KR20240034430A - Apparatus and method for producing PVA hydrogel for ultrasonic acoustic bonding - Google Patents

Abstract

An apparatus for producing a PVA hydrogel for ultrasonic acoustic bonding according to an embodiment of the present invention includes a first mixed solvent in which water and dimethyl sulfoxide (DMSO) are mixed, and water and polyethylene glycol (PEG). A solvent producer for producing at least one solvent among the mixed second mixed solvents; The solvent discharged from the solvent generator is introduced, polyvinyl alcohol (PVA) is added through an input path different from that of the solvent, and then the stirrer generates a PVA solution by stirring the solvent and polyvinyl alcohol. ; A deaeration device that receives the PVA solution from the stirrer and removes internal air from the PVA solution; A mold into which the PVA solution discharged from the deaerator is injected into the internal space; And when the molding mold is input, a chamber that causes the molding mold to undergo a curing process so that the PVA hydrogel is molded in the inner space of the molding mold; wherein the PVA hydrogel is a solvent that forms the PVA solution. Depending on the type, it can be neutralized through a neutralization process.

Description

Apparatus and method for producing PVA hydrogel for ultrasonic acoustic bonding}

The present invention relates to an apparatus and method for manufacturing PVA hydrogel for ultrasonic sound bonding, and more specifically, to PVA for ultrasonic sound bonding in a semi-solid state to ensure that ultrasound generated by an ultrasonic generator is easily transmitted to biological tissue without being scattered. It relates to an apparatus and method for producing PVA hydrogel for ultrasonic acoustic bonding that can produce hydrogel.

Ultrasound refers to sound waves that exceed the human audible frequency band, and is currently used for various medical diagnoses.

For example, focused ultrasound, which is used for the purpose of non-invasively heating tumor tissue to cause necrosis, or focusing ultrasound energy on the desired focus, is transmitted to the brain or peripheral nerve tissue to non-invasively improve the function of these nerve tissues. It is used as a control method.

At this time, the focused ultrasound waves used are generated by an ultrasonic generator, and when the ultrasonic generator is used on the human body, a space may be created between the device and the human skin. As a result, the ultrasonic waves cannot penetrate the space, so air is removed to fill the space. A method is used in which a bag filled with water (deaerated water) or a human body is immersed in water from which air has been removed.

However, when degassed water is used to transmit the ultrasonic waves from the ultrasonic generator to biological tissue, there is a problem that it takes a long time to generate degassed water, so a lot of time is required before treatment of biological tissue, and at the same time, degassed water is Due to its nature, there was a problem that caused inconvenience in handling.

Republic of Korea Intellectual Property Office Registered Patent Publication KR101143645 B1 Republic of Korea Intellectual Property Office Registered Patent Publication KR101190910 B1

Therefore, the present invention was devised to improve the problems of degassed water as described above. According to one embodiment of the present invention, the purpose of the present invention is to replace conventional degassed water, which causes inconvenience in production time and handling. To provide an apparatus and method for manufacturing PVA hydrogel for ultrasonic-acoustic bonding, which can produce PVA hydrogel for ultrasonic-acoustic bonding in a semi-solid state so that the ultrasonic waves generated by an ultrasonic generator are not scattered and are easily transmitted to biological tissues. .

In particular, the purpose of the present invention is to combine ultrasonic sound with various degrees of ultrasonic penetration and transparency by subjecting a PVA solution based on polyvinyl alcohol (PVA), which is environmentally friendly and harmless to the human body, to curing and neutralizing processes at various temperatures. To provide a PVA hydrogel manufacturing apparatus and method for ultrasonic acoustic bonding that can manufacture PVA hydrogel for ultrasonic acoustic bonding.

However, the technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly apparent to those skilled in the art from the description below. It will be understandable.

In order to achieve the above object, a PVA hydrogel manufacturing apparatus for ultrasonic acoustic bonding according to an embodiment of the present invention includes a first mixed solvent in which water and dimethyl sulfoxide (DMSO) are mixed, water and A solvent producer for producing at least one solvent among a second mixed solvent containing polyethylene glycol (PEG); The solvent discharged from the solvent generator is introduced, polyvinyl alcohol (PVA) is added through an input path different from that of the solvent, and then the stirrer generates a PVA solution by stirring the solvent and polyvinyl alcohol. ; A deaeration device that receives the PVA solution from the stirrer and removes internal air from the PVA solution; A mold into which the PVA solution discharged from the deaerator is injected into the internal space; And when the molding mold is input, a chamber that causes the molding mold to undergo a curing process so that the PVA hydrogel is molded in the inner space of the molding mold; wherein the PVA hydrogel is a solvent that forms the PVA solution. Depending on the type, it can be neutralized through a neutralization process.

In addition, the method for producing PVA hydrogel for ultrasonic sound bonding performed by the PVA hydrogel production device for ultrasonic sound bonding includes a) a solvent producer comprising a first mixed solvent in which water and dimethyl sulfoxide are mixed, and water and polyethylene. Preparing at least one solvent among a second mixed solvent containing glycol; b) generating a PVA solution by using a stirrer to stir the solvent input from the solvent generator and polyvinyl alcohol input through an input path different from that of the solvent; c) a deaerator receiving the PVA solution from the stirrer and removing the internal air of the PVA solution; d) injecting the PVA solution discharged from the deaerator into the inner space of the mold; e) when the mold is introduced into the chamber, the chamber causes the mold to undergo a curing process so that the PVA hydrogel is formed in the inner space of the mold; and f) after the PVA hydrogel is discharged from the mold, the PVA hydrogel is neutralized through a neutralization process depending on the type of solvent constituting the PVA solution.

According to one embodiment of the present invention, the present invention replaces the conventional degassed water, which is inconvenient in terms of production time and handling, and provides a semi-solid product for easily transmitting ultrasonic waves generated by an ultrasonic generator to biological tissues without scattering. It has the effect of providing users with an apparatus and method for manufacturing PVA hydrogel for ultrasonic sound bonding that can produce PVA hydrogel for ultrasonic sound bonding.

In addition, the present invention allows the polyvinyl alcohol-based PVA solution, which is environmentally friendly and harmless to the human body, to undergo a curing and neutralization process at various temperatures to produce PVA hydrogels for ultrasonic sound bonding with various degrees of ultrasonic penetration and transparency. It has the effect of providing users with an apparatus and method for manufacturing PVA hydrogel for ultrasonic acoustic bonding.

However, the effects that can be obtained from the present invention are not limited to the effects mentioned above, and other effects not mentioned above will be clearly understood by those skilled in the art from the description below. You will be able to.

