KR20240052801A - 플라비바이러스 치료를 위한 2'-클로로-2'-플루오로-n2-아미노-n6-메틸아미노 퓨린 뉴클레오티드 - Google Patents

플라비바이러스 치료를 위한 2'-클로로-2'-플루오로-n2-아미노-n6-메틸아미노 퓨린 뉴클레오티드 Download PDF

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Publication number
KR20240052801A
KR20240052801A KR1020247010025A KR20247010025A KR20240052801A KR 20240052801 A KR20240052801 A KR 20240052801A KR 1020247010025 A KR1020247010025 A KR 1020247010025A KR 20247010025 A KR20247010025 A KR 20247010025A KR 20240052801 A KR20240052801 A KR 20240052801A
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South Korea
Prior art keywords
compound
virus
administered
alkyl
pharmaceutical composition
Prior art date
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Pending
Application number
KR1020247010025A
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English (en)
Korean (ko)
Inventor
장-피에르 솜마도시
아델 무사
Original Assignee
아테아 파마슈티컬즈, 인크.
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Application filed by 아테아 파마슈티컬즈, 인크. filed Critical 아테아 파마슈티컬즈, 인크.
Priority claimed from PCT/US2022/042545 external-priority patent/WO2023034617A1/en
Publication of KR20240052801A publication Critical patent/KR20240052801A/ko
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020247010025A 2021-09-03 2022-09-02 플라비바이러스 치료를 위한 2'-클로로-2'-플루오로-n2-아미노-n6-메틸아미노 퓨린 뉴클레오티드 Pending KR20240052801A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163240578P 2021-09-03 2021-09-03
US63/240,578 2021-09-03
PCT/US2022/042545 WO2023034617A1 (en) 2021-09-03 2022-09-02 2'-chloro-2'-fluoro-n2-amino-n6-methylamino purine nucleotides for flavivirus treatment

Publications (1)

Publication Number Publication Date
KR20240052801A true KR20240052801A (ko) 2024-04-23

Family

ID=85380756

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247010025A Pending KR20240052801A (ko) 2021-09-03 2022-09-02 플라비바이러스 치료를 위한 2'-클로로-2'-플루오로-n2-아미노-n6-메틸아미노 퓨린 뉴클레오티드

Country Status (7)

Country Link
US (1) US20240226131A1 (https=)
EP (1) EP4395787A4 (https=)
JP (1) JP2024533122A (https=)
KR (1) KR20240052801A (https=)
CN (1) CN118234499A (https=)
AU (1) AU2022339679A1 (https=)
CA (1) CA3174107A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL308921A (en) 2021-06-17 2024-01-01 Atea Pharmaceuticals Inc Combination anti-HCV therapy is beneficial

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018048937A1 (en) * 2016-09-07 2018-03-15 Atea Pharmaceuticals, Inc. 2'-substituted-n6-substituted purine nucleotides for rna virus treatment
WO2021173713A1 (en) * 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19

Also Published As

Publication number Publication date
CA3174107A1 (en) 2023-03-03
CN118234499A (zh) 2024-06-21
EP4395787A1 (en) 2024-07-10
EP4395787A4 (en) 2025-07-23
US20240226131A1 (en) 2024-07-11
AU2022339679A1 (en) 2024-03-07
JP2024533122A (ja) 2024-09-12

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