KR20240049697A - Liquid composition for aerosol inhalers - Google Patents

Abstract

The present invention provides a liquid composition for an aerosol inhaler, a cartridge containing the same, and an aerosol inhaler having a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m.

Description

Liquid composition for aerosol inhalers}

The present invention relates to a liquid composition for an aerosol inhaler, a cartridge containing the same, and an aerosol inhaler.

In general, tobacco refers to a perennial plant of the dicotyledonous plant family Solanaceae, but recently, it is also commonly referred to as a product manufactured for smoking purposes by wrapping tobacco leaves in cigarette paper and forming a filter section on one side. There are thousands of types of such cigarettes worldwide, and they are released in various shapes and forms.

Among these, as an alternative to complement the shortcomings of combustion-type cigarettes such as cigarettes, cigars, and pipe tobacco, it is a method of generating aerosol as the aerosol-generating material in the cigarette is heated, rather than a method of generating aerosol by burning the cigarette. Methods such as heating a liquid containing a nicotine solution to vaporize it and inhaling the vaporized aerosol are being used, and demand for this method is increasing.

Meanwhile, an aerosol inhaler used in one of the above methods is a device used to inhale a composition such as a drug as a liquid or gas through the oral or nasal cavity during the inhalation process. This aerosol inhaler has a container containing an inhalable composition. Provided, the composition can be inhaled by the user by being sprayed from the container through a thin tube into the oral cavity or nasal cavity through an inlet.

When inhaling a liquid containing a propellant through an aerosol inhaler, aerosolization by the propellant is almost dominant, so it is very important to specifically control the composition of the medium to improve the smoking sensation.

The above-mentioned background technology is possessed or acquired by the inventor in the process of deriving the disclosure of the present application, and cannot necessarily be said to be known technology disclosed to the general public before the present application.

Republic of Korea Patent Publication No. 10-2015-0046318 (2015.04.29)

One object of the present invention is to provide a liquid composition for an aerosol inhaler, a cartridge containing the same, and an aerosol inhaler that improves the transport characteristics of the liquid phase and adjusts the size of the aerosol to enable proper spraying.

However, the problem to be solved by the present invention is not limited to the problems mentioned above, and other problems not mentioned can be clearly understood by those skilled in the art from the description below.

According to one embodiment of the present invention, a liquid composition for an aerosol inhaler is provided, which has a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m.

According to one side, a cartridge is provided, comprising a liquid composition for an aerosol inhaler having a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m.

According to another aspect of the invention, a battery providing power for an aerosol inhaler, a control unit for controlling the operation of the aerosol inhaler, a nozzle comprising one or more needles, and a surface having a viscosity of 15 cp or less and 20 to 30 mN/m. An aerosol inhaler comprising a cartridge containing a liquid composition for a tensioned aerosol inhaler is provided.

When the liquid composition according to one aspect of the present invention is used in an aerosol inhaler, the spray characteristics of the aerosol can be improved, similar spray characteristics can be obtained, and due to excellent fullness, persistence, and impact, the user's It can improve the feeling of smoking.

The effects of the liquid composition for aerosol inhaler, the cartridge containing the same, and the aerosol inhaler according to an embodiment of the present invention are not limited to the above effects, and all that can be inferred from the detailed description or claims of the present invention. It should be understood as including effects.

Figure 1 is a perspective view of a needle-type aerosol inhaler (test kit design) having a configuration of a canister, a valve, a connection part, and a needle, according to an embodiment of the present invention.
Figure 2 is a cross-sectional view of a needle-type aerosol inhaler (test kit design) having a configuration of a canister, a valve, a connection part, and a needle, according to an embodiment of the present invention.
Figure 3 is a diagram showing viscosity values for each liquid composition (sample) according to an embodiment of the present invention.
Figure 4 is a diagram showing the contact angle and surface tension for each liquid composition (sample) according to an embodiment of the present invention.
Figure 5 is a graph showing the spray angle (A), spray arrival distance (B), and spray time (C) according to the surface tension of the liquid composition according to an embodiment of the present invention.
Figure 6 is a graph showing the spray angle (A) and spray arrival distance (B) according to the surface tension of the liquid composition according to an embodiment of the present invention in high-density spraying.
Figure 7 is a graph showing the trajectory (A), size change (B), and speed (C) of large aerosols generated from spraying.
Figure 8 is a graph showing the average speed (A) and average size (B) of large aerosols depending on the medium.