Figure 1 is a diagram showing the components of a PVA hydrogel production apparatus according to an embodiment of the present invention.
FIG. 2 is a diagram showing the types of solvent and components of the solvent that can be produced from the solvent producer shown in FIG. 1.
Figure 3 is a diagram showing the production process of the first PVA solution based on the first mixed solvent shown in Figure 2.
Figure 4 is a diagram showing the production process of the second PVA solution based on the second mixed solvent shown in Figure 2.
Figure 5 is a diagram showing an example of the mold shown in Figure 1.
FIG. 6 is a diagram showing the types of components and operation modes of the chamber shown in FIG. 1.
Figure 7 is a diagram showing the neutralization process of the PVA hydrogel molded from the mold shown in Figure 5.
Figure 8 is a diagram showing the use state of the PVA hydrogel molded from the mold shown in Figure 5.
Figure 9 is a diagram showing a PVA hydrogel manufacturing method performed by the PVA hydrogel manufacturing apparatus according to an embodiment of the present invention.
Figure 10 is a diagram showing the detailed process of the solvent preparation step for producing the first mixed solvent.
Figure 11 is a diagram showing the detailed process of the solvent preparation step for producing the second mixed solvent.
Figure 12 is a diagram showing the detailed process of the PVA solution generation step shown in Figure 9.
Figure 13 is a diagram showing the detailed process of the curing step shown in Figure 9.
Figure 14 is a diagram showing the detailed process of the neutralization step shown in Figure 9.

Hereinafter, with reference to the attached drawings, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, since the description of the present invention is only an example for structural or functional explanation, the scope of the present invention should not be construed as limited by the examples described in the text. In other words, since the embodiments can be modified in various ways and can have various forms, the scope of rights of the present invention should be understood to include equivalents that can realize the technical idea. In addition, the purpose or effect presented in the present invention does not mean that a specific embodiment must include all or only such effects, so the scope of the present invention should not be understood as limited thereby.

The meaning of terms described in the present invention should be understood as follows.

Terms such as “first” and “second” are used to distinguish one component from another component, and the scope of rights should not be limited by these terms. For example, a first component may be named a second component, and similarly, the second component may also be named a first component. When a component is referred to as being “connected” to another component, it should be understood that it may be directly connected to the other component, but that other components may also exist in between. On the other hand, when a component is referred to as being “directly connected” to another component, it should be understood that there are no other components in between. Meanwhile, other expressions that describe the relationship between components, such as "between" and "immediately between" or "neighboring" and "directly neighboring" should be interpreted similarly.

Singular expressions should be understood to include plural expressions, unless the context clearly indicates otherwise, and terms such as “comprise” or “have” refer to the specified features, numbers, steps, operations, components, parts, or them. It is intended to specify the existence of a combination, and should be understood as not excluding in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

All terms used herein, unless otherwise defined, have the same meaning as commonly understood by a person of ordinary skill in the field to which the present invention pertains. Terms defined in commonly used dictionaries should be interpreted as consistent with the meaning they have in the context of the related technology, and cannot be interpreted as having an ideal or excessively formal meaning unless clearly defined in the present invention.

PVA hydrogel manufacturing device for ultrasonic acoustic bonding

Figure 1 is a diagram showing the components of a PVA hydrogel production apparatus according to an embodiment of the present invention.

Referring to Figure 1, the PVA hydrogel manufacturing apparatus (1, hereinafter referred to as 'PVA hydrogel manufacturing apparatus (1)') for ultrasonic acoustic bonding according to an embodiment of the present invention is a semi-solid PVA hydrogel. To manufacture (43), it includes a solvent producer (10), a stirrer (20), a deaerator (30), a mold (40), and a chamber (50).

In one embodiment, the solvent producer 10 produces a solvent to be added to the stirrer 20 through heat treatment or the like. The types of solvents to be produced in the solvent producer 10 are as shown in FIG. 2.

FIG. 2 is a diagram showing the types of solvent and components of the solvent that can be produced from the solvent producer shown in FIG. 1.

Referring to FIG. 2, the solvent that can be produced by the solvent manufacturer 10 may be the first mixed solvent 11 and the second mixed solvent 12.

That is, in one embodiment, the solvent producer 10 can produce at least one solvent among the first mixed solvent 11 and the second mixed solvent 12, and the solvent mentioned below is the first mixed solvent 11. ) and the second mixed solvent 12.

In one embodiment, the first mixed solvent 11 is formed when water 11a, dimethyl sulfoxide (DMSO, hereinafter referred to as '11b'), and preservative 11c are added to the solvent generator 10. It can be manufactured from the solvent manufacturing machine 10.

In one embodiment, the water 11a may be purified water (or ultrapure water) from which all impurities such as dissolved ions, solid particles, microorganisms, organic matter, and dissolved gases contained in water have been removed.

In one embodiment, dimethyl sulfoxide (11b) is a colorless liquid and an industrial solvent that has been proposed as an effective analgesic and anti-inflammatory agent for arthritis and bursitis, as well as a penetrating solvent that improves the absorption of therapeutic agents in the skin.

The preservative 11c may be at least one of hexanediol, parabens, phenoxyethanol, imidazolidinyl urea, sorbic acid, and salicylic acid to prevent shrinkage and decay of the PVA hydrogel 43.

In one embodiment, the preservative 11c may be prepared with hexanediol, an effective preservative that is biologically safe and good for the skin.

In one embodiment, the weight ratio of the first mixed solvent 11 is 40 to 60 wt% of water (11a), 40 to 60 wt% of dimethyl sulfoxide (11b), and the remainder is a preservative (11a) based on 100 wt%. 11c).

In one embodiment, the second mixed solvent 12 is the solvent when water 12a, polyethylene glycol (PEG, hereinafter referred to as '12b'), and preservative 12c are added to the solvent generator 10. It can be manufactured from the manufacturing machine 10.

In one embodiment, the water 12a may be the same purified water as the water 11a for preparing the first mixed solvent 11.

In one embodiment, polyethylene glycol (12b) is produced by polycondensation of ethylene glycol and is an amphiphilic polymer that is highly soluble in organic solvents and water.

In one embodiment, the preservative (12c) is the same as the preservative (11c) for preparing the first mixed solvent 11, at least one of hexanediol, parabens, phenoxyethanol, imidazolidinyl urea, sorbic acid, and salicylic acid. It could be one.

In one embodiment, the weight ratio of the second mixed solvent 12 is 70 to 95 wt% of water (12a), 5 to 30 wt% of polyethylene glycol (12b), and the remainder is preservative (12c) based on 100 wt%. It can be.

In one embodiment, the stirrer 20 generates a PVA solution by stirring the solvent discharged from the solvent generator 10 and polyvinyl alcohol (PVA, hereinafter referred to as '21'), and the stirrer 20 The process of generating the PVA solution is as shown in Figures 3 and 4.

Figure 3 is a diagram showing the production process of the first PVA solution based on the first mixed solvent shown in Figure 2, and Figure 4 is a diagram showing the production of the second PVA solution based on the second mixed solvent shown in Figure 2 This is a drawing showing the process.

