KR20240034216A - Novel aerosol-generating substrates containing cumin species - Google Patents

Abstract

Aerosol-generating article 1000 (4000a, 4000b) 5000 includes an aerosol-generating substrate 1020, which is formed of a homogenized cumin material comprising cumin seed particles, an aerosol former, and a binder. The aerosol-generating substrate contains at least 15 micrograms of procumenol per gram of substrate on a dry weight basis; at least 20 micrograms of cuminaldehyde per gram of substrate on a dry weight basis; and at least 10 micrograms of isothymol per gram of substrate on a dry weight basis.

Description

Novel aerosol-generating substrates containing cumin species

The present invention relates to aerosol-generating substrates comprising homogenized plant material formed from cumin seed particles, and aerosol-generating articles comprising such aerosol-generating substrates. The present invention also relates to aerosols derived from aerosol-generating substrates comprising cumin seed particles.

Aerosol-generating articles in which an aerosol-generating substrate, such as a tobacco-containing substrate, is heated without combustion are known in the art. Typically, in such articles, aerosols are generated by heat transfer from a heat source to a physically separate aerosol-generating substrate or material that is in contact with the heat source and may be located within, around, or downstream of the heat source. do. During use of an aerosol-generating article, volatile compounds are released from the substrate by heat transfer from the heat source and are entrained in the air drawn through the article. As the released compounds cool, they condense and form an aerosol.

Some aerosol-generating articles contain flavoring agents that are delivered to the consumer during use of the article to provide the consumer with a different sensory experience, for example, to enhance the flavor of the aerosol. Flavorants can be used to impart a gustatory sensation (taste), an olfactory sensation (smell), or both taste and olfactory sensations to the user who inhales the aerosol. It is known to provide heated aerosol-generating articles containing flavoring agents.

It is also known to provide flavoring to conventional combustible cigarettes, which are smoked by lighting the end of the cigarette opposite the mouthpiece so that the tobacco rod combusts and produces inhalable smoke. One or more flavoring agents are typically mixed with the tobacco in the tobacco load to provide additional flavor to the mainstream smoke when the tobacco is burned. These flavoring agents may be provided, for example, as essential oils.

Aerosols from conventional cigarettes, containing a number of components that interact with receptors located in the mouth, provide a "mouth-full" feeling, i.e., a relatively high mouthfeel. As used herein, “texture” refers to the physical sensation in the mouth caused by a food, beverage, or aerosol, and is distinct from taste. In addition to taste and smell, it is the basic sensory properties that determine the overall flavor of a food item or aerosol.

There are difficulties in replicating the consumer experience provided by conventional combustible cigarettes with an aerosol-generating article in which the aerosol-generating substrate is heated rather than combusted. This is partly due to the low temperatures reached during heating of these aerosol-generating articles, causing different profiles of volatile compounds to be released.

It would be desirable to provide a new aerosol-generating substrate for heated aerosol-generating articles that provides aerosols with improved flavor and mouth fill. It would be particularly desirable if such aerosol-generating substrates could provide aerosols with a sensory experience similar to that provided by conventional combustible cigarettes. Additionally, it would be particularly desirable if such aerosol-generating substrates could provide aerosols with reduced levels of undesirable aerosol compounds compared to existing aerosol-generating substrates containing only tobacco, for example.

It would also be desirable to provide such aerosol-generating substrates that can be readily incorporated into aerosol-generating articles and manufactured using existing high-throughput methods and equipment.

The present disclosure relates to an aerosol-generating article comprising an aerosol-generating substrate, wherein the aerosol-generating substrate is formed from homogenized plant material comprising cumin seeds, referred to herein as “homogenized cumin material.” The homogenized cumin material may further include an aerosol former. The homogenized cumin material may further include a binder. The aerosol-generating substrate may further comprise at least about 15 micrograms of procumenol per gram of substrate, on a dry weight basis. The aerosol-generating substrate may further comprise at least about 20 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis. The aerosol-generating substrate may further comprise at least about 10 micrograms of isothymol per gram of substrate, on a dry weight basis.

According to the present invention, there is provided an aerosol-generating article comprising an aerosol-generating substrate, wherein the aerosol-generating substrate is formed from a homogenized cumin seed material comprising cumin seed particles. According to the invention, the homogenized plant material comprises cumin seed particles, an aerosol former and a binder. The aerosol-generating substrate contains at least about 15 micrograms of procumenol per gram of substrate on a dry weight basis; at least about 20 micrograms of cuminaldehyde per gram of substrate on a dry weight basis; and at least about 10 micrograms of isothymol per gram of substrate on a dry weight basis.

According to the invention according to Test Method A described below, upon heating the aerosol-generating substrate of the aerosol-generating article, the generated aerosol preferably contains at least 25 micrograms per gram of substrate on a dry weight basis of proccumenol; at least 2 micrograms of cuminaldehyde per gram of substrate on a dry weight basis; and at least 1 microgram of benzyl isothymol per gram of substrate on a dry weight basis.

Preferably, upon heating the aerosol-generating substrate according to Test Method A, the aerosol generated from the aerosol-generating substrate may comprise procougmenol in an amount of at least about 0.5 micrograms per puff of aerosol. Upon heating the aerosol-generating substrate according to Test Method A, the aerosol generated from the aerosol-generating substrate may include cuminaldehyde in an amount of at least about 0.05 micrograms per puff of aerosol. Upon heating the aerosol-generating substrate according to Test Method A, the aerosol generated from the aerosol-generating substrate may contain isothymol in an amount of at least about 0.01 micrograms per aerosol puff. A puff of aerosol has a volume of 55 milliliters as produced by a smoking machine.

According to the present invention, there is provided an aerosol-generating article comprising an aerosol-generating substrate, wherein the aerosol-generating substrate is formed from a homogenized cumin seed material comprising cumin seed particles. The aerosol-generating substrate contains at least about 15 micrograms of procumenol per gram of substrate on a dry weight basis; at least about 20 micrograms of cuminaldehyde per gram of substrate on a dry weight basis; and at least about 10 micrograms of isothymol per gram of substrate on a dry weight basis.

The present disclosure also relates to an aerosol-generating substrate formed from homogenized plant material comprising cumin seeds, wherein the aerosol-generating substrate is referred to herein as “homogenized cumin material.” The homogenized cumin material may further include an aerosol former. The homogenized plant material may further comprise a binder. The aerosol-generating substrate may comprise at least about 15 micrograms of procumenol per gram of substrate, on a dry weight basis. The aerosol-generating substrate may comprise at least about 20 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis. The aerosol-generating substrate may comprise at least about 10 micrograms of isothymol per gram of substrate, on a dry weight basis.

