KR20240038930A - 치료용 올리고뉴클레오타이드를 중추신경계로 전달하기 위한 조성물 및 방법 - Google Patents

치료용 올리고뉴클레오타이드를 중추신경계로 전달하기 위한 조성물 및 방법 Download PDF

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KR20240038930A
KR20240038930A KR1020237045431A KR20237045431A KR20240038930A KR 20240038930 A KR20240038930 A KR 20240038930A KR 1020237045431 A KR1020237045431 A KR 1020237045431A KR 20237045431 A KR20237045431 A KR 20237045431A KR 20240038930 A KR20240038930 A KR 20240038930A
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formula
ribonucleoside
divalent cations
nucleotides
linkage
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Korean (ko)
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매튜 하슬러
가르쓰 에이. 킨버거
브루노 미겔 다 크루즈 고디노
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아탈란타 테라퓨틱스, 인크.
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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KR1020237045431A 2021-06-02 2022-06-02 치료용 올리고뉴클레오타이드를 중추신경계로 전달하기 위한 조성물 및 방법 Pending KR20240038930A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163195993P 2021-06-02 2021-06-02
US63/195,993 2021-06-02
PCT/US2022/032014 WO2022256565A2 (en) 2021-06-02 2022-06-02 Compositions and methods for delivering therapeutic oligonucleotides to the central nervous system

Publications (1)

Publication Number Publication Date
KR20240038930A true KR20240038930A (ko) 2024-03-26

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KR1020237045431A Pending KR20240038930A (ko) 2021-06-02 2022-06-02 치료용 올리고뉴클레오타이드를 중추신경계로 전달하기 위한 조성물 및 방법

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Country Link
US (1) US20240287526A1 (https=)
EP (1) EP4346845A2 (https=)
JP (1) JP2024521897A (https=)
KR (1) KR20240038930A (https=)
CN (1) CN117795069A (https=)
AU (1) AU2022286420A1 (https=)
CA (1) CA3222212A1 (https=)
IL (1) IL308994A (https=)
WO (1) WO2022256565A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL319764A (en) * 2022-09-28 2025-05-01 Atalanta Therapeutics Inc Compositions and methods for treating Huntington's disease
WO2024169770A1 (zh) * 2023-02-17 2024-08-22 苏州时安生物技术有限公司 一种抑制SCN9A基因表达的siRNA、其药物组合物及用途
JP2026509929A (ja) * 2023-03-23 2026-03-25 アタランタ セラピューティクス，インコーポレーテッド 改善された遺伝子サイレンシングのための組成物及び方法
WO2025111497A1 (en) * 2023-11-21 2025-05-30 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating acute activation
WO2025193786A1 (en) * 2024-03-12 2025-09-18 University Of Massachusetts Oligonucleotides for prnp modulation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015125147A1 (en) * 2014-02-20 2015-08-27 B. G. Negev Technologies And Applications Ltd Anionic polyplexes for use in the delivery of nucleic acids
WO2019122279A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage

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Publication number Publication date
AU2022286420A1 (en) 2024-01-04
IL308994A (en) 2024-01-01
WO2022256565A2 (en) 2022-12-08
WO2022256565A3 (en) 2023-01-05
EP4346845A2 (en) 2024-04-10
CA3222212A1 (en) 2022-12-08
CN117795069A (zh) 2024-03-29
US20240287526A1 (en) 2024-08-29
JP2024521897A (ja) 2024-06-04

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