Referring to FIG. 3, when the solvent discharged from the solvent generator 10 is the first mixed solvent 11, the stirrer 20 mixes polyvinyl through an input path different from that of the first mixed solvent 11. After adding alcohol 21, the first mixed solvent 11 and polyvinyl alcohol 21 may be stirred to produce a first PVA solution 22.

Referring to FIG. 4, when the solvent discharged from the solvent generator 10 is the second mixed solvent 12, the stirrer 20 mixes polyvinyl through an input path different from that of the second mixed solvent 12. After adding alcohol 21, the second mixed solvent 12 and polyvinyl alcohol 21 may be stirred to produce a second PVA solution 23.

In one embodiment, the stirrer 20 adds 5 to 10 wt% of polyvinyl alcohol 21 based on the total weight of the solvent introduced from the solvent generator 10, and then stirs at a temperature between 90 ° C. and 130 ° C. The first PVA solution 22 or the second PVA solution 23 can be produced by stirring the solvent and polyvinyl alcohol 21 for more than 90 minutes.

That is, in one embodiment, the stirrer 20 may produce at least one PVA solution of the first PVA solution 22 and the second PVA solution 23, and the PVA solution mentioned below is the first PVA solution ( 22) and the second PVA solution (23).

In one embodiment, the stirrer 20 is configured to mix the first mixed solvent 11 or the second mixed solvent 12 when 100 L or more of the first mixed solvent 11 or the second mixed solvent 12 is added. An antifoaming agent (24) is added to remove air bubbles (or bubbles) generated in the PVA solution during the stirring process of the polyvinyl alcohol (21).

In one embodiment, the stirrer 20 removes air bubbles from the PVA solution through the antifoam agent 24, thereby preventing bubbles from being generated in the PVA hydrogel 43 and simultaneously destroying air bubbles generated in the PVA solution. The molding process of PVA hydrogel (43), which will be carried out later, will be improved.

In one embodiment, the stirrer 20 does not necessarily add the antifoaming agent 24 when 100 L or more of the first mixed solvent 11 or the second mixed solvent 12 is added, and the stirrer 20 does not necessarily add the antifoaming agent 24, but rather removes the bubbles generated in the PVA solution. If the amount is determined to be added, the antifoaming agent 24 can be added to the PVA solution.

In one embodiment, whether or not the defoaming agent 24 is introduced into the stirrer 20 is determined by the user checking the bubbles generated in the PVA solution with the naked eye from the upper side of the stirrer 20, or by a photographing means installed in the stirrer 20 ( It can be determined based on the amount of air bubbles identified through the process of photographing the PVA solution with an image camera, etc.).

In one embodiment, the defoamer 24 may be at least one of a silicone defoamer, a mineral oil defoamer, and a polymer defoamer.

Referring again to FIG. 1, when the PVA solution discharged from the stirrer 20 is introduced into the internal space, the deaerator 30 removes the internal air of the PVA solution introduced into the internal space.

In one embodiment, the PVA solution is discharged from the stirrer 20 and before being introduced into the inner space of the deaerator 30, containing urea, thiourea, creatinine, cyanuric acid, alkyl hydantoin, mono- or di- It can be stabilized by adding a stabilizer that can be selected from the group consisting of ethanolamine, organic sulfonamide, biuret, sulfamic acid, organic sulfamate, and melamine.

In one embodiment, the stabilization time of the PVA solution may be at least 10 minutes, and the PVA solution may be maintained at a temperature between 90° C. and 130° C. during the stabilization process.

In one embodiment, the deaerator 30 may be a vacuum deaerator for removing internal air from the PVA solution. However, the deaeration device 30 is not limited to the vacuum deaeration device described above, and may be replaced with another device capable of removing the internal air of the PVA solution.

The mold 40 is injected into the inner space of the PVA solution from which the internal air discharged from the deaerator 30 has been removed. The structure of the mold 40 for injecting the PVA solution into the inner space is shown in Figure 5. As shown.

Figure 5 is a diagram showing an example of the mold shown in Figure 1.

Referring to Figure 5, the mold 40 is molded (or converted) into a PVA hydrogel 43 when the PVA solution injected into the internal space undergoes a curing process within the chamber 50. This PVA hydrogel ( In order to mass-produce 43), a stack structure may be formed in which a plurality of mold bodies each having an internal space into which the PVA solution is injected are stacked.

In one embodiment, the mold 40 has a stack structure in which the first mold body 41 is disposed at the lowest layer, and the second mold body 42 is stacked on the upper side of the first mold body 41. It can be done with

Here, the mold 40 is described as a stack of the first and second mold bodies 41 and 42 for convenience in explaining the stack structure, but this is not limited, and for mass production of the PVA hydrogel 43 Although not shown in the drawings, it would be preferable to have a stack structure in which not only the first and second mold bodies 41 and 42 but also a plurality of separately provided mold bodies are further stacked.

In one embodiment, the mold 40 includes the upper and lower sides of the second mold body 42 and the remaining mold bodies excluding the first mold body 41 of the lowest layer and the mold body of the uppermost layer forming a stack structure. In the form of an opening, a PVA solution flowing part is provided to receive the PVA solution from the upper mold body and inject the PVA solution into the lower mold body, so that the PVA solution is injected into each mold through a single PVA solution injection process. It is injected into the internal space of the main body (41, 42).

In one embodiment, the mold 40 may be provided with an air removal unit that communicates with the internal space of each mold body 41 and 42, although not shown in the drawings.

In one embodiment, the air removal unit of the mold 40 removes the air in the inner space of each mold body 41 and 42 before the PVA solution is injected into the inner space of each mold body 41 and 42. By doing so, the internal space of each mold body 41 and 42 is kept in a vacuum state.

In this configuration, when the PVA solution is injected into the inner space of each mold body (41, 42), bubbles are formed in the PVA solution by the air remaining in the inner space of each mold body (41, 42). To block the occurrence of a closed space in the inner space of each mold body (41, 42) where the PVA solution is not injected by air into the inner space of each mold body (41, 42). It is for this purpose.

In one embodiment, the mold 40 is not shown in the drawings, but when the internal space of each mold body 41 and 42 is brought into a vacuum state by the air removal unit, each mold body 41 and 42 It can be connected to a bubble removal unit to remove residual bubbles of the PVA solution injected into the internal space of the.

In one embodiment, the bubble removal unit may be equipped with a vacuum pump for processing the PVA solution in a low vacuum state (e.g., 1/1000 mmHg), and the vacuum pump is installed inside each mold body 41 and 42. When communicating with the space, the PVA solution injected into the inner space of each mold body (41, 42) is treated in a low vacuum state to remove air bubbles in the PVA solution injected into the inner space of each mold body (41, 42). ensure that is removed.