According to the present invention, an aerosol-generating substrate formed from a homogenized cumin material is also provided, wherein the homogenized cumin material includes cumin seed particles, an aerosol former and a binder. The aerosol-generating substrate contains at least 15 micrograms of procumenol per gram of substrate on a dry weight basis; at least 20 micrograms of cuminaldehyde per gram of substrate on a dry weight basis; and at least 10 micrograms of isothymol per gram of substrate on a dry weight basis.

The present disclosure also relates to aerosols produced upon heating of an aerosol-generating substrate. The aerosol may include procumenol in an amount of at least about 0.5 micrograms per puff of aerosol. The aerosol may contain cuminaldehyde in an amount of at least about 0.05 micrograms per puff of aerosol. The aerosol may include isothymol in an amount of at least about 0.01 micrograms per puff of aerosol. A puff of aerosol has a volume of 55 milliliters as produced by a smoking machine.

According to the invention, there is further provided an aerosol generated upon heating of the aerosol-generating substrate, said aerosol comprising: proccumenol in an amount of at least 0.5 micrograms per aerosol puff; Cuminaldehyde in an amount of at least 0.05 micrograms per aerosol puff; and isothymol in an amount of at least 0.01 micrograms per aerosol puff, wherein the aerosol puff has a volume of 55 milliliters as generated by the smoking machine.

The present invention involves forming a slurry comprising cumin seed particles, water, an aerosol former, a binder and optionally tobacco particles; Casting or extruding the slurry into the form of sheets or strands; and drying the sheet or strand, preferably at a temperature of 80°C to 160°C. When sheets of the aerosol-generating substrate are formed, the sheets can optionally be cut into strands or the sheets gathered together to form rods. The sheets may optionally be crimped prior to the gathering step.

Any references below to aerosols and aerosol-generating substrates of the invention should be considered applicable to all aspects of the invention, unless otherwise noted.

As used herein, the term “aerosol-generating article” refers to an article for producing an aerosol, wherein the article is suitable for being heated or burned to release volatile compounds capable of forming an aerosol and is intended to do so. Includes occurrence description. Conventional cigarettes light when the user applies a flame to one end of the cigarette and draws air through the other end. The local heat provided by the flame, and the oxygen in the air drawn through the cigarette cause the end of the cigarette to ignite, and the resulting combustion produces inhalable smoke. In contrast, in a “heated aerosol-generating article” the aerosol is generated by heating the aerosol-generating substrate, rather than burning the aerosol-generating substrate. Known heated aerosol-generating articles include, for example, electrically heated aerosol-generating articles and aerosol-generating articles in which aerosols are generated by heat transfer from a combustible fuel element or heat source to a physically separate aerosol-generating substrate.

Aerosol-generating articles configured for use in an aerosol-generating system that supplies an aerosol-forming agent to the aerosol-generating article are also known. In such systems, the aerosol-generating substrate within the aerosol-generating article contains substantially less aerosol-forming agent compared to the aerosol-generating substrate, which carries and provides substantially all of the aerosol-forming agent used to form the aerosol during operation.

As used herein, the term “aerosol-generating substrate” refers to a substrate that is capable of producing volatile compounds upon heating, which are capable of forming an aerosol. Aerosols generated from aerosol-generating substrates may or may not be visible to the human eye and include vapors (e.g., particulates of gaseous substances that are usually liquid or solid at room temperature), as well as liquids of gases and condensed vapors. May contain enemies.

As used herein, the term “homogenized plant material” encompasses any tobacco material formed by agglomeration of particles of the plant. For example, a sheet or web of homogenized plant material for the aerosol-generating substrate of the present invention may be agglomerated particles of plant material obtained by micronizing, milling or grinding cumin plant material and, optionally, tobacco material such as tobacco leaves and tobacco leaf blades. It can be formed through the following steps. Homogenized plant material may be produced by casting, extrusion, papermaking processes, or any other suitable process known in the art.

As used herein, the term “homogenized cumin material” refers to homogenized plant material comprising cumin seed particles, optionally in combination with tobacco particles. The term “homogenized tobacco material” refers to homogenized plant material comprising tobacco particles but not cumin seed particles and is therefore not subject to the invention.

As used herein, the term “cumin seed particles” includes particles derived from the dried seeds of cumin ( cuminium cyminium) . Cumin cyminium is a herbaceous plant of the Apiaceae family , which is native to southwestern Asia and the Middle East. Cumin seeds are commonly used as a spice to provide a unique flavor to foods.

In contrast, cumin seed oil is a distillate extracted from the seeds of the cumin plant. Primary flavor compounds in cumin seed essential oil include cuminaldehyde and cymene.

The present invention provides an aerosol-generating article comprising an aerosol-generating substrate formed from homogenized plant material comprising cumin particles, referred to herein as homogenized cumin material. The present invention also provides aerosols derived from such aerosol-generating substrates. The inventors of the present invention have discovered that through the incorporation of cumin seed particles into an aerosol-generating substrate, it is advantageously possible to create aerosols that provide novel sensory experiences. These aerosols can provide a unique flavor and provide an increased level of mouth fill.

Additionally, the inventors have discovered that it is advantageously possible to produce aerosols with improved cumin aroma and flavor compared to aerosols produced through the addition of cumin additives such as cumin seed oil. Cumin seed oil (Chemical Abstracts Service Registration No. 8014-13-9) is obtained by steam distillation from the seeds of the cumin plant, possibly due to a distillation process that may selectively remove or retain certain flavoring agents, which differ from the cumin seed particles. It has a flavoring composition. Cuminaldehyde is the main component of cumin seed oil.

Additionally, in certain aerosol-generating substrates provided herein, cumin seed particles may be included at a level sufficient to provide the desired cumin seed flavor while retaining sufficient tobacco material to provide the consumer with the desired level of nicotine.

Additionally, surprisingly, the inclusion of cumin seed particles in the aerosol-generating substrate provides a significant reduction in certain undesirable aerosol compounds compared to aerosols generated from an aerosol-generating substrate containing 100% tobacco particles without cumin seed particles. It was discovered that it does. In particular, as shown below, surprisingly, the inclusion of cumin seed particles in the aerosol-generating substrate provides a significant reduction in phenols compared to aerosols produced from an aerosol-generating substrate comprising 100% tobacco particles without cumin seed particles. it was discovered Additionally, this reduction was found to be greater than expected on a proportional basis as a result of the reduction in tobacco particles.

