KR20240038558A - System for determining and evaluating tumor treatment plan using dose based on impulse - Google Patents

Abstract

A cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention classifies organs and tumors in a patient's medical image containing organs and tumors, and classifies the images by distinguishing the three-dimensional positional relationship between organs and tumors. An information receiving unit that receives information, physical property information including electrical conductivity and dielectric constant of each area classified in the image classification information, and the type of tumor, a prescription receiving unit that receives prescription information based on the impact amount for the tumor, information Using information provided from the receiver and prescription receiver, a candidate treatment plan is established including the number of treatment electrodes, treatment electrode location, treatment frequency, treatment electromagnetic force, and treatment time, but candidate treatment that establishes multiple different candidate treatment plans. It may include a plan establishment unit and a treatment plan decision unit that determines one candidate treatment plan as the selected treatment plan among a plurality of candidate treatment plans, and establishes and applies a treatment plan in which the shock amount can be optimized within the human body. Therefore, there is an effect of performing treatment with the greatest amount of prescription shock given to the tumor and the least amount of shock given to the surrounding normal tissue.

Description

Cancer treatment plan decision system and cancer treatment plan evaluation system using impulse dose-based prescription {System for determining and evaluating tumor treatment plan using dose based on impulse}

The present invention relates to a cancer treatment plan decision system and a cancer treatment plan evaluation system using impulse-based prescription. More specifically, the impulse-based prescription expressed as the product of electromagnetic force and time given to each tissue in the human body is determined, A cancer treatment plan decision system and cancer treatment plan evaluation system using shock dose-based prescription that determines a cancer treatment plan so that the prescription shock dose is given to the tumor and the surrounding normal tissue is given to a minimum, and performs treatment based on this. will be.

In the early 2000s, Yoram Palti, an Israeli professor of biophysics, first discovered the phenomenon of delayed division or death of dividing cancer cells when an alternating electric field is applied to dividing cancer cells. In 2004, he published the world's first study on the effects of electric field cancer treatment in the journal Cancer Research. The results were announced (see Non-Patent Document 1). Since then, several research papers on electric field cancer treatment have been published, and the cancer treatment community is paying great attention to electric field therapy due to its three strengths.

The first strength of electric field therapy is that the electric field is known to have a significant effect only on dividing cells, so it will have a concentrated effect on cancer cells, which divide faster than normal cells, and side effects are expected to be very minimal compared to existing treatments. This is possible (see Non-Patent Document 2). In fact, according to a paper published in 2013 (see Non-Patent Document 3), the side effects of electric field treatment were found to be significantly lower in 7 out of 9 items comparing the side effects of chemotherapy and electric field therapy, and for 2 items, the side effects of electric field treatment were significantly lower than those of anticancer treatment. Treatment and electric field therapy showed almost equal levels of side effects.

Second, although cancer treatment using electric fields is still in its early stages, it is showing better results than existing treatments in terms of treatment efficacy. For example, if a patient with malignant glioblastoma multiforme (GBM), one of the incurable cancers, received only chemotherapy, the Progression Free Survival (PFS), Overall Survival (OS), and survival probability for more than 2 years were 4.0 months and 16.0 months, respectively. On the other hand, when electric field treatment was added, the results were 6.7 months, 20.9 months, and 43%, showing about 1.7, 1.3, and 1.4 times better results than existing treatments (Non-patent Document 4).

Lastly, the third strength is that if the electric field is applied broadly, including the treatment area, it is expected to be effective in treating even very small tumors that are not visible in medical images such as CT. When an electric field is applied centered on a tumor, an electric field that cannot be ignored is transmitted not only to the tumor but also to the surrounding area, so the electric field affects even tumors that exist around the tumor but are too small to be seen with the naked eye, thereby suppressing the division of cancer cells. It is expected that the probability of cancer metastasis can be dramatically reduced (see Non-Patent Document 5).

Currently, the electric field cancer treatment method has been approved by the US FDA for relapsed glioblastoma cancer in 2011 and for first diagnosed glioblastoma in 2015. It has also obtained the CE mark in Europe and is being used in approximately 1,000 hospitals in the US, Germany, Switzerland, etc. It is being implemented through , and has also been approved for treatment in Japan for patients with relapsed glioblastoma. In addition, the number of patients treated is rapidly increasing every year, showing a more than 50-fold increase from 152 in 2014 to 8,813 in 2018 (see Non-Patent Document 6).

As for the principle by which this electric field cancer treatment method actually inhibits the division of cancer cells, the division inhibition mechanism by dielectrophoresis is known to be the main mechanism (see Non-Patent Document 2). Here, the dielectrophoresis phenomenon refers to the non-uniformity of non-polar particles. When exposed to an alternating electric field, it refers to the phenomenon of receiving a dielectrophoretic force depending on the voltage and frequency of the alternating electric field, and the permittivity and conductivity of the medium.

In fact, during the process of dividing cancer cells into two cells, a valley is formed between the two daughter cells. When the daughter cells forming this valley are placed in a non-uniform electric field, a gradient of the electric field is formed and at the same time, a force due to dielectrophoresis is generated. It grows larger, and ultimately, due to this force, polar substances such as tubulin inside the cell gather toward the division center, inhibiting cell division.

According to preclinical research results to date, the effect of electric field therapy on cancer cells varies depending on the intensity of the electric field applied to the tissue and the application time of the electric field. Specifically, the greater the electric field intensity and application time, the greater the effect of suppressing death and division on cancer cells, so it can be said that the electric field intensity and application time are proportional to the cell death effect of the electric field (see Non-Patent Documents 7 and 8) ).

However, in the case of currently commercialized electric field cancer treatment systems, the intensity of the electric field used is limited to applying the maximum electric field within the range that does not cause side effects to the skin, and the treatment time is almost all day as long as the patient can accept it (18 -24 hours/day) Treatment is being carried out by applying an electric field (see Non-Patent Documents 7 and 9).

In other words, the current electric field therapy does not have a set appropriate electric field strength or treatment time to treat a specific tumor, and treatment is carried out with the maximum electric field strength and maximum treatment time within the range of no side effects. In other words, electric field therapy does not have the concept of dose commonly used in radiation therapy or chemotherapy, and it can be said to be a treatment that does not apply prescription doses that are applied differently depending on the type or condition of the tumor.

However, when treatment is performed without a prescribed dose, the intensity of the electric field must be applied to the tumor and for how long to achieve the optimal treatment effect. The treatment effect depends on the intensity of the electric field, the time of application of the electric field, and the function of the electric field and treatment time. It is impossible to know which item matches best, and no criteria can be provided. In other words, it can be assumed that the intensity of the electric field and the time of application of the electric field are proportional to the treatment effect, but it is not clear whether the relationship is linear or has a more complex relationship, so treatment planning in electric field therapy cannot be optimized and treatment cannot proceed effectively.

