KR20240036382A - Continuous analyte device including electrochemical sensor with double-sided electrode - Google Patents

Abstract

The continuous analyte measuring device of the present invention is an electrochemical device comprising a distal portion formed with a plurality of electrodes that react with analytes in the body, a proximal portion formed with a sensor pad connected to the electrodes, and an intermediate portion located between the distal portion and the proximal portion. It may include a main board on which at least one of a sensor, a power supply unit, a communication unit, and a control unit is formed, a housing in which the main board is stored, and a transmitter attached to the skin.
The electrochemical sensor of the present invention may include a flexible base layer, a conductive layer laminated on the base layer, and an insulating layer attached on the conductive layer.
The electrode closer to the end of the distal part of the present invention may be referred to as the front electrode, and the electrode less close to the end of the distal part than the front electrode may be referred to as the rear electrode, and the most anterior electrode may be the one closest to the end of the distal part among the front electrodes, Electrodes may be provided on both sides of the distal portion.

Description

Continuous analyte device including electrochemical sensor with double-sided electrode}

The present invention relates to a continuous analyte measuring device including an electrochemical sensor formed on both sides of electrodes that react with analytes in the body.

When using the inserter as a reference position, one end of the electrochemical sensor connected to the main board is located close to the inserter and can be called the proximal portion, and the other end of the electrochemical sensor inserted into the body is located far from the inserter. It can be called distal.

The proximal portion of the electrochemical sensor may be electrically connected to the main board of the transmitter, and at least a portion of the distal portion of the electrochemical sensor may be inserted into the body. The proximal portion and the distal portion may be located at opposite ends. The proximal portion of the electrochemical sensor may be electrically connected to the main board of the transmitter, which includes the electrical circuitry necessary for measuring analytes, including glucose.

The base layer of the electrochemical sensor can be flexible to relieve pain during invasion and reduce foreign body sensation when worn, and the thickness and size of the electrochemical sensor need to be minimized.

As the size of the electrochemical sensor becomes smaller, the area of the electrode formed at the distal part may also become smaller. If the electrode area is not sufficiently secured, signal disturbance due to noise may occur, so when manufacturing an electrochemical sensor, it is necessary to consider both aspects of reducing the size of the sensor and securing the electrode area.

Electrochemical sensors need to be as small as possible in size to relieve pain and reduce foreign body sensation during invasion. As the size of the electrochemical sensor becomes smaller, the area of the electrode formed at the distal part may also become smaller. If the electrode area is not sufficiently secured, signal disturbance due to noise may occur, so when manufacturing an electrochemical sensor, it is necessary to satisfy both the trade-off relationship between reducing the size of the sensor and securing the electrode area.

The continuous analyte measuring device of the present invention can provide an embodiment of the distal portion including an electrode, via hole, or lead with improved reactivity with analytes in the body while minimizing the width and length of the distal portion, at least a portion of which is immersed in the body. there is.

The continuous analyte measuring device of the present invention is an electrochemical device comprising a distal portion formed with a plurality of electrodes that react with analytes in the body, a proximal portion formed with a sensor pad connected to the electrodes, and an intermediate portion located between the distal portion and the proximal portion. It may include a main board on which at least one of a sensor, a power supply unit, a communication unit, and a control unit is formed, a housing in which the main board is stored, and a transmitter attached to the skin.

The electrochemical sensor of the present invention may include a flexible base layer, a conductive layer laminated on the base layer, and an insulating layer attached on the conductive layer. The electrode closer to the end of the distal part of the present invention may be referred to as the front electrode, and the electrode less close to the end of the distal part than the front electrode may be referred to as the rear electrode, and the most anterior electrode may be the one closest to the end of the distal part among the front electrodes, Electrodes may be provided on both sides of the distal portion.

The first front electrode of the present invention can be electrically connected to the second front electrode through a via hole formed to penetrate the base layer, and the lead connected backward from the second front electrode is located at the rear of the second rear electrode. It may be electrically connected to the first surface through a via hole formed in or in the middle portion. The first front electrode of the present invention may be electrically connected to the second front electrode through a via hole formed to penetrate the base layer, the opening may be formed in the first front electrode, and the opening may be formed in the second front electrode. The opening may not be formed.

An upper electrode may be provided on the upper surface of the distal portion of the present invention, and a first lower electrode may be provided on the lower surface of the distal portion, and the first lower electrode of the present invention extends without being divided from one end of the distal portion to the other end. It can be.

A second lower electrode may be disposed around the first lower electrode of the present invention, and a lead may be provided to electrically connect the electrode and the sensor pad, and the width of the lead may be smaller than the width of the electrode.

The upper electrode of the upper surface of the present invention is energized to the second lower electrode of the lower surface through a via hole penetrating the base layer, and the second lower electrode is connected backward from the second lower electrode. The sensor pad is energized along the lead of the sensor pad, or the second bottom electrode of the lower surface is energized to the upper electrode of the upper surface through a via hole penetrating the base layer, and the upper electrode is connected backward from the upper electrode. Electricity may be supplied to the sensor pad along the leads on the upper surface.

The front electrode of the present invention and the rear electrode disposed continuously to the front electrode may be formed to completely fill the distal portion in an elongated rectangular shape extending along the longitudinal direction of the distal portion.

The tightly packed electrode of the present invention may mean an electrode without lead wiring around the electrode along the distal longitudinal direction. The width of the packed electrode may be substantially equal to the width of the distal portion.

In addition, the meaning of a fully filled electrode in the present invention may mean that the distal part is completely filled with electrodes, excluding the edge trench, along the width direction of the distal part. The edge trench is formed at the outer edge of the electrochemical sensor and may surround the circumference of the electrode. Along the width direction of the distal portion, the width of the edge trench plus the width of the electrode may be equal to the width of the distal portion.

Leads may not be disposed around the front electrode of the present invention and around the rear electrode disposed to be continuous with the front electrode. The front electrode and the rear electrode can be formed to completely fill the distal area without a lead, thereby increasing the reactivity between the electrode and the analyte.

The elongated electrode of the present invention may have a plurality of openings in the insulating layer facing each other. In the case of facing a plurality of openings, a selective transmission layer performed by a method such as dispensing can be uniformly applied to the openings, compared to the case of facing a plurality of openings that are elongated to resemble the shape of the electrode.

The two elongated rectangular-shaped electrodes of the present invention can be placed continuously without leads around them, and at least one of the two electrodes can be electrically connected to opposite sides through a via hole formed to penetrate the base layer of the electrochemical sensor. You can.

The width of the most anterior electrode and neighboring electrodes of the present invention may match the width of the distal portion. The lead connecting the frontmost electrode to the rear may not be arranged around the neighboring electrode including the adjacent side.

The first most anterior electrode and the adjacent first rear electrode disposed on one side of the distal portion of the present invention may be formed to completely fill the distal portion, and the second rear electrode adjacent to the second most anterior electrode disposed on the other side of the distal portion may be formed to fill the distal portion. It may not be formed to fill completely. A lead extending from the second front electrode may be formed around the second rear electrode, and the lead may be arranged in parallel with the second rear electrode and extend in the longitudinal direction together with the second rear electrode. In this case, the sum of the width of the second rear electrode adjacent to the second most anterior electrode disposed on the other surface of the distal portion and the width of the leads disposed around the second rear electrode may correspond to the width of the distal portion. .

The present invention may include a merge electrode that extends from one end of the distal portion to the other end without being divided. A plurality of openings may be continuously arranged along the longitudinal direction of the distal portion, thereby increasing the reactivity between the electrode and the analyte.

1 is a perspective view of the combination between an inserter, an electrochemical sensor, and a transmitter of the present invention.
Figure 2 is an explanatory diagram of the trench of the present invention.
Figure 3 is an explanatory diagram of the manufacturing method of the electrochemical sensor of the present invention.
Figure 4 (a) is a plan view of an embodiment of the electrode arrangement of the distal part of the present invention, and Figure 4 (b) is a rear view of an embodiment of the electrode arrangement of the distal part of the present invention.
Figure 5 is a schematic diagram of Figure 4.
Figure 6 shows other embodiments of Figure 4.
Figure 7 (a) is a plan view of another embodiment of the electrode arrangement of the distal part of the present invention, and Figure 7 (b) is a rear view of another embodiment of the electrode arrangement of the distal part of the present invention.
Figure 8 is a schematic diagram of Figure 7.
Figure 9 shows other embodiments of Figure 7.

Hereinafter, an example will be described where the electrochemical sensor 400 of the present invention is used in a continuous glucose monitoring system (CGMS) that measures interstitial fluid or blood glucose concentration. However, the continuous blood glucose device of the present invention is not limited to measuring glucose concentration in the body and can be expanded to a continuous analyte measuring device for measuring other biomarkers.

<Inserter and transmitter>

FIG. 1 may illustrate one example of a combination between the inserter 100, the electrochemical sensor 400, and the transmitter 200 of the present invention. FIG. 1 may illustrate a state in which the electrochemical sensor 400 and the transmitter 200 are mounted inside the inserter 100 before they leave the inserter 100 and invade or attach to the body.

Referring to Figure 1, the electrochemical sensor 400 of the present invention can be attached to the skin together with the transmitter 200. The transmitter 200 can control the signal measured by the electrochemical sensor 400 and transmit continuously measured blood sugar levels to an external terminal, including a mobile device.

The external terminal is provided separately from the transmitter 200 attached to the skin, and can continuously receive measurement data of the electrochemical sensor 400 wirelessly from the transmitter 200. The user can continuously monitor and diagnose measurement data of the electrochemical sensor 400 for biomarkers (bio-makers) including glucose, lactate, etc.

The electrochemical sensor 400 and the transmitter 200 may be provided to the user while being loaded into the inserter 100 before attachment to the skin. By the user's attachment action, the electrochemical sensor 400 and the transmitter 200 may be separated from the inserter 100 and attached to the skin.