In one embodiment, the mold 40 is used for molding the PVA hydrogel 43 when bubbles in the PVA solution injected into the inner space of each mold body 41 and 42 are removed by the bubble removal unit. It is put into the internal space of the chamber 50.

In one embodiment, the mold 40 may be provided in each mold body 41 and 42 with a discharge means for discharging the PVA hydrogel 43, which has been molded by the chamber 50, to the outside.

The chamber 50 is preferably provided with a means for introducing the mold 40 into the inner space.

In one embodiment, the chamber 50 proceeds with the curing process according to the type of solvent that makes up the PVA solution so that the PVA hydrogel 43 in a semi-solid state is molded in the inner space of each mold body 41 and 42. Components for molding the PVA hydrogel 43 are as shown in FIG. 6.

FIG. 6 is a diagram showing the types of components and operation modes of the chamber shown in FIG. 1.

Referring to FIG. 6, the chamber 50 includes an input unit 51 capable of inputting a signal, and is operated in a curing mode 52 according to a signal input from the input unit 51. A temperature control unit 53 for controlling the temperature of the internal space of the chamber 50 into which the mold 40 is introduced so that the curing process is implemented, and a control unit 54 for controlling the operation of the temperature control unit 53. ) includes.

The input unit 51 is provided with a signal input means for operating the chamber 50 in the hardening mode 52. The signal input means is a first signal input means for operating the chamber 50 in the freeze hardening mode 52a. It may be composed of a means, a second signal input means for operating the chamber 50 in the low temperature curing mode (52b), and a third signal input means for operating the chamber 50 in the room temperature curing mode (52c).

In one embodiment, the input unit 51 is a fourth signal input for inputting information about the type of solvent constituting the PVA solution injected into the inner space of the mold 40, as well as the operation input of the curing mode 52. Additional means may be provided

In one embodiment, the first, second, third, and fourth signal input means of the input unit 51 are devices (e.g., buttons) that enable direct signal input by the user, or communicate with a terminal provided by the user to communicate with the terminal (e.g., : It may be a communication device that operates the chamber 50 in the curing mode 52 through a remote method based on a signal transmitted from a smartphone, tablet, computer, etc.).

In one embodiment, the chamber 50 receives a fourth signal while information on the curing mode 52 is input from at least one of the first, second, and third signal input means before the PVA hydrogel 43 is molded. When information about the type of solvent is input from the input means, the ultrasonic wave of the PVA hydrogel 43 to be molded when the mold 40 goes through the curing process is based on the information input from each signal input means of the control unit 54. After conducting a simulation to provide the user with the degree of transparency and transparency, the mold 40 undergoes a curing process within the chamber 50.

In one embodiment, the control unit 54 may be configured with an algorithm for simulating the degree of ultrasonic transmission and transparency of the PVA hydrogel 43, and the chamber 50, although not shown in the drawing, may be configured to simulate the PVA hydrogel that is the result of the simulation. (43) A display may be provided to output the degree of ultrasonic transmission and transparency.

In one embodiment, the display of the chamber 50 outputs the degree of ultrasonic transmission and transparency of the PVA hydrogel 43 according to the results of the simulation, thereby providing the user with information about the degree of ultrasonic transmission and transparency of the PVA hydrogel 43. can be provided to.

In one embodiment, the settings of the chamber 50 may be changed through the input unit 51 so that the simulation process of the control unit 54 is omitted. In other words, the simulation process of the control unit 54 may not necessarily be a process.

In one embodiment, the curing mode 52 is divided into a freeze curing mode (52a), a low temperature curing mode (52b), and a room temperature curing mode (52c) to produce PVA hydrogels (43) with different degrees of ultrasonic penetration and transparency. can be distinguished.

In one embodiment, the freeze hardening mode 52a is an operation mode of the chamber 50 for allowing the mold 40 inserted into the internal space of the chamber 50 to undergo a freeze hardening process at a temperature of -5 to -20 ° C. You can.

In one embodiment, the low-temperature curing mode 52b may be an operation mode of the chamber 50 for allowing the mold 40 inserted into the internal space of the chamber 50 to undergo a low-temperature curing process of 1 to 5 ° C. .

In one embodiment, the room temperature curing mode 52c may be an operation mode of the chamber 50 for allowing the mold 40 inserted into the internal space of the chamber 50 to undergo a room temperature curing process of 18 to 25 ° C. .

When a signal is input to at least one of the first, second, and third signal input means of the input unit 51, the temperature control unit 53 operates the chamber 50 in the freeze curing mode 52a or the low temperature curing mode. The temperature of the internal space of the chamber 50 is adjusted to operate in at least one of the operation modes 52b and room temperature curing mode 52c.

In one embodiment, the temperature control unit 53 is a control unit that receives a signal from the signal input means when a signal is input to at least one of the first, second, and third signal input means of the input unit 51. The operation can be controlled by (54).

The control unit 54 not only controls the operation of the temperature control unit 53, but also controls the operation of the chamber 50, including turning the power on/off (oN/off) of the chamber 50 and inserting the mold 40. It is preferable to understand it as a device that controls the entire operation.

In one embodiment, the control unit 54 is provided in the chamber 50 or a terminal (e.g., a smartphone, tablet, computer, etc.).

In one embodiment, the chamber 50, according to the curing mode 52 set by the control unit 54, is a PVA hydrogel (PVA hydrogel) having different degrees of ultrasonic transmission and transparency in the molding mold 40 inserted into the internal space as follows. 43) is formed.

Below, the degree of ultrasonic transmission of the PVA hydrogel 43 will be described based on the PVA hydrogel 43 having a thickness of 0.1 to 30 mm in the inner space of the mold 40 through the chamber 50. would.

In one embodiment, when the chamber 50 is operated in the freeze hardening mode 52a, the chamber 50 is transparent or attenuates the degree of ultrasonic transmission to less than 0.1% depending on the type of PVA solution injected into the inner space of the mold 40. The PVA hydrogel 43 in an opaque state (e.g. white) is formed.

Hereinafter, for convenience of explanation, the PVA hydrogel 43 is divided into a first PVA hydrogel 43a formed from the first PVA solution 22, and a second PVA hydrogel 43b formed from the second PVA solution 23. ), and the PVA hydrogel 43 mentioned below is preferably understood as at least one of the first PVA hydrogel 43a and the second PVA hydrogel 43b.

As a specific example, when the first PVA solution 22 is injected into the internal space of the mold 40, the chamber 50 in the freeze hardening mode 52a reduces the degree of ultrasonic transmission in the mold 40 to 0.1%. The first PVA hydrogel (43a) in a transparent state that is attenuated to less than 100% is molded, and in contrast, when the second PVA solution (23) is injected into the inner space of the mold (40), the mold (40) The second PVA hydrogel (43b) is formed in an opaque state that reduces the degree of ultrasonic transmission to less than 0.1%.