According to the results of a recent clinical study that performed electric field therapy on 340 brain tumor patients, the power loss density, which is the unit of power loss per unit volume in electric field therapy, is greater than 0.77 mW/cm ³ in the tumor. It showed a significantly better prognosis compared to , and when the compliance rate, which represents the electric field treatment time, is more than 75%, it shows a better prognosis (see Non-Patent Documents 10 and 13). Even though the unit called power loss density can be considered as the standard for almost the only prescription presented to date for electric field therapy, there are fatal limitations in using this unit as a dose unit for electric field therapy.

In other words, even though the degree of death of cancer cells is proportional to the electric field application time, the power loss density does not include an item related to the total treatment time (i.e., the electric field application time) that the patient must receive, so based on this, Prescriptions cannot be made and treatment cannot be optimized (see Non-Patent Document 8).

For these reasons, power loss density may be suitable to be used as a factor predicting the prognosis of electric field therapy, but it has limitations in using it as a dose unit for electric field therapy, and it is a practical and reasonable concept that takes into account both electric field strength and application time. There is a need for units of electric field therapy dose.

Republic of Korea Patent Publication No. 10-2022-0009764

Eilon D. Kirson et al, disruption of cancer cell replication by alternating electric fields, cancer research, 64, 3288-3295 (2004) Miklos Pless, Uri Weinberg, tumor treating fields: concept, evidence, future, Expert Opinion, 20(8), 1099-1106 (2011) Angela M. Davies et al, Tumor treating fields: a new frontier in cancer therapy, Annals of the New York academy of sciences, 1291, 86-95 (2013) Stupp et al, Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial, Journal of the American Medical Association, 318(23), 2306-2316 (2017) Eilon D. Kirson et al. Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs, Clin Exp Metastasis 26, 633-640 (2009) Novocure Corporate Presentation (https://3sj0u94bgxp33grbz1fkt62h-wpengine.netdna-ssl.com/wp-content/uploads/2019/05/201905_NVCR_Corporate_Presentation_vFF.pdf) Eilon D. Kirson et al, alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors, PNAS, 104(24), 10152-10157 (2007) Yunhui Jo et al, Effectiveness of a Fractionated Therapy Scheme in Tumor Treatment Fields Therapy, Technology in Cancer Research & Treatment,18, 1-10 (2019) Denise Fabian et al, Treatment of Glioblastoma (GBM) with the Addition of Tumor-Treating Fields (TTF): A Review, Cancers, 11, 174 (2019) Matthew T. Ballo et al, Correlation of Tumor Treatment Fields Dosimetry to Survival Outcomes in Newly Diagnosed Glioblastoma: A Large-Scale Numerical Simulation-Based Analysis of Data from the Phase 3 EF-14 Randomized Trial, Int J Radiation Oncol Biol Phys, Vol. . 104, no. 5, pp. 1106-1113 (2019) Dimitris J. Panagopoulos et al, Evaluation of Specific Absorption Rate as a Dosimetric Quantity for Electromagnetic Fields Bioeffects, PLoS One, 8(6), e62663 (2013) Stefano Mandija et al. Opening a new window on MR-based Electrical Properties Tomography with deep learning, Scientific Reports, 9, 8895 (2019) Martin Glas et al. The Impact of Tumor Treatment Fields on Glioblastoma Progression Patterns, Int J Radiation Oncol Biol Phys, Vol. 112, no. 5, pp. 1269-1278 (2022)

The purpose of the present invention to solve the above problems is to provide a cancer treatment plan decision system and a cancer treatment plan evaluation system using shock dose-based prescription.

To solve the above problems, a cancer treatment plan decision system using shock dose-based prescription according to an embodiment of the present invention classifies organs and tumors in medical images of patients containing organs and tumors, and includes the organs and tumors. An information receiver that receives three-dimensional image information and physical property information including electrical conductivity and dielectric constant of the medical image; a prescription receiver that receives prescription information based on the impact dose for the tumor; Using the information provided from the information receiver and the prescription receiver, a candidate treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time is established, and at least one candidate treatment plan is established. Candidate treatment plan establishment department that establishes; and a treatment plan determination unit that determines one candidate treatment plan as the selected treatment plan among the at least one candidate treatment plan.

Here, the impulse is the charge It is the impulse per dose, ( is the basic charge a positive integer multiple of

It is expressed as,

The international unit system may be Ns/C (N: newton, s: second, C: coulomb).

Here, the impulse is the basic charge is the amount of shock received,

It is expressed as,

The international unit system may be Ns (N: newton, s: second).

Here, the impulse is the charge is the amount of shock received, ( is the basic charge a positive integer multiple of

It is expressed as,

The international unit system may be Ns (N: newton, s: second).

Here, the impulse-based prescription information is expressed as a product of the treatment electromagnetic force and the treatment time, and the current generating the treatment electromagnetic force converted to a current density divided by the electrode area may be less than 100 mArms/cm ² .

Here, the impulse dose-based prescription information may decrease the treatment time while increasing the treatment electromagnetic force, or increase the treatment time while decreasing the treatment electromagnetic force, while the impulse dose-based prescription information is constant. You can.

Here, in the candidate treatment plan establishment unit, the number of treatment electrodes and the location of the treatment electrode are determined using the three-dimensional position of the tumor and the physical property information, the type of the tumor is further provided by the information reception unit, and the type of the tumor is determined. The treatment frequency is determined depending on the type,

The treatment electromagnetic force and treatment time may be determined using the impulse-based prescription information and the physical property information.

Here, the plurality of different candidate treatment plans may differ in at least one of the number of treatment electrodes, the location of the treatment electrodes, the treatment electromagnetic force, and the treatment time.

Here, in the candidate treatment plan establishment unit, the candidate treatment plan is extracted from a treatment plan database that stores treatment plans. The treatment plan database stores predetermined treatment plans cumulatively, and the shock dose is the largest given to the tumor. It may also be stored with the treatment plan result data, which is least likely to be given to surrounding normal tissue.

Here, determining the selected treatment plan in the treatment plan decision unit may be to determine that the prescribed shock amount is given to the tumor and the least amount is given to the surrounding normal tissue.

Here, the impulse-based prescription information is generated as a real number multiple greater than or equal to 1 of the standard impulse, and the reference impulse is when the change in impulse is calculated for each section,

It may be the smallest impulse value among the impulse values that satisfy.