One end of the electrochemical sensor 400 connected to the electrical component 230 of the transmitter 200 may be referred to as the proximal part 402, and the other end of the electrochemical sensor 400, at least part of which is invasive into the body, may be referred to as the distal part 406. ), the proximal part 402 and the distal part 406 are connected to each other, and the part disposed between the proximal part 402 and the distal part 406 can be called the middle part 404, and in the middle part 404 The part that is flexibly bent and where the direction of the electrochemical sensor 400 changes greatly can be referred to as the folded part 405.

Infiltration may mean inserting at least a portion of the distal portion 406 of the electrochemical sensor 400 into the body.

The transmitter 200 and the electrochemical sensor 400 may be provided to the user in a state that is already adhered to each other before being attached to the skin.

The transmitter 200 is located in the first position while loaded in the inserter 100, and the transmitter 200 moves from the first position to the second position by the user's action. At the second position, the transmitter 200 It may adhere to the skin. The insertion direction of the transmitter 200 and the electrochemical sensor 400 may be from the first position to the second position.

The needle 300 has a portion exposed in the longitudinal direction, and a portion of the electrochemical sensor 400 may be disposed inside the needle 300. The needle 300 may function to incise the skin so that at least a portion of the distal portion 406 can invade into the human body along the insertion direction and guide the electrochemical sensor 400.

The inserter 100 may include a driving unit 102 that operates the transmitter 200 and the electrochemical sensor 400 from the first position to the second position.

The drive unit 102 may advance the needle 300 or the transmitter 200 from a first position to a second position such that the needle 300 or the distal portion 406 is inserted into the skin.

The drive unit 102 attaches the transmitter 200 and the electrochemical sensor 400 to the skin in the second position, and then retracts the needle 300 from the second position to the third position to move the needle 300 to the transmitter 200. ) and can be separated from the electrochemical sensor 400.

The driving unit 102 may be connected to the needle handle 310 on which the needle 300 is fixed. The needle handle 310 can be attached to or detached from the driving unit 102.

An internal space may be provided between the upper housing 210 and the lower housing 220 of the transmitter 200.

One side of the electrochemical sensor 400 on which the sensor pad 428 is formed may face the main board 202, and the other side of the electrochemical sensor 400 may be exposed to the internal space of the transmitter 200.

A contact pad 612 electrically connected to the sensor pad 428 may be formed on the main substrate 202 at the proximal portion 402 of the electrochemical sensor 400.

Since at least a portion of the electrochemical sensor 400 invades into the skin, the electrochemical sensor 400 or the base layer 410 may be flexible to relieve pain upon invasion and reduce foreign body sensation when worn.

The distal portion 406 of the electrochemical sensor 400 may be disposed on an exposed portion along the longitudinal direction of the needle 300. The end of the needle 300 is in a more protruding position than the end of the distal portion 406. The distal portion 406 of the electrochemical sensor 400 may be inserted into the body after the skin is incised by the needle 300.

<Electrochemical sensor>

The electrochemical sensor 400 of the present invention can selectively react with some of various analytes including glucose in the body through the electrode 424 of the distal part 406 that invades the body.

A voltage is applied to the electrode 424 of the present invention so that analytes in the body, including glucose, can be oxidized and reduced, and a current can flow due to the electrons generated at this time. The generated current can be determined according to the concentration of the analyte in the body, so that the signals of biomarkers, including blood sugar levels, can be quantified.

An electrode 424 that can be inserted into the body and perform an oxidation or reduction reaction with sugar may be formed in the distal portion 406. The electrode 424 may include at least one of a working electrode, a counter electrode, and a reference electrode.

A sensor pad 428 connected to the electrode 424 may be formed in the proximal portion 402. The current generated through an electrochemical reaction with glucose in the body in the distal part 406 may be connected to the sensor pad 428 in the proximal part 402 along the lead 426 formed on the base layer 410. The sensor pad 428 may be electrically connected to the main board 202 through a contact pad.

The middle portion 404 may be provided with a plurality of leads 426 connecting the electrode 424 and the sensor pad 428. The plurality of leads 426 may be formed using a laser etching method in which a portion of the base layer 410 is removed by irradiating a laser to the base layer 410 . Accordingly, each lead 426 can be arranged so as not to cross each other and be twisted.

The electrode 424 may include at least one working electrode and a reference electrode. A plurality of counter electrodes may be formed as needed. A counter electrode may be provided when three or more types of electrodes are used to obtain precise data.

The working electrode may be a porous platinum electrode or may be fabricated from porous platinum colloid.

The reference electrode may be an electrode that has a constant potential and can serve as a reference. The reference electrode may be one of a silver chloride (Ag/AgCl) electrode, a calomel electrode, and a mercury (I) sulfate electrode. For in vivo invasive applications when the biomarker is glucose, a silver chloride (Ag/AgCl) electrode can be used as the reference electrode.

In the case of the invasive electrochemical sensor 100, the size needs to be minimized as much as possible for reasons such as relieving pain during invasion and reducing foreign body sensation when worn. As the size of the electrochemical sensor 400 becomes smaller, the area of the electrode 424 may also become smaller. If the area of the electrode 424 is not sufficiently secured, signal disturbance due to noise may occur, so when manufacturing the electrochemical sensor 400, it is necessary to consider both aspects of reducing the size of the sensor 100 and securing the area of the electrode 424. There is.

The length at which the invasive electrochemical sensor 400 is inserted into the skin may range from 3 to 12 mm. If the insertion length is 3 mm or less, the stability of the sensor itself and signal stability may be reduced due to movement of the living body after the sensor is inserted into the living body. If the insertion length exceeds 12 mm, it is located in a range where pain points in the human body are distributed, which can increase pain and damage internal tissues such as blood vessels and nerves. Additionally, the width of the invaded portion of the distal portion 406 may range from 100 to 600 μm. The thickness of the invaded portion of the distal portion 406 may range from 10 to 300 μm, and preferably may range from 50 to 150 μm.

Since at least a portion of the distal part 406 is inserted into the body, if the width of the distal part 406 is too wide, pain and foreign body sensation may increase during invasion, so there is a need to reduce it to a predetermined width (for example, 600㎛) or less. If all three or more electrodes 424 are placed on only one side of the distal part 406 that invades the body, the width of the distal part 406 is It should be wide, but in terms of pain relief, it may be limited to a certain width (for example, 600㎛) or less. Both trade-off relationships must be satisfied.

When the transmitter 200 is attached to the skin and the electrochemical sensor 400 is invaded into the body, the folded portion 405 may remain bent for a considerable period of time. In order to reduce the torsional load of the folded portion 405, the width of the middle portion 404 or the folded portion 405 may be formed to be narrower than the width of the proximal portion 402 or the distal portion 406.

The number of leads 426 formed in the middle portion 404 or the folded portion 405 may increase in proportion to the number of electrodes disposed in the distal portion 406. As the plurality of leads 426 are arranged in the folded portion 405, the insulation deteriorates and a short circuit may occur. It is necessary to optimize the width between leads 426, the number of leads 426, the number of electrodes 424, or the width of the folded portion 405.

The electrodes 424 may be placed on both sides of the distal portion 406 to minimize the size of the distal portion 406 that invades the body and secure sufficient space for placement of the electrodes 424.

In order to increase accuracy when detecting an electrochemical signal from the electrode 424 of the distal part 406, the number of working electrodes (WE) disposed in the distal part 406 may be increased.

A plurality of working electrodes including the first working electrode and the second working electrode may be provided on the same side of the distal part 406, or at least one working electrode may be provided on both sides of the distal part 406.

Biomarkers to be reacted at the electrode 424 may include glucose, lactose, or ketone.

The first working electrode and the second working electrode are composed of the same type of biomarker, which can increase the reaction force and improve the detection accuracy of electrochemical signals. The first working electrode and the second working electrode are composed of different types of biomarkers and can measure a plurality of electrochemical signals at the same time. Additionally, the first working electrode and the second working electrode may be complementary to measuring one biomarker. If the first working electrode measures the blood sugar concentration, the second working electrode may measure the concentration of acetaminophen. When taking acetaminophen, the blood sugar level measured in the body may be higher than the actual level, and the blood sugar concentration measured at the first working electrode needs to be judged in consideration of the acetaminophen concentration measured at the second working electrode.

The electrochemical sensor 400 of the present invention may include a flexible base layer 410, a conductive layer 412 laminated on the base layer 410, and an insulating layer 416 attached on the conductive layer 412. there is.

The trench 420 may be formed by laser etching the conductive layer 412. The widths (W1, W2) of the trench 420 obtained by laser etching may be 2 to 200 ㎛. The laser head 490 that irradiates the laser moves multiple times and laser etching is performed multiple times, and the widths (W1, W2) of the trench can be increased.

The electrode 424 and the sensor pad 428 may be formed by a laser etching method in which a portion of the conductive layer 412 is removed by irradiating a laser to the conductive layer 412. After the conductive layer 412 is stacked, the edge boundary of the electrode 424 and the edge boundary of the sensor pad 428 may be formed. The leads 426 connecting the electrode 424 and the sensor pad 428, respectively, may be formed by cutting a portion of the conductive layer 412 in the vertical direction, like the electrode 424 and the sensor pad 428. The insulating layer 416 may be attached after the edge boundary of the electrode 424 and the edge boundary of the sensor pad 428 are formed.

The trench 420 may be engraved in the conductive layer 412, and the conductive island 430 may be patterned in the conductive layer 412 accordingly. The height of the trench 420 may be the same as the thickness of the conductive layer 412. The thickness of the conductive layer 412, electrode 424, and sensor pad 428 may all be the same.

The width of the electrochemical sensor 400 may be 600 micrometers or less, and the length of the electrochemical sensor 400 may be 3 cm or less. The width of the electrode 424 and the sensor pad 428 may be 500 micrometers or less, and the width of the lead 426 may be 150 micrometers or less.

