 (1) 영유아용 맞춤형 식단을 제공하는 데이터베이스 시스템에, 맞춤형 식단을 제공받고자 하는 영유아의 개월수, 키, 체중, 부모 및 영유아의 식품 알러지에 대한 기본정보를 입력하는 단계;The present invention includes the steps of (1) inputting basic information about the number of months, height, weight, parents, and food allergies of the infant and child for whom a customized diet is to be provided into a database system that provides a customized diet for infants and young children;
(2) 상기 단계 (1)에서, 기본정보를 입력한 영유아의 키성장 관련 유전자 GDF5(growth differentiation factor 5) 및 IGF1R(insulin-like growth factor 1 receptor) 돌연변이 유무에 대한 결과값과 장내미생물 검사 결과값을 입력하는 단계;(2) In step (1) above, results of mutations in the growth-related genes GDF5 (growth differentiation factor 5) and IGF1R (insulin-like growth factor 1 receptor) and intestinal microorganism test results for infants who entered basic information in step (1) above. Entering a value;
(3) 상기 단계 (2)에서 입력한 유전자 GDF5 및 IGF1R의 돌연변이 여부가 적용된 GDF5 및 IGF1R 단백질에 대한 영양성분의 결합능 및 장내 미생물 분포도 가중치를 적용하여 영유아에게 필요한 영양성분을 선별하는 단계; 및(3) selecting nutrients needed for infants and young children by applying weights to the binding ability of nutrients to the GDF5 and IGF1R proteins and the distribution of intestinal microorganisms based on the mutation of the genes GDF5 and IGF1R entered in step (2); and
(4) 상기 단계 (3)에서 선별한 영양성분을 포함하는 식품을 맵핑하여, 상기 단계 (1)에서 입력한 영유아의 개월수에 맞춰 식품의 양과 조리법을 선정하여 제공하는 단계;를 포함하는 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법에 관한 것이다.(4) mapping the food containing the nutritional ingredients selected in step (3), and selecting and providing the amount and recipe of the food according to the number of months of the infant entered in step (1). This is about a method of providing a customized diet for infants and young children for height growth based on growth-related genes and intestinal microorganism tests.
상기 단계 (1)에서 사용자가 정보를 입력하는 방법은 웹(Web) 또는 앱(App)을 이용하여 입력하며, 정보의 제공은 상기 웹 또는 앱을 통해 실시간으로 제공되는 것이지만, 이에 한정하는 것은 아니며, PC 또는 모바일 접속을 통해 실시간으로 맞춤형 식단을 제공받을 수 있고, 사용자(영유아)의 건강상태 또는 식습관을 실시간으로 입력할 수 있다.In step (1), the user enters information using the web or app, and the information is provided in real time through the web or app, but is not limited to this. , you can receive a customized diet in real time through PC or mobile access, and the health status or eating habits of the user (infant or child) can be entered in real time.
상기 유전자 GDF5의 돌연변이가 발생하지 않은 경우, 루고신 E(Rugosin E), 발로라진산(Valolaginic acid), 루고신 D(Rugosin D), 에스터린귤라토사이드(Asterlingulatoside D), 세칼로사이드(Secaloside C), 파베탄닌 C1(Pavetannin C1), 마테사포닌 3(Matesaponin 3), 24-에틸-24(25)-디하이드로라토스테롤(24-Ethyl-24(25)-dehydrolathosterol), 글루코키닌(Glucokinin) 및 에피카테킨-(4β->6)-카테킨(Epicatechin-(4β->6)-catechin) 중에서 선택된 하나 이상의 영양성분을 포함하는 식품을 맵핑하는 것이 바람직하고, 상기 유전자 GDF5의 돌연변이가 발생하지 않은 경우, 필요한 영양성분을 포함하는 식품은 개암나무 및 구아바 중에서 선택된 하나 이상인 것이 바람직하지만, 이에 한정하는 것은 아니다.If mutation of the gene GDF5 does not occur, Rugosin E, Valolaginic acid, Rugosin D, Asterlingulatoside D, and Secaloside C ), Pavetannin C1, Matesaponin 3, 24-Ethyl-24(25)-dehydrolathosterol, Glucokinin and It is desirable to map foods containing one or more nutrients selected from epicatechin-(4β->6)-catechin, and if mutation of the gene GDF5 does not occur, Foods containing the necessary nutrients are preferably one or more selected from hazelnuts and guava, but are not limited thereto.
상기 유전자 GDF5의 돌연변이가 발생한 경우, 시스-리구스틸라이드(cis-Ligustilide), D(+)-탈수소카르본(D(+)-dehydrocarvone), 락토-N-데카오스(Lacto-N-decaose), 탈수소카파인 II(Dehydrocarpaine II), 아레카탄닌 B1 3,3'-디갈레이트(Arecatannin B1 3,3'-digallate), 헬리안토사이드 B(Helianthoside B), 신남탄닌 III(Cinnamtannin III), 28-[글루코실-(1->6)-글루코실]올레놀산 3-[글루코실-(1->3)-[아라비노실-(1->4)]-글루큐로나이드](28-[Glucosyl-(1->6)-glucosyl] oleanolic acid 3-[glucosyl-(1->3)-[arabinosyl-(1->4)]-glucuronide]), 에피카테킨-(4β->8)-카테킨 3-갈레이트(Epicatechin-(4β->8)-catechin 3-gallate) 및 α-카르본(α-Carvone) 중에서 선택된 하나 이상의 영양성분을 포함하는 식품을 맵핑하는 것이 바람직하고, 상기 유전자 GDF5의 돌연변이가 발생한 경우, 필요한 영양성분을 포함하는 식품은 파슬리 및 파파야 중에서 선택된 하나 이상인 것이 바람직하지만, 이에 한정하는 것은 아니다.If a mutation in the gene GDF5 occurs, cis-Ligustilide, D(+)-dehydrocarvone, Lacto-N-decaose , Dehydrocarpaine II, Arecatannin B1 3,3'-digallate, Helianthoside B, Cinnamtannin III, 28- [glucosyl-(1->6)-glucosyl]olenolic acid 3-[glucosyl-(1->3)-[arabinosyl-(1->4)]-glucuronide](28-[ Glucosyl-(1->6)-glucosyl] oleanolic acid 3-[glucosyl-(1->3)-[arabinosyl-(1->4)]-glucuronide]), epicatechin-(4β->8)-catechin It is desirable to map foods containing one or more nutrients selected from 3-gallate (Epicatechin-(4β->8)-catechin 3-gallate) and α-Carvone, and the gene GDF5 In the event of a mutation, the food containing the necessary nutrients is preferably at least one selected from parsley and papaya, but is not limited thereto.
상기 유전자 IGF1R의 돌연변이가 발생하지 않은 경우, 카다비신(Cadabicine), 루고신 D(Rugosin D), 비스뮤라야폴린 E(Bismurrayafoline E), 퀘르세틴 3-루티노사이드 3',7-글루코사이드(Quercetin 3-rutinoside 3',7-diglucoside), 아피우모사이드(Apimoside), 캄페롤 3,7,4'-O-트리글루코사이드(Kaempferol 3,7,4'-O-triglucoside), 6"-아세틸아핀(6"-Acetylapiin), 캄페롤 3-람노실-(6"-아세틸)갈로사이드 7-람노사이드(kaempferol 3-rhamnosyl-(6"-acetyl)galactoside 7-rhamnoside) 및 세칼로사이드 A(Secaloside A) 중에서 선택된 하나 이상의 영양성분을 포함하는 식품을 맵핑하는 것이 바람직하고, 상기 유전자 IGF1R의 돌연변이가 발생하지 않은 경우, 필요한 영양성분을 포함하는 식품은 미나리 및 체리 중에서 선택된 하나 이상인 것이 바람직하지만 이에 한정하는 것은 아니다.If mutation of the above gene IGF1R has not occurred, Cadabicine, Rugosin D, Bismurrayafoline E, Quercetin 3-rutinoside 3',7-glucoside (Quercetin) 3-rutinoside 3',7-diglucoside), Apimoside, Kaempferol 3,7,4'-O-triglucoside, 6"-acetylafine (6"-Acetylapiin), kaempferol 3-rhamnosyl-(6"-acetyl)galactoside 7-rhamnoside and Cecaloside A A) It is desirable to map a food containing one or more nutrients selected from among, and if a mutation in the gene IGF1R does not occur, the food containing the necessary nutrients is preferably one or more selected from water parsley and cherry, but is limited thereto. It's not like that.