To solve the above problems, a cancer treatment plan decision system using shock dose-based prescription according to another embodiment of the present invention classifies organs and tumors in medical images of patients containing organs and tumors, and includes the organs and tumors. When 3D image information is provided and the medical image is expressed as a 3D volume model formed of a plurality of voxels, the electrical conductivity and permittivity of each voxel constituting the medical image are included. An information receiving unit that receives physical property information; a prescription receiver that receives prescription information based on the impact dose for the tumor; Using the information provided from the information receiver and the prescription receiver, a candidate treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time is established, and at least one candidate treatment plan is established. Candidate treatment plan establishment department that establishes; and a treatment plan determination unit that determines one candidate treatment plan as the selected treatment plan among the at least one candidate treatment plan.

Here, the amount of impact is the amount of impact received by a unit voxel,

It is expressed as ( , )

The international unit system may be Ns (N: newton, s: second).

Here, determining the selected treatment plan in the treatment plan decision unit may be to determine that the prescribed shock amount is given to the tumor and the least amount is given to the surrounding normal tissue.

To solve the above problems, the cancer treatment plan evaluation system using shock dose-based prescription according to an embodiment of the present invention classifies organs and tumors in medical images of patients containing organs and tumors, and includes the organs and tumors. An information receiver that receives three-dimensional image information and physical property information including electrical conductivity and dielectric constant of the medical image; a prescription receiver that receives prescription information based on the impact dose for the tumor; a treatment plan establishment unit that establishes a treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time using the information provided from the information receiver and the prescription receiver; and a treatment plan evaluation unit that evaluates the amount of impact given to the tumor and the amount given to surrounding normal tissue with respect to the established treatment plan.

Here, the impulse is the charge It is the impulse per dose, ( is the basic charge a positive integer multiple of It is expressed as,

The international unit system may be Ns/C (N: newton, s: second, C: coulomb).

Here, the impulse is the basic charge is the amount of shock received,

It is expressed as,

The international unit system may be Ns (N: newton, s: second).

Here, the impulse is the charge is the amount of shock received, ( is the basic charge a positive integer multiple of

It is expressed as,

The international unit system may be Ns (N: newton, s: second).

Here, the shock dose-based prescription information is

Expressed as the product of the treatment electromagnetic force and treatment time,

The current generating the therapeutic electromagnetic force converted into current density divided by the electrode area may be less than 100 mArms/cm ² .

Here, the shock dose-based prescription information is

Reduce the treatment time while increasing the treatment electromagnetic force while the impulse-based prescription information is constant, or

It may be possible to increase the treatment time while reducing the treatment electromagnetic force.

Here, in the treatment planning department:

The number of treatment electrodes and the location of the treatment electrodes are determined using the three-dimensional position of the tumor and the physical property information,

The type of tumor is further provided from the information receiver, and the treatment frequency is determined according to the type of tumor,

The treatment electromagnetic force and treatment time may be determined using the impulse-based prescription information and the physical property information.

Here, the shock dose-based prescription information is

It is generated as a real number times the standard impulse amount greater than or equal to 1,

The standard impulse amount is, when calculating the change in impulse quantity by section,

It may be the smallest impulse value among the impulse values that satisfy.

According to the cancer treatment plan decision system and cancer treatment plan evaluation system using impulse-based prescription according to an embodiment of the present invention, a dielectrophoresis phenomenon that is substantially proportional to the cell proliferation inhibition effect when electromagnetic force is applied to dividing cells. The standard of treatment can be set based on the concept of impulse that takes into account both the force and the application time of the electromagnetic force, and based on this, the clinical standard value applicable to each tumor treatment can be determined. Through this, it becomes possible to establish and evaluate a systematic treatment plan, which has been impossible until now due to the absence of a standard unit in treatment.

Furthermore, a treatment plan is established so that the shock dose can be optimized within the human body, and the parameters derived through this are applied to the treatment, so that the shock dose is delivered to the tumor as much as possible while at the same time delivering the minimum amount to the surrounding normal tissue. becomes possible to perform.

In addition, statistical analysis of clinical results can be performed, which makes it possible to establish a reasonable treatment plan and at the same time enables new treatment methods such as a split treatment method that takes into account both the strength of electromagnetic force and the time for applying electromagnetic force. It has the advantage of maximizing the therapeutic effect of treatment.

Figure 1 is for explaining a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, and is a diagram showing details of the simulation model and method performed in Figures 2 and 3.
Figure 2 is to illustrate a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, showing the change in the size of the electric field measured inside the cell as the voltage applied outside the cell increases when the electric field is applied. It is a drawing.
Figure 3 is to explain a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention. When an electric field is applied, the dielectrophoresis phenomenon applied inside the cell as the electromagnetic force per unit charge measured outside the cell increases. This is a diagram showing the change in the size of force due to .
Figure 4 is for explaining a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, and is a diagram illustrating the process of calculating impulse distribution in the body using medical images of a patient during electromagnetic force treatment.
Figure 5 is to illustrate a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, and shows the cell proliferation inhibition effect according to the size of electromagnetic force per unit charge when the electromagnetic force application time is constant. This is a drawing.
Figure 6 is to illustrate a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention. When the size of the electromagnetic force applied from the outside is constant, the cell proliferation inhibition effect according to the time of applying the electromagnetic force is shown. It is a drawing showing.
Figure 7 is to illustrate a cancer treatment plan decision system using shock dose-based prescription according to an embodiment of the present invention. The cell proliferation inhibition effect according to the size of the shock dose considering both the electromagnetic force per unit charge and the time for applying the electromagnetic force. This is a drawing showing .
Figure 8 is for explaining a cancer treatment plan decision system using shock dose-based prescription according to an embodiment of the present invention, and is a general flowchart of a cancer treatment plan method using shock dose-based prescription.
Figure 9 is a diagram for explaining a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention.
Figure 10 is a diagram for explaining a cancer treatment plan evaluation system using impulse-based prescription according to an embodiment of the present invention.

Hereinafter, with reference to the attached drawings, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. The present invention may be implemented in many different forms and is not limited to the embodiments described herein.

In order to clearly explain the present invention, parts that are not relevant to the description are omitted, and identical or similar components are assigned the same reference numerals throughout the specification.

Throughout the specification, when a part is said to be "connected" to another part, this includes not only cases where it is "directly connected," but also cases where it is "electrically connected" with another element in between. . Additionally, when a part "includes" a certain component, this means that it may further include other components rather than excluding other components, unless specifically stated to the contrary.

When a part is referred to as being “on” another part, it may be directly on top of the other part or it may be accompanied by another part in between. In contrast, when a part is said to be "directly above" another part, it does not entail any other parts in between.