The electrode 424 and the trench 420 can be formed without burrs through laser etching, no matter how complex the pattern of the electrode 424 is and how narrow the width of the trench 420 is. To simplify the process, it may be desirable for the conductive layer 412 to be sputtered with a metal containing gold or copper over the entire exposed area of the base layer 410.

A via hole 411 penetrating the base layer 410 may be provided.

Through the via hole 411, the conductive layers 412 on both sides stacked on the base layer 410 may be electrically connected to each other.

The via hole 411 may be formed by a laser etching method in which a portion of the base layer 410 is removed by irradiating a laser to the base layer 410 .

When forming the double-sided electrode 424, both the top and back surfaces of the base layer 410 where the via hole 411 is formed can be sputtered with metal. The formation of the double-sided conductive layer 412 may be performed on the top and back surfaces at different times, or may be performed on both surfaces simultaneously.

The electrodes 424 or the leads 426 may be electrically separated from each other by the trench 420 . The narrower the trench 420 is, the more likely it is to secure a sufficient area of the electrode 424 for analyte reaction. Conversely, the narrower the trench 420 is, the worse the insulation may be. By laser etching trench formation, the trade-off between miniaturization and insulation can be satisfied. As the width of the folded portion 405 is formed narrower, torsional force can be reduced, and fatigue failure can be prevented even if the folded portion 405 remains bent and fixed for a considerable period of time.

By using the trench 420, it is easy to secure a sufficient area for the lead 426, the electrode 424, or the sensor pad 428, thereby improving the signal transmission rate and reducing the short circuit defect rate.

The base layer 410 may include at least one of synthetic resin, polyimide (PI), and polyethylene terephthalate (PET) as an insulating material, and is preferably used for the thin and flexible electrochemical sensor 400. Polyimide (PI) may be used as a material for the base layer 410. The thickness of the base layer or insulating layer may be 100 micrometers or less.

The conductive layer 412 may be formed on the base layer 410 using a method such as sputtering. The thickness of the conductive layer 412, which is laminated by blowing metal into atoms or molecules, may be 10 micrometers or less. The conductive layer 412 may be formed by sputtering metal over the entire exposed area of the base layer 410 before the edge boundary of the electrode 424 and the edge boundary of the sensor pad 428 are formed.

The electrode 424 and sensor pad 428 may be formed by a laser etching method that removes a portion of the conductive layer 412 by irradiating a laser to the conductive layer 412, thereby satisfying the trade-off between miniaturization and insulation. You can do it.

A trench 420 may be formed in the conductive layer 412 before bonding the insulating layer 416 to the conductive layer 412 by the bonding layer 414 . The conductive layer 412 may be separated into different members by a trench 420. The conductive layer 412 can be divided into different types of electrodes 424, different leads 426, and different sensor pads 428 by the trench 420. there is.

After forming the conductive layer 412, the insulating layer 416 may be attached. The insulating layer 416 with a portion of the insulating layer 416 corresponding to the electrode 424 and the sensor pad 428 removed so that the electrode 424 and the sensor pad 428 are exposed to the outside is formed into a conductive layer 412. ) can be glued on.

A portion of the insulating layer 416 may be removed using a cutter or punching machine. When the size of the opening 422 of the insulating layer 416 is small and fine processing is required, the laser etching method used to form the trench 420 of the conductive layer 412 is used to process the opening 422 of the insulating layer 412. You can use it.

The same may be true for the base layer 410. Since the via hole 411 required for double-sided formation requires micro-processing, the laser etching method used to form the trench 420 of the conductive layer 412 can be used to process the via hole 411 of the base layer 410.

When the via hole 411 is formed by cutting a portion of the base layer 412, the conductive layer 412 is formed seamlessly along the top surface of the base layer 410, the surface of the via hole 411, and the back surface of the base layer 410. Double-sided sputtering can be done using the same continuous metal material.

A penetrating opening 422 may be formed in the insulating layer 416. The electrode 424 and the sensor pad 428 formed on the conductive layer 412 may be exposed to the outside through the opening 422. A proximal opening 422a may be formed in the proximal portion 402, and a distal opening 422b may be formed in the distal portion 406. A portion of the sensor pad 428 may be exposed to the outside through the proximal opening 162, and a portion of the sensor pad 428 exposed by the proximal opening 162 may be electrically connected to the contact pad of the main board 202. can be connected

A portion of the electrode 424 may be exposed to the outside through the distal opening 164, and a portion of the electrode 424 exposed by the distal opening 164 may contact interstitial fluid or blood flow and undergo an electrochemical reaction with the analyte. can cause

The electrochemical sensor 400 may include a porous selectively transparent layer 418 surrounding the surface of the electrode 424. The selectively transparent layer 418 is intended to react with an analyte that reacts in the body and may be applied to the electrode 424 of the distal portion 406.

The selectively transparent layer 418 may have mesoporous characteristics. The size of the mesopores may be 2 to 50 nm.

The type of selective transmission layer 418 may be determined depending on the type of analyte in the body to react with the electrode 424 and may vary depending on the type of electrode 424 to be applied. For example, if the analyte is glucose and the electrode 424 on which the selectively transparent layer 418 is applied is the working electrode, the selectively transparent layer 418 may be mesoporous platinum. Porous platinum can be produced from porous platinum colloids. If the analyte is glucose and the electrode 424 on which the selectively transparent layer 418 is applied is a reference electrode, the selectively transparent layer 418 may be silver chloride (Ag/AgCl).

The selectively transparent layer 418 may be applied to the electrode 424 through the distal opening 422b with the base layer 410, conductive layer 412, and insulating layer 416 stacked. When the plurality of distal openings 422b face different types of electrodes, the first selectively transparent layer 418a to the fourth selectively transparent layer 418d may each include different types of materials.

A bonding layer 414 may be provided to attach the insulating layer 416 to the conductive layer 412. Bonding layer 414 may be located between conductive layer 412 and insulating layer 416. When forming the opening 422 in the insulating layer 416, the opening 422 may also be formed in the bonding layer 414.

To repeatedly form the selective transmission layer 418, at least one of dip coating, spray coating, and paste methods may be performed.

The electrochemical sensor 400 may form a sensor array by connecting base layers 410 to each other. For the electrochemical sensor 400, at least one of forming a conductive layer 412 for each sensor on one base layer 410 or forming a trench 420 by laser etching, etc. may be performed. The formation of the insulating layer 416 and the selective transmission layer 418 may also be performed at the same time.

The plurality of electrochemical sensors 400 may be individually separated from each other after undergoing a sensor manufacturing process simultaneously in the form of an array connected to each other.

When the electrodes 424 are formed on both sides of the distal portion 406, the conductive layer 412 may be formed to surround the base layer 410, and the conductive layer 412 may be formed on both sides of the distal portion 406. can be formed. With the opening 422 penetrating the insulating layer 416 formed, the insulating layer 416 may be adhered onto the conductive layer 412 . The electrode 424 and the sensor pad 428 may be exposed to the outside through the opening 422.

After the conductive layer 412 is deposited on the base layer 410 using a method such as sputtering, a trench 420 may be formed using a method such as laser etching.

A plurality of conductive islands 430 separated from each other may be provided in the conductive layer 412 by laser etching, etc. Each conductive island 430 forms a closed curved surface and may be electrically insulated from each other.

The base layer 410 is exposed at the bottom of the trench 420, and the adjacent conductive islands 430 may be insulated by the trench 420.

The conductive island 430 of the proximal portion 402 may form a sensor pad 428, and the conductive island 430 of the middle portion 404 or fold 405 may form a lead 426, Conductive island 430 of distal portion 406 may form electrode 424 .

The conductive island 430 includes a conductive island 430 in which parts corresponding to the electrode 424 and the sensor pad 428 are exposed to the outside through a cut portion of the insulating layer 416, and a part exposed to the outside. It can be divided into a dummy part completely covered by the insulating layer 416.

When forming conductive islands 430 that are separated from each other by forming a closed curved surface, a dummy portion may be formed between the conductive islands 430. The dummy portion can be used as a conductive island 430 with electrodes 424 or sensor pads 428 when the insulating layer is exposed. The dummy portion can be completely removed by repeated laser etching, etc. However, since only electrical insulation needs to be achieved by the trench, there is no need to remove the dummy portion. This is another advantage of the present invention.

After forming the trench 420 pattern in the conductive layer 412, when a dummy portion that is too wide is formed in the lower part covered with the insulating layer 416, the dummy portion is not removed to prevent part of the insulating layer 416 from sinking to the bottom. It can remain as is.

A trench 420 may be formed in the conductive layer 412 by laser etching, which removes a portion of the conductive layer 412 with a laser irradiated to the conductive layer 412. A plurality of conductive islands 430 separated from each other may be formed in the conductive layer 412 by the trench 420.

By the trench 420, the conductive layer 412 is formed with a conductive island 430 on which the electrode 424 and the sensor pad 428 are formed, or a dummy part covered with an insulating layer 416 so that no part is exposed to the outside. It can be included.

The sensor pad 428 may be formed on only one side of the proximal portion 402 or on both sides of the proximal portion 402.

Each of the double-sided electrodes 424 formed on both sides of the distal part 406 is electrically connected to each sensor pad 428 on both sides of the proximal part 402 along the leads 426 formed on both sides of the middle part 404. can be connected In this case, the via hole 411 for electrically connecting the conductive layer 412 formed on one side of the base layer 410 and the conductive layer 412 formed on the other side of the base layer 410 may not need to be formed. there is.

Meanwhile, if the sensor pad 428 is formed on both sides of the proximal portion 402, it may be difficult to electrically connect it to the contact pad of the main board 202 using a simple alignment method. For example, a separate connector portion may be needed to insert or sandwich the proximal portion 402, or a mutual cross-cross structure to energize the sensor pad 428 and the contact pad. Accordingly, the sensor pad 428 may be formed only on one side of the proximal portion 402.