The presence of cumin seeds in homogenized plant material (such as cast leaves) can be reliably identified by DNA barcoding. Methods for performing DNA barcoding based on the nuclear genes ITS2, rbcL and matK systems as well as the plastid intergenic spacer trnH-psbA are well known and available in the art (Chen S, Yao H, Han J, Liu C, Song J, et al. (2010) Validation of the ITS2 Region as a Novel DNA Barcode for Identifying Medicinal Plant Species. PLoSONE 5(1): e8613; Hollingsworth PM, Graham SW, Little DP (2011) Choosing and Using a Plant DNA Barcode. PLoS ONE 6(5): e19254).

The present inventors have attempted to conduct a complex analysis and characterization of aerosols generated from the aerosol-generating substrate of the invention comprising cumin seed particles and mixtures of cumin and tobacco particles, and to compare these aerosols with existing aerosols formed from tobacco material without cumin seed particles. Comparisons were made with those produced from aerosol-generating substrates. On this basis, the inventors were able to identify a group of “characteristic compounds”, which are compounds present in aerosols and derived from cumin seed particles. Therefore, detection of these characteristic compounds in aerosols within a certain range of weight percentages can be used to identify aerosols derived from aerosol-generating substrates containing cumin seed particles. These characteristic compounds are specifically absent in aerosols generated from tobacco materials. Moreover, the ratio of the characteristic compounds in the aerosol and the ratio of the characteristic compounds to each other clearly indicate the use of cumin plant material and not cumin oil. Likewise, the presence of certain proportions of these characteristic compounds in an aerosol-generating substrate indicates that the substrate contains cumin seed particles.

In particular, defined levels of characteristic compounds in the substrate and aerosol are specific to the cumin seed particles present in the homogenized cumin seed material. The level of each characteristic compound depends on how the cumin seed particles were processed during creation of the homogenized cumin seed material. The level will also depend on the composition of the homogenized cumin material and will be particularly influenced by the levels of other components within the homogenized cumin material. The level of a characteristic compound in a homogenized cumin material will differ from the level of the same compound in the starting cumin material. This will also differ from the levels of the characteristic compounds in materials containing cumin seed particles, but are not in accordance with the invention as defined herein.

To perform the characterization of aerosols, we used high-resolution accurate mass spectrometry coupled to two-dimensional gas chromatography (GCxGC-TOFMS) in parallel with time-of-flight mass spectrometry. Complementary non-targeted differential screening (NTDS) using liquid chromatography (LC-HRAM-MS) was used.

Non-targeted screening (NTS) is performed by matching unknown detected compound features against a spectral database (suspect screening assay [SSA]), or, if prior knowledge is not matched, for example from a compound database . A key methodology for characterizing the chemical composition of complex matrices by using primary fragmentation (MS/MS)-derived information matched to predicted fragments in silico to reveal unknown structures (non-targeted analysis [NTA]). am. Multiple small molecules from a sample can be measured and semi-quantitated simultaneously using an unbiased approach.

As described above, the focus is on comparing two or more aerosol samples to assess in an unsupervised manner any significant differences in chemical composition between the samples, or when preliminary knowledge about the group is available across samples. , non-targeted differential screening (NTDS) can be performed. A comprehensive approach to identify the most relevant differences in aerosol composition between aerosols derived from articles comprising 100% by weight cumin seeds as particulate plant material and aerosols derived from articles comprising 100% by weight tobacco as particulate plant material. To ensure analytical coverage, complementary use of liquid chromatography coupled to high-resolution accurate mass spectrometry (LC-HRAM-MS) in parallel with two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GCxGC-TOFMS) A differential screening approach was applied.

Aerosols were generated and collected using the apparatus and methodology detailed below.

LC-HRAM-MS analysis was performed using a Thermo QExactive ^™ high-resolution mass spectrometer in both full scan mode and data-dependent mode. Overall, three different methods were applied to cover a wide range of materials with different ionization properties and compound classes. Samples were analyzed using RP chromatography using heated electrospray ionization (HESI) in both positive and negative modes and atmospheric pressure chemical ionization (APCI) in positive mode. The methods are described below: Arndt, D. et al ., "In depth characterization of chemical differences between heat-not-burn tobacco products and cigarettes using LC-HRAM-MS-based non-targeted differential screening" (DOI:10.13140/ RG.2.2.11752.16643); Wachsmuth, C. et al ., “Comprehensive chemical characterization of complex matrices through integration of multiple analytical modes and databases for LC-HRAM-MS-based non-targeted screening” (DOI: 10.13140/RG.2.2.12701.61927); and “Buchholz, C. et al ., “Increasing confidence for compound identification by fragmentation database and in silico fragmentation comparison with LC-HRAM-MS-based non-targeted screening of complex matrices” (DOI: 10.13140/RG.2.2.17944.49927), all from the 66th ASMS Conference on Mass Spectrometry and Allied Topics, San Diego, USA (2018). Methods are further described below: Arndt, D. et al ., "A complex matrix characterization approach, applied to cigarette smoke, that integrates multiple analytical methods and compound identification strategies for non-targeted liquid chromatography with high-resolution mass spectrometry" (DOI: 10.1002/rcm.8571).

GCxGC-TOFMS analysis was performed using an Agilent GC Model 6890A or 7890A equipped with an automatic liquid injector (Model 7683B) and a thermal modulator coupled to a LECO Pegasus 4D ^TM mass spectrometer, measuring three different samples for non-polar, polar and highly volatile compounds in aerosols. was performed using the method. The methods are described below: Almstetter et al ., "Non-targeted screening using GCХGC-TOFMS for in-depth chemical characterization of aerosol from a heat-not-burn tobacco product" (DOI: 10.13140/RG.2.2.36010.31688/ One); and Almstetter et al ., “Non-targeted differential screening of complex matrices using GCХGC-TOFMS for comprehensive characterization of the chemical composition and determination of significant differences” (DOI: 10.13140/RG.2.2.32692.55680), from the 66th and 64th ASMS Conferences on Mass Spectrometry and Allied Topics, San Diego, USA.