Terms such as first, second, and third are used to describe, but are not limited to, various parts, components, regions, layers, and/or sections. These terms are used only to distinguish one part, component, region, layer or section from another part, component, region, layer or section. Accordingly, the first part, component, region, layer or section described below may be referred to as the second part, component, region, layer or section without departing from the scope of the present invention.

The terminology used herein is only intended to refer to specific embodiments and is not intended to limit the invention. As used herein, singular forms include plural forms unless phrases clearly indicate the contrary. As used in the specification, the meaning of "comprising" refers to specifying a particular characteristic, area, integer, step, operation, element and/or ingredient, and the presence or presence of another characteristic, area, integer, step, operation, element and/or ingredient. This does not exclude addition.

Terms indicating relative space, such as “below” and “above,” can be used to more easily describe the relationship of one part shown in the drawing to another part. These terms are intended to include other meanings or operations of the device in use along with the meaning intended in the drawings. For example, if the device in the drawing is turned over, some parts described as being “below” other parts will be described as being “above” other parts. Accordingly, the exemplary term “down” includes both upward and downward directions. The device may be rotated by 90 degrees or other angles, and terms indicating relative space are interpreted accordingly.

Although not defined differently, all terms including technical and scientific terms used herein have the same meaning as those generally understood by those skilled in the art in the technical field to which the present invention pertains. Terms defined in commonly used dictionaries are further interpreted as having meanings consistent with related technical literature and currently disclosed content, and are not interpreted in ideal or very formal meanings unless defined.

Hereinafter, with reference to the attached drawings, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein.

The 'fractionated treatment' referred to in the present invention refers to dividing the total dose to be delivered to the tumor into several days, hours, etc. when performing actual cancer treatment (radiation therapy, electric field therapy, etc.) and then proceeding with the treatment at intervals, thereby It refers to a method of efficiently performing treatment while reducing damage. In addition, the total treatment time and electric field application time mentioned in the present invention are defined as the product of the treatment time per day (fraction time) and the total treatment days (duration), and are expressed by Equation 1 below.

[Equation 1]

Meanwhile, Figure 1 is for explaining a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, and is a diagram illustrating the contents of the simulation model and method performed in Figures 2 and 3.

Figure 1(a) shows a dividing cell model in a three-dimensional space, one side is set as a potential plane, the other side is set as a ground plane, and an electric field is applied. 1(b) shows the distribution of the electric field intensity on that surface by cutting the cross-section (Cut plane) of the part marked in red in Figure 1(a) after applying the electric field, and Figures 2 and 3 show the corresponding drawings and The simulation was conducted in the same manner.

In addition, in Figures 5 to 7, after applying an electric field with a strength of ~1.2 V/cm and a frequency of 150 kHz to four different types of cancer cells (AGS, B16F10, HPAF-II and U373) for 72 hours under various experimental conditions. The viability of cells is compared to the control group through cell counting, and the inhibitory effect of cell proliferation of the cell line (experimental group) to which an electric field was applied is expressed as a percentage compared to the control group. This result represents the average value after three experiments were conducted, and the percentage of cell proliferation inhibition effect compared to the control group was calculated using Equation 2 below.

[Equation 2]

For example, if the number of surviving cells in the experimental group to which the electric field was applied is 80% compared to the control group, the cell proliferation inhibition effect of the experimental group compared to the control group is 20%.

Figure 2 is to illustrate a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, showing the change in the size of the electric field measured inside the cell as the voltage applied outside the cell increases when the electric field is applied. It is a drawing.

Figures 2 (a), (b), and (c) show dividing cells when the magnitude of electric field measured at a point outside the cell is 0.45, 1.36, and 2.26 V/cm, respectively. It shows the internal and external electric field distribution, and (d) is a graph showing the relationship between the electric field intensity value measured at a point outside the dividing cell and the electric field intensity value measured at the center inside the dividing cell.

Referring to Figure 2(d), it can be seen that as the intensity of the electric field outside the dividing cell increases, the intensity of the electric field applied inside the dividing cell increases proportionally. Here, the intensity of the electric field measured outside the cell is directly proportional to the voltage applied externally to create the electric field, which means the external voltage applied to create the electric field in the body and the strength of the electric field applied inside the dividing cell in the body. This means that there is a proportional relationship.

Figure 3 is to explain a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention. When an electric field is applied, the dielectrophoresis phenomenon applied inside the cell as the electromagnetic force per unit charge measured outside the cell increases. This is a diagram showing the change in the size of force due to .

Here, the electromagnetic force per unit charge and the force due to the dielectrophoresis phenomenon can be calculated according to Equation 3 and Equation 4 below, respectively.

[Equation 3]

[Equation 4]

In Figures 3 (a), (b), and (c), the magnitude of electromagnetic force per unit charge measured at a point outside the cell is 45, 136, and 226 N/C, respectively. (d) represents the distribution of the force (the magnitude of dielectrophoretic force) due to dielectrophoretic phenomenon inside and outside the dividing cell, and (d) represents the electromagnetic force per unit charge (the magnitude of electromagnetic force) measured at a point outside the dividing cell. This is a graph showing the relationship between the force per unit charge value and the magnitude of dielectrophoretic force measured at the center of the dividing cell.

Referring to Figure 3(d), it can be seen that the force due to dielectrophoresis inside a dividing cell increases in nonlinear proportion to the electromagnetic force per unit charge outside the dividing cell. Here, the electromagnetic force per unit charge measured at a point outside the cell is directly proportional to the strength of the electric field measured at that point, which means the strength of the electric field measured externally and the force due to dielectrophoresis inside the dividing cell. This means nonlinear proportionality.

Figure 4 is for explaining a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, and is a diagram illustrating the process of calculating impulse distribution in the body using medical images of a patient during electromagnetic force treatment.

Referring to FIG. 4, first, a medical image of a patient scheduled for treatment can be imported and then a region of interest can be divided.

Afterwards, treatment plan conditions (for example, electrode location, electric field strength for each electrode, etc.) can be set and information on the electrical conductivity and dielectric constant of each tissue of the human body can be obtained. Based on the treatment plan conditions and information about human tissue, the distribution of the electric field in the body based on the externally applied voltage can be calculated.

Afterwards, when it is desired to calculate the distribution of electromagnetic force per unit charge, the distribution of electromagnetic force per three-dimensional unit charge within the human body can be calculated according to Equation 3 above. Finally, considering the actual electric field total treatment time, the impulse distribution per unit charge due to the 3D electric field within the human body can be calculated.