In one embodiment, when the chamber 50 is operated in the low temperature curing mode 52b, the chamber 50 is an opaque material that attenuates the degree of ultrasonic transmission to less than 2% depending on the type of PVA solution injected into the inner space of the mold 40. The PVA hydrogel (43) in its current state is allowed to be molded.

As a specific example, when the first PVA solution 22 is injected into the internal space of the mold 40, the chamber 50 in the low temperature curing mode 52b increases the degree of ultrasonic transmission in the mold 40 by 2%. When the first PVA hydrogel (43a) in an opaque state that is attenuated to less than 100% is molded, and the second PVA solution (23) is injected into the inner space of the mold (40), the mold (40) An opaque second PVA hydrogel (43b) with a polyethylene glycol content of 20% or more is formed while reducing the degree of ultrasonic transmission to less than 2%.

In one embodiment, when the chamber 50 is operated in the room temperature curing mode 52c, the degree of ultrasonic transmission is attenuated to less than 5% depending on the type of PVA solution injected into the inner space of the mold 40 to perform low temperature curing. The PVA hydrogel 43 is molded in a more opaque state than the PVA hydrogel 43 molded in mode 52b.

As a specific example, when the first PVA solution 22 is injected into the internal space of the mold 40, the chamber 50 in the room temperature curing mode 52c increases the degree of ultrasonic transmission in the mold 40 by 5%. The first PVA hydrogel (43a) is molded in a more opaque state than the first PVA hydrogel (43a) molded in the low-temperature curing mode (52b) by attenuating to less than 50%, and in contrast, the internal space of the mold (40) is formed. When the second PVA solution 23 is injected into the mold 40, the ultrasonic transmission degree is attenuated to less than 5%, the polyethylene glycol content is 20% or more, and the agent is molded in the low temperature curing mode 52b. 2 The second PVA hydrogel (43b) is formed in a more opaque state than the PVA hydrogel (43b).

In one embodiment, the mold 40 undergoes at least one of the freeze curing mode (52a), low temperature curing mode (52b), and room temperature curing mode (52c) in the inner space of the chamber 50 to form PVA hydro. When the molding of the gel 43 is completed, the PVA hydrogel 43 is discharged to the outside through a discharge means.

The PVA hydrogel 43 can be neutralized through a neutralization process depending on the type of solvent that makes up the PVA solution before being molded.

In one embodiment, when the PVA hydrogel 43 is molded from the first PVA solution 22 based on the first mixed solvent 11, it may be neutralized through a neutralization process as shown in FIG. 7.

Figure 7 is a diagram showing the neutralization process of the PVA hydrogel molded from the mold shown in Figure 5.

Referring to Figure 7, when the first PVA hydrogel (43a) molded from the first PVA solution (22) is completed in the mold (40) by the chamber (50), the mold (40) When discharged from the discharge means, it is sequentially placed into the first container 61 containing acetone, the second container 62 containing ether, and the first container 61 or the third container 63 containing acetone for a certain period of time. After being supported, it can be neutralized through a neutralization process in which liquid carbon dioxide heated to 60°C is stored in the fourth container 64.

In one embodiment, the time for the first PVA hydrogel 43a to be immersed in acetone and ether from the first container 61 to the third container 63 may be 1 to 24 hours.

The first PVA hydrogel (43a) must be neutralized through a neutralization process when the first PVA hydrogel (43a), in which dimethyl sulfoxide (11b) is used as a solvent, is exposed to the air. The side (11b) evaporates quickly, reducing the overall volume size of the first PVA hydrogel (43a). By reducing the volatility of dimethyl sulfoxide (11b) of the solid gel through neutralization, the first PVA hydrogel This is to prevent a decrease in the volume size of (43a).

In addition, the first PVA hydrogel (43a) must be neutralized through a neutralization process because the smell of dimethyl sulfoxide (11b) is unpleasant, so the first PVA hydrogel (43a) must be used for medical treatment together with the ultrasonic generator (100). When used as a device, the smell causes discomfort to the patient, and the purpose is to prevent this by removing (or deodorizing) the smell of dimethyl sulfoxide (11b) through neutralization.

In addition, the first PVA hydrogel (43a) must be neutralized through a neutralization process when using the first PVA hydrogel (43a) as a medical device in conducting a biological safety test to confirm whether it is safe for humans. Accordingly, a very accurate test method (in vitro) or a device that labels a substance or its antibody with a radioactive isotope and measures the concentration of trace substances in the body to determine the presence or extent of a disease is used by the patient or user. An in vivo biocompatibility test is conducted to determine whether the device works as intended while mitigating the biological risk caused by the device without causing adverse events or harmful effects to the human body. Cytotoxicity and skin sensitization, which are sample tests, are conducted. By testing skin irritation, etc., it is confirmed whether the semi-solid first PVA hydrogel (43a) can be used as a medical device. In the case of dimethyl sulfoxide (11b), it can be problematic when used in large quantities, so a biological stability test is required. This is to ensure that it is converted into a biologically safe material through neutralization to pass the (sample test).

In one embodiment, the second PVA hydrogel 43b formed from the second PVA solution 23 may be completed without the neutralization process.

In one embodiment, the first PVA hydrogel 43a or the second PVA hydrogel 43b can be used for the treatment of biological tissue (not shown) together with the ultrasonic generator 100 shown in FIG. 8.

Figure 8 is a diagram showing the use state of the PVA hydrogel molded from the mold shown in Figure 5.

Referring to FIG. 8, the PVA hydrogel 43 can be positioned between the ultrasonic generator 100 and the biological tissue so that the ultrasonic waves generated by the ultrasonic generator 100 are not scattered and are easily transmitted to the biological tissue. .

In one embodiment, the PVA hydrogel manufacturing apparatus 1 manufactures PVA hydrogel 43 with various ultrasonic transmittances and transparency, depending on the type of biological tissue to be treated with ultrasound generated by the ultrasonic generator 100. PVA hydrogel 43, which allows ultrasound to be easily transmitted to the biological tissue, can be provided to the user, thereby allowing ultrasound-based biological tissue treatment to proceed efficiently.

Method for manufacturing PVA hydrogel for ultrasonic acoustic bonding

Hereinafter, the process of the PVA hydrogel manufacturing method for ultrasonic acoustic bonding (S10, hereinafter referred to as 'PVA hydrogel manufacturing method (S10)') performed by the PVA hydrogel manufacturing apparatus (1) will be described in detail. would.

Figure 9 is a diagram showing a PVA hydrogel manufacturing method performed by the PVA hydrogel manufacturing apparatus according to an embodiment of the present invention.

Referring to Figure 9, the PVA hydrogel production method (S10) according to an embodiment of the present invention includes a solvent preparation step (S11), a PVA solution generation step (S12), a degassing step (S13), and a PVA solution injection step (S14). ), curing step (S15), neutralization step (S16), and PVA hydrogel production completion step (S17).