상기 유전자 IGF1R의 돌연변이가 발생한 경우, 아르토민 A(Artomin A), 트라고포곤사포닌(Tragopogonsaponin), 탈수소카르파인 I(Dehydrocarpaine I), 비니페롤 A(Viniferol A), 알바닌 H(Albanin H), 페덤큘라긴(Pedunculagin), 쥬키니 인자 B(Zucchini factor B), 테아플라바테 A(Theaflavate A), 카슈아리닌(Casuarinin), 스타키린(Stachyrin), 람베르티아닌 B(Lambertianin AB), 산규인 H6(Sanguiin H6), 람베르티아닌 A(Lambertianin A), 철(III)이인산(Fe4(P2O7)3)(Iron(III) diphosphate(Fe4(P2O7)3)), 철 피로포스페이트 구연산나트륨(Ferric pyrophospate sodium citrate), 몬골리카인 A(Mongolicain A), 카수아리인(Casuariin) 및 프리제이쥬레네(Pregeijerene) 중에서 선택된 하나 이상의 영양성분을 포함하는 식품을 맵핑하는 것이 바람직하고, 상기 유전자 IGF1R의 돌연변이가 발생한 경우, 필요한 영양성분을 포함하는 식품은 잭프룻트, 파파야, 석류 및 구아바 중에서 선택된 하나 이상인 것이 바람직하지만 이에 한정하는 것은 아니다. When a mutation in the above gene IGF1R occurs, Artomin A, Tragopogonsaponin, Dehydrocarpaine I, Viniferol A, Albanin H, Pedunculagin, Zucchini factor B, Theaflavate A, Casuarinin, Stachyrin, Lambertianin AB, Sangyuin H6 ( Sanguiin H6), Lambertianin A, Iron(III) diphosphate(Fe4(P2O7)3), Ferric pyrophosphate sodium It is desirable to map foods containing one or more nutrients selected from citrate, Mongolicain A, Casuariin, and Pregeijerene, and it is desirable to map foods containing one or more nutrients selected from the group consisting of IGF1R mutations. In this case, the food containing the necessary nutrients is preferably one or more selected from jackfruit, papaya, pomegranate, and guava, but is not limited thereto.
또한, 본 발명은 맞춤형 식단을 제공하고자 하는 기본정보, 유전자 돌연변이 분석결과값 및 장내미생물분석 결과값 입력부; 상기 영유아의 개월수, 키, 체중, 부모 및 영유아의 식품 알러지에 대한 기본정보를 저장하는 제1 저장부, 키성장 유전자 GDF5 및 IGF1R의 돌연변이 결과값을 저장하는 제2 저장부, 장내 미생물 분석 결과값을 저장하는 제3 저장부, 키성장 유전자 돌연변이-영양성분 결합능 및 장내미생물 분포도 가중치를 저장하는 제4 저장부, 영양성분 및 식품의 상관관계를 저장하는 제5 저장부 및 식품 및 조리법을 저장하는 제6 저장부; 상기 제1~6 저장부의 데이터로부터 개인별 맞춤형 식단을 계산하는 계산부; 및 키성장 촉진용 맞춤형 식단 출력부;를 포함하는 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단 제공용 데이터베이스 시스템에 관한 것이다(도 1 내지 도 3).In addition, the present invention includes an input unit for basic information to provide a customized diet, genetic mutation analysis results, and intestinal microorganism analysis results; A first storage unit that stores basic information about the infant's months, height, weight, and food allergies of parents and infants, a second storage unit that stores mutation results of height growth genes GDF5 and IGF1R, and intestinal microorganism analysis results. A third storage unit that stores values, a fourth storage unit that stores height growth gene mutation-nutrient binding ability and intestinal microorganism distribution weights, a fifth storage unit that stores correlations between nutrients and foods, and stores food and recipes. a sixth storage unit; a calculation unit that calculates a customized diet for each individual from the data of the first to sixth storage units; It relates to a database system for providing a customized diet for infants and children for height growth based on height growth-related genes and intestinal microorganism tests, including a customized diet output unit for promoting height growth (FIGS. 1 to 3).
상기 입력부는 사용자 모드 또는 관리자 모드로 로그인할 수 있으며, 사용자 모드로 입력하는 경우, 기본정보를 입력하거나 수정할 수 있으며, 관리자 모드로 입력하는 경우, 유전자 돌연변이 검사값 및 장내미생물 분석값을 입력할 수 있다.The input unit can log in in user mode or administrator mode. When entering in user mode, basic information can be entered or modified. When entering in administrator mode, genetic mutation test values and intestinal microorganism analysis values can be entered. there is.
상기 시스템은 PC 또는 모바일을 통한 웹 또는 앱으로 이용할 수 있으므로, 실시간으로 맞춤형 식단을 제공받을 수 있을 뿐만 아니라, 매끼, 1일, 1주일 또는 1개월 단위를 설정하여 자동적으로 맞춤형 식단을 제공받을 수 있다. The system can be used as a web or app via PC or mobile, so you can not only receive a customized diet in real time, but also automatically receive a customized diet by setting it for each meal, per day, per week, or per month. there is.
상기 유전자 검사 결과값 및 장내미생물 분포도 이외에 사용자의 성별, 개월수, 체중, 부모 또는 영유아의 알러지 정보 및 기호도 중에서 선택된 하나 이상의 정보를 고려하여 상기 식단을 구성하는 음식의 종류를 동일한 영양소를 갖는 다른 음식으로 대체하거나 음식의 양을 수정할 수 있다. 이때 각각의 성분의 결합 에너지와 식품에 그 성분의 함유량에 따라 가중치를 주어 식품의 선택이 영유아의 개인의 유전자 변이에 따라 자동으로 식단에 반영되어 추천되고, 영유아의 알러지 반응을 고려하여 3일에 한번씩 새로운 식품으로 바꾸어서 추천하도록 한다. In addition to the genetic test results and the distribution of intestinal microorganisms, the type of food constituting the diet is selected by considering one or more information selected from the user's gender, number of months, weight, parent or infant's allergy information, and preference, and other foods with the same nutrients. You can replace it with or modify the amount of food. At this time, weighting is given based on the binding energy of each ingredient and the content of the ingredient in the food, so the choice of food is automatically reflected in the diet according to the infant's individual genetic variation and recommended. Taking the infant's allergic reaction into consideration, food selection is recommended every 3 days. Recommend new foods every now and then.
본 발명에서 제공되는 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단은 음식으로 제공되는 것이 아니라, 식품으로 제공되고 그 식품을 연령별로 미음, 죽, 등의 형태로 주는 것이 특징이다. The customized diet for infants and young children for height growth based on height growth-related genes and intestinal microorganism tests provided in the present invention is not provided as food, but is provided as food, and the food is given in the form of rice, porridge, etc. according to age. am.