Figure 5 is to illustrate a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention, and shows the cell proliferation inhibition effect according to the size of electromagnetic force per unit charge when the electromagnetic force application time is constant. This is a drawing.

Figure 5 (a), (b), (c), and (d) shows that four different types of cancer cells (AGS, B16F10, HPAF-II and U373) were exposed to an externally applied voltage reference unit for a certain period of 72 hours. This is a graph showing the correlation between the size of the electromagnetic force per unit charge and the cell proliferation inhibition effect when the magnitude of the electromagnetic force per charge is set to 60, 90, and 120 N/C.

Referring to Figure 5, it can be seen that as the electromagnetic force per unit charge increases in the actual four types of cancer cells, the cell proliferation inhibition effect increases proportionally, as shown in Figures 5 (a), (b), (c), and (d). ) It can be seen that they all showed similar trends.

In particular, looking at the electromagnetic force corresponding to the circle represented by the red dotted line in all of Figure 5 (a), (b), (c), and (d), the larger the electromagnetic force per unit charge in all four types of cancer cells, the more the cell. It can be seen that the proliferation inhibition effect continues to increase proportionally, which makes it difficult to specify the minimum electromagnetic force that shows the treatment effect, making it difficult to use electromagnetic force alone as a standard for prescription in a treatment plan.

Figure 6 is to illustrate a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention. When the size of the electromagnetic force applied from the outside is constant, the cell proliferation inhibition effect according to the time of applying the electromagnetic force is shown. It is a drawing showing.

Figure 6 shows that an external voltage is applied to four different types of cancer cells (AGS, B16F10, HPAF-II and U373) for 3 hours, 6 hours, 12 hours, and 24 hours a day based on 24 hours a day, and the same Cell experiments were conducted using a method that was repeated for 3 days. For example, if the x-axis of the graph was 3, the cell experiment was conducted by applying external voltage for only 3 hours a day on the first, second, and third days each, and without applying voltage for the remaining 21 hours. Figure 6 (a), (b), (c), and (d) are graphs showing the correlation between the time for applying an electric field and the cell proliferation inhibitory effect based on the experimental results using the above method.

Referring to Figures 6 (a), (b), (c), and (d), the cell proliferation inhibitory effect increased steeply as the time for applying the electric field increased until a certain period of time (approximately 6 to 8 hours), but remained constant. After this time, even as the time for applying the electric field increased, the cell proliferation inhibitory effect showed a very gradual increase, and this showed a similar tendency in all four types of cancer cells.

In particular, looking at the application time corresponding to the circle represented by the red dotted line in all of Figure 6 (a), (b), (c), and (d), as the application time increases, cell proliferation increases in all four types of cancer cells. It can be seen that the inhibitory effect continues to increase, and like the electromagnetic force in Figure 5, it is difficult to specify the minimum application time that shows the treatment effect, so it is difficult to use only the application time as a standard for prescription in a treatment plan. You will find out.

Considering Figures 5 and 6 comprehensively, it can be seen that the actual cell proliferation inhibition effect is proportional to the time (s) for applying the electric field as well as the electromagnetic force per unit charge.

Also, what should be noted here is that the cell proliferation inhibitory effect increased steeply up to a certain time period. If we interpret this from a different perspective, we can compare the therapeutic effect of currently commercialized electric field therapy, which is performed for over 18 hours out of 24 hours a day, and the therapeutic effect of applying the electric field only for a certain period of time (approximately 6 to 8 hours in the results) and having a rest period. It can be predicted that the treatment effect of the split treatment method may show similar treatment effects. If it is confirmed that the two methods show similar treatment effects through actual animal experiments and clinical trials, it can be seen that the existing commercialized treatment method that applies electric fields for more than 18 hours a day is an inefficient treatment method, and electric field treatment It can be said that a more rational and efficient treatment method is to divide the 24 hours a day into several sections and apply an electric field to perform split treatment.

Based on this, the concept of prescription dose, which can be a standard in quantifying the actual cell proliferation inhibition effect in electric field therapy, is more reasonable and practical than the concept of impulse, which includes both electromagnetic force and time per unit charge. It means the product of the physically applied force and the change in time when the force is applied. Furthermore, it also includes the concept of absorbed shock dose, which applies the concept of absorbed dose, which is currently used as the concept of prescription dose in the field of radiation therapy. Here, the concept of absorbed shock amount refers to the shock amount actually absorbed by the tumor that is the target of treatment.

Figure 7 is to illustrate a cancer treatment plan decision system using shock dose-based prescription according to an embodiment of the present invention. The cell proliferation inhibition effect according to the size of the shock dose considering both the electromagnetic force per unit charge and the time for applying the electromagnetic force. This is a drawing showing .

The amount of impulse per unit charge can be calculated according to Equation 5 below.

[Equation 5]

In Figure 7 (a), (b), (c), and (d), an electric field was applied to four different types of cancer cells (AGS, B16F10, HPAF-II and U373) in the same manner as in Figure 5. , This is a graph showing the correlation between the impulse per unit charge and the cell proliferation inhibition effect when the magnitude of the electromagnetic force per unit charge based on the externally applied voltage is set to 120 N/C. Referring to Figure 7, it can be seen that the cell proliferation inhibitory effect increases proportionally as the impulse per unit charge increases in the actual four types of cancer cells, and (a), (b), (c), and (d) of Figure 7 ) It can be seen that they all showed similar trends.

Here, what should be noted is that the cell proliferation inhibitory effect shown in FIG. 7 increased steeply up to the magnitude of the impulse per certain charge. If we reinterpret this by comprehensively considering FIGS. 5 to 7, the time for applying the electromagnetic force and electric field per unit charge is adjusted within a certain range based on the target impulse value at which the cell proliferation inhibition effect increases steeply, and the corresponding target impulse is It can be expected that it will be possible to develop a treatment plan that meets the values.

For example, a method of satisfying the target impulse value by keeping the electromagnetic force at a constant value and changing only the composition of the treatment time, a method of satisfying the target impulse value by changing the size of the electromagnetic force while leaving the treatment time the same, and a method of satisfying the target impulse value by changing the size of the electromagnetic force while leaving the treatment time the same, and using both the electromagnetic force and the treatment time. An example is how to meet the target impulse value by changing it.

In addition, in the case of a treatment planning system based on impulse, treatment is possible by comprehensively considering the strength of electromagnetic force and the time of application of electromagnetic force, so in the case of special patients who cannot receive treatment for more than a certain amount of time, it is within the time range acceptable to the patient. It is expected that patient-tailored split treatment will be possible by reorganizing the treatment time. In fact, when electric field therapy is performed using these treatment methods, it is expected that more diverse and variable treatments will be possible, unlike the currently commercialized electric field treatment method, which is inefficient and continuously applied for 18 hours out of 24 hours a day. do.