First, the solvent producer 10 produces a first mixed solvent 11 in which water (11a) and dimethyl sulfoxide (11b) are mixed, and a second mixed solvent in which water (12a) and polyethylene glycol (12b) are mixed ( 12) At least one solvent can be prepared (S11).

Afterwards, the stirrer 20 stirs the solvent and polyvinyl alcohol 21 introduced from the solvent generator 10 to generate at least one PVA solution among the first PVA solution 22 and the second PVA solution 23. You can do it (S12).

Afterwards, the deaerator 30 can receive the PVA solution from the stirrer 20 and remove the internal air of the PVA solution (S13).

After this, the PVA solution discharged from the deaerator 30 can be injected into the internal space of the mold 40 (S14).

Afterwards, the chamber 50 causes the mold 40 to undergo a curing process so that the PVA hydrogel 43 is formed in the inner space of the mold 40 (S15).

Afterwards, the PVA hydrogel 43 can be discharged from the mold 40 and then neutralized through a neutralization process depending on the type of solvent forming the PVA solution (S16).

In one embodiment, the neutralization process of the neutralization step (S16) is not essential, and the PVA hydrogel 43 molded in the inner space of the mold 40 can be omitted in the case of the second PVA hydrogel 43b. there is.

In one embodiment, the PVA hydrogel 43 undergoes a curing step (S15) and a neutralization step (S16), or a curing step (S16) is omitted, depending on the type of solvent constituting the PVA solution. Manufacturing can be completed through only S15) (S17).

First mixed solvent manufacturing method

Hereinafter, the first mixed solvent manufacturing method for producing the first mixed solvent 11 in the solvent manufacturing step (S11) will be described in detail.

Figure 10 is a diagram showing the detailed process of the solvent preparation step for producing the first mixed solvent.

Referring to FIG. 10, in the solvent preparation step (S11), the solvent preparation machine 10 uses 40 to 60 wt% of purified water (11a) and 40 to 60 wt% of water (11a), based on the weight ratio of 100 wt% of the first mixed solvent (11). wt% of dimethyl sulfoxide (11b) can be mixed (S11a).

After this, the solvent producer 10 may add a preservative (11c) to prevent shrinkage and decay of the PVA hydrogel (43) by the remaining weight ratio based on the weight ratio of 100 wt% of the first mixed solvent (11). There is (S11b).

Afterwards, the solvent producer 10 produces the first mixed solvent 11 through heat treatment or the like (S11c).

Second mixed solvent manufacturing method

Hereinafter, the second mixed solvent manufacturing method for producing the second mixed solvent 12 in the solvent manufacturing step (S11) will be described in detail.

Figure 11 is a diagram showing the detailed process of the solvent preparation step for producing the second mixed solvent.

Referring to FIG. 11, in the solvent preparation step (S11), the solvent preparation machine 10 uses 70 to 95 wt% of purified water (12a) and 5 to 30 wt% of purified water based on a weight ratio of 100 wt% of the second mixed solvent 12. wt% of polyethylene glycol (12b) can be mixed (S11d).

After this, the solvent producer 10 may additionally add a preservative (12c) to prevent shrinkage and decay of the PVA hydrogel (43) by the remaining weight ratio based on the weight ratio of 100 wt% of the second mixed solvent (12). There is (S11e).

Afterwards, the solvent producer 10 produces the second mixed solvent 12 through heat treatment or the like (S11f).

How to create a PVA solution

Below, the PVA solution generation method for generating the PVA solution in the PVA solution generation step (S12) will be described in detail.

Figure 12 is a diagram showing the detailed process of the PVA solution generation step shown in Figure 9.

Referring to FIG. 12, in the PVA solution generation step (S12), at least one solvent of the first mixed solvent 11 and the second mixed solvent 12 generated in the solvent generator 10 is added to the stirrer 20. , when the addition of the solvent is completed, 5 to 10 wt% of polyvinyl alcohol (21) based on the total weight of the solvent may be added through an injection path different from that of the solvent (S12a).

Afterwards, the stirrer 20 stirs the solvent and polyvinyl alcohol 21 for more than 90 minutes at a temperature between 90 ℃ and 130 ℃ (S12b), and mixes them in the first PVA solution 22 and the second PVA solution 23. At least one PVA solution can be produced (S12c).

At this time, if at least one solvent of 100 L or more of the first mixed solvent 11 and the second mixed solvent 12 is added to the stirrer 20 and bubbles are generated in the PVA solution during the stirring process (S12d-YES) , the stirrer 20 can remove bubbles generated in the PVA solution by adding an antifoaming agent 24 to the PVA solution (S12e).

On the other hand, if less than 100 L of the first mixed solvent 11 or the second mixed solvent 12 is added to the stirrer 20, or more than 100 L of the first mixed solvent 11 and the second mixed solvent 12 are added to the stirrer 20. If bubbles are not generated in the PVA solution during the stirring process even if at least one of the solvents is added (S12d-NO), the stirrer 20 may omit the addition of the antifoaming agent 24 to the PVA solution (S12f).

Curing method

Below, the curing method for forming the PVA hydrogel 43 in the curing step (S15) will be described in detail.

Figure 13 is a diagram showing the detailed process of the curing step shown in Figure 9.

Referring to FIG. 13, in the curing step (S15), the mold 40 may be placed into the inner space of the chamber 50 to undergo a curing process (S15a).

Afterwards, in the input unit 51, information about the curing mode 52 in which the curing process will be performed can be input through at least one of the first, second, and third signal input means, and the fourth signal input means is used. Through this, information about the type of solvent that makes up the PVA solution injected into the inner space of the mold 40 can be input (S15b).

After this, the chamber 50 may undergo the simulation process of the control unit 54, but the temperature control unit 53 is installed inside the chamber 50 to operate in the curing mode 52 based on the case where the simulation process is omitted. The space temperature can be adjusted.

At this time, if the temperature of the internal space is adjusted so that the chamber 50 is operated in the freeze hardening mode 52a by the temperature control unit 53 (S15c-YES), freeze hardening is performed in the inner space of the mold 40. The PVA hydrogel (43) that has gone through the process can be molded (S15f).

In one embodiment, the PVA hydrogel 43 in the freeze-curing mode 52a transmits ultrasonic waves in the mold 40 when the first PVA solution 22 is injected into the inner space of the mold 40. It can be molded with the first PVA hydrogel (43a) in a transparent state that reduces the degree to less than 0.1%. In contrast, when the second PVA solution (23) is injected into the inner space of the mold (40), the molding In the mold 40, the second PVA hydrogel 43b can be molded in an opaque state that reduces the degree of ultrasonic transmission to less than 0.1%.