The results of the analytical methods provided information on the main compounds responsible for the differences in aerosols produced by these articles. The focus of the untargeted differential screening using both the analytical platforms LC-HRAM-MS and GCxGC-TOFMS was the aerosol according to the invention containing 100% cumin seed particles compared to a comparison sample of an aerosol-generating substrate containing 100% tobacco particles. There were compounds present in higher amounts in the aerosols of the samples that occurred. The NTDS methodology is described in the papers listed above.

Based on this information, the inventors were able to identify specific compounds in the aerosol that could be considered as “characteristic compounds” derived from cumin seed particles in the substrate. Characteristic compounds derived from cumin seeds include, but are not limited to: Proccumenol, (3-hydroxy-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3 ,3a,4,5,6,8a-octahydroazulen-6-one), formula: C ₁₅ H ₂₂ O ₂ , Chemical Abstracts Service Registration No. 21698-40-8); Cuminaldehyde, (4-isopropylbenzaldehyde), Chemical Formula: C ₁₀ H ₁₂ O, Chemical Abstracts Service Registry Number 122-03-2); and isothymol, also known as carvacrol (5-isopropyl-2-methylphenol), formula: C ₁₀ H ₁₄ O, see Chemical Abstracts Service Registration No. 499-75-2.

For the purposes of the present invention, targeted screening was performed on samples of aerosol-generating substrates to be able to identify the presence and amount of each characteristic compound in the substrate. These targeted screening methods are described below. As explained, characteristic compounds can be detected and measured both in aerosol-generating substrates and in aerosols derived from aerosol-generating substrates.

As defined above, the aerosol-generating article of the present invention comprises an aerosol-generating substrate formed from homogenized plant material containing cumin seed particles. As a result of incorporating cumin seed particles, the aerosol-generating substrate contains a certain proportion of the “characteristic compounds” of cumin seeds, as described above. In particular, the aerosol-generating substrate contains, on a dry weight basis, at least 15 micrograms of procumenol per gram of substrate, at least 20 micrograms of cuminaldehyde per gram of substrate, and at least 10 micrograms of isothymol per gram of substrate. Preferably it includes.

By defining the aerosol-generating substrate for the desired level of the characteristic compound, consistency between products can be ensured despite potential differences in the level of the characteristic compound in the raw materials. This advantageously allows more effective control of the quality of the product.

Preferably, the aerosol-generating substrate comprises, on a dry weight basis, at least about 100 micrograms of procumenol per gram of substrate, more preferably at least about 200 micrograms of procumenol per gram of substrate. Alternatively or additionally, the aerosol-generating substrate preferably contains, on a dry weight basis, no more than about 1800 micrograms of proccumenol per gram of substrate, more preferably no more than about 1500 micrograms of proccumenol per gram of substrate, More preferably, it contains less than about 1000 micrograms of procumenol per gram of substrate.

For example, the aerosol-generating substrate may comprise, on a dry weight basis, about 15 micrograms to about 1800 micrograms of procumenol per gram of substrate, or about 100 micrograms to about 1500 micrograms of procumenol per gram of substrate. , or from about 200 micrograms to about 1000 micrograms of procumenol per gram of substrate.

In certain particularly preferred embodiments, the aerosol-generating substrate contains about 100 micrograms to about 300 micrograms of procumenol per gram of aerosol-generating substrate, more preferably about 200 micrograms to about 250 micrograms per gram of aerosol-generating substrate. It may contain grams of procomenol. For example, the level of proccumenol may be within these ranges for a preferred embodiment of the invention wherein the aerosol-generating substrate comprises 10% by weight cumin seed particles, on a dry weight basis.

Preferably, the aerosol-generating substrate comprises, on a dry weight basis, at least about 100 micrograms of cuminaldehyde per gram of substrate, more preferably at least about 250 micrograms of cuminaldehyde per gram of substrate. Alternatively or additionally, the aerosol-generating substrate preferably contains, on a dry weight basis, less than or equal to about 2500 micrograms of cuminaldehyde per gram of substrate, more preferably less than or equal to about 1500 micrograms of cuminaldehyde per gram of substrate. Typically, it contains less than about 1000 micrograms of cuminaldehyde per gram of substrate.

For example, the aerosol-generating substrate may have, on a dry weight basis, about 20 micrograms to about 2500 micrograms of cuminaldehyde per gram of substrate, or about 100 micrograms to about 1500 micrograms of cuminaldehyde per gram of substrate, or It may comprise from about 250 micrograms to about 1000 micrograms of cuminaldehyde per gram of substrate.

In a particularly preferred embodiment, the aerosol-generating substrate contains from about 250 micrograms to about 400 micrograms of cuminaldehyde per gram of the aerosol-generating substrate, more preferably from about 300 micrograms to about 350 micrograms of cumin per gram of the aerosol-generating substrate. May contain aldehydes. For example, the level of cuminaldehyde may be within these ranges for a preferred embodiment of the invention wherein the aerosol-generating substrate comprises 10% by weight cumin seed particles, on a dry weight basis.

Preferably, the aerosol-generating substrate comprises at least about 50 micrograms of isothymol per gram of substrate, more preferably at least about 100 micrograms of isothymol per gram of substrate, on a dry weight basis. Alternatively or additionally, the aerosol-generating substrate preferably contains, on a dry weight basis, less than or equal to about 1200 micrograms of isothymol per gram of substrate, more preferably less than or equal to about 1000 micrograms of isothymol per gram of substrate. Typically, it contains less than about 750 micrograms of isothymol per gram of substrate.

For example, the aerosol-generating substrate may comprise, on a dry weight basis, about 10 micrograms to about 1200 micrograms isothymol per gram of substrate, or about 50 micrograms to about 1000 micrograms isothymol per gram of substrate, or It may comprise from about 100 micrograms to about 750 micrograms of isothymol per gram of substrate.

In certain particularly preferred embodiments, the aerosol-generating substrate contains from about 50 micrograms to about 200 micrograms of isothymol per gram of the aerosol-generating substrate, more preferably from about 100 micrograms to about 150 micrograms per gram of the aerosol-generating substrate. May contain isothymol. For example, the level of isothymol may be within these ranges for a preferred embodiment of the invention wherein the aerosol-generating substrate comprises 10% by weight cumin seed particles, on a dry weight basis.

Preferably, the ratio of the characteristic compounds in the aerosol-generating substrate is such that, on a dry weight basis, the amount of cuminaldehyde per gram of substrate is at least equal to the amount of procumenol per gram of substrate, more preferably the amount of procuminaldehyde per gram of substrate is at least equal to It should be at least 1.25 times the amount of chcumenol.