일례로, ET-P 장형 어린이에게는 보리밥, 무우, 자색 당근, 소고기 또는 바나나 중에서 채택하여 제공하고, ET-E 장형 어린이에게는 오트밀, 미역, 버섯, 닭고기 및 오렌지 중에서 채택하여 제공할 수 있다. 이유 초기에는 한가지 식품에, 하나씩 첨가하도록 하며, 양은 나이에 맞춰 제공할 수 있다. ET-E와 ET-P 장형에서 각각 왜소증에 있는 많은 균은 성장을 저해시키고, 정상인에는 많은 균 중 유익균을 증가시키는 식품을 매끼 식단에 반영하여 자동 추천할 수 있다. For example, children with ET-P long-type children can be provided with barley rice, radish, purple carrots, beef, or bananas, and ET-E long-type children can be provided with oatmeal, seaweed, mushrooms, chicken, and oranges. In the early stages of weaning, each food should be added one at a time, and the amount can be provided according to age. In the ET-E and ET-P long forms, many bacteria in dwarfism inhibit growth, while foods that increase beneficial bacteria among the many bacteria in normal people can be automatically recommended by reflecting them in the diet for each meal.
이하, 구체적으로 본 발명의 영유아용 맞춤형 식단 제공용 데이터베이스 시스템에 대하여 설명한다. Hereinafter, the database system for providing customized diets for infants and young children of the present invention will be described in detail.
1. 아동의 프로필 생성 및 정보 입력 1. Create a child’s profile and enter information
(1) 기본 정보(필수 입력값): 이름(별명), 개월수/나이, 키, 체중, 부모의 식품 알러지, 아동의 식품 알러지 정보 입력(도 3)(1) Basic information (required input values): Enter name (nickname), months/age, height, weight, parent's food allergy, child's food allergy information (Figure 3)
(2) 추가 정보(선택 입력값): 가족력, 가족 또는 아동의 유전자 및 장내 미생물 검사 값, 건강기록(두위,흉위 등) 값 입력(2) Additional information (optional input values): Enter family history, family or child's genetic and intestinal microorganism test values, and health record (head circumference, chest circumference, etc.) values.
(3) 기타 정보: 성장기록, 메모(3) Other information: growth records, notes
2. 유전자 검사 및 장내미생물 검사2. Genetic testing and intestinal microorganism testing
- 이유식/유아식 추천에 검사 결과가 연동되고, 검사를 신청하지 않은 경우 기본 입력한 정보만으로 결과가 출력된다. - Test results are linked to baby food/baby food recommendations, and if a test is not requested, the results are output only with the basic information entered.
(1) 유전자 검사(1) Genetic testing
유전자 검사의 경우, 키 관련 유전자인 GDF5 및 IGF1R의 변이를 분석하고, 유전적 변이의 유무에 따라 유전자의 발현에 관여하는 맞춤 식재료를 추천하기 위하여, 본 발명에서 실시하는 영유아/어린이 키 성장 관련 유전자 검사(GDF5, IGF1R)는 질병관리청 질병보건통합관리시스템에 등록한 방법에 따라 실시하였다.In the case of genetic testing, the present invention analyzes mutations in height-related genes GDF5 and IGF1R and recommends customized food ingredients involved in the expression of genes depending on the presence or absence of genetic mutations. Tests (GDF5, IGF1R) were conducted according to the method registered in the Korea Disease Control and Prevention Agency's Disease and Health Integrated Management System.
① GDF5(growth differentiation factor 5)는 뼈와 연골 형성에 관여하며, 연골의 발달 및 연골조직의 분화를 조절하는 역할을 한다. ① GDF5 (growth differentiation factor 5) is involved in bone and cartilage formation and plays a role in regulating the development of cartilage and differentiation of cartilage tissue.
한국인 도시데이터(출처: 질병관리본부)에서 키 147cm을 초과한 정상인 57,533명과 키가 147cm 이하인 왜소증 환자 1,168명의 전체 유전체 상관 분석연구(genome-wide association study: GWAS)를 실시한 결과, AA(TT) allele를 가진 사람에 대비하여, GG(CC) allele를 가진 사람의 키 성장이 더 높은 것으로 나타났다(p<1.76E-04 (OR: 0.86; SE: 0.04)).As a result of conducting a genome-wide association study (GWAS) of 57,533 normal people with a height exceeding 147 cm and 1,168 dwarfism patients with a height of 147 cm or less in Korean urban data (source: Korea Centers for Disease Control and Prevention), AA(TT) allele Compared to people with , people with the GG(CC) allele showed higher height growth (p<1.76E-04 (OR: 0.86; SE: 0.04)).
20,000종의 영양성분에 대하여, GDF5 및 IGF1R 단백질의 돌연변이 여부에 따른 결합능을 분석하여 데이터베이스로 구축하였다. For 20,000 types of nutrients, the binding ability of GDF5 and IGF1R proteins was analyzed according to the mutation status and a database was constructed.
GDF5 단백질(missense)의 활성이 저해되는 경우, 키성장이 방해되므로, 분자 도킹 및 분자 역학 시뮬레이션(autodock program)을 통해 GDF5 단백질 변이가 일어난 부분에 대한 천연 화합물의 결합 관계를 분석하였다(도 4). When the activity of the GDF5 protein (missense) is inhibited, height growth is hindered, so the binding relationship of natural compounds to the mutated part of the GDF5 protein was analyzed through molecular docking and molecular dynamics simulation (autodock program) (Figure 4) .
그 결과, GDF5의 돌연변이가 발생하지 않은 경우, 루고신 E(Rugosin E), 발로라진산(Valolaginic acid), 루고신 D(Rugosin D), 에스터린귤라토사이드(Asterlingulatoside D), 세칼로사이드(Secaloside C), 파베탄닌 C1(Pavetannin C1), 마테사포닌 3(Matesaponin 3), 24-에틸-24(25)-디하이드로라토스테롤(24-Ethyl-24(25)-dehydrolathosterol), 글루코키닌(Glucokinin) 및 에피카테킨-(4β->8)-갈로카테킨(Epicatechin-(4β->8)-gallocatechin)이 GDF5 단백질에 대한 높은 친화도를 가지는 것으로 나타났고, GDF5의 돌연변이가 발생한 경우는 시스-리구스틸라이드(cis-Ligustilide), D(+)-탈수소카르본(D(+)-dehydrocarvone), 락토-N-데카오스(Lacto-N-decaose), 탈수소카파인 II(Dehydrocarpaine II), 아레카탄닌 B1(Arecatannin B1), 헬리안토사이드 B(Helianthoside B), 신남탄닌 III(Cinnamtannin III), 에피카테킨-(4β->8)-갈로카테킨(Epicatechin-(4β->8)-gallocatechin) 및 α-카르본(α-Carvone)이 GDF5 단백질과의 결합력이 우수하였다. 이러한 결합을 통해 GDF5의 활성을 촉진시키므로, GDF5의 활성을 촉진시키는 영양성분이 많이 들어 있는 식품을 추천하여 키성장에 도움을 주고자 하였다(도 5). As a result, if GDF5 mutation did not occur, Rugosin E, Valolaginic acid, Rugosin D, Asterlingulatoside D, and Secaloside C), Pavetannin C1, Matesaponin 3, 24-Ethyl-24(25)-dehydrolathosterol, Glucokinin And epicatechin-(4β->8)-gallocatechin was found to have high affinity for GDF5 protein, and in case of mutation of GDF5, cis-ligustilide (cis-Ligustilide), D(+)-dehydrocarvone, Lacto-N-decaose, Dehydrocarpaine II, Arecatannin B1 ( Arecatannin B1), Helianthoside B, Cinnamtannin III, Epicatechin-(4β->8)-gallocatechin and α-carvone ( α-Carvone) had excellent binding ability to GDF5 protein. Since this combination promotes the activity of GDF5, we attempted to recommend foods containing a lot of nutrients that promote the activity of GDF5 to help with height growth (Figure 5).