In particular, the shock amount rose sharply up to the second point (represented by a red dotted circle), but shows a gentle slope after the second point. Therefore, in terms of treatment efficiency, the shock amount applied is based on the shock amount at the second point. can be determined as the reference dose.

Figure 8 is for explaining a cancer treatment plan decision system using shock dose-based prescription according to an embodiment of the present invention, and is a general flowchart of a cancer treatment plan method using shock dose-based prescription.

Referring to FIG. 8, first, medical images (eg, CT, MRI) of a patient to be treated can be imported into the treatment planning system and regions of interest, such as target tumors and important organs, can be divided. Afterwards, a shock dose-based prescription method can be set, and prescription information including prescription dose, number of treatments, total treatment time, treatment frequency, etc. can be determined according to the set prescription method. Afterwards, considering the location of the tumor and important organs around the tumor, the number of electrodes, the location of the electrodes, and the voltage intensity for each electrode can be initially set, and then the dose distribution in the body based on the shock dose can be calculated based on this. Afterwards, the treatment plan can be evaluated based on the calculated body dose distribution and a treatment plan optimization process can be performed. Afterwards, parameters from which an optimized treatment plan is derived can be calculated, and the calculated parameters can be applied to the treatment system to perform electric field treatment.

Meanwhile, Figure 9 is a diagram for explaining a cancer treatment plan decision system using impulse-based prescription according to an embodiment of the present invention.

Referring to FIG. 9, the cancer treatment plan decision system 1000 using shock dose-based prescription according to an embodiment of the present invention classifies organs and tumors in a medical image of a patient containing organs and tumors, and determines the organs and tumors. An information receiver 1100 that receives three-dimensional image information including, and receives physical property information including electrical conductivity and dielectric constant of the medical image; A prescription receiver 1200 that receives prescription information based on the impact dose for the tumor; Using the information provided from the information receiver and the prescription receiver, a candidate treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time is established, and at least one candidate treatment plan is established. a candidate treatment plan establishment unit (1300) that establishes; and a treatment plan determination unit 1400 that determines one candidate treatment plan as the selected treatment plan among the at least one candidate treatment plan.

The information receiver 1100 may classify organs and tumors in a medical image of a patient containing organs and tumors, and may receive image classification information that classifies the three-dimensional positional relationship between the organs and tumors. In the image classification information, physical property information including electrical conductivity and dielectric constant of each classified region may be provided, and the type of the tumor may be provided.

Meanwhile, the impulse is the electric charge It is the impulse per dose, ( is the basic charge a positive integer multiple of), It is expressed as,

The international unit system may be Ns/C (N: newton, s: second, C: coulomb).

In addition, the impulse amount is the basic charge is the amount of shock received, It is expressed as,

The international unit system may be Ns (N: newton, s: second).

In addition, the impulse amount is the electric charge is the amount of shock received, ( is the basic charge a positive integer multiple of) , It is expressed as,

The international unit system may be Ns (N: newton, s: second).

The prescription receiver 1200 may receive prescription information based on the impact amount for the tumor. In other words, when a doctor creates prescription information for a patient's cancer treatment, the prescription information can be created using the impulse.

Meanwhile, the impulse-based prescription information is expressed as a product of the treatment electromagnetic force and treatment time, and the value converted to a current density obtained by dividing the current generating the treatment electromagnetic force by the electrode area may be less than 100 mArms/cm ² . This is to minimize side effects on the patient's skin. Preferably, the current generating the therapeutic electromagnetic force converted into current density divided by the electrode area may be less than 31 mArms/cm ² . This is because if the value of the treatment electromagnetic force converted to current density exceeds 31 mArms/cm ² , the possibility of causing burns to the patient's skin during the treatment process gradually increases.

In addition, the impulse dose-based prescription information may be capable of decreasing the treatment time while increasing the treatment electromagnetic force, or increasing the treatment time while decreasing the treatment electromagnetic force, while the impulse dose-based prescription information is constant. there is. In particular, under conditions where the value expressed as the product of the treatment electromagnetic force and the treatment time is constant, it may be possible to change the treatment electromagnetic force and the treatment time simultaneously.

The candidate treatment plan establishment unit 1300 uses the information provided from the information receiver 1100 and the prescription receiver 1200 to determine the number of treatment electrodes, treatment electrode location, treatment frequency, treatment voltage or current density, and treatment time. A candidate treatment plan may be established that includes, but at least one candidate treatment plan may be established.

In the candidate treatment plan establishment unit 1300, the number of treatment electrodes and the positions of the treatment electrodes are determined using the three-dimensional position of the tumor and the physical property information, the type of the tumor is further provided by the information receiving unit, and the type of the tumor is determined. The treatment frequency may be determined depending on the type, and the treatment electromagnetic force and treatment time may be determined using the impulse-based prescription information and the physical property information.

In particular, the at least one candidate treatment plan may be different in at least one of the number of treatment electrodes, the location of the treatment electrodes, the treatment electromagnetic force, and the treatment time.

In the candidate treatment plan establishment unit 1300, the candidate treatment plan is extracted from a treatment plan database that stores treatment plans. The treatment plan database stores predetermined treatment plans cumulatively, and the shock dose is given the greatest amount to the tumor. It may also be stored with the treatment plan result data, which is least likely to be given to surrounding normal tissue.

In other words, all candidate treatment plans established in the treatment plan database can be stored cumulatively, and the result data of the treatment plan can also be stored. Accordingly, establishing the candidate treatment plan in the candidate treatment plan establishment unit 1300 may be extracted from a pre-stored treatment plan database, and through this, a more efficient and more optimized candidate treatment plan can be established. .

The impulse dose-based prescription information is generated as a real number times greater than or equal to 1 of the standard impulse dose,

The standard impulse amount is, when calculating the change in impulse quantity by section,

It may be the smallest impulse value among the impulse values that satisfy.

Referring again to FIG. 7, in all of (a), (b), (c), and (d) of FIG. 7, the impulse increased rapidly up to the second point (represented by a red dotted circle), but after the second point, Since the curve shows a gentle slope, it can be seen that in terms of treatment efficiency, the applied impulse can be determined as the standard dose based on the impulse at the second point.

In particular, in order to more strictly judge the treatment efficiency, the smallest impulse value among the impulse values that satisfy Equation 6 below can be selected as the reference impulse.