Since the part of the electrochemical sensor 400 that is inserted into the body is the distal part 406, if the size of the distal part 406 is minimized, pain and foreign body sensation felt by the user can be reduced. Since the continuous analyte measuring device of the present invention is not for intermittent and temporary measurement, but is for continuous measurement for a predetermined period of time while invasive or attached to the body, minimizing the distal portion 406 is important.

The leads 426 connected to the plurality of electrodes 424 can also be distributed and disposed on both sides of the middle portion 424, which has the effect of reducing the width of the middle portion 424 compared to the number of electrodes 424 formed. can be given.

The effect of reducing the size of the distal part 406 and the width of the middle part 424 can be similarly applied when the via hole 411 is formed in the distal part 406.

According to the present invention, when measuring an analyte, the transmitter 200 may be attached to the skin, the proximal portion 402 may be connected to the contact pad of the transmitter 200, and at least a portion of the distal portion 406 may be invaded into the body. there is. When measuring an analyte in an invasive state, the electrochemical sensor 400 needs to be maintained in a flexible bent state at the folded portion 405 of the middle portion 424. Therefore, it may be advantageous for the measurement stability of the electrochemical sensor 400 to have a narrow width of the middle portion 424.

If the sensor pad 428 is disposed to be exposed only on one side of the proximal portion 402, the width may be increased. However, since the sensor pad 428 of the proximal part 402 is electrically connected to the contact pad of the transmitter 200, there may be no problem even if the sensor pad 428 is longer than the distal part 406 that invades the body.

When the via hole 411 is formed in the distal portion 406, the first electrode disposed on the first side of the distal portion 406 by the via hole 411 and the second electrode disposed on the second side of the distal portion 406 are Can be electrically connected. The first electrode and the second electrode may be provided as the same type of electrode, one of a working electrode, a reference electrode, and a counter electrode.

When electrodes having the same function are disposed on both sides of the distal part 406, the via hole 411 of the distal part 406 is used in the direction in which the electrochemical sensor 400 is inserted into the body, or the direction in which the electrochemical sensor 400 is inserted into the body. Measurement instability due to the arrangement relationship between the guiding needle 300 and the distal portion 406 can be reduced.

When the via hole 411 is formed in the distal part 406, the lead 426 and the sensor pad 428 may be formed only on the first side of the base layer 410, and the electrode 424 in the distal part 406 The excluded second side of the middle portion 424 or the proximal portion 424 may be surrounded by an insulating layer 416 and blocked from contact with the outside. Since there is no need to provide complex leads 426 on both sides of the thin electrochemical sensor 400, the stability of electric flow throughout the electrochemical sensor 400, including short circuits between leads, can be improved.

When the via hole 411 is formed in the distal portion 406, both one side and the other side of the first via hole 411a are blocked from contact with the outside by the insulating layer 416, thereby preventing contamination. One end and the other end of the second via hole 411b may be exposed to the outside through the distal opening 422b.

By the second via hole 411b, the electrode on one side of the base layer 411 and the electrode on the other side of the base layer 411 can be placed and connected to the same electrode type, thereby improving the directionality of the invaded distal portion 406. Regardless, electrochemical reactivity between the electrode 424 and the reactant can be increased.

With reference to FIG. 2, the trench 420 of the present invention will be described.

After the conductive layer 412 is deposited on the base layer 410 using a method such as sputtering, a trench 420 may be formed using a method such as laser etching.

A plurality of conductive islands 430 separated from each other may be provided in the conductive layer 412 by laser etching, etc. Each conductive island 430 forms a closed curved surface and may be electrically insulated from each other.

The base layer 410 is exposed at the bottom of the trench 420, and the adjacent conductive islands 430 may be insulated by the trench 420.

The conductive island 430 of the proximal portion 402 may form a sensor pad 428, and the conductive island 430 of the middle portion 404 or fold 405 may form a lead 426, Conductive island 430 of distal portion 406 may form electrode 424 .

The conductive island 430 includes a conductive island 430 in which parts corresponding to the electrode 424 and the sensor pad 428 are exposed to the outside through a cut portion of the insulating layer 416, and a part exposed to the outside. It can be divided into a dummy part 432 that is entirely covered with an insulating layer 416.

A first conductive island 430a, a second conductive island 430b, and a third conductive island 430c including different electrodes 424 may be formed. The first conductive island 430a may include a first sensor pad 428a in the proximal portion 402, a first lead 426a in the folded portion 405, and a first electrode 424a in the distal portion 406. .

The second conductive island 430b may include a second sensor pad 428b in the proximal portion 402, a second lead 426b in the folded portion 405, and a second electrode 424b in the distal portion 406. . The third conductive island 430c may include a third sensor pad 428c in the proximal portion 402, a third lead 426c in the folded portion 405, and a third electrode 424c in the distal portion 406. .

The first electrode 424a, the second electrode 424b, and the third electrode 424c may be any one of a working electrode, a counter electrode, and a reference electrode.

When forming conductive islands 430 that are separated from each other by forming a closed curved surface, a dummy portion 432 may be formed between the conductive islands 430. The dummy portion 432 can be used as a conductive island 430 with electrodes 424 or sensor pads 428 when the insulating layer is exposed. The dummy portion 432 can be completely removed through repeated laser etching. However, since only electrical insulation needs to be achieved by the trench, there is no need to remove the dummy portion 432. This is another advantage of the present invention.

After forming the trench 420 pattern on the conductive layer 412, when an overly wide dummy portion 432 is formed in the lower part covered with the insulating layer 416, a dummy portion is formed to prevent part of the insulating layer 416 from sinking to the bottom. Portion 432 may remain intact without being removed.

Trench 420 may include an inner trench 420a or an edge trench 420b. The internal trench 420a may insulate the conductive islands 430 from each other. The internal trench 420a may be disposed at least one of the electrodes 424, the leads 426, and the sensor pads 428.

Meanwhile, when the conductive layer 412 is exposed to the edge of the electrochemical sensor 400, the insulation deteriorates, so it is necessary to prevent side exposure of the conductive layer 412. After the conductive layer 412 is laminated, a portion of the conductive layer 412 may be cut along the edge of the electrochemical sensor 400. This is the edge trench 420b. Accordingly, an insulating layer 416 is attached to the edge of the electrochemical sensor 400 on the base layer 410 and can be insulated. An insulating layer 416 may be attached to the inner edge of the electrochemical sensor 400 on the conductive layer 412 stacked on the base layer 410.

The width W1 of the inner trench 420a or the width W2 of the edge trench 420b may range from 5 to 30 μm.

Area A in FIGS. 2 and 3 may represent a portion of the edge trench 420b.

Edge trench 420b may form the outermost edge of conductive layer 412.

The edge trench 420b may prevent the conductive layer 412 from protruding to the side of the electrochemical sensor 400. The edge trench 420b may serve to insulate the conductive island 430 located at the outermost part of the electrochemical sensor 400 from the outside of the sensor 400.

When the electrochemical sensor 400 is processed as an array, the edge trench 420b can prevent short circuits between adjacent sensors 400 or spaced apart adjacent conductive islands 430 from occurring.

The edge trench 420b is created by stacking the conductive layer 412 on the base layer 410 by full-scale sputtering, etc., and then removing the conductive layer 412 at the outer edge of the electrochemical sensor 400 using a laser, etc. You can. All of the conductive layer 410 on the base layer 410 may be cut away, and the base layer 410 may be exposed on the lower surface of the edge trench 420b. Accordingly, the insulating layer 416 or the bonding layer 414 can be directly attached to the edge trench 420b without the conductive layer 412.

A step of the conductive layer 412 may be provided at the edge of the electrochemical sensor 400 by the edge trench 420b.

Referring to FIG. 3, the manufacturing method of the electrochemical sensor 400 of the present invention will be described overall.

The electrochemical sensor manufacturing method includes a conductive layer step of laminating a conductive layer 412 on the flexible base layer 410 of the electrochemical sensor 400, and attaching an insulating layer 416 to the conductive layer 412. An insulating layer step may be included.

The electrochemical sensor manufacturing method may include a via hole step in which a via hole 411 penetrating the base layer 410 is formed.

The via hole 411 may be formed using a laser or mechanical method. The via hole 411 may be formed by a laser etching method that removes a portion of the base layer 410 by irradiating a laser from the laser head 490 to the base layer 410.

The via hole step may be performed before the conductive layer step. The conductive layer forming step may be performed by a physical vapor deposition method including sputtering.

The via hole 411 may include a first via hole 411a and a second via hole 411b.

The first via hole 411a may be blocked from the outside by the insulating layer 416, and at least one of both sides of the second via hole 411b may be exposed to the outside.

The conductive layer step includes a first conductive layer step of forming the conductive layer 412 on one side of the base layer 410, and a second conductive layer step of forming the conductive layer 412 on the other side of the base layer 410. can do.

By the first conductive layer step and the second conductive layer step, the conductive layer 412 is formed into an identical layer that is seamlessly continuous along the top surface of the base layer 410, the surface of the via hole 411, and the back surface of the base layer 410. It can be laminated with metal materials.

This aspect of the present invention is to stack a plurality of layers corresponding to the number of electrodes 424 or the number of sensor pads 428 in order to form the electrodes 424 or sensor pads 428 on the base layer 410. This may be a difference from other technologies. When stacking a plurality of layers corresponding to the number of poles 424 or the number of sensor pads 428 on the electrochemical sensor 400 in which the via hole 411 is formed, several layers are formed around the via hole 411. Seams such as overlapping may occur. When the conductive layer is stacked so that there is a seam such as an overlap, the thickness of the conductive layer around the via hole 411 may be uneven, which may be a factor in increasing the defect rate such as short circuit.

Therefore, the conductive layer of the present invention is one layer or a layer that is the same as one, and may be formed on the inner peripheral surface of the via hole 411, the upper surface of the base layer 410, and the lower surface of the base layer 410, and the via hole 411 ) Short circuit defects such as overlap at both ends can be minimized, and the conduction defect rate of the via hole 411 itself can also be reduced.