추천 식품은 상기 분자 도킹 모델에서 사용한 푸드데이터베이스(https://foodb.ca/)에 있는 데이터(식품) 또는 상기 성분이 포함된 식품(저널 및 종래 데이터베이스(https://pubchem.ncbi.nlm.nih.gov )를 활용하여 확인한 식품)을 채택하였다.Recommended foods are data (food) in the food database (https://foodb.ca/) used in the molecular docking model or foods containing the above ingredients (journal and conventional database (https://pubchem.ncbi.nlm). Foods identified using nih.gov) were adopted.
② IGF1R(insulin-like growth factor 1 receptor) 유전자는 성장 및 발달에 중요하며, IGF1R 돌연변이를 비활성화시키면 키가 작고, 혈청 내 인슐린 유사 성장인자 1(Insulin like growth factor 1; IGF-1)의 수치가 높아지는 것으로 알려져 있다(도 6). ② The IGF1R (insulin-like growth factor 1 receptor) gene is important for growth and development, and when the IGF1R mutation is inactivated, the person becomes shorter and the level of insulin-like growth factor 1 (IGF-1) in the serum decreases. It is known to increase (Figure 6).
GDF5 유전자와 동일한 조건으로 GWAS를 실시한 결과, 키성장에 유의미한 차이를 나타냈다(p< 7.67E-03 (OR: 1.24; SE: 0.08)수준).As a result of GWAS conducted under the same conditions as the GDF5 gene, a significant difference in height growth was shown (p< 7.67E-03 (OR: 1.24; SE: 0.08) level).
유전자 및 식품의 상관관계에 대하여, 분자 모델링(Autodock) 분석 결과를 기반으로 유전적 변이에 따라 키성장에 영향을 미치는 식품에 대하여 탐색하였고 해당 결과는 추천 시 반영하였다. 키성장과 관련하여, 돌연변이가 발생한 IGF1R 단백질(missense)이 활성화되는 경우, 키성장을 방해하는 것으로 해석하였고, 분자 도킹 및 분자 역학 시뮬레이션(autodock program)을 사용하여 돌연 변이가 일어난 부분에 대한 천연 화합물의 결합 관계를 분석하였다. Regarding the correlation between genes and foods, based on the results of molecular modeling (Autodock) analysis, foods that affect height growth according to genetic variation were explored, and the results were reflected in recommendations. Regarding height growth, when the mutated IGF1R protein (missense) is activated, it was interpreted as interfering with height growth, and molecular docking and molecular dynamics simulation (autodock program) were used to identify natural compounds for the mutated area. The binding relationship was analyzed.
그 결과, IGF1R 단백질의 돌연변이가 없는 경우, 카다비신(Cadabicine), 루고신 D(Rugosin D), 비스뮤라야폴린 E(Bismurrayafoline E), 퀘르세틴 3-글루코사이드(Quercetin 3-glucoside), 아피우모사이드(Apimoside), 캄페롤 3,7,4'-트리메틸에테르(Kaempferol 3,7,4'-trimethyl ether), 6"-아세틸아핀(6"-Acetylapiin), 캄페롤 3-o-글루코사이드(kaempferol 3-o-glucoside) 및 세칼로사이드 A(Secaloside A)가 IGF1의 활성을 촉진하는 것으로 나타났으며, IGF1R 단백질의 돌연변이가 발생한 경우, 아르토민 A(Artomin A), 트라고포곤사포닌(Tragopogonsaponin), 탈수소카르파인 I(Dehydrocarpaine I), 비니페롤 A(Viniferol A), 알반인 H(Albanin H), 페덤큘라긴(Pedunculagin), 쥬키니 인자 B(Zucchini factor B), 테아플라바테 A(Theaflavate A), 카슈아리닌(Casuarinin), 산규인 H6(Sanguiin H6), 람베르티아닌 A(Lambertianin A), 몬골리카인 A(Mongolicain A), 카수아리인(Casuariin) 및 프리제이쥬레네(Pregeijerene)의 친화력이 우수한 것으로 나타났다(도 7).As a result, in the absence of a mutation in the IGF1R protein, Cadabicine, Rugosin D, Bismurrayafoline E, Quercetin 3-glucoside, and Apiumoside (Apimoside), Kaempferol 3,7,4'-trimethyl ether, 6"-Acetylapiin, Kaempferol 3-o-glucoside (kaempferol 3) -o-glucoside) and Secaloside A have been shown to promote the activity of IGF1, and when mutations in the IGF1R protein occur, Artomin A, Tragopogonsaponin, and dehydrogenase Dehydrocarpaine I, Viniferol A, Albanin H, Pedunculagin, Zucchini factor B, Theaflavate A, Cashew Excellent affinity for Casuarinin, Sanguiin H6, Lambertianin A, Mongolicain A, Casuariin and Pregeijerene It was found that (Figure 7).
Autodock 결과를 반영하기 위하여, 본 발명의 데이터베이스 시스템은 유용성분과 식품과의 관계를 맵핑한 DB(DB2-DB6)를 가지고 있다. In order to reflect the Autodock results, the database system of the present invention has a DB (DB2-DB6) that maps the relationship between useful ingredients and food.
일례로, 하기 표 1에 유용성분을 함유한 식품정보를 포함한다.As an example, Table 1 below includes information on foods containing useful ingredients.
(Dehydrocarpaine I)Dehydrocarpaine I
(Dehydrocarpaine I)
(2) 장내 미생물 검사(2) Intestinal microorganism test
키성장을 주제로 키가 작은 유아, 청소년들의 장내미생물의 변화를 확인하기 위해 NCBI SRA 데이터베이스에서 총 1만1천여개의 장내미생물 시료를 수집하였고, 해당 시료 중에서 키, 나이, 성별 등 분석조건을 충족하는 500여개의 시료를 선정하여 분석을 실시하였다. In order to check changes in the intestinal microorganisms of short infants and adolescents on the topic of height growth, a total of 11,000 intestinal microorganism samples were collected from the NCBI SRA database, and among those samples, analysis conditions such as height, age, and gender were met. About 500 samples were selected and analyzed.
대변을 이용한 in vitro 실험 결과를 데이터베이스로 구축하였다. 상기 데이터베이스는 대변에 존재하는 미생물의 장형별로 특정 균을 증가시키거나 감소시키는 식이섬유소, 채소 또는 과일을 선별하는데 활용되며, 왜소증에 많은 균들을 줄이고, 정상어린이에 많은 유익균을 증가시킬 수 있는 영양성분 또는 식품을 선별하도록 프로그램으로 구축하였다. 일례로, 특정균을 입력하면 그 균을 높일 수 있는 영양성분 또는 식품, 낮출수 잇는 영양성분 또는 식품을 동시에 선별할 수 있도록 구축하였다. The results of in vitro experiments using feces were established as a database. The database is used to select dietary fiber, vegetables, or fruits that increase or decrease specific bacteria according to the intestinal type of microorganisms present in the stool, and provides nutrients that can reduce the number of bacteria in dwarfism and increase the number of beneficial bacteria in normal children. Or, a program was built to select food. For example, when a specific bacteria is entered, it is built to simultaneously select nutrients or foods that can increase the bacteria and nutrients or foods that can lower it.
연령별 키에 대한 z-스코어를 계산하여 z-스코어 -1.15(하위 30% 수준)를 기준으로, 키가 작은 실험군으로 분류하였다.The z-score for height by age was calculated, and based on the z-score of -1.15 (bottom 30% level), the experimental group was classified as short.