Preferably, the ratio of the characteristic compounds in the aerosol-generating substrate is such that, on a dry weight basis, the amount of proccumenol per gram of substrate is at least equal to the amount of isothymol per gram of substrate, more preferably It should be at least 1.5 times the amount of thymol.

These ratios of procurcumenol to cuminaldehyde and isothymol are characterized by the inclusion of cumin seed particles in the aerosol-generating substrate.

As defined above, the present invention also provides an aerosol-generating article comprising an aerosol-generating substrate formed from homogenized plant material comprising cumin seed particles, wherein upon heating the aerosol-generating substrate, the cumin seeds " An aerosol containing “characteristic compounds” is generated.

For the purposes of the present invention, the aerosol-generating substrate is heated according to “Test Method A”. In Test Method A, an aerosol-generating article comprising an aerosol-generating substrate is heated in a Tobacco Heating System 2.2 holder (THS2.2 holder) under the Health Canada machine-smoking regimen. For the purpose of performing Test Method A, the aerosol-generating substrate is provided in an aerosol-generating article compatible with the THS2.2 holder.

The Tobacco Heating System 2.2 Holder (THS2.2 Holder) is described in Smith et al., 2016, Regul. Toxicol. Pharmacol. 81 (S2) corresponds to the commercially available IQOS device (Philip Morris Products SA, Switzerland) as described in S82-S92. Aerosol-generating articles for use with the IQOS device are also commercially available.

Health Canada's smoking regime is a well-defined and accepted smoking protocol in Health Canada 2000 - Tobacco Product Information Regulations SOR/2000-273, Schedule 2; Published by Ministry of Justice Canada. The test method is described in ISO/TR 19478-1:2014. In the Health Canada smoking test, aerosols are collected from a sample aerosol-generating substrate over 12 puffs with a puff volume of 55 millimeters, a puff duration of 2 seconds, and a puff interval of 30 seconds, with all ventilation, if present, blocked. .

Therefore, in the context of the present invention, the expression “on heating of an aerosol-generating substrate according to Test Method A” refers to Health Canada 2000 - Tobacco Product Information Regulations SOR/2000-273, Schedule 2 (published by Justice Canada, the test method means upon heating of an aerosol-generating substrate in a THS2.2 holder under Health Canada mechanical smoking therapy as defined in ISO/TR 19478-1:2014.

에서 유지시킨, 메탄올 및 내부 표준(ISTD) 용액(10 mL) 각각을 함유하는 연속 마이크로-임핀저(micro-impinger)(20 mL)를 사용하여 필터 패드로부터 하류로 수집한다. 이어서, 포획된 미립자 상과 기체상을 재결합하고 샘플을 흔들고, 5분 동안 와류하고 원심분리(4500 g, 5분, 10

하여 마이크로 임핀저로부터의 메탄올을 사용하여 추출한다. 생성된 추출물을 메탄올로 희석하고 Eppendorf ThermoMixer(5℃, 2000 rpm)에서 혼합한다. 추출물로부터의 시험 샘플을 특징적인 화합물의 식별을 위해서 조합된 전체 스캔 모드 및 데이터 의존적 단편화 모드에서 LC-HRAM-MS에 의해 분석한다. 본 발명의 목적을 위해, LC-HRAM-MS 분석은 프로크쿠메놀의 식별 및 정량화에 적합하다.For analysis, aerosols generated from heating of the aerosol-generating substrate are captured using a suitable device, depending on the analysis method to be used. In a suitable method for generating samples for analysis by LC-HRAM-MS, the particulate phase is filtered using a conditioned 44 mm Cambridge glass fiber filter pad (according to ISO 3308) and a filter holder (according to ISO 4387 and ISO 3308). captured. Residual gas phase was purified to -60 °C using a dry ice-isopropanol mixture.

Collect downstream from the filter pad using a continuous micro-impinger (20 mL) containing methanol and internal standard (ISTD) solution (10 mL) each, maintained at . The captured particulate phase and the gas phase were then recombined and the sample was shaken, vortexed for 5 min and centrifuged (4500 g, 5 min, 10 min).

Then, it is extracted using methanol from a micro impinger. The resulting extract was diluted with methanol and mixed in an Eppendorf ThermoMixer (5°C, 2000 rpm). Test samples from the extract are analyzed by LC-HRAM-MS in combined full scan mode and data dependent fragmentation mode for identification of characteristic compounds. For the purposes of the present invention, LC-HRAM-MS analysis is suitable for the identification and quantification of proccumenol.

Samples for analysis by GCxGC-TOFMS can be generated in a similar manner, but for GCxGC-TOFMS analysis, different solvents are suitable for extracting and analyzing polar, non-polar, and volatile compounds separated from the total aerosol. do.

For non-polar and polar compounds, the total aerosol was collected using a conditioned 44 mm Cambridge glass fiber filter pad (according to ISO 3308) and a filter holder (according to ISO 4387 and ISO 3308), followed by two micro-impingers. Connect in series and seal. Each micro-impinger (20 mL) contains 10 mL dichloromethane/methanol (80:20v/v) containing internal standard (ISTD) and retention index marker (RIM) compounds. The micro-impinger is maintained at -80°C using a dry ice-isopropanol mixture. For the analysis of non-polar compounds, the particulate phase of the total aerosol is extracted from a glass fiber filter pad using the contents of a micro-impinger. Water is added to an aliquot (10 mL) of the resulting extract, the sample is shaken and centrifuged as described above. The dichloromethane layer is separated, dried with sodium sulfate and analyzed by GCxGC-TOFMS in full scan mode. For the analysis of polar compounds, the remaining water layer from the non-polar sample preparation described above is used. ISTD and RIM compounds are added to the water layer and then directly analyzed by GCxGC-TOFMS in full scan mode.

For volatile compounds, the total aerosol was generated using two serially connected and sealed micro-impingers (20 mL), each filled with 10 mL N,N-dimethylformamide (DMF) containing ISTD and RIM compounds. Collect. The micro-impinger is maintained at -50 to -60°C using a dry ice-isopropanol mixture. After collection, the contents of the two micro-impingers are combined and analyzed by GCxGC-TOFMS in full scan mode.

For the purposes of the present invention, GCxGC-TOFMS analysis is suitable for the identification and quantification of cuminaldehyde, and isothymol.

The aerosol generated upon heating of the aerosol-generating substrate of the invention according to test method A is characterized by the amounts and proportions of the characteristic compounds, proccumenol, cuminaldehyde and isothymol, as defined above.