In the insulating layer stage, the first via hole 411a may face the insulating layer 416, and the second via hole 411b may face the opening 422 of the insulating layer 416.

The insulating layer 412 may be adhered on the conductive layer 412 with an opening 422 penetrating the insulating layer 412 formed in the insulating layer stage. The electrode 424 may be exposed to the outside through the opening 422 and react with the analyte in the body. Electrodes 424 may be formed on both sides of the distal portion 406.

The electrochemical sensor manufacturing method may include a trench step in which a trench 420 is formed in the conductive layer 412.

The trench 420 may be formed by laser etching, which removes a portion of the conductive layer 412 with a laser irradiated to the conductive layer 412.

If necessary, a heat treatment step may be performed after the conductive layer step or the conductive layer step.

The electrochemical sensor manufacturing method may include a selectively transparent layer step of applying a selectively transparent layer 418 to the opening 422 of the insulating layer 416 by dispensing or the like.

The material of the selective transmission layer 418 may be determined depending on the type of analyte in the body that is to electrochemically react with the electrode 424. For example, in the selectively transparent layer step, a selectively transparent layer containing platinum may be applied to the working electrode, and a selectively transparent layer containing silver chloride may be applied to the reference electrode.

After the selective transmission layer step, a coating process such as a membrane may be additionally performed on the electrochemical sensor 400.

<Electrode placement>

4 to 9, the arrangement of the electrode 424 and the via hole 411 formed in the distal portion 406 of the present invention will be described.

A lead 426 may be provided to electrically connect the electrode 424 of the distal part 406 and the sensor pad 428 of the proximal part 402.

The sensor pad 428 will be described as an example in which the sensor pad 428 is formed to be exposed only on one side of the proximal portion 402.

The width of the lead 426 may be smaller than the width of the electrode 424 or the width of the sensor pad 428.

The direction of invasion in which the distal part 406 is invaded into the body may coincide with the longitudinal direction of the distal part 406, and the width direction of the distal part 406 or the width direction of the lead 426 may be perpendicular to the direction of invasion. there is.

The lid 426 may be provided in at least one of the proximal part 402, the middle part 404, and the distal part 406.

The middle part 404 is located in the middle of the proximal part 402 and the distal part 406, and electrically connects the sensor pad 428 of the proximal part 402 and the electrode 424 of the distal part 406, so the middle part ( In 404), the electrode 424 and the sensor pad 428 may not be disposed, and only the lead 426 may be disposed. This is because the middle portion 404 needs to remain flexible and bent when the electrochemical sensor 400 is invaded into the body for analyte measurement, and this is to reduce the width of the middle portion 404 or the folded portion 405. It can be. The narrower the width of the middle portion 404 or the folded portion 405, the more the torsional force can be reduced, and fatigue failure can be prevented even if the middle portion 404 or the folded portion 405 is bent and fixed for a considerable period of time. You can.

A location closer to the end of the electrochemical sensor 400 may be referred to as the front, and a location less close to the end of the electrochemical sensor 400 than the front may be referred to as the rear. Alternatively, when an electric path connecting the sensor pad 428 of the proximal part 402 and the electrode 424 of the distal part 406 is formed, a position closer to both ends of the electric path is forward, and a position less close to both ends of the electric path than the front. can be called the rear.

The lead 426 may be placed around the rear electrode such that the front electrode of the distal part 406 is electrically connected to the middle part 404 or the proximal part 402, or may be placed alone rather than around the electrode.

The lead 426 disposed on one side of the rear electrode may extend in parallel along the longitudinal direction of the distal portion 406 together with the rear electrode. When the lead 426 is disposed alone, the lead 426 may be connected to the electrode 424 located at the rearmost part of the distal portion 406.

The electrode closer to the end of the distal portion 406 may be referred to as the front electrode, and the electrode less close to the end of the distal portion than the front electrode may be referred to as the rear electrode. The most anterior electrode may mean the one closest to the distal end of the anterior electrodes.

The terms anterior electrode, posterior electrode, and most anterior electrode described below refer to the position of the electrode 424 disposed in the distal portion 406, and mean that at least two electrodes, the anterior electrode and the posterior electrode, are necessarily disposed on both sides. No.

At least one electrode 424 may be provided on both sides of the distal portion 406.

The width of the electrode 424 may not change along the longitudinal direction of the distal portion 406.

The front electrode and the rear electrode adjacent to the front electrode may be formed to completely fill the distal portion 406 in an elongated rectangular shape extending along the longitudinal direction of the distal portion 406.

A fully filled electrode may mean an electrode without lead 426 wiring around the electrode 424 along the length direction of the distal part 406, and the width of the fully filled electrode 424 is equal to the width of the distal part 406. may be substantially the same.

The lead 426 may not be placed around the front-most electrode, and the lead 426 may be placed around the rear electrode that is continuously placed adjacent to the front-most electrode.

The front electrode can be formed to completely fill the area of the distal portion 406 without the surrounding lead 426, thereby increasing the reactivity between the electrode 424 and the analyte in the body. If the lead 426 is formed around the rear electrode adjacent to the front electrode, the via hole 411 may not be formed in the front electrode, and the via hole 411 may be formed in the lead 426 extending backward from the front electrode. You can.

Additionally, fully filling the electrode may mean that the electrode 424 is formed along the width direction of the distal portion 406 except for the edge trench 420b. The width of electrode 424, plus edge trench 420b, may match the width of distal portion 406.

A first edge trench may be formed on one side of the distal portion 406, and a second edge trench may be formed on the other side of the distal portion 406. Along the width direction of the distal portion 406, the first edge trench, the electrode 424, and the second edge trench may be arranged in this order. The width of the first edge trench, the width of the electrode 424, and the width of the second edge trench plus the width of the distal portion 406 may be equal to the width of the distal portion 406.

The arrangement of the first edge trench, the electrode 424, and the second edge trench in that order along the width direction of the distal portion 406 includes at least two different electrodes 424 along the longitudinal direction of the distal portion 406. It can be located in .

The electrode 424 may react with an analyte in the body through the opening 422. Since one electrode 424 is electrically connected, the same selective transmission layer 418 can be applied to the plurality of openings 422 formed in one electrode 424.

A plurality of openings 422 may be formed along the longitudinal direction of the distal portion 406 in at least one of the frontmost electrode and the rear electrode continuously disposed on the frontmost electrode. In this way, the electrode extending along the longitudinal direction of the distal portion 406 and forming a plurality of openings 422 may be referred to as a merge electrode. Conversely, electrodes that do not extend along the longitudinal direction of the distal portion 406 may be referred to as split electrodes. The split electrode may be large enough to form a single circular opening 422 compared to the merged electrode.

The reference electrode may be disposed on the split electrode, and due to the nature of the reference electrode, it may be sufficient to have one opening 422 disposed.

The length of the distal portion 406 of the merged electrode along the invasion direction may be within 2 to 20 times the length of the distal portion 406 of the split electrode along the invasion direction.

Since at least a portion of the distal portion 406 is inserted into the body, the distal portion 406 may be long in the insertion direction and needs to be thin. Accordingly, the distal portion 406 may have a flat rectangular parallelepiped shape, and the cross-section of the electrode 424 formed on the distal portion 406 may have a rectangular shape. The merged electrode may have a rectangular shape extending long along the longitudinal direction of the distal portion 406.

The merge electrode may have a selective transmission layer 418 applied to the opening 422 using a method such as dispensing. When the selective transmission layer 418 is applied to the opening 422 in the shape of a spherical water droplet during the dispensing process, the uniformity of application may be reduced in the single rectangular opening 424, so that a plurality of circular openings 422 are formed. There may be frequent cases where it faces the electrode 424. In the drawings of the present invention, a case in which a plurality of circular openings 422 are formed in the merge electrode is described, but a case in which only one large rectangular opening 422 similar to the merge electrode is formed may also be included.

The merged electrode may be an electrode in which a plurality of openings are provided along the longitudinal direction of the distal portion among the frontmost electrode and the rear electrode continuously disposed on the frontmost electrode.

The merging electrode may be either a working electrode or a counter electrode. The electrode that mainly reacts with the analyte in the body may be the working electrode, and in order to maximize the reactivity with the analyte, it is necessary to secure the maximum area of the working electrode.

A first front electrode, which is the frontmost electrode of the first side, and a first rear electrode adjacent to the first front electrode may be provided on the first side of the distal portion 406, and on the second side of the distal portion 406, A second front electrode, which is the front electrode of the second surface, and a second rear electrode continuously disposed on the second front electrode may be provided.

The lead 426 may not be formed along the longitudinal direction of the distal portion 406 around the first most front electrode on the first side, around the first rear electrode, and around the second most front electrode on the second side. .

The width of the first front electrode plus the width of the edge trench 420b, the width of the first rear electrode plus the width of the edge trench 420b, and the width of the second front electrode plus the edge trench 420b. ) plus the width of the distal portion 406 may match the width of the distal portion 406 .

The width of the second rear electrode, the width of the edge trench 420b, and the width of the lead 426 formed on the second rear electrode plus the width may match the width of the distal portion 406.

An internal trench 420a may be provided to insulate the second rear electrode and the lead 426 formed around the second rear electrode from each other.

The internal trench 420a may function to insulate the objects formed in the electrochemical sensor 400 from each other. Objects insulated from each other by the internal trench 420a may include the lead 426 and the electrode 424. When the lead 426 is formed around the second rear electrode, an internal trench 420a that separates the lead 426 and the second rear electrode from each other may be disposed between the lead 426 and the second rear electrode. .

The width of the second back electrode, the width of the edge trench 420b, the width of the lead 426 formed on the second back electrode, and the width of the inner trench 420a plus the width of the distal portion 406 may match the width of the distal portion 406. there is.