① 균의 다양성 및 장형 검사① Bacterial diversity and intestinal type testing
장내미생물 검사는 분석을 의뢰한 사람의 장형이 키가 작은 특징을 가지는 장형에 속하는지, 균의 다양성이 정상 수준과 비교하였을 때 낮은지, 높은지를 확인할 수 있으며, 검사자의 건강에 도움을 줄 수 있는 맞춤형 프리/프로 바이오틱스를 분석해 줄 수 있다.The intestinal microorganism test can confirm whether the person requesting analysis belongs to the intestinal type characterized by short stature and whether the diversity of bacteria is low or high compared to the normal level, and can help the tester's health. We can analyze customized pre/pro biotics.
- 다양성: 균의 다양성이 높을수록 건강한 장환경을 가지는 것으로 해석하였고, 균의 다양성이 낮을수록 영양공급이 부족하거나 다양한 종류의 식품 섭취가 요구되는 것으로 해석하였다. - Diversity: The higher the diversity of bacteria, the more healthy the intestinal environment is. The lower the diversity of bacteria, the less nutritional supply or the need to consume a variety of foods.
어린이의 장내 미생물 분포는 두 타입의 장형으로 분류 하였는데, 첫번 째는 Enterobacteriaceae가 많은 장형(ET-E), 다른 하나는 Prevotellaecae가 많은 장형(ET-P)으로 분류하였다. ET-E 장형에서는 키가 작은 비율이 16.4%, ET-P 장형에서 키가 작은 비율이 67.9%로 분석되어 ET-P로 분류되면 정상보다 키가 작을 확율이 높은 것으로 나타났다. The distribution of children's intestinal microorganisms was classified into two types: the first type was rich in Enterobacteriaceae (ET-E), and the other was rich in Prevotellaecae (ET-P). In the ET-E long type, the proportion of short height was 16.4%, and in the ET-P long type, the proportion of short height was 67.9%, showing that there is a high probability of being shorter than normal if classified as ET-P.
키가 작은 어린이에서 두 장형에서 모두 균의 다양성이 낮았으며, ET-E 장형인 경우, 정상 어린이 대비 작은 어린이의 장에는 비피도박테리움(Bifidobacterium), 스트렙토코커스(Streptococcus) 및 프레보텔라(Prevotella)의 함량이 높고, 에쉬리키아(Escherichia)의 함량이 낮았다(도 8). In short children, bacterial diversity was low in both intestinal types, and in the case of the ET-E intestinal type, Bifidobacterium , Streptococcus , and Prevotella were present in the intestines of small children compared to normal children. ) was high, and the content of Escherichia was low (Figure 8).
ET-P 장형인 경우, 정상 어린이 대비 작은 어린이의 장에는 프레보텔라(Prevotella) 및 비피도박테리움(Bifidobacterium)의 함량이 높고, 스트렙토코커스(Streptococcus) 및 페칼리박테리움(Faecalibacterium)의 함량이 낮았다(도 9). In the case of ET-P intestinal type, the intestines of small children compared to normal children have higher contents of Prevotella and Bifidobacterium , and higher contents of Streptococcus and Faecalibacterium . It was low (Figure 9) .
또한, 키성장을 유도하는 것에 관련된 장내미생물 DB(DB3)를 구축하였고, 장형별로 각 미생물의 증식을 억제하거나 촉진시키는 한약재나 식이 섬유소에 대한 DB(DB5)를 구축하였다. 상기 DB는 장형별 대변을 식이섬유소나 한약재와 함께 배양했을 때, 특정 균의 성장의 촉진이나 억제할 수 있는 것을 실험적으로 확인하였고, 그 결과를 데이터베이스로 구축한 것이다(도 10).In addition, a DB (DB3) for intestinal microorganisms related to inducing height growth was constructed, and a DB (DB5) for herbal medicine or dietary fiber that inhibits or promotes the growth of each microorganism by intestinal type was constructed. The DB experimentally confirmed that the growth of specific bacteria can be promoted or inhibited when stool for each intestinal type was cultured with dietary fiber or herbal medicine, and the results were constructed as a database (FIG. 10).
본 발명의 데이터베이스 시스템을 이용하는 경우, 장형별로 한약재나 식이섬유소 등을 대변과 배양했을 때, 변화하는 정도를 정량화(점수화)하여 데이터베이스로 구축하였으며, 특정 균의 증가 또는 감소시키는 식이섬유소를 선택하여 추천할 수 있다. When using the database system of the present invention, when herbal medicine or dietary fiber, etc., are cultured with feces for each intestinal type, the degree of change is quantified (scored) and a database is constructed, and dietary fiber that increases or decreases specific bacteria is selected and recommended. can do.
또한, 장형에 따른 장내미생물 균기능을 분석하여 키 작은 어린이의 경우, ET-E 및 ET-P형 모두 바이오틴 합성이 감소하였고, 인슐린 신호전달이 감소한 것을 확인하였다(도 11 및 12). In addition, by analyzing the function of intestinal microorganisms according to intestinal type, it was confirmed that in short children, biotin synthesis was decreased in both ET-E and ET-P types, and insulin signaling was decreased (Figures 11 and 12).
3. 이유식 및 유아식의 시기별 형태 및 특징에 대한 정보3. Information on the forms and characteristics of baby food and baby food by period
이유식과 유아식으로 분류되며, 이유식은 초기, 중기, 후기 및 완료기로, 유아식은 초기, 후기로 분류한다.It is classified into baby food and baby food. Baby food is classified into early, middle, late, and complete stages, and baby food is classified into early and late stages.
(1) 이유식(1) Baby food
① 초기 이유식: 초기 이유식은 분유나 모유 외에 음식을 처음 접하는 시기로, 다양한 식품을 경험하고 식품 알러지가 있는지 관찰하는 시기이다. ① Early weaning : Early weaning is the first time a child is exposed to food other than formula or breast milk, and is a time to experience a variety of foods and observe whether there are food allergies.
일반적으로, 4~6개월 경에 시작하지만 수유방법 및 여러가지 상황에 따라 시작 시기가 다르다Generally, it starts around 4 to 6 months, but the starting time varies depending on the feeding method and various situations.
모유 또는 분유가 주식인 시기로, 이유식은 40~60g 정도 이하 섭취할 수 있으며, 통곡물/잡곡 분쇄한 것을 5~10%정도 혼합하여 줄 수 있다.This is the period when breast milk or powdered milk is the staple food, and less than 40 to 60 g of baby food can be consumed, and 5 to 10% of whole grains/ground grains can be mixed.
- 제공 횟수: 하루 1회, 10시(일별 기준으로, 처음 수유 후)- Number of servings: Once a day, 10 o'clock (daily basis, after the first feeding)
- 이유식 재료: 쌀가루 20~30g, 물 100㎖ (미음, 으깬죽 5~30g), 단백질 5~10g, 채소 5~10g.- Baby food ingredients: 20-30g rice flour, 100ml water (rice drink, 5-30g mashed porridge), 5-10g protein, 5-10g vegetables.
- 초기 이유식에서는 곡류나 채소, 소고기나 닭고기를 하루에 한가지씩 같은 것으로 3일씩 공급하고, 처음 먹는 식재료를 포함하는 식사는 13시 이전 섭취하여 알러지 반응을 살핀다.- In the early stages of weaning, feed the same grains, vegetables, beef or chicken once a day for 3 days, and eat meals containing ingredients for the first time before 13:00 to check for allergic reactions.
- 분유나 모유 제공 횟수 시간: 처음 수유와 두번째 수유 사이에 제공한다.- Number of times to provide formula or breast milk: Provided between the first and second feedings.