Hereinafter, embodiments will be described in detail with reference to the attached drawings. However, various changes can be made to the embodiments, so the scope of the patent application is not limited or limited by these embodiments. It should be understood that all changes, equivalents, or substitutes for the embodiments are included in the scope of rights.

The terms used in the examples are for descriptive purposes only and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as “comprise” or “have” are intended to designate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as generally understood by a person of ordinary skill in the technical field to which the embodiments belong. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and should not be interpreted in an ideal or excessively formal sense unless explicitly defined in the present application. No.

In addition, when describing with reference to the accompanying drawings, identical components will be assigned the same reference numerals regardless of the reference numerals, and overlapping descriptions thereof will be omitted. In describing the embodiments, if it is determined that detailed descriptions of related known technologies may unnecessarily obscure the gist of the embodiments, the detailed descriptions are omitted.

Additionally, in describing the components of the embodiment, terms such as first, second, A, B, (a), and (b) may be used. These terms are only used to distinguish the component from other components, and the essence, order, or order of the component is not limited by the term.

Components included in one embodiment and components including common functions will be described using the same names in other embodiments. Unless stated to the contrary, the description given in one embodiment may be applied to other embodiments, and detailed description will be omitted to the extent of overlap.

The term "aerosol inhaler" used herein refers to a device that delivers aerosol of nicotine-related substances, aerosol generated by the reaction of nicotine-related substances and organic acid substances, etc. into the user's lungs through the user's oral cavity.

According to one embodiment of the present invention, the viscosity is 15 cp or less,

Having a surface tension of 20 to 30 mN/m,

A liquid composition for an aerosol inhaler is provided.

The liquid composition for an aerosol inhaler has a viscosity of 15 cp or less, so that the composition can be sprayed smoothly when used in an aerosol inhaler.

Large aerosols can cause a user to have a negative feeling of smoking when using an aerosol inhaler, and unpleasant liquid splashes occur on the user's neck depending on the speed, size, and trajectory of the large aerosols.

If the viscosity exceeds 15 cp, when spraying the liquid composition for an aerosol inhaler, a large amount of large aerosol that can cause a negative smoking sensation is generated, which causes the problem of poor spraying.

Additionally, the liquid composition according to an embodiment of the present invention may have a surface tension of 20 to 30 mN/m.

If the surface tension is less than 20 mN/m or smaller, aerosolization is hardly achieved or is not formed well, so it may not be suitable as a liquid composition for an aerosol inhaler.

In addition, when the surface tension exceeds 30 mN/m, the droplet size of the aerosol formed may be small, but a problem may arise in that excessively volatile ethanol must be added when preparing the composition, resulting in The surface tension is preferably 20 mN/m to 30 mN/m, and more preferably 23 mN/m to 28 mN/m.

Additionally, the liquid composition according to an embodiment of the present invention may have a contact angle of 45° or less with respect to a hydrophobic polydimethylsiloxane (PDMS) substrate. If the contact angle is greater than 45°, it is undesirable because the size of the aerosol droplet may increase.

In addition, when preparing a liquid composition for an aerosol inhaler, a contact angle of 45 degrees or less can be achieved as described above by adding 0.769% to 1.538% by weight of ethanol, so the proportion of ethanol can be adjusted to 0.5% to 2% by weight. It is desirable to include as much as %.

Meanwhile, the liquid composition according to an embodiment of the present invention may contain nicotine-related substances in that it is used in an aerosol inhaler for smoking.