Preferably, in an aerosol-generating article comprising an aerosol-generating substrate, as described above, upon heating the aerosol-generating substrate according to Test Method A, at least 25 micrograms of procumenol per gram of substrate on a dry weight basis; at least 2 micrograms of cuminaldehyde per gram of substrate on a dry weight basis; and at least 1 microgram of isothymol per gram of substrate on a dry weight basis. The ranges define the respective amounts of the characteristic compounds in the generated aerosol per gram of aerosol-generating substrate (also referred to herein as “substrate”). This corresponds to the total amount of characteristic compounds measured in the aerosols collected during Test Method A divided by the dry weight of the aerosol-generating substrate before heating.

Upon heating the aerosol-generating substrate according to Test Method A, an aerosol is preferably generated, preferably comprising at least about 100 micrograms of procumenol per gram of substrate, on a dry weight basis. More preferably, the aerosol generated from an aerosol-generating substrate according to the present invention comprises at least about 250 micrograms of procumenol per gram of substrate, on a dry weight basis.

Alternatively or additionally, the aerosol generated from the aerosol-generating substrate preferably comprises up to about 3500 micrograms of procumenol per gram of substrate, on a dry weight basis. More preferably, the aerosol generated from the aerosol-generating substrate comprises up to about 2500 micrograms of procumenol per gram of substrate, on a dry weight basis. Even more preferably, the aerosol generated from the aerosol-generating substrate comprises up to about 1000 micrograms of procumenol per gram of substrate, on a dry weight basis.

Upon heating the aerosol-generating substrate according to Test Method A, an aerosol is generated, preferably comprising at least about 50 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis. More preferably, the aerosol generated from an aerosol-generating substrate according to the present invention comprises at least about 100 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis.

Alternatively or additionally, the aerosol generated from the aerosol-generating substrate preferably comprises up to about 500 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis. More preferably, the aerosol generated from the aerosol-generating substrate comprises up to about 350 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis. Even more preferably, the aerosol generated from the aerosol-generating substrate comprises up to about 250 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis.

Upon heating the aerosol-generating substrate according to Test Method A, an aerosol is generated, preferably comprising at least about 10 micrograms of isothymol per gram of substrate, on a dry weight basis. More preferably, the aerosol generated from an aerosol-generating substrate according to the present invention comprises at least about 25 micrograms of isothymol per gram of substrate, on a dry weight basis.

Alternatively or additionally, the aerosol generated from the aerosol-generating substrate preferably comprises up to about 200 micrograms of isothymol per gram of substrate, on a dry weight basis. More preferably, the aerosol generated from the aerosol-generating substrate comprises up to about 150 micrograms of isothymol per gram of substrate, on a dry weight basis. Even more preferably, the aerosol generated from the aerosol-generating substrate comprises up to about 100 micrograms of isothymol per gram of substrate, on a dry weight basis.

Preferably, the aerosol generated from an aerosol-generating substrate according to the invention during Test Method A contains at least about 0.1 micrograms of nicotine per gram of substrate, more preferably at least about 1 microgram per gram of substrate on a dry weight basis. of nicotine, more preferably at least about 2 micrograms of nicotine per gram of substrate. Preferably, the aerosol contains on a dry weight basis at most about 10 micrograms of nicotine per gram of substrate, more preferably at most about 7.5 micrograms of nicotine per gram of substrate, more preferably at most about 4 micrograms of nicotine per gram of substrate. Contains micrograms of nicotine. For example, the aerosol may contain, on a dry weight basis, about 0.1 micrograms to about 10 micrograms of nicotine per gram of substrate, about 1 microgram to about 7.5 micrograms of nicotine per gram of substrate, or about 2 micrograms of nicotine per gram of substrate. It may contain from micrograms to about 4 micrograms of nicotine. In some embodiments of the invention, the aerosol may contain 0 micrograms of nicotine.

A variety of methods known in the art can be applied to measure the amount of nicotine in an aerosol.

Alternatively or additionally, the aerosol generated from an aerosol-generating substrate according to the invention during Test Method A may optionally contain, on a dry weight basis, at least about 20 milligrams of cannabinoid compound per gram of substrate, more preferably at least about 20 milligrams per gram of substrate. It may comprise about 50 milligrams of a cannabinoid compound, more preferably at least about 100 milligrams of a cannabinoid compound per gram of substrate. Preferably, the aerosol contains, on a dry weight basis, at most about 250 milligrams of cannabinoid compound per gram of substrate, more preferably at most about 200 milligrams of cannabinoid compound per gram of substrate, more preferably at most about 150 milligrams per gram of substrate. Contains milligrams of cannabinoid compounds. For example, the aerosol may contain, on a dry weight basis, about 20 milligrams to about 250 milligrams of a cannabinoid compound per gram of substrate, or about 50 milligrams to about 200 milligrams of a cannabinoid compound per gram of substrate, or about 100 milligrams per gram of substrate. It may contain from about 150 milligrams of cannabinoid compounds. In some embodiments of the invention, the aerosol may contain 0 micrograms of cannabinoid compounds.

Preferably, the cannabinoid compound is selected from CBD and THC. More preferably, the cannabinoid compound is CBD.

A variety of methods known in the art can be applied to determine the amount of cannabinoid compounds in an aerosol.

Carbon monoxide may be present in the aerosol generated from the aerosol-generating substrate according to the invention during Test Method A and may be measured and used to further characterize the aerosol. Oxides of nitrogen, such as nitrogen oxides and nitrogen dioxide, can also be present in aerosols and can be measured and used to further characterize aerosols.

According to the invention, the aerosol generated from the aerosol-generating substrate during Test Method A preferably has an amount of proccumenol per gram of substrate that is at least 5 times the amount of cuminaldehyde per gram of substrate. Therefore, the ratio of proccumenol to cuminaldehyde is at least 5:1. More preferably, the amount of procuminol in the aerosol generated from the aerosol-generating substrate during Test Method A is at least 7.5 times the amount of cuminaldehyde per gram of substrate, such that the ratio of procuminaldehyde to cuminaldehyde is at least 7.5:1. am.

According to the invention, the aerosol generated from the aerosol-generating substrate during Test Method A preferably has an amount of proccumenol per gram of substrate that is at least 15 times the amount of isothymol per gram of substrate. Therefore, the ratio of proccumenol to isothymol is at least 15:1. More preferably, the amount of proccumenol in the aerosol generated from the aerosol-generating substrate during Test Method A is at least 20 times the amount of isothymol per gram of substrate, such that the ratio of proccumenol to isothymol is at least 20:1. am.