On the other hand, if the temperature of the internal space is not adjusted so that the chamber 50 is operated in the freeze-hardening mode 52a by the temperature control unit 53 (S15c-NO), the chamber 50 adjusts the temperature. The temperature of the internal space can be operated by the unit 53 in a low temperature curing mode (52b) or a room temperature curing mode (52c).

At this time, if the temperature of the internal space is adjusted so that the chamber 50 is operated in the low-temperature curing mode (52b) by the temperature control unit 53 (S15d-YES), low-temperature curing is performed in the internal space of the mold 40. The PVA hydrogel (43) that has gone through the process can be molded (S15f).

In one embodiment, the PVA hydrogel 43 by the low-temperature curing mode 52b transmits ultrasonic waves in the mold 40 when the first PVA solution 22 is injected into the inner space of the mold 40. It can be molded with the first PVA hydrogel (43a) in an opaque state that reduces the degree to less than 2%. In contrast, when the second PVA solution (23) is injected into the inner space of the mold (40), the In the mold 40, the second PVA hydrogel 43b can be molded in an opaque state with a polyethylene glycol content of 20% or more while reducing the degree of ultrasonic transmission to less than 2%.

On the other hand, if the temperature of the internal space is not adjusted so that the chamber 50 is operated in the low temperature curing mode (52b) by the temperature control unit 53 (S15d-NO), the chamber 50 is operated in the room temperature curing mode. (52c) can be operated.

At this time, if the temperature of the internal space is adjusted so that the chamber 50 is operated in room temperature curing mode 52c by the temperature control unit 53 (S15e-YES), room temperature curing is performed in the internal space of the mold 40. The PVA hydrogel (43) that has gone through the process can be molded (S15f).

In one embodiment, the PVA hydrogel 43 in the room temperature curing mode 52c transmits ultrasonic waves in the mold 40 when the first PVA solution 22 is injected into the inner space of the mold 40. By reducing the degree to less than 5%, the first PVA hydrogel (43a) can be molded in a more opaque state than the first PVA hydrogel (43a) molded in the low temperature curing mode (52b). In contrast, the mold ( When the second PVA solution 23 is injected into the internal space of the mold 40, the degree of ultrasonic transmission in the mold 40 is attenuated to less than 5%, the polyethylene glycol content is 20% or more, and at the same time, the low temperature curing mode (52b) ) can be molded into a second PVA hydrogel (43b) that is more opaque than the second PVA hydrogel (43b) molded in ).

On the other hand, if the chamber 50 is not operated in the curing mode 52 because the temperature of the internal space is not adjusted to operate in the room temperature curing mode (52c) by the temperature control unit 53 (S15e-NO), The chamber 50 can communicate with a terminal provided by the user through the display or control unit 54 and request the user to inform the user of an operation error and re-operate the input unit 51 (S15g).

Neutralization method

Below, a neutralization method for neutralizing the first PVA hydrogel (43a) that has passed from the neutralization step (S16) to the curing step (S15) will be described in detail.

Figure 14 is a diagram showing the detailed process of the neutralization step shown in Figure 9.

Referring to FIG. 14, the first PVA hydrogel (43a) molded through the curing process in the curing step (S15), which is a step before the neutralization step (S16), will be discharged to the outside through the discharge means of the mold 40. (S16a).

Afterwards, the first PVA hydrogel (43a) is mixed with a first container (61) containing acetone, a second container (62) containing ether, and the first container (62) containing acetone for a certain period of time (e.g., 1 to 24 hours). 61) Alternatively, it may be sequentially supported in a third container 63 containing acetone (S16b).

Afterwards, the first PVA hydrogel (43a) is supported in the fourth container (64) storing liquid carbon dioxide heated to 60° C. (S16c), and can be neutralized through this neutralization process.

A detailed description of preferred embodiments of the invention disclosed above is provided to enable any person skilled in the art to make or practice the invention. Although the present invention has been described above with reference to preferred embodiments, those skilled in the art will understand that various modifications and changes can be made to the present invention without departing from the scope of the present invention. For example, a person skilled in the art may use each configuration described in the above-described embodiments by combining them with each other. Accordingly, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

The present invention may be embodied in other specific forms without departing from the technical spirit and essential features of the present invention. Accordingly, the above detailed description should not be construed as restrictive in all respects and should be considered illustrative. The scope of the present invention should be determined by reasonable interpretation of the appended claims, and all changes within the equivalent scope of the present invention are included in the scope of the present invention. The present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. In addition, claims that do not have an explicit reference relationship in the patent claims can be combined to form an embodiment or included as a new claim through amendment after filing.

1: PVA hydrogel manufacturing device, 10: solvent manufacturing machine,
11: first mixed solvent, 11a, 12a: water,
11b: dimethyl sulfoxide, 11c, 12c: preservative,
12b: polyethylene glycol, 12: second mixed solvent,
20: stirrer, 21: polyvinyl alcohol,
22: first PVA solution, 23: second PVA solution,
24: defoaming agent, 30: defoamer,
40: forming frame, 41: first forming frame body,
42: second mold body, 43: PVA hydrogel,
43a: first PVA hydrogel, 43b: second PVA hydrogel,
50: chamber, 51: input unit,
52: curing mode, 52a: freeze curing mode,
52b: low temperature curing mode, 52c: room temperature curing mode,
53: temperature control unit, 54: control unit,
61: first vessel, 62: second vessel,
63: 3rd vessel, 64: 4th vessel,
100: Ultrasonic generator.

Claims (16)