Among the electrodes 424, an electrode that electrically connects the electrodes 424 without forming an opening 422 may be referred to as a dummy electrode. The dummy electrode may have no opening 422 and all contact with the outside is blocked by the insulating layer 416. The dummy electrode may be included in the dummy portion.

Different types of selective transmission layers 418 may be applied to each opening 422 formed corresponding to each electrode 424. A first opening 423a may face the first electrode 424a, and a first selective transmission layer 418a may be applied to the first opening 423a. The same applies to the second electrodes 424b to 5th electrodes 424e, the second openings 423b to 5th openings 423e, and the second selective transmission layers 418b to 5th selective transmission layers 418e. You can.

The dummy electrode may provide a bypass path that allows the electrode on the first side of the distal portion 406 to be energized back to the first side through the electrode on the second side of the distal portion 406.

The dummy electrode can increase the rigidity, such as maintaining the appearance of the electrochemical sensor 400.

FIG. 4 may be a first arrangement of electrodes 424 disposed in the distal portion 406 , and FIG. 7 may be a second disposition of electrodes 424 disposed in the distal portion 406 .

Figure 5 may be a schematic diagram of the entire electrochemical sensor for the first batch.

Figure 6 may show other embodiments of the first arrangement.

Figure 8 may be a schematic diagram of the entire electrochemical sensor for the second arrangement.

Figure 9 may show other embodiments of the second arrangement.

In the first arrangement, the working electrode is disposed on the first side and the counter electrode is disposed on the second side to have the simplest double-sided structure. By arranging the working electrode and the counter electrode on opposite sides with the largest area, the area utilization of each of the working electrode and the counter electrode can be maximized.

Select the reference electrode as the most anterior electrode on the first side, select the working electrode as the first posterior electrode, select the dummy electrode as the second most anterior electrode on the second side, and select the second counter electrode as the second posterior electrode. It can be placed like this.

By viewing both sides of the distal portion 406 vertically and spatially, a reference electrode can be placed between the working electrode and the counter electrode, and the reactivity between the analyte in the body and the electrochemical sensor 400 can be increased. If the via hole 411 is not formed in the base layer 410, the lead 426 connecting the reference electrode to the rear may be formed around the side including the side of the working electrode, which has the effect of reducing the area of the working electrode. I can give it. Accordingly, a via hole 411 can be formed in the base layer 410 corresponding to the reference electrode, and the lead 426 connected to the reference electrode can be placed on the second surface.

If the first front electrode is a reference electrode and it is sufficient to have only one reference electrode, the second front electrode may be formed as a dummy electrode 425, and the dummy electrode 425 may be formed by a via hole 411 connected to the first front electrode. It may be sufficient to have an area that can be connected to. As a result, the area of the counter electrode, which is the second rear electrode, can be expanded.

Meanwhile, if the opening 422 is also formed in the frontmost electrode on the second side, the second frontmost electrode may not be the dummy electrode 425, and the second frontmost electrode may also be disposed as an electrode with the same function as the first front electrode. there is.

A via hole 411 may be formed to connect the electrode on the second side to the lead 426 on the first side. The via hole 411 can be freely placed in any one of the distal part 406, the middle part 404, and the proximal part 402.

When the sensor pad 428 of the proximal portion 402 is installed on the first side of the electrochemical sensor 428, the leads 426 connected to the electrodes of the second side are connected to the distal portion 406, the middle portion 404, and the proximal portion. It may be electrically connected to the lead 426 on the first side or the sensor pad 428 on the first side through the via hole 411 formed in any one of (402).

When the via hole 411 is formed in the distal portion 406, the lead 426 may be formed on only one side of the electrochemical sensor 400 from the portion where the via hole 411 is formed to the sensor pad 428, and on the other side. Since the lead 426 is not formed, lead placement can be simplified.

In order to maximize the electrode area on both sides of the distal part 406 that invades the body, the part connected to the other side through the via hole 411 is formed at the end of the distal part 406 or the beginning of the middle part 404. It can be. Since the via hole 411 is formed by a fine laser process, the electrode 424 on the other side is connected to one side to be connected to the sensor pad 428 formed on one side to quickly and accurately check whether the via hole 411 has been formed properly. The via hole 411 may be formed near the end of the distal portion 406 or the beginning of the middle portion 404.

4 and 5, the third electrode 424c may be the front electrode of the first side of the distal portion 406, and the first electrode 424a may be the rear electrode of the second side of the distal portion 406. You can. The dummy electrode 425 may be a front electrode of the second side, and the second electrode 424b may be a rear electrode of the second side. The third electrode 424c may be the frontmost electrode on the first side, and the dummy electrode 425 may be the frontmost electrode on the second side.

As an example of the first arrangement, the first electrode 424a may be a working electrode, the second electrode 424b may be a counter electrode, and the third electrode 424c may be a reference electrode. The merged electrode may be the working electrode and the counter electrode, and the split electrode may be the reference electrode.

The third electrode 424c on the first side is electrically connected to the dummy electrode 425 on the second side through the via hole 411, and the dummy electrode 425 is a lead extending rearward from the dummy electrode 425. It can be electrically connected to the lead 426 of the middle portion 404 or the sensor pad 428 of the proximal portion 402 through 426, and the lead 426 extending rearward from the dummy electrode 425 is connected to the distal portion ( It can be connected back to the first side through the via hole 411 formed at the rear end or middle portion 404 of 406.

Accordingly, the third electrode 424c on the first side may use the dummy electrode 425, which is the frontmost electrode on the second side, as a bypass path and be connected back to the first side.

When the opening 422 is formed in the second front electrode 425, the same type of analyte can be measured at the second front electrode 425 and the first front electrode 424c. If the second foremost electrode 425 is a dummy electrode 425, the opening 422 may not be formed in the second foremost electrode 425.

A first front electrode 424c and a first rear electrode 423a disposed continuously to the first front electrode 424c may be provided on the first surface of the distal portion 406.

A second front electrode 425 and a second rear electrode 423b disposed continuously to the second front electrode 425 may be provided on the second surface of the distal portion 406.

The lead 426 may not be formed along the longitudinal direction of the distal portion 406 around the first front electrode 424c, around the first rear electrode 423a, and around the second front electrode 425. there is.

Around the second rear electrode 423b, a lead 426 connected backward from the second front electrode 425 may be formed along the longitudinal direction of the distal portion 406.

The width of the first front electrode 424c, the first rear electrode 423a, and the second front electrode 425 on the first side may be substantially equal to the width of the distal portion 406.

The width of the second rear electrode 423b plus the width of the lead 426 connected rearward from the second front electrode 425 may be substantially equal to the width of the distal portion 406.

In addition, an inner trench 420a that insulates and separates the electrode 424 or lead 426, and an edge trench 420b that insulates the individual electrochemical sensors 400 from each other are formed at the outer edge of the electrochemical sensor 400. It can be prepared accordingly.

If the electrode 424 is formed to completely fill the distal portion without a lead, it may be arranged in the order of the first edge trench, the electrode 424, and the second edge trench along the width direction of the distal portion 406. For a packed electrode, the width of the first edge trench, the width of the electrode 424, and the width of the second edge trench plus the width of the distal portion 406 may be equal to the width of the distal portion 406.

If the edge trench 420b forms an outline with a uniform width, the width of the first edge trench 424c may be the same as the width of the second edge trench 420b.

If necessary, an internal trench (not shown) may be formed between the edge trench 420b and the electrode 424. This may be to reliably insulate the outside of the electrode 424 and the individual electrochemical sensor 400. This may be similar to building the inner wall of the inner trench in addition to building the outer wall of the edge trench 420b to insulate the electrode 424.

The trench 420 can be formed to be wide by the repeated reciprocating motion of the laser head, so that, depending on the user's choice, only the edge trench 420b is formed, both the edge trench 420b and the inner trench are formed, or a long trench is formed. Only one edge trench 420b can be formed.

When the internal trench 420a is formed between the edge trench 420b and the electrode 424, the first edge trench 420b, the first internal trench, the electrode 424, and the first edge trench 420b are formed along the width direction of the distal portion 406. It may be arranged in the following order: 2 internal trenches, and a second edge trench 420b. The width of the edge trench 420b, the width of the inner trench, and the width of the electrode 424 plus the width of the distal portion 406 may be equal to the width of the distal portion 406. The information regarding the inner trench 420a adjacent to the edge trench 420b may also be applied to other embodiments.

When a lead 426 connected backward from the front electrode to the electrode 424 is provided around the rear electrode, an internal trench 420a may be provided to insulate the lead 426 from the electrode 423b. This rear electrode has a first edge trench 420b, a lead 426, an inner trench 420a, an electrode 424, and a second edge trench 420b sequentially along the width direction of the distal portion 406. can be arranged.

The first most front electrode 424c, the first rear electrode 423a, and the second most front electrode 425 on the second side may be electrodes that completely fill the distal portion 406. ) may be arranged in the order of the first edge trench 420b, the electrode 424, and the second edge trench 420b along the width direction.

A lead 426 may be formed around the second rear electrode 424b on the second side, and a first edge trench 420b, a lead 426, and an internal trench 420a may be formed along the width direction of the distal portion 406. ), the electrode 424, and the second edge trench 420b may be arranged.

The first front electrode 424c and the first rear electrode 423a can be formed to fill the area of the distal portion 406 without the lead 426, thereby increasing the reactivity between the electrode 424 and the analyte.

The first front electrode 424c may be electrically connected to the second front electrode 425 through the via hole 411. In order to increase the responsiveness of the first front electrode 424c, when the lead 426 is not formed around the first front electrode 424c, the front electrode 425 on the second side is used to electrically connect to the rear. To do this, it may be necessary to form a via hole 411 in the base layer 410 corresponding to the first front electrode 424c.

When the first front electrode 424c is electrically connected to the second front electrode 425 through the via hole 411, the lead 426 connected backward from the second front electrode 425 is connected to the second rear electrode ( It can be electrically connected back to the first surface through the via hole 426 formed at the rear position of 423b) or the via hole 426 formed at the middle portion 404.