The term 'nicotine-related substance' as used herein is a concept that includes nicotine. For example, the nicotine-related substance includes nicotine, nicotine salt, nicotine alkaloid, and nicotine derivatives. It may include etc.

In addition, the liquid composition according to an embodiment of the present invention may include an organic acid, saccharin, alcohol, and/or a propellant along with the nicotine-related substances.

Here, the organic acids are acetic acid, pyruvic acid, 3-methyl-2-oxobutyric acid, 2-oxovaleric acid, 3-methyl- 3-methyl-2-oxovaleric acid, 4-methyl-2-oxovaleric acid, 2-oxalic acid, 2-oxooctanoic acid (2 It may correspond to one or more selected from the group consisting of -oxoocatanoic acid) and lactic acid.

Additionally, the alcohol may include both monohydric alcohol and polyhydric alcohol. For example, it may be a monohydric alcohol or dihydric alcohol with 4 or less carbon atoms, preferably ethanol.

The propellant may include one or more of 1,1,1,2-Tetrafluoroethane (HFA-134a) and chlorofluorocarbon (CFC), preferably may be HFA-134a.

In addition, in addition to the nicotine-related substances, organic acids, propellants, etc., flavor liquids containing specific flavor substances may be additionally included so that users who use aerosol inhalers can meet the various preferences they have when smoking.

The flavor liquid may include a specific flavor material and a solvent capable of dissolving it, and the solvent may specifically correspond to ethanol, propylene glycol, glycerin, etc.

The flavoring substances include rosemary, eucalyptol, licorice, sucrose, fructose syrup, isosweetener, cocoa, lavender, cinnamon, cardamom, celery, fenugreek, cascarilla, sandalwood, bergamot, geranium, honey essence, and rose. A group consisting of oil, vanilla, lemon oil, orange oil, mint oil, mandarin oil, catechin, grapefruit, caraway, cognac, jasmine, cocoa, menthol, cinnamon, ylang-ylang, sage, spearmint, ginger, coriander and coffee. It may be one or more selected from, but is not limited to.

Meanwhile, the overall spray characteristics when using the liquid composition for an aerosol inhaler according to an embodiment of the present invention can be evaluated in terms of spray time, spray reach distance, spray angle, spray time, etc.

The spraying time is something that can bring about a positive feeling of continuous smoking in the smoker, and is the time from when the first aerosol generated when the liquid composition is sprayed from the nozzle of an aerosol inhaler to when the last aerosol is sprayed. can be defined.

As an example, in an example of the present invention described in detail below, the time from when the visualized aerosol was first sprayed to the moment when it was not sprayed for more than 50 ms was measured.

According to an embodiment of the present invention, in the case of a liquid composition with a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m, it was confirmed that the spraying time was all in the range of 2000 ms to 3000 ms (Figure 5(A)), it can be seen that compositions with the corresponding composition have similar spray properties.

In addition, the spray reach distance is defined as the maximum distance that the generated aerosol moves, which can cause the smoker to experience a positive smoking sensation.

As a specific method of measuring the spray arrival distance, for example, it can be derived by taking an image of an aerosol spray image, securing the spray boundary, and then measuring the maximum distance.

As shown in Figure 5 (B), in the case of a liquid composition having a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m according to an embodiment of the present invention, the spray reach distance is all 70 to 170 mN/m. As it falls within the range of mm, it can be seen that compositions having the corresponding composition have similar spray characteristics.

Furthermore, the spray angle is a measure of the fullness of the positive smoking sensation that indicates the degree of spread of the aerosol. As a specific measurement standard, the spray angle is the spread angle of the aerosol from the nozzle entrance to half the spray reach distance (spray reach distance/2). It can be derived by measuring.

Through (C) of Figure 5, in the case of a liquid composition having a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m according to an embodiment of the present invention, the spray angle is all 15 to 40 degrees. It can be confirmed that the liquid composition has a viscosity of 15 cp or less and a surface tension of 20 to 30 mN/m, showing similar spray characteristics.