[Equation 6]

For example, shock dose-based prescription information could be generated at 1x, 1.5x, 1.7x, and 2.3x the standard impulse dose, which would mean that the doctor could determine the intensity of treatment for the patient's tumor. In addition, the reason why prescription information is generated at more than one time the standard shock amount is because in order to maintain high treatment efficiency, the treatment efficiency must be equal to or greater than the standard shock dose with the highest treatment efficiency.

The treatment plan decision unit 1400 may determine, among the plurality of candidate treatment plans, one candidate treatment plan that provides the least amount to surrounding normal tissue as the selected treatment plan.

In addition, the treatment plan decision unit 1400 may determine that the selected treatment plan is to provide the prescribed shock amount to the tumor and the least amount to the surrounding normal tissue.

Determining one candidate treatment plan as the selected treatment plan among the plurality of candidate treatment plans determines that the prescribed shock amount is given to the tumor and the least amount is given to the surrounding normal tissue, that is, treatment efficiency and treatment stability. This highest single candidate treatment plan may be determined as the selected treatment plan.

In order to solve the above problems, a cancer treatment plan decision system (1000) using shock dose-based prescription according to another embodiment of the present invention classifies organs and tumors in a medical image of a patient containing organs and tumors, and classifies the organs and tumors in the medical image of the patient. When 3D image information including a tumor is provided, and the medical image is expressed as a 3D volume model formed of a plurality of voxels, the electrical conductivity in each voxel constituting the medical image An information receiver 1100 that receives physical property information including dielectric constant; A prescription receiver 1200 that receives prescription information based on the impact dose for the tumor; Using the information provided from the information receiver and the prescription receiver, a candidate treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time is established, and at least one candidate treatment plan is established. a candidate treatment plan establishment unit (1300) that establishes; and a treatment plan determination unit 1400 that determines one candidate treatment plan as the selected treatment plan among the at least one candidate treatment plan.

The information receiver 1100 classifies organs and tumors in a patient's medical image containing organs and tumors, receives 3D image information including the organs and tumors, and divides the medical image into a plurality of voxels. When expressed as a three-dimensional volume model, physical property information including electrical conductivity and dielectric constant in each voxel constituting the medical image may be provided.

Meanwhile, the medical image may be expressed as a 3D volume model, and the 3D volume model may be formed of a plurality of voxels. In addition, when the medical image is expressed as a three-dimensional volume model formed of a plurality of voxels, the impulse is the impulse received by a unit voxel, It is expressed as ( , ) The international unit system may be Ns (N: newton, s: second).

In addition, determining the selected treatment plan in the treatment plan decision unit 1400 may mean that the prescribed shock amount is given to the tumor and the least amount is given to the surrounding normal tissue.

To solve the above problems, the cancer treatment plan evaluation system (2000) using shock dose-based prescription according to an embodiment of the present invention classifies organs and tumors in medical images of patients containing organs and tumors, and classifies the organs and tumors in the medical image of the patient. An information receiver 2100 that receives three-dimensional image information including a tumor and physical property information including electrical conductivity and dielectric constant of the medical image; A prescription receiver (2200) that receives prescription information based on the impact dose for the tumor; A treatment plan establishment unit 2300 that establishes a treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time using the information provided from the information receiver and the prescription receiver; and a treatment plan evaluation unit 2400 that evaluates the amount of impact given to the tumor and the amount given to surrounding normal tissue with respect to the established treatment plan.

The impulse is the electric charge It is the impulse per dose, ( is the basic charge a positive integer multiple of It is expressed as,

The international unit system may be Ns/C (N: newton, s: second, C: coulomb).

Additionally, the impulse amount is the basic charge is the amount of shock received,

It is expressed as,

The international unit system may be Ns (N: newton, s: second).

In addition, the impulse amount is the electric charge is the amount of shock received, ( is the basic charge a positive integer multiple of It is expressed as,

The international unit system may be Ns (N: newton, s: second).

Meanwhile, the impulse-based prescription information is expressed as a product of the treatment electromagnetic force and treatment time, and the value converted to a current density obtained by dividing the current generating the treatment electromagnetic force by the electrode area may be less than 100 mArms/cm ² .

In addition, the impulse dose-based prescription information may decrease the treatment time while increasing the treatment electromagnetic force, or increase the treatment time while decreasing the treatment electromagnetic force, while the impulse dose-based prescription information is constant. .

In addition, in the treatment plan establishment unit, the number of treatment electrodes and the location of the treatment electrode are determined using the three-dimensional position of the tumor and the physical property information, the type of the tumor is further provided by the information receiver, and the type of the tumor The treatment frequency may be determined, and the treatment electromagnetic force and treatment time may be determined using the impulse-based prescription information and the physical property information.

In addition, the impulse-based prescription information is generated as a real number times the standard impulse quantity greater than or equal to 1,

The standard impulse amount is, when calculating the change in impulse quantity by section,

It may be the smallest impulse value among the impulse values that satisfy.

Although embodiments of the present invention have been described above with reference to the attached drawings, those skilled in the art will understand that the present invention can be implemented in other specific forms without changing the technical idea or essential features. You will be able to understand it. For example, a person skilled in the art may change the material, size, etc. of each component depending on the field of application, or combine or substitute the disclosed embodiments to implement the present invention in a form not clearly disclosed in the embodiments of the present invention, but this also may be done in a form not clearly disclosed in the embodiments of the present invention. It does not go beyond the scope of the invention. Therefore, the embodiments described above are illustrative in all respects and should not be understood as limiting, and such modified embodiments should be considered to be included in the technical idea described in the claims of the present invention.

1000: Cancer treatment plan decision system using shock dose-based prescription
1100, 2100: Information receiving unit
1200, 2200: Prescription receiver
1300: Candidate treatment planning department
1400: Treatment plan decision unit
2000: Cancer treatment plan evaluation system using shock dose-based prescription
2300: Treatment planning department
2400: Treatment plan evaluation unit

Claims (22)

An information receiver that classifies organs and tumors in a patient's medical image containing organs and tumors, receives 3D image information including the organs and tumors, and receives physical property information including electrical conductivity and dielectric constant of the medical image. ;
a prescription receiver that receives prescription information based on the impact dose for the tumor;
Using the information provided from the information receiver and the prescription receiver, a candidate treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time is established, and at least one candidate treatment plan is established. Candidate treatment plan establishment department that establishes; and
a treatment plan determination unit that determines one candidate treatment plan as the selected treatment plan among the at least one candidate treatment plan;
A cancer treatment plan decision system using shock dose-based prescription including. According to paragraph 1,
The impulse is the electric charge It is the impulse per dose, ( is the basic charge a positive integer multiple of
It is expressed as,

A cancer treatment plan decision system using impulse-based prescription, characterized in that the international unit system is Ns/C (N: newton, s: second, C: coulomb). According to paragraph 1,
The impulse is the basic charge is the amount of shock received,
It is expressed as,