In Figure 6(a), the first front electrode 424c on the first side may be electrically connected along the lead on the first side without passing through the via hole 411. In this case, compared to the first rear electrode 424a on the first side, the first front electrode 424b on the second side may be formed to fill the distal portion 406 without the lead 426 around it.

In (b) of FIG. 6, the first front electrode 424a may be a merged electrode, and the first rear electrode 424c may be a split electrode. The first front electrode 424a on the first side may be electrically connected along the lead on the first side without passing through the via hole 411. In this case, compared to the first rear electrode 424a on the first side, the first front electrode 424b on the second side may be formed to fill the distal portion 406 without the lead 426 around it. In this case, the counter electrode may be arranged to fill the distal portion 406 to the maximum extent.

(c) in FIG. 6 may be a case where the positions of the third electrode 424c and the dummy electrode 425 in FIG. 3 are changed. The first front electrode may be the dummy electrode 425, and the second front electrode may be the third electrode 424c. Most effects may be similar to the case of FIG. 3, but there may be differences in that the distance between the reference electrode and the working electrode and the distance between the reference electrode and the counter electrode are different. The reference electrode 424c and the counter electrode 424b may be formed to fill the distal portion 406 without a peripheral lead compared to the working electrode 424a.

(d) in FIG. 6 may be a case where the reference electrode 424c is the second front electrode, which is the front electrode of the second surface. The second front electrode 424c on the second side may be electrically connected along the lead on the second side without passing through the via hole 411. In this case, compared to the second rear electrode 424b on the second side, the first front electrode 424a on the first side may be formed to fill the distal portion 406 without the lead 426 around it. In this case, the working electrode may be positioned to fill the distal portion 406 to its fullest extent.

Referring to FIGS. 7 to 9 , in the second arrangement, a first working electrode may be placed as the frontmost electrode, and a second working electrode may be placed as the rear electrode. The first working electrode and the second working electrode may be long rectangular electrodes having a plurality of openings. In this case, the first working electrode and the second working electrode have their leads disposed on opposite sides through the via hole, so that the first working electrode and the second working electrode can be formed together on the same side and have the same area as each other. This can improve the measurement accuracy of analytes.

The reference electrode may be disposed between the first working electrode and the second working electrode so that the distance between the first working electrode and the reference electrode and the distance between the second working electrode and the reference electrode match. Via holes may be formed in the first working electrode and the reference electrode, and no leads are formed around the first working electrode, the reference electrode, and the second working electrode, so that the area of the distal portion can be maximized. The first working electrode and the reference electrode disposed on the first side are connected along a lead disposed on the second side, which is the opposite side, and are electrically connected back to the first side through a via hole formed in the rear end or middle portion of the distal portion. You can.

In the second arrangement, the first electrode 424a is the first working electrode, the second electrode 424b is the second working electrode, the third electrode 424c is the counter electrode, and the fourth electrode 424d is the reference electrode. It may be an electrode. The merged electrode may be the first working electrode, the second working electrode, and the counter electrode, and the split electrode may be the reference electrode.

Referring to FIGS. 7 and 8 , on the first side of the distal portion 406, there is a front-most electrode 424a, a first rear electrode 424d disposed continuously on the front-most electrode 424a, and a first rear electrode 424d. ) A second rear electrode 424b located further rear may be formed. In this case, a via hole 411 may be provided at a position of the base layer 410 facing the front electrode 424a and a position of the base layer 410 facing the first rear electrode 424d.

This is because the lead 426 may not be disposed around the first rear electrode 424d and the second rear electrode 424b, so the area of the first rear electrode 424d and the area of the second rear electrode 424b can be secured as much as possible, and the area of the first rear electrode 424d and the area of the second rear electrode 424b can fill the area of the distal portion 406.

The frontmost electrode 424a and the first rear electrode 424d on the first side may be connected to the second side through the via hole 411, and the second rear electrode 424b may be connected to the middle portion 404 through the rear lead. It can be connected to . The frontmost electrode 424a, the first rear electrode 424d, and the second rear electrode 424b may be disposed as electrodes that fill the distal portion 406 without the lead 426 around it. The frontmost electrode 424a, the first rear electrode 424d, and the second rear electrode 424b are formed along the width direction of the distal portion 406, the first edge trench 420b, and the electrodes 424a, 424d, and 424b. , and the second edge trench 420b may be arranged in order.

If the electrode on the first side is called an upper electrode, the upper electrode may include a frontmost electrode 424a, a first rear electrode 424d, and a second rear electrode 424b. If the electrode on the second side is called a lower electrode, the lower electrode may include a merge electrode 424c and a peripheral electrode 425.

The frontmost electrode 424a or the first rear electrode 424d on the first side may be connected to the peripheral electrode 425 on the second side through the via hole 411, and a lead connected backward from the peripheral electrode 425 It may be connected to the middle portion 404 along 426.

The merge electrode 424c may extend long from the end of the distal portion 406 to the middle portion 404 without being separated. The peripheral electrode 425 may be formed around the side surface of the merge electrode 424c.

The peripheral electrode 425 or lead 426 is not formed around the sides of the merge electrode 424c, but the first region fills the distal portion 406, and the peripheral electrode 425 is formed around the merge electrode 424c. At least one of a second area formed and a third area formed around the merge electrode 424c with a lead 426 connected backward from the peripheral electrode 425 may be provided.

A plurality of peripheral electrodes 425 may be provided equal to the number of electrodes connected from the first side to the second side through the via hole 411.

When the plurality of peripheral electrodes 425 are provided, a lead connected backward from the first peripheral electrode and a second peripheral electrode are formed around the merge electrode 424c on the second surface of the distal portion 406. A region may be provided, and a fifth region may be provided in which a lead connected backward from the first peripheral electrode and a lead connected backward from the second peripheral electrode are formed.

A sixth region may be provided in which the first peripheral electrode and the second peripheral electrode are formed around the merge electrode 424c. The merged electrode 424c can increase reactivity with the analyte by forming a wide opening 422 along the longitudinal direction of the distal portion 406. Depending on the area design of the opening, the first peripheral electrode and the second peripheral electrode may be located at different locations along the length direction of the merge electrode 424c, or the first peripheral electrode and the second peripheral electrode may be located at the same peripheral location. there is.

In the first region of the distal portion 406, a first edge trench 420b, a merge electrode 424c, and a second edge trench 420b may be disposed along the width direction of the distal portion 406.

In the second region of the distal portion 406, a first edge trench 420b, a first peripheral electrode 425, an inner trench 420a, and a merge electrode 424c are disposed along the width direction of the distal portion 406. It can be.

In the third region of the distal portion 406, along the width direction of the distal portion 406, a first edge trench 420b, a lead 426 connected backward from the first peripheral electrode 425, and an inner trench 420a. , and the merge electrode 424c may be disposed.

In the fourth region of the distal portion 406, along the width direction of the distal portion 406, a first edge trench 420b, a lead 426 connected backward from the first peripheral electrode 425, and a first internal trench ( 420a), a merge electrode 424c, a second internal trench 420a, a second peripheral electrode 425, and a second edge trench 420b may be disposed.

In the fifth region of the distal portion 406, along the width direction of the distal portion 406, a first edge trench 420b, a lead 426 connected backward from the first peripheral electrode 425, and a first internal trench ( 420a), a merge electrode 424c, a second internal trench 420a, a lead 426 connected backward from the second peripheral electrode 425, and a second edge trench 420b may be disposed.

In the sixth region of the distal portion 406, along the width direction of the distal portion 406, a first edge trench 420b, a first peripheral electrode 425, a first inner trench 420a, a merge electrode 424c, A second internal trench 420a, a second peripheral electrode 425, and a second edge trench 420b may be disposed.

The sum of the widths of each element arranged in the first to sixth regions may be equal to the width of the distal portion 406.

Referring to (b) of FIG. 7, upper electrodes 424a, 424b, and 424d may be provided on the upper surface of the distal portion 406, and a first lower electrode 424c may be provided on the lower surface.

The first lower electrode 424c may extend from one end of the distal portion 406 to the other end without being divided. A plurality of openings 422 may be formed throughout the distal portion 406 of the first lower electrode 424c. This first lower electrode 424c is a combined electrode and has the advantage of maximizing the reaction area with analytes in the body.

A second lower electrode 425 may be disposed around the first lower electrode 424c.

The top electrodes 424a and 424b on the upper surface may be electrically connected to the second lower electrode 425 on the lower surface through a via hole 411 penetrating the base layer 410.

At this time, the via hole 411 connecting the first lower electrode 424c and the upper electrodes 424a, 424b, and 424d may not be formed. The via hole 411 that allows the first lower electrode 424c to be electrically connected to the opposite side according to the position of the sensor pad 428 may be formed in the rear position or middle portion 404 of the second rear electrode 424b. You can.

The upper electrode 424a disposed on the upper surface of the distal portion 406 may be electrically connected to the second lower electrode 425 disposed on the lower surface of the distal portion 406 through the via hole 411. The second lower electrode 425 may be electrically connected to the sensor pad 428 along the lead 426 on the lower surface connected backward from the second lower electrode 425.

In addition, the second bottom electrode disposed on the lower surface may be energized to the upper electrode of the upper surface through the via hole, and the upper electrode may be energized to the sensor pad along the lead of the upper surface connected backward from the upper electrode. .

If the second lower electrode 425 is a dummy electrode, the opening 422 may not be formed. The second lower electrode 425 may provide an electrical bypass path for the upper electrodes 424a and 424d. In this case, the area of the second lower electrode 425 may be sufficient if it is an area corresponding to the via hole 411. By narrowing the width of the second lower electrode 425 as much as possible, space for the opening 423c can be secured at the location of the first lower electrode 424c where the second lower electrode 425 is located.