Meanwhile, the aerosol inhaler according to an embodiment of the present invention may include a battery that provides power used to operate the aerosol inhaler, a control unit that generally controls the operation of the aerosol inhaler, a nozzle including one or more needles, and a cartridge. You can.

Here, the cartridge may contain the liquid composition for an aerosol inhaler described in detail previously.

In addition, the nozzle is connected to the cartridge so as to communicate fluidly with the cartridge, and is configured to spray nicotine-related substances, organic acids, hyphae, etc. of the cartridge.

Furthermore, the nozzle may include one or more needles including an elongated hollow tube, through which an aerosol of the liquid composition can be sprayed from an end of the needle along the longitudinal direction of the needle.

Hereinafter, the configuration of the present invention and its effects will be described in more detail through examples and comparative examples. However, these examples are for illustrating the present invention in more detail, and the scope of the present invention is not limited to these examples.

<Example>

- Example 1: Measurement of viscosity, surface tension and contact angle

A total of 7 types of liquid compositions (samples) for aerosol inhalers were produced (samples No. 1 to 7), and measured at room temperature at 25°C using a viscosity vibration type viscosity meter, surface tension contact angle meter, and surface tension meter (Brookfield DV1 viscometer). Under these conditions, the viscosity, surface tension, and contact angle with respect to the PDMS substrate were measured for each composition (sample).

As a result, a liquid composition with a viscosity of 15 cp or less, a surface tension of 20 to 30 mN/m, and a contact angle of 45 degrees or less is shown in Figures 3 and 4.

- Example 2: Measurement of spray angle, spray arrival distance, and spray time in spraying using a working mock-up (related to Figure 5)

Samples F01, F06 ~ F09, which are liquid compositions, were prepared (Table 1 below), their surface tension was measured with a surface tension meter, and the spraying scene of each sample was captured with a high-speed camera at 7,000 ~ 20,000 frames for 2 seconds. The images were taken, and each corresponding image was analyzed to track and analyze the aerosol angle, spray distance, and trajectory of large droplets larger than 200㎛.

recipe
No. weight% F01 F06 F07 F08 F09 Gly Instead of Gly
PEG 0.349 0.256 0.405 0.769 - EtOH 1.189 1.282 1.133 0.769 1.538 Gly:EtOH
ratio 1:3.4
(PEG:EtOH) 1:5 1:2.8 1:1 -

As a result, the surface tension values of samples F01, F06 to F09 are shown in Table 2 below, and the results for the aerosol angle, spray distance, and spray time according to the surface tension values are shown in Figure 5.

F01 F06 F07 F08 F09 surface tension
[dyne] 24.125 24.555 25.721 27.176 23.129

- Example 3: Measurement of spray angle, spray arrival distance, and spray time of walking mock-up spray in high-density spray (related to Figure 6)

When walking mock-up spraying was performed using the same sample and method as in Example 2, the spray angle and spray reach distance when sprayed at the highest density are shown in Figures 6 (A) and (B).

Through Figures 6 (A) and (B), it can be seen that in high-density spraying, the spray angles are all at the level of 15° to 30°, and the spray reach distances are all between 70 mm and 130 mm.

- Example 4: Measurement of trajectory, size change and velocity of large aerosols over 200㎛ (related to Figure 7)

Using an image processing method using frame analysis of a high-speed camera, the trajectory, size change, and speed of large aerosols larger than 200㎛ were measured, and the results are shown in Figure 7.

- Example 5: Measurement of average velocity and average size of large aerosols depending on the medium in spray using a walking mock-up (related to Figure 8)

Using the liquid compositions (samples) F01 and F06 ~ F09 used in Example 2, etc., the average velocity and average size of large aerosols for each sample were measured in spraying using a walking mock-up, and the results are shown in FIG. 8.