A defined ratio of proccumenol to cuminaldehyde and isothymol characterizes the aerosol derived from cumin seed particles. In contrast, in an aerosol generated from cumin oil, the ratio of procumenol to cuminaldehyde and isothymol will be significantly different.

The aerosol produced from an aerosol-generating substrate according to the invention during Test Method A contains at least about 5 milligrams of aerosol former per gram of aerosol-generating substrate, or at least about 10 milligrams of aerosol per gram of substrate, or at least about 10 milligrams of aerosol per gram of substrate. It may additionally contain 15 milligrams of an aerosol former. Alternatively or additionally, the aerosol comprises up to about 30 milligrams of aerosol former per gram of substrate, or up to about 25 milligrams of aerosol former per gram of substrate, or up to about 20 milligrams of aerosol former per gram of substrate. can do. For example, the aerosol may contain from about 5 milligrams to about 30 milligrams of aerosol former per gram of substrate, or from about 10 milligrams to about 25 milligrams of aerosol former per gram of substrate, or from about 15 milligrams to about 20 milligrams of aerosol former per gram of substrate. May contain milligrams of aerosol former. In alternative embodiments, the aerosol may comprise less than 5 milligrams of aerosol former per gram of substrate. This may be appropriate, for example, if the aerosol former is provided separately within the aerosol-generating article or aerosol-generating device.

Suitable aerosol formers for use in the present invention are set forth below.

A variety of methods known in the art can be applied to determine the amount of aerosol former in an aerosol.

As mentioned above, the presence of the characteristic compounds in the aerosol in defined amounts and proportions indicates the inclusion of cumin seed particles in the homogenized plant material forming the aerosol-generating substrate.

Preferably, the aerosol-generating substrate according to the invention comprises homogenized plant material comprising at least about 0.5% by weight cumin seed particles on a dry weight basis. Preferably, the homogenized cumin seed material contains, on a dry weight basis, at least about 0.75% cumin seed particles, more preferably at least about 1.5% cumin seed particles, more preferably at least 2.5% cumin seed pressure particles, by weight. , more preferably at least about 3% by weight of cumin seed particles, more preferably at least about 4% by weight of cumin seed particles, more preferably at least about 5% by weight of cumin seed particles, more preferably at least about 6% by weight. % by weight of cumin seed particles, more preferably at least about 7% by weight of cumin seed particles, more preferably at least about 8% by weight of cumin seed particles, more preferably at least about 9% by weight of cumin seed particles, Preferably it includes at least about 10% by weight cumin seed particles.

In certain embodiments of the invention, the plant particles forming the homogenized cumin seed material comprise at least 98% by weight of cumin seed particles or at least 95% by weight cumin seed particles or at least 90% by weight, based on the dry weight of the plant particles. May contain cumin seed particles. Accordingly, in this embodiment, the aerosol-generating substrate includes cumin seed particles, substantially no other plant particles. For example, the plant particles forming the homogenized cumin seed material may include about 100% cumin seed particles by weight.

In alternative embodiments of the invention, the homogenized cumin material may include cumin seed particles in combination with at least one of tobacco particles or cannabis particles, as described below.

In the following description of the invention, the term “particulate plant material” is used to collectively refer to particles of plant material used to form homogenized plant material. The particulate plant material may consist substantially of cumin seed particles, or may be tobacco particles, cannabis particles, or a mixture of cumin seed particles with both tobacco particles and cannabis particles.

The homogenized cumin material may comprise up to about 100% cumin seed particles by weight on a dry weight basis. Preferably, the homogenized plant material contains, on a dry weight basis, at most about 90% cumin seed particles, more preferably at most about 80% cumin seed particles, more preferably at most about 70% cumin seed particles by weight. , more preferably at most about 60% by weight of cumin seed particles, more preferably at most about 50% by weight of cumin seed particles.

For example, the homogenized cumin material can be from about 0.5% to about 100% cumin seed particles, or from about 5% to about 90% cumin seed particles, or from about 10% to about 80% cumin seed particles, by weight, on a dry weight basis. % by weight of cumin seed particles, or from about 15% to about 70% by weight of cumin seed particles, or from about 20% to about 60% by weight of cumin seed particles, or from about 30% to about 50% by weight of cumin seeds. May contain particles.

In certain particularly preferred embodiments of the invention, the homogenized cumin material comprises from about 10% to about 15% by weight cumin seed particles on a dry weight basis. For example, in one particularly preferred embodiment, the homogenized cumin material comprises about 10% by weight cumin seed particles on a dry weight basis.

As mentioned above, the inventors have identified a number of “characteristic compounds” that are characteristic compounds of the cumin plant and thus indicative of the inclusion of cumin seed particles in an aerosol-generating substrate.

The amounts of characteristic compounds present in pure cumin seed particles are expected to differ from those present in the aerosol-generating substrate. The process of preparing a substrate, including hydration in a slurry or suspension, and drying at high temperatures, and the presence of other ingredients such as aerosol formers, will differentially alter the amount of each characteristic compound. The integrity of the cumin seed particles and the stability of the compound under certain temperatures and through manipulation during manufacturing will also affect the final amount of compound present in the substrate. Therefore, it is contemplated that after the cumin seed particles have been incorporated into the substrate in various physical forms, such as sheets, strands and granules, the ratio of the characteristic compounds to each other will be different.

The presence of cumin in the aerosol-generating substrate and the proportion of cumin provided in the aerosol-generating substrate can be determined by measuring the amount of the characteristic compound in the substrate and comparing it to the corresponding amount of the characteristic compound in the pure cumin material. The presence and amount of characteristic compounds can be determined using any suitable technique known to those skilled in the art.

In a suitable technique, 250 milligrams of aerosol-generating substrate sample is mixed with 5 ml of methanol, shaken and vortexed for 5 minutes, and extracted by centrifugation (4500 g, 5 minutes, 10°C). An aliquot of the extract (300 μL) is transferred to a silanized chromatography vial and diluted with methanol (600 μL) and internal standard (ISTD) solution (100 μL). Close the vial and mix for 5 minutes using an Eppendorf ThermoMixer (5°C, 2000 rpm). Test samples from the resulting extract are analyzed by LC-HRAM-MS in combined full scan mode and data dependent fragmentation mode for identification of characteristic compounds.