- 수유/분유량: 800~1000㎖- Breastfeeding/formulated milk volume: 800~1000㎖
② 중기 이유식: 7~9개월 경에 시작하며, 첫니가 나기 시작하고, 이유식의 비중이 증가하는 시기이며, 식사 전 또는 식 간에 빨대나 컵을 이용하여 물을 먹을 수 있고, 핑거 푸드를 잡고 먹는 연습을 하는 시기이다(뻥튀기 등의 잡고 먹을 수 있는 식품). ② Mid-term baby food : Starts around 7 to 9 months, is the period when the first teeth begin to erupt and the proportion of baby food increases. Children can drink water using a straw or cup before or between meals, and can eat finger foods. It is time to practice (foods that can be held and eaten, such as fried rice).
수유나 식사 후 거즈나 아기칫솔을 사용하여 이를 닦아주어 충치가 생기지 않도록 관리해줘야 한다.After feeding or eating, you should brush your baby's teeth with gauze or a baby toothbrush to prevent cavities from forming.
- 제공횟수: 하루 2회, 10시, 14시(처음 수유 다음, 처음 이유식 혹은 두번째 수유 다음)- Frequency of provision: 2 times a day, 10:00, 14:00 (after the first feeding, after the first baby food or the second feeding)
- 이유식 재료: 쌀가루 20~30g, 물 100㎖(묽은죽, 보통죽 50~80g), 단백질 10~20g, 채소 20~30g- Baby food ingredients: 20-30g rice flour, 100ml water (thin porridge, 50-80g regular porridge), 10-20g protein, 20-30g vegetables
- 이미 경험한 식품을 2~3가지 혼합 가능(예를 들면 곡류+채소+육류)- You can mix 2~3 types of foods you have already experienced (e.g. grains + vegetables + meat)
- 수유/분유량: 600~800㎖- Breastfeeding/formulated milk volume: 600~800㎖
③ 후기 이유식: 10~12개월에 시작하며 수유와 이유식을 분리하여 진행하고 수유는 간식 정도로 제공한다. 밥, 국수, 주먹밥, 핑거푸드 등 다양한 식사가 가능하며, 아이가 혼자 밥을 먹을 수 있도록 자기주도식사를 권장한다. 음식을 엎거나 쏟는 것을 성장을 위한 단계로 인식하고 혼내지 않도록 한다. ③ Late weaning : Starts at 10 to 12 months. Feeding and baby food are separated, and feeding is provided as a snack. A variety of meals are available, including rice, noodles, rice balls, and finger foods, and self-directed meals are recommended so that children can eat alone. Recognize spilling or spilling food as a step towards growth and avoid scolding them.
- 제공횟수: 하루 3회, 10시, 14시, 18시- Number of times provided: 3 times a day, 10:00, 14:00, 18:00
- 이유식 재료: 쌀(쌀가루) 30g, 물 60㎖(된죽~진밥 60~90g), 단백질 20~30g, 채소 30~40g- Baby food ingredients: 30g of rice (rice flour), 60ml of water (60-90g of pork porridge or rice), 20-30g of protein, 30-40g of vegetables
- 이유식 거부 증상이 있는 경우, 아이의 컨디션이 좋을 때 잘 먹으므로 모유 혹은 분유 먹는 시간보다 약간 일찍 제공하는 것을 권장- If there are symptoms of baby food refusal, it is recommended to provide it slightly earlier than the time of breastfeeding or formula, as the child eats well when his condition is good.
- 수유, 분유량: 400~600㎖ - Breastfeeding, powdered milk volume: 400~600ml
④ 완료기 이유식: 13~16개월 정도에 진행하며 일품 형태에서 밥과 반찬을 따로 주는 유아식도 제공할 수 있는 시기이고, 생우유를 마실 수 있는 시기이며, 처음 먹는 경우, 따뜻하게 데워주면 소화에 도움을 줄 수 있다. ④ Complete stage baby food : This is provided at around 13 to 16 months. This is the period when baby food can be provided in the form of a la carte, with rice and side dishes provided separately. This is the period when the baby can drink raw milk. If the baby is eating it for the first time, warming it can help with digestion. I can give it.
- 제공횟수: 하루 3회, 10시, 14시, 18시- Number of times provided: 3 times a day, 10:00, 14:00, 18:00
- 이유식 재료: 쌀(쌀가루) 30g, 물 60㎖(된죽~진밥 60~90g), 단백질 20~30g, 채소 30~40g- Baby food ingredients: 30g of rice (rice flour), 60ml of water (60-90g of pork porridge or rice), 20-30g of protein, 30-40g of vegetables
- 이유식 거부 증상이 있는 경우, 아이의 컨디션이 좋을 때 잘 먹으므로 모유 혹은 분유 먹는 시간보다 약간 일찍 제공하는 것을 권장- If there are symptoms of baby food refusal, it is recommended to provide it slightly earlier than the time of breastfeeding or formula, as the child eats well when his condition is good.
- 수유, 분유량: 400~600㎖ - Breastfeeding, powdered milk volume: 400~600ml
(2) 유아식(2) Baby food
① 초기 유아식: 12~16개월 정도에 시작하며 36개월정도까지 제공한다. 이유식과 달리 한식, 일품, 국수 등의 다양한 형태의 식사가 가능하다. 하지만, 아직 이가 자라는 단계이므로, 단단한 음식은 부드럽게 다지고, 작게 잘라서 제공한다. ① Early baby food : Starts at around 12 to 16 months and is provided until around 36 months. Unlike baby food, various types of meals are possible, such as Korean food, Ilpoom, and noodles. However, since their teeth are still growing, chop hard foods gently and cut them into small pieces before serving.
- 편식이 있는 경우(고기편식, 채소편식, 우유편식 등) 다른 조리법으로 조리하거나 식품의 질감을 부드럽게 하는 연육작업을 진행하여 식품을 제공한다.- If there is a picky eater (picky meat eater, picky vegetable eater, picky milk eater, etc.), provide food by cooking it using a different recipe or by tenderizing the food to soften its texture.
- 제공횟수: 하루 3회, 아침, 점심, 저녁- Frequency of serving: 3 times a day, breakfast, lunch, dinner
간식 1회를 포함하여 1일 3식 + 간식을 포함하는 식단을 제공Provides a diet that includes 3 meals per day + snacks, including 1 snack
- 식재료: 쌀 30g, 된죽~진밥 90g(1주걱), 단백질 30g, 채소 30~50g, 우유 200~400㎖, 간식: 식빵 1쪽- Ingredients: 30g rice, 90g (1 scoop) of soybean porridge or rice, 30g protein, 30-50g vegetables, 200-400ml milk, snack: 1 slice of white bread
② 후기 유아식: 36개월부터 60개월(5세)까지 진행하며 초기 유아식과 유사하지만 비교적 단단한 음식이나 크기가 큰 크기의 음식을 먹을 수 있고, 성인이 먹는 음식은 거의 모두 먹을 수 있지만, 조리할 때 소금이나 설탕 음식에 간을 거의 하지 않고 음식 고유의 맛으로 조리하는 것을 권장한다. ② Late baby food : It lasts from 36 months to 60 months (5 years old) and is similar to early baby food, but relatively hard foods or large-sized foods can be eaten. Almost all foods that adults eat can be eaten, but when cooking It is recommended to cook food to its own taste without seasoning it with much salt or sugar.