Through Examples 4 and 5, it can be seen that when the liquid composition according to an embodiment of the present invention has a specific viscosity and surface tension range, the spray characteristics are determined, and the characteristics of the large aerosol are determined more than the characteristics of the medium. It can be seen that it is controlled by adjusting the spray method.

Although the embodiments have been described with limited drawings as described above, those skilled in the art can apply various technical modifications and variations based on the above. For example, the described techniques are performed in a different order than the described method, and/or components of the described system, structure, device, circuit, etc. are combined or combined in a different form than the described method, or other components are used. Alternatively, appropriate results may be achieved even if substituted or substituted by an equivalent.

Therefore, other implementations, other embodiments, and equivalents of the claims also fall within the scope of the following claims.

Claims (14)

Viscosity is 15 cp or less,
Having a surface tension of 20 to 30 mN/m,
Liquid composition for aerosol inhaler.
According to paragraph 1,
The contact angle to the polydimethylsiloxane (PDMS) substrate is 45 degrees or less,
Liquid composition for aerosol inhaler.
According to paragraph 1,
The liquid composition contains one or more nicotine-related substances selected from the group consisting of nicotine, nicotine salt, nicotine alkaloid, and nicotine derivatives,
Liquid composition for aerosol inhaler.
According to paragraph 1,
The liquid composition contains saccharin and monohydric or dihydric alcohol,
Liquid composition for aerosol inhaler.
According to paragraph 1,
The liquid composition includes a propellant,
Liquid composition for aerosol inhaler.
According to clause 5,
The propellant is a liquid for aerosol inhaler containing one or more of 1,1,1,2-Tetrafluoroethane (HFA-134a) and chlorofluorocarbon (CFC) Composition.
According to paragraph 1,
The liquid composition includes acetic acid, pyruvic acid, 3-methyl-2-oxobutyric acid, 2-oxovaleric acid, 3-methyl- 3-methyl-2-oxovaleric acid, 4-methyl-2-oxovaleric acid, 2-oxalic acid, 2-oxooctanoic acid (2 Containing one or more organic acids selected from the group consisting of -oxoocatanoic acid) and lactic acid,
Liquid composition for aerosol inhaler.
According to paragraph 1,
The liquid composition further includes a hyangax,
Liquid composition for aerosol inhaler.
According to clause 8,
The scent includes rosemary, eucalyptol, licorice, sucrose, fructose syrup, isosweetener, cocoa, lavender, cinnamon, cardamom, celery, fenugreek, cascarilla, sandalwood, bergamot, geranium, honey essence, and rose oil. , from the group consisting of vanilla, lemon oil, orange oil, mint oil, mandarin oil, catechin, grapefruit, caraway, cognac, jasmine, cocoa, menthol, cinnamon, ylang-ylang, sage, spearmint, ginger, coriander and coffee. one or more flavor substances selected,
A mixed solution of one or more of ethanol, propylene glycol, and glycerin,
Liquid composition for aerosol inhaler.
According to paragraph 1,
When spraying the liquid composition, the spraying time is 2000 ms to 3000 ms,
The nebulization time is defined as the time from the time the first aerosol is sprayed from the nozzle of the aerosol inhaler to the time the last aerosol is sprayed,
Liquid composition for aerosol inhaler.
According to paragraph 1,
When spraying the liquid composition, the spraying distance is 70 to 170 mm,
The spray reach distance is defined as the maximum distance that the aerosol moves,
Liquid composition for aerosol inhaler.
According to clause 11,
When spraying the liquid composition, the spray angle is 15° to 40°,
The spray angle is defined as the spread angle of the aerosol from the nozzle entrance of the aerosol inhaler to the spray arrival distance/2,
Liquid composition for aerosol inhaler.
A cartridge comprising the liquid composition according to claim 1.
a battery that provides power for the aerosol inhaler;
A control unit that controls the operation of the aerosol inhaler,
a nozzle comprising one or more needles; and
An aerosol inhaler comprising the cartridge of claim 13.

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