In some embodiments, the homogenized cumin material further comprises up to about 75% by weight tobacco particles, on a dry weight basis.

For example, the homogenized cumin material preferably contains, on a dry weight basis, about 10% to about 75% tobacco particles, more preferably about 15% to about 70% tobacco particles by weight, more preferably About 20% to about 65% tobacco particles by weight, more preferably about 25% to about 60% tobacco particles by weight, more preferably about 30% to about 70% tobacco particles by weight.

In some preferred embodiments, the homogenized cumin material comprises from about 5% to about 20% cumin seed particles and from about 55% to about 70% tobacco particles by weight, on a dry weight basis.

The weight ratio of cumin seed particles to tobacco particles in the particulate plant material forming the homogenized cumin seed material can be varied depending on the desired flavor characteristics and the composition of the aerosol. Preferably, the homogenized cumin material comprises a weight ratio of cumin seed particles to tobacco particles of about 1:4 or less. This means that cumin seed particles make up less than 20% of the total particulate plant material. More preferably, the homogenized cumin seed material comprises a weight ratio of cumin seed particles to tobacco particles of about 1:5 or less, and even more preferably 1:6 or less.

For example, in a first preferred embodiment, the weight ratio of cumin seed particles to tobacco particles is about 1:4. A ratio of 1:4 corresponds to a particulate plant material consisting of about 20% by weight cumin seed particles and about 80% by weight tobacco particles. For a homogenized cumin material formed of about 75% by weight particulate plant material, this corresponds to about 15% cumin seed particles and about 60% tobacco particles by weight in the homogenized cumin material, on a dry weight basis.

In another embodiment, the homogenized cumin material comprises a 1:9 weight ratio of cumin seed particles to tobacco particles. In another embodiment, the homogenized cumin material comprises a 1:30 weight ratio of cumin seed particles to tobacco particles.

With reference to the present invention, the term “tobacco particles” describes particles of any plant member of the genus Nicotiana . The term “tobacco particles” includes ground or powdered tobacco blades, ground or powdered tobacco petioles, tobacco dust, tobacco fines, and other particulate tobacco by-products formed during the processing, handling and shipping of tobacco. In a preferred embodiment, the tobacco particles are derived substantially entirely from tobacco leaves. In contrast, isolated nicotine and nicotine salts are derived from tobacco, but are not considered tobacco particles for the purposes of this invention and are not included in the percentage of particulate plant material.

Tobacco particles can be prepared from one or more tobacco plant varieties. Any type of tobacco may be used in the blend. Examples of types of tobacco that may be used include, but are not limited to, yellow tobacco, yellow tobacco, Burley tobacco, Maryland tobacco, Oriental tobacco, Virginia tobacco, and other specialty tobacco.

Hwagun is a method of drying tobacco, especially used for Virginia tobacco. During the fire-curing process, heated air is circulated through densely packed tobacco. During the first stage, the tobacco leaves turn yellow and wilt. During the second stage, the leaf blades are completely dried. During the third stage, the petioles are completely dried.

Burley tobacco plays an important role in many tobacco blends. Burley tobacco has a unique flavor and aroma, and also has the ability to absorb a large amount of cases.

Oriental is a type of tobacco with small leaves and high aromatic qualities. However, Orient tobacco has a milder flavor than, for example, Burley. Generally, Oriental tobaccos are used in relatively small proportions in tobacco blends.

Kasturi, Madhura and Jatim are the sub-types of dry tobacco available. Preferably, Kasturi tobacco and xanthoma tobacco can be used in a blend to produce tobacco particles. Accordingly, the tobacco particles in the particulate plant material may include a blend of kasturi and xanthoma tobacco.

The tobacco particles may have a nicotine content of at least about 2.5% by weight on a dry weight basis. More preferably, the tobacco particles have a nicotine content of at least about 3%, even more preferably at least about 3.2%, even more preferably at least about 3.5%, and most preferably at least about 4% by dry weight. You can have it. When the aerosol-generating substrate contains tobacco particles in combination with cumin seed particles, tobacco with a higher nicotine content is preferred to maintain similar levels of nicotine compared to a typical aerosol-generating substrate without cumin seed particles, which would otherwise be desirable. This is because the total amount of nicotine will be reduced due to the replacement of tobacco particles with cumin seed particles.

Alternatively, the tobacco particles may have a nicotine content of at least less than about 2.5% by weight on a dry weight basis. For example, the tobacco particles may have a nicotine content of less than about 2%, less than about 1.5%, or less than about 1% by weight. In some embodiments, the tobacco particles can have substantially zero nicotine levels.

As a result of including tobacco particles, the aerosol-generating substrate of this embodiment, and the aerosol generated from the aerosol-generating substrate, contain a certain proportion of the “characteristic compounds” of tobacco. Characteristic compounds produced from tobacco include, but are not limited to, anatabine, cotinine, and damacinon.

Although nicotine will be considered a non-tobacco substance for purposes of this invention, nicotine may optionally be included in the aerosol-generating substrate. Nicotine may include one or more nicotine salts selected from the list consisting of nicotine lactate, nicotine citrate, nicotine pyruvate, nicotine bitartrate, nicotine benzoate, nicotine pectate, nicotine alginate, and nicotine salicylate. . Nicotine can be additionally incorporated into tobacco with a low nicotine content, or nicotine can be incorporated into an aerosol-generating substrate with reduced or zero tobacco content.

In certain embodiments of the invention, the aerosol-generating substrate comprises a homogenized cumin material formed from particulate plant material consisting solely of cumin seed particles, with nicotine, such as a nicotine salt, incorporated into the aerosol-generating substrate.

Preferably, the aerosol-generating substrate comprises at least about 0.1 milligrams of nicotine per gram of substrate, on a dry weight basis. More preferably, the aerosol-generating substrate has, on a dry weight basis, at least about 0.5 milligrams of nicotine per gram of substrate, more preferably at least about 1 milligram of nicotine per gram of substrate, and more preferably at least about 1 milligram of nicotine per gram of substrate. About 1.5 milligrams of nicotine, more preferably at least about 2 milligrams of nicotine per gram of substrate, more preferably at least about 3 milligrams of nicotine per gram of substrate, more preferably at least about 4 milligrams of nicotine per gram of substrate. , more preferably at least about 5 milligrams of nicotine per gram of substrate.

Preferably, the aerosol-generating substrate comprises up to about 50 milligrams of nicotine per gram of substrate, on a dry weight basis. More preferably, the aerosol-generating