본 발명에서 제공하는 이유식 및 유아식 맞춤형 식단에서, 이유식/유아식을 추천하는 영양 산출 기준은 한국인 권장 섭취량과 충분섭취량을 기준으로 계산하였고, 우선 순위 영양소는 철분, 아연, 영양 권장량, 히스티딘이 적거나 없는 것(히스티딘은 알러지 유발하는 히스타민(histamine)의 전구물질)In the customized baby food and baby food diet provided by the present invention, the nutritional calculation standard for recommending baby food/baby food was calculated based on the recommended intake and sufficient intake for Koreans, and the priority nutrients are iron, zinc, recommended nutritional intake, and low or no histidine. (Histidine is a precursor to histamine, which causes allergies)
- 제공횟수: 초기유아식과 동일- Number of servings: Same as early baby food
- 식재료: 쌀밥 130g(1과 1/2주걱), 단백질 40~50g, 채소 40~60g, 3회 섭취, 우유 200~400㎖, 간식: 식빵 2쪽- Ingredients: 130g of rice (1 and 1/2 spoons), 40~50g of protein, 40~60g of vegetables, 3 servings, 200~400ml of milk, Snack: 2 slices of white bread
(kcal)unit
(kcal)
(12-35개월)1-3 years old
(12-35 months)
(36-60개월)3-5 years old
(36-60 months)
영양산출 기준: 한국인권장섭취량, 충분섭취량 등을 기준으로 계산.Nutritional calculation standard: Calculated based on the Korean recommended human intake, sufficient intake, etc.
우선순위 영양소: 철분, 아연, 영양권장량, 히스티딘이 적거나 없는 것(히스티딘은 알러지 유발하는 히스타민의 전구물질)Priority nutrients: iron, zinc, RDA, low or no histidine (histidine is a precursor to histamine, which causes allergies)
- 곡류 1 교환 단위: 쌀밥, 보리밥 70g(1/3공기), 쌀죽 140g(2/3공기), 삶은 국수 90g(1/2공기), 감자 140g(중 1개), 고구마 70g(중 1/2개), 떡류 50g.- Grain 1 exchange unit: rice, barley 70g (1/3 bowl), rice porridge 140g (2/3 bowl), boiled noodles 90g (1/2 bowl), potato 140g (1 piece), sweet potato 70g (1/3 bowl) 2 pieces), rice cakes 50g.
- 어육류 1 교환단위: 고기류 40g(소1토막), 생선류 50g(소1토막), 두부 80g (420g 포장두부의 1/5), 계란 55g (중 1개), 치즈 30g(1.5장).- Fish and meat 1 exchange unit: 40g of meat (1 piece of beef), 50g of fish (1 piece of beef), 80g of tofu (1/5 of 420g packaged tofu), 55g of egg (1 piece), 30g of cheese (1.5 pieces).
-채소류 1 교환단위 : 대부분 채소류 70g, 버섯류 50g, 김치류 50g, 우유 1교환단위: 우유류 200g.-1 exchange unit of vegetables: 70g of most vegetables, 50g of mushrooms, 50g of kimchi, 1 exchange unit of milk: 200g of milk.
- 과일 1 교환단위: 귤 120g, 바나나 생것 중 1/2개 (50g), 배 110g (대1/4개), 오렌지 (대1/2개, 100g), 사과 80g (중 1/3개) 등- 1 fruit exchange unit: 120g of tangerine, 1/2 of a raw banana (50g), 110g of a pear (1/4 of a large), orange (1/2 of a large, 100g), 80g of an apple (1/3 of a large) etc.
- 지방군 1 교환 단위: 견과류 8g, 식물성 기름류 5g, 드레싱류 10g - Fat group 1 exchange unit: 8g nuts, 5g vegetable oil, 10g dressing
4. 이유식 및 유아식의 식재료 및 조리법4. Ingredients and recipes for baby food and baby food
키관련 유전자 GDF5와 IGF1R의 단백질, 이 유전자의 돌연변이(missense) 단백질에서 활성 부위를 정하여 각각 분자모델링 툴(Autodock Tools)을 사용하여 식품성분 30,000여개(Food Database)와의 결합능을 유전적 변이가 있을 때와 없을 때의 조건을 나누어 분석하고, 결합능이 -10 이하인 것을 분석한다. By determining the active site in the proteins of the key-related genes GDF5 and IGF1R and the missing proteins of these genes, the binding ability to 30,000 food ingredients (Food Database) was measured using molecular modeling tools (Autodock Tools), respectively, when there is a genetic mutation. Analyze the conditions for and without, and analyze those with a binding capacity of -10 or less.
해당 식품성분을 함유하는 식품을 유전자의 활성을 향상시키는 물질로 간주하여 물질을 함유한 식품을 키성장 관련 식품으로 추천한다. Foods containing the relevant food ingredient are considered to be substances that improve gene activity, and foods containing the substance are recommended as foods related to height growth.
(1) 식재료 추천 (1) Ingredients recommendation
① 유전자 검사: GDF5(Growth Differentiation Factor 5)① Genetic test: GDF5 (Growth Differentiation Factor 5)
② 유전적 변이가 없거나 있는 상태의 기능성 물질을 함유한 급원식품 정보를 탐색하고, 유전적 변이와 기능성 물질 간의 값이 낮을수록 키성장에 크게 관여하므로 해당 급원식품을 식재료를 1주일에 1-2회 이상 추천한다.② Search for information on food sources that contain functional substances with or without genetic mutations, and the lower the value between genetic mutations and functional substances, the greater the involvement in height growth, so consume the food sources 1-2 times a week. Recommended at least once.
③ 유전적 변이가 없는 상태의 기능성물질 우선순위: 개암나무, 구아바 등③ Priority for functional substances without genetic mutation: hazelnut tree, guava, etc.
④ 장내미생물의 분포에 따라 분류하면, ET-E 장형에서 증가시켜야 하는 균은 박테로이데스 우니포르미스(Bacteroides uniformis), 오실리박터 발레리제네시스(Oscillibacter valericigenes), 페칼리박테리움 프라우스니티즈이(Faecalibacterium prausnitizii)이고, ET-E 장형에서 감소시켜야 하는 균은 프레보텔라 코프리(Prevotella copri), 루미오코커스 그나부스(Rumiococcus gnavus)이며, ET-P 장형에서 증가시켜야 하는 균은 유박테리움 렉탈레(Eubacterium rectale), 박테로이드스 유니포미스(Bacteroides uniformis)이고, ET-P 장형에서 감소시켜야 하는 균은 프레보텔라 코프리(Prevotella copri), 루미오코커스 그나부스(Rumiococcus gnavus)이다. ④ If classified according to the distribution of intestinal microorganisms, the bacteria that need to be increased in the ET-E enterotype are Bacteroides uniformis , Oscillibacter valericigenes , and Fecalibacterium prausnitisii ( Faecalibacterium prausnitizii ), and the bacteria that need to be reduced in the ET-E type are Prevotella copri and Rumiococcus gnavus , and the bacteria that need to be increased in the ET-P type are Eubacterium lec. Eubacterium rectale and Bacteroides uniformis , and the bacteria that need to be reduced in ET-P enterotypes are Prevotella copri and Rumiococcus gnavus .
(2) 추천 식재료의 조리법(2) Recipes using recommended ingredients
등록한 부모의 알러지, 아동의 알러지, 가족질환등의 정보기반 식재료 출력Output of food ingredients based on information such as registered parent's allergies, children's allergies, family diseases, etc.
① 초기 이유식① Early baby food
- 쌀(잡곡)을 믹서기로 곱게 간다- Grind rice (multigrain) finely in a blender.
- 야채(과일, 두부)는 깨끗하게 세척 후 곱게 간다.- Wash vegetables (fruit, tofu) thoroughly and grind them finely.
- 고기, 육류는 흐르는 물에 한번 세척 후 힘줄이나 지방부위를 제거하고 곱게 간다.- Wash meat and meat once under running water, remove tendons or fat, and grind finely.
- 쌀: 물의 비율을 1: 5~10 정도로 하고 야채, 고기를 함께 넣고 끓인다.- Make a rice:water ratio of about 1:5~10, add vegetables and meat, and boil.
- 끓은 죽을 적당히 식혀서 제공한다. - Cool the boiled porridge appropriately before serving.
(소분하여 냉장보관할 경우 3일, 냉동보관할 경우 7일까지 보관한다)(If divided into small portions and stored in the refrigerator, they can be stored for up to 3 days. If stored in the freezer, they can be stored for up to 7 days.)