A cancer treatment plan decision system using impulse-based prescription, characterized in that the international unit system is Ns (N: newton, s: second). According to paragraph 1,
The impulse is the electric charge is the amount of shock received,
( is the basic charge a positive integer multiple of
It is expressed as,

A cancer treatment plan decision system using impulse-based prescription, characterized in that the international unit system is Ns (N: newton, s: second). According to paragraph 1,
The impulse dose-based prescription information is
Expressed as the product of the treatment electromagnetic force and treatment time,
A cancer treatment plan decision system using impulse-based prescription, characterized in that the value converted to current density by dividing the current generating the therapeutic electromagnetic force by the electrode area is less than 100 mArms/cm ² . According to paragraph 1,
The impulse dose-based prescription information is
With the shock dose-based prescription information constant,
decreasing the treatment time while increasing the treatment electromagnetic force;
A cancer treatment plan decision system using impulse-based prescription, characterized in that the treatment time can be increased while reducing the treatment electromagnetic force. According to paragraph 1,
In the Candidate Treatment Planning Department
The number of treatment electrodes and the location of the treatment electrodes are determined using the three-dimensional position of the tumor and the physical property information,
The type of tumor is further provided from the information receiver, and the treatment frequency is determined according to the type of tumor,
A cancer treatment plan decision system using impulse-based prescription, characterized in that the treatment electromagnetic force and treatment time are determined using the impulse-based prescription information and the physical property information. According to paragraph 1,
The at least one candidate treatment plan is
A cancer treatment plan decision system using impulse-based prescription, wherein at least one of the number of treatment electrodes, the location of the treatment electrodes, the treatment electromagnetic force, and the treatment time is different. According to paragraph 1,
In the Candidate Treatment Planning Department
The candidate treatment plan is extracted from a treatment plan database storing treatment plans,
The treatment plan database cumulatively stores predetermined treatment plans, and stores treatment plan result data in which the shock dose is given the most to the tumor and the least to the surrounding normal tissue. Cancer treatment plan decision system using prescriptions. According to paragraph 1,
The treatment plan decision section determines the selected treatment plan.
A cancer treatment plan decision system using shock dose-based prescription, characterized in that it determines that the prescribed shock amount is given to the tumor and the smallest amount is given to the surrounding normal tissue. According to paragraph 1,
The impulse dose-based prescription information is
It is generated as a real number times the standard impulse amount greater than or equal to 1,
The standard impulse amount is, when calculating the change in impulse quantity by section,
A cancer treatment plan decision system using impulse-based prescription, characterized in that the impulse value is the smallest among the impulse values that satisfy. Classifies organs and tumors in a patient's medical image containing organs and tumors, receives 3D image information including the organs and tumors, and uses a 3D volume model in which the medical image is formed into multiple voxels. When expressed, an information receiver that receives physical property information including electrical conductivity and dielectric constant in each voxel constituting the medical image;
a prescription receiver that receives prescription information based on the impact dose for the tumor;
Using the information provided from the information receiver and the prescription receiver, a candidate treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time is established, and at least one candidate treatment plan is established. Candidate treatment plan establishment department that establishes; and
a treatment plan determination unit that determines one candidate treatment plan as the selected treatment plan among the at least one candidate treatment plan;
A cancer treatment plan decision system using shock dose-based prescription including. According to clause 12,
The amount of impact is the amount of impact received by a unit voxel,
It is expressed as ( , )
A cancer treatment plan decision system using impulse-based prescription, characterized in that the international unit system is Ns (N: newton, s: second). According to clause 12,
The treatment plan decision section determines the selected treatment plan.
A cancer treatment plan decision system using shock dose-based prescription, characterized in that it determines that the prescribed shock amount is given to the tumor and the smallest amount is given to the surrounding normal tissue. An information receiver that classifies organs and tumors in a patient's medical image containing organs and tumors, receives 3D image information including the organs and tumors, and receives physical property information including electrical conductivity and dielectric constant of the medical image. ;
a prescription receiver that receives prescription information based on the impact dose for the tumor;
a treatment plan establishment unit that establishes a treatment plan including the number of treatment electrodes, treatment electrode position, treatment frequency, treatment voltage or current density, and treatment time using the information provided from the information receiver and the prescription receiver; and
a treatment plan evaluation unit that evaluates the amount of impact given to the tumor and the amount given to surrounding normal tissue with respect to the established treatment plan;
Cancer treatment plan evaluation system using shock dose-based prescription including. According to clause 15,
The impulse is the electric charge It is the impulse per dose, ( is the basic charge a positive integer multiple of
It is expressed as,

A cancer treatment plan evaluation system using impulse-based prescription, characterized in that the international unit system is Ns/C (N: newton, s: second, C: coulomb). According to clause 15,
The impulse is the basic charge is the amount of shock received,
It is expressed as,

A cancer treatment plan evaluation system using impulse-based prescription, characterized in that the international unit system is Ns (N: newton, s: second). According to clause 15,
The impulse is the electric charge is the amount of shock received,
( is the basic charge a positive integer multiple of
It is expressed as,

A cancer treatment plan evaluation system using impulse-based prescription, characterized in that the international unit system is Ns (N: newton, s: second). According to clause 15,
The impulse dose-based prescription information is
Expressed as the product of the treatment electromagnetic force and treatment time,
A cancer treatment plan evaluation system using impulse-based prescription, characterized in that the value converted to current density by dividing the current generating the therapeutic electromagnetic force by the electrode area is less than 100 mArms/cm ² . According to clause 15,
The impulse dose-based prescription information is
With the shock dose-based prescription information constant,
decreasing the treatment time while increasing the treatment electromagnetic force;
A cancer treatment plan evaluation system using impulse-based prescription, characterized in that the treatment time can be increased while reducing the treatment electromagnetic force. According to clause 15,
In the treatment planning department
The number of treatment electrodes and the location of the treatment electrodes are determined using the three-dimensional position of the tumor and the physical property information,
The type of tumor is further provided from the information receiver, and the treatment frequency is determined according to the type of tumor,
A cancer treatment plan evaluation system using impulse-based prescription, characterized in that the treatment electromagnetic force and treatment time are determined using the impulse-based prescription information and the physical property information. According to clause 15,
The impulse dose-based prescription information is
It is generated as a real number times the standard impulse amount greater than or equal to 1,
The standard impulse amount is, when calculating the change in impulse quantity by section,
A cancer treatment plan evaluation system using impulse-based prescription, characterized in that it is the smallest impulse value among the impulse values that satisfy.