In the PVA hydrogel manufacturing device for ultrasonic acoustic bonding,
A solvent producer for producing at least one solvent among a first mixed solvent containing water and dimethyl sulfoxide (DMSO) and a second mixed solvent containing water and polyethylene glycol (PEG);
The solvent discharged from the solvent generator is introduced, polyvinyl alcohol (PVA) is added through an input path different from that of the solvent, and then the stirrer generates a PVA solution by stirring the solvent and polyvinyl alcohol. ;
A deaeration device that receives the PVA solution from the stirrer and removes internal air from the PVA solution;
A mold into which the PVA solution discharged from the deaerator is injected into the internal space; and
When the molding mold is input, a chamber that causes the molding mold to undergo a curing process so that the PVA hydrogel is molded in the inner space of the molding mold,
The PVA hydrogel,
A PVA hydrogel manufacturing device for ultrasonic acoustic bonding, characterized in that it is neutralized through a neutralization process depending on the type of solvent constituting the PVA solution. According to claim 1,
The first mixed solvent is,
PVA hydrogel for ultrasonic sound bonding, characterized in that 40-60 wt% of water and 40-60 wt% of dimethyl sulfoxide are mixed, and a preservative is additionally added to prevent shrinkage and decay of the PVA hydrogel. manufacturing device. According to claim 1,
The second mixed solvent is,
A PVA hydrogel manufacturing device for ultrasonic acoustic bonding, characterized in that 70 to 95 wt% of water and 5 to 30 wt% of polyethylene glycol are mixed, and a preservative is additionally added to prevent shrinkage and decay of the PVA hydrogel. . According to claim 1,
The stirrer,
After adding 5 to 10 wt% of polyvinyl alcohol based on the total weight of the solvent introduced from the solvent generator, the solvent and polyvinyl alcohol are stirred for more than 90 minutes at a temperature between 90 ℃ and 130 ℃ to produce a PVA solution. A PVA hydrogel manufacturing device for ultrasonic acoustic bonding, characterized in that. According to claim 1,
The chamber is,
When a mold in which the PVA solution based on the first mixed solvent or the PVA solution based on the second mixed solvent is injected into the inner space, the inner space of the mold is processed through each freezing, low temperature, and room temperature curing process. A PVA hydrogel manufacturing device for ultrasonic acoustic bonding, characterized in that the PVA hydrogel is molded. According to claim 5,
The chamber is,
The PVA solution based on the first mixed solvent is molded into a transparent PVA hydrogel that reduces the degree of ultrasonic transmission to less than 0.1% during the freeze-curing process at -5 to -20 ° C,
In a separate curing method, a low-temperature curing process of 1 to 5 ° C, the gel is molded into an opaque PVA hydrogel that reduces the ultrasonic transmission degree to less than 2%,
PVA hydrogel for ultrasonic-acoustic bonding, characterized in that in a separate curing method, room temperature curing at 18 to 25 ° C, the gel is molded into a more opaque PVA hydrogel that reduces the ultrasonic transmission degree to less than 5%. manufacturing device. According to claim 6,
The PVA hydrogel,
When molding is completed by the chamber, it is discharged from the mold and sequentially supported in acetone, ether, and acetone for a certain period of time, and then neutralized through a neutralization process in which liquid carbon dioxide heated to 60° C. is stored in a container. A device for manufacturing PVA hydrogel for ultrasonic acoustic bonding. According to claim 5,
The chamber is,
The PVA solution based on the second mixed solvent is molded into an opaque PVA hydrogel that reduces the degree of ultrasonic transmission to less than 0.1% during the freeze-curing process at -5 to -20 ° C,
In a separate curing method, a low-temperature curing process of 1 to 5 ° C, the gel is molded into an opaque PVA hydrogel with a polyethylene glycol content of 20% or more while reducing the degree of ultrasonic transmission to less than 2%,
In a separate curing method, room temperature curing at 18 to 25 ℃, the gel is molded into a more opaque PVA hydrogel with a polyethylene glycol content of 20% or more while reducing the degree of ultrasonic transmission to less than 5%. A device for manufacturing PVA hydrogel for ultrasonic acoustic bonding. In the method of manufacturing PVA hydrogel for ultrasonic acoustic bonding,
a) a step of preparing at least one solvent among a first mixed solvent mixed with water and dimethyl sulfoxide and a second mixed solvent mixed with water and polyethylene glycol by a solvent producer;
b) generating a PVA solution by using a stirrer to stir the solvent input from the solvent generator and polyvinyl alcohol input through an input path different from that of the solvent;
c) a deaerator receiving the PVA solution from the stirrer and removing the internal air of the PVA solution;
d) injecting the PVA solution discharged from the deaerator into the inner space of the mold;
e) when the mold is introduced into the chamber, the chamber causes the mold to undergo a curing process so that the PVA hydrogel is formed in the inner space of the mold; and
f) After the PVA hydrogel is discharged from the mold, the PVA hydrogel is neutralized through a neutralization process according to the type of solvent constituting the PVA solution. According to clause 9,
In step a),
Ultrasonic acoustic bonding, characterized in that the first mixed solvent is a mixture of 40 to 60 wt% of water and 40 to 60 wt% of dimethyl sulfoxide, and a preservative is additionally added to prevent shrinkage and decay of the PVA hydrogel. Method for manufacturing PVA hydrogel. According to clause 9,
In step a),
PVA for ultrasonic acoustic bonding, characterized in that the second mixed solvent is a mixture of 70 to 95 wt% of water and 5 to 30 wt% of polyethylene glycol, and a preservative is additionally added to prevent shrinkage and decay of the PVA hydrogel. Hydrogel manufacturing method. According to clause 9,
In step b),
The stirrer adds 5 to 10 wt% of polyvinyl alcohol based on the total weight of the solvent introduced from the solvent generator, and then stirs the solvent and polyvinyl alcohol at a temperature between 90 ° C. and 130 ° C. for more than 90 minutes to form PVA. A method for producing a PVA hydrogel for ultrasonic acoustic bonding, characterized in producing a solution. According to clause 9,
In step e),
When the chamber is equipped with a molding mold in which the PVA solution based on the first mixed solvent or the PVA solution based on the second mixed solvent is injected into the inner space, the molding mold undergoes a curing process at each freezing, low temperature, and room temperature. A method of manufacturing PVA hydrogel for ultrasonic acoustic bonding, characterized in that the PVA hydrogel is molded in the internal space of. According to claim 13,
In step e),
The chamber is such that the PVA solution based on the first mixed solvent is molded into a transparent PVA hydrogel that reduces the degree of ultrasonic transmission to less than 0.1% during the freeze-curing process at -5 to -20 ° C,
In a separate curing method, a low-temperature curing process of 1 to 5 ° C, the gel is molded into an opaque PVA hydrogel that reduces the ultrasonic transmission degree to less than 2%,
PVA hydrogel for ultrasonic-acoustic bonding, characterized in that in a separate curing method, room temperature curing at 18 to 25 ° C, the gel is molded into a more opaque PVA hydrogel that reduces the ultrasonic transmission degree to less than 5%. Manufacturing method. According to claim 14,
In step f),
When the PVA hydrogel is completely molded by the chamber, it is discharged from the mold and sequentially supported in acetone, ether, and acetone for a certain period of time, and then neutralized in a container storing liquid carbon dioxide heated to 60 ° C. A method of manufacturing a PVA hydrogel for ultrasonic acoustic bonding, characterized in that it is neutralized through a process. According to claim 13,
In step e),
The chamber is such that the PVA solution based on the second mixed solvent is molded into an opaque PVA hydrogel that reduces the degree of ultrasonic transmission to less than 0.1% during the freeze-curing process at -5 to -20 ° C,
In a separate curing method, a low-temperature curing process of 1 to 5 ° C, the gel is molded into an opaque PVA hydrogel with a polyethylene glycol content of 20% or more while reducing the degree of ultrasonic transmission to less than 2%,
In a separate curing method, room temperature curing at 18 to 25 ℃, the gel is molded into a more opaque PVA hydrogel with a polyethylene glycol content of 20% or more while reducing the degree of ultrasonic transmission to less than 5%. Method for manufacturing PVA hydrogel for ultrasonic acoustic bonding.

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