② 중기, 후기 이유식② Middle and late baby food
- 쌀(잡곡)을 적당히 갈아준다.- Grind the rice (multigrain) appropriately.
- 야채(과일, 두부)는 깨끗하게 세척 후 끓는 물에 데친 후 잘게 다진다.- Wash vegetables (fruit, tofu) thoroughly, blanch them in boiling water, and chop them finely.
- 고기, 육류는 흐르는 물에 한번 세척 후 힘줄이나 지방부위를 제거하고 다진다.- Wash meat and meat once under running water, remove tendons or fat, and chop.
- 쌀: 물의 비율을 1: 5~6 정도로 하고 끓이다가 고기를 함께 넣고 끓이고, 마지막에 야채를 넣는다.- Boil the rice:water ratio at about 1:5~6, then add the meat and boil, and add the vegetables at the end.
- 잘 섞어준 후 적당히 식혀서 제공한다. - Mix well, cool appropriately and serve.
③ 유아식③ Baby food
- 쌀(잡곡)을 적당히 분쇄하거나 일반 쌀을 사용한다(잡곡은 분쇄과정이 필요함)- Grind rice (miscellaneous grains) appropriately or use regular rice (miscellaneous grains require a grinding process)
- 쌀: 물의 비율을 1: 2~3 정도로 밥을 짓는다.- Cook rice with a water to rice ratio of 1:2-3.
- 고기, 육류는 흐르는 물에 한번 세척 후 힘줄이나 지방부위를 제거하고 적당한 크기로 자른후, 볶음, 구이 등의 조리법으로 조리하고 소금, 간장 등의 양념은 거의 하지 않는다.- Wash meat once under running water, remove tendons or fat, cut into appropriate sizes, and cook using cooking methods such as stir-frying or grilling. Seasoning such as salt or soy sauce is rarely used.
- 야채(과일, 두부)는 깨끗하게 세척 후 끓는 물에 데친 후 작게 자르고, 볶음, 나물, 샐러드 등의 반찬으로 만들고 양념은 거의 하지 않는다.- Wash vegetables (fruits, tofu) thoroughly, blanch them in boiling water, cut them into small pieces, and make them into side dishes such as stir-fries, vegetables, salads, etc., with little seasoning.
- 국은 필요 시 제공하고 양념은 거의 하지 않는다.- Soup is provided when necessary and seasoning is rarely used.
- 잘 섞어준 후 적당히 식혀서 제공한다. - Mix well, cool appropriately and serve.
(3) 식단 정보(3) Diet information
각 식사 추천에 들어가는 식품은 식사형태, 식품별 알러지, 제철식품, 자주먹는 정도, 교환단위 등의 정보를 포함하여 이유식 및 유아식 식단에 제공한다.Foods included in each meal recommendation are provided in baby food and infant food diets, including information such as meal type, food allergies, seasonal foods, frequency of eating, and exchange units.
(4) 알러지 평가(4) Allergy evaluation
부모가 가지고 있는 알러지 식품 등록, 부모가 가지고 있는 알러지 식품은 12개월 이후에 추천하며, 알러지 항목을 평가하고 하나라도 해당되는 경우 알러지 유발 물질로 분류하고, 알러지 유발 물질은 6개월 후에 다시 먹어보고 개선되었는지 확인한다.Register food allergies that parents have. Foods that parents have allergies to are recommended after 12 months. Allergy items are evaluated, and if any of them apply, they are classified as allergens. Allergens are eaten again after 6 months for improvement. Check if it is done.
알러지 평가 항목 중 하나라도 해당 시 식사를 즉시 중단하고 상태에 따라 병원에 방문해야 한다.If any of the allergy evaluation items occur, you must immediately stop eating and visit a hospital depending on the condition.
- 두드러기, 가려움 등의 반응이 있는가- Are there any reactions such as hives or itching?
- 입, 볼, 얼굴, 배등 몸에 붉은 반점이나 홍반, 발진 등이 생겼는가- Do you have red spots, erythema, or rashes on your mouth, cheeks, face, stomach, etc.?
- 구역질, 설사, 기침, 호흡곤란, 맥박상승 등의 반응을 보이는가 - Are you experiencing reactions such as nausea, diarrhea, coughing, difficulty breathing, or increased pulse?
(5) 배변 평가 (5) Defecation evaluation
변의 점도, 색상, 음식소화 정도 평가(2세 이후 평가 여부를 선택할 수 있다)Evaluation of stool viscosity, color, and degree of food digestion (can be evaluated after 2 years of age)
- 점도: 설사 -> 이유식 혹은 분유에 들어가는 물의 양을 늘릴 것- Viscosity: Diarrhea -> Increase the amount of water in baby food or formula
변비-> 물의 양을 줄일 것. Constipation -> Reduce the amount of water.
- 색상: 황색, 녹색, 갈색->정상, 붉은색, 검은색->이상- Color: Yellow, green, brown->normal, red, black->abnormal
- 음식소화 정도: 음식의 형태가 보임-> 더 잘게 갈기- Degree of food digestion: the shape of the food is visible -> grind it into smaller pieces
(6) 기피식품 평가(6) Evaluation of foods to avoid
음식 선호도를 평가하고 잘 먹지 않고 남길 경우 기피식품으로 분류->조리법 변경Evaluate food preferences and classify food as avoided if left uneaten -> change recipe
(7) 좋아하는 식품 평가(7) Evaluation of favorite foods
좋아하고 잘 먹는 경우, 즐겨찾기 음식으로 분류If you like it and eat it well, classify it as a favorite food.
Claims (12)
(2) 상기 단계 (1)에서, 기본정보를 입력한 영유아의 키성장 관련 유전자 GDF5(growth differentiation factor 5) 및 IGF1R(insulin-like growth factor 1 receptor) 돌연변이 유무에 대한 결과값과 장내미생물 검사 결과값을 입력하는 단계;
(3) 상기 단계 (2)에서 입력한 유전자 GDF5 및 IGF1R의 돌연변이 여부가 적용된 GDF5 및 IGF1R 단백질에 대한 영양성분의 결합능 및 장내 미생물 분포도 가중치를 적용하여 영유아에게 필요한 영양성분을 선별하는 단계; 및
(4) 상기 단계 (3)에서 선별한 영양성분을 포함하는 식품을 맵핑하여, 상기 단계 (1)에서 입력한 영유아의 개월수에 맞춰 식품의 양과 조리법을 선정하여 제공하는 단계;를 포함하는 키성장 관련 유전자 및 장내 미생물 검사기반 키성장을 위한 영유아용 맞춤형 식단을 제공하는 방법.(1) Entering basic information about the number of months, height, weight, parents, and food allergies of the infant and child for whom a customized diet is to be provided into a database system that provides a customized diet for infants and young children;
(2) In step (1) above, results of mutations in the growth-related genes GDF5 (growth differentiation factor 5) and IGF1R (insulin-like growth factor 1 receptor) and intestinal microorganism test results for infants who entered basic information in step (1) above. Entering a value;
(3) selecting the nutrients needed for infants and young children by applying weights to the binding ability of nutrients to the GDF5 and IGF1R proteins and the distribution of intestinal microorganisms based on the mutation of the genes GDF5 and IGF1R entered in step (2); and
(4) mapping the food containing the nutritional ingredients selected in step (3), and selecting and providing the amount and recipe of the food according to the number of months of the infant entered in step (1). A method of providing customized diets for infants and young children for height growth based on growth-related genes and intestinal microorganism tests.
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| KR1020220146001A KR20240064226A (en) | 2022-11-04 | 2022-11-04 | Method for providing customized diet menu of infant based on height-related gene and intestinal microbiological examination |
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