When a plurality of second lower electrodes 425 are provided, the positions of the distal portions 406 of each second lower electrode 425 along the longitudinal direction may be different. This may be to prevent the width of the first lower electrode 423c from becoming too narrow.

When the frontmost electrode 424a and the second rear electrode 424b on the first side are different from each other, such as the first working electrode and the second working electrode, the second back electrode 424a is connected to the frontmost electrode 424a through the via hole 411. The lower electrode 425 and the second lower electrode 425 connected to the first rear electrode 424d and the via hole 411 are located on opposite sides with respect to the center line of the first lower electrode 424c. You can. This may be to minimize interference between the leads 426 electrically connecting the two second lower electrodes 425 and the rear middle portion 404 or the proximal portion 402 and to prevent short circuits between them.

When the front electrode 424a and the second rear electrode 424b on the first side are the same electrode type, the second lower electrode 425 connected to the front electrode 424a and the via hole 411, and the first electrode 425 are connected to the front electrode 424a through the via hole 411. The rear electrode 424d and the second lower electrode 425 connected through the via hole 411 may share a lead 426 that electrically connects the rear middle portion 404 or the proximal portion 402.

8 may be a case where, in the second arrangement, the reference electrode, which is a split electrode, is located between the first and second working electrodes, which are merged electrodes, and in this case, the reference electrode that acts as a detection or sensor is the first working electrode. and the second working electrode, the measurement accuracy of the reference electrode can be increased.

Figure 9(a) may be a case where the first working electrode and the second working electrode, which are merged electrodes, are arranged continuously, and the reference electrode, which is a split electrode, is located at the rearmost, and Figure 9(b) is a merged electrode. This may be the case where the first working electrode and the second working electrode are arranged sequentially, and the reference electrode, which is a split electrode, is located at the frontmost position.

8 and 9, the first lower electrode 424c, which is a merge electrode that extends from one end of the distal portion 406 without being divided to the other end and has a plurality of openings 422 formed throughout the distal portion 406, is highlighted. For this purpose, only the case where only one merged electrode is shown on the second side is shown, but the discussion can be expanded and applied to cases where split electrodes or merged electrodes are additionally located on part of the second side.

100... inserter 102... driving unit
200... transmitter 202... main board
300... needle 310... needle handle
400... electrochemical sensor 402... proximal
404... middle part 405... folded part
406... distal 410... basal layer
411... via hole 411a... first via hole
411b... second via hole 412... conductive layer
414...bonding layer 416...insulating layer
418... selectively transparent layer 420... trench
420a...inner trench 420b...edge trench
422... opening 422a... proximal opening
422b... distal opening 423a... first opening
423b... second opening 423c... third opening
423d... fourth opening 424... electrode
424a... first electrode 424b... second electrode
424c... third electrode 424d... fourth electrode
424e... fifth electrode 425... dummy electrode
426...lead
426a... first lead 426b... second lead
426c... 3rd lead 426d... 4th lead
428... sensor pad
428a... first sensor pad 428b... second sensor pad
428c... 3rd sensor pad 428d... 4th sensor pad
430... conductive island
430a... first conductive island 430b... second conductive island
430c... third conductive island 432... dummy portion
432a... first dummy portion 432b... second dummy portion
490...laser head W1,W2...trench width

Claims (14)

An electrochemical sensor including a distal part formed with a plurality of electrodes that react with analytes in the body, a proximal part formed with a sensor pad connected to the electrodes, and an intermediate part located between the distal part and the proximal part;
A transmitter including a main board on which at least one of a power supply unit, a communication unit, and a control unit is formed, a housing in which the main board is stored, and attached to the skin; Including,
The electrochemical sensor includes a flexible base layer, a conductive layer laminated on the base layer, and an insulating layer attached on the conductive layer,
The electrode closer to the end of the distal part is called the front electrode, and the electrode less close to the end of the distal part than the front electrode is called the back electrode,
The most anterior electrode is the one closest to the distal end of the anterior electrodes,
A continuous analyte measuring device in which the electrodes are provided on both sides of the distal portion.
According to claim 1,
At least one of the front electrode disposed on one surface of the distal portion and the rear electrode disposed continuous with the front electrode has a long rectangular shape extending along the longitudinal direction of the distal portion,
The front electrode and the rear electrode disposed continuously to the front electrode are formed to completely fill the distal portion along the width direction.
According to claim 1,
The conductive layer is a continuous analyte measuring device including a double-sided conductive layer in which metal is sputtered on both the upper and rear surfaces of the base layer where the via hole is formed and the via hole.
According to claim 1,
A lead is formed in the distal portion to electrically connect the electrode and the sensor pad,
The width of the lead is smaller than the width of the electrode,
A continuous analyte measuring device in which the lead is not formed along the longitudinal direction of the distal portion around the front electrode and around the rear electrode adjacent to the front electrode.
According to claim 1,
A continuous analyte meter wherein the width of the front electrode and the width of a rear electrode adjacent to the front electrode are consistent with the width of the distal portion.
According to claim 1,
The conductive layer is laminated on the base layer by full sputtering,
An edge trench is provided by removing a portion of the conductive layer corresponding to the outer edge of the electrochemical sensor,
A first edge trench is formed on one side of the distal portion, and a second edge trench is formed on the other side of the distal portion,
Along the width direction of the distal portion, the first edge trench, the electrode, and the second edge trench are arranged in that order,
The width of the first edge trench, the width of the electrode, and the width of the second edge trench plus the width of the distal portion is equal to the width of the distal portion.
According to claim 1,
The conductive layer is laminated on the base layer by full sputtering,
An edge trench is provided by removing a portion of the conductive layer corresponding to the outer edge of the electrochemical sensor,
The remainder excluding the edge trench along the width direction of the distal portion is filled with the electrode,
The width of the edge trench plus the width of the electrode is equal to the width of the distal portion,
The arrangement of the edge trench and the electrode in the width direction of the distal portion is a continuous analyte measuring device in which both the front electrode and the rear electrode adjacent to the front electrode are disposed.
According to claim 1,
An opening is formed in the insulating layer to expose a portion of the electrode to the outside,
At least one of the frontmost electrode and the rear electrode adjacent to the frontmost electrode has a long rectangular shape extending along the longitudinal direction of the distal portion,
A continuous analyte measuring device in which a plurality of openings are formed in at least one of the front electrode and the rear electrode adjacent to the front electrode, along the longitudinal direction of the distal portion.
According to claim 1,
The electrode is one of a working electrode (WE), a counter electrode, and a reference electrode,
An opening is formed in the insulating layer to expose a portion of the electrode to the outside,
Among the front electrode and the rear electrode continuously disposed on the front electrode, the electrode in which the openings are provided in plural numbers along the longitudinal direction of the distal portion is one of a working electrode and a counter electrode. Continuous analyte measuring device.
According to claim 1,
A via hole is provided to electrically connect electrodes on both sides of the distal portion,
The via hole is formed to penetrate the base layer,
The via hole is a continuous analyte measuring device provided at a position facing the front electrode.
According to claim 1,
A first front electrode, which is the frontmost electrode of the first side, and a first rear electrode disposed continuously to the first front electrode are provided on the first surface of the distal portion,
The second surface of the distal portion is provided with a second most anterior electrode, which is the most anterior electrode of the second surface, and a second rear electrode disposed continuously to the second most anterior electrode,
A lead is provided to electrically connect the electrode and the sensor pad,
The width of the lead is smaller than the width of the electrode,
The lead is not formed along the longitudinal direction of the distal portion around the first most anterior electrode, around the first rear electrode, and around the second most anterior electrode,
Around the second posterior electrode, a lead connected backward from the second most anterior electrode is formed along the longitudinal direction of the distal portion,
The width of the first most anterior electrode, the width of the first posterior electrode, and the width of the second most anterior electrode are consistent with the width of the distal portion,
A continuous analyte meter in which the width of the second posterior electrode plus the width of a lead connected posteriorly from the second most anterior electrode is equal to the width of the distal portion.
According to claim 1,
A first front electrode, which is the frontmost electrode of the first side, and a first rear electrode disposed continuously to the first front electrode are provided on the first surface of the distal portion,
The second surface of the distal portion is provided with a second most anterior electrode, which is the most anterior electrode of the second surface, and a second rear electrode disposed continuously to the second most anterior electrode,
A lead is provided to electrically connect the electrode and the sensor pad,
The width of the lead is smaller than the width of the electrode,
The lead is not formed along the longitudinal direction of the distal portion around the first most anterior electrode, around the first rear electrode, and around the second most anterior electrode,
The conductive layer is laminated on the base layer by full sputtering,
An edge trench is provided by removing a portion of the conductive layer corresponding to the outer edge of the electrochemical sensor,
An internal trench is provided to insulate the second rear electrode and the leads formed around the second rear electrode from each other,
The width of the first front electrode plus the width of the edge trench, the width of the first rear electrode plus the width of the edge trench, and the width of the second front electrode plus the width of the edge trench are: Matches the width of the distal part,
The width of the second back electrode, the width of the edge trench, the width of the lead formed on the second back electrode, and the width of the inner trench plus the width of the distal portion is equal to the width of the distal portion.
According to claim 1,
A via hole is provided to electrically connect electrodes on both sides of the distal portion,
The via hole is formed to penetrate the base layer,
On one surface of the distal portion, the frontmost electrode, a first rear electrode disposed continuously to the front electrode, and a second rear electrode located further rear than the first rear electrode are formed,
A continuous analyte measuring device in which via holes are provided at a position of the base layer facing the front electrode and a position of the base layer facing the first rear electrode.
According to claim 1,
An upper electrode is provided on the upper surface of the distal part, and a first lower electrode is provided on the lower surface of the distal part,
The first lower electrode extends without being divided from one end of the distal portion to the other end,
A second lower electrode is disposed around the first lower electrode,
The upper electrode is electrically connected to the second lower electrode through a via hole penetrating the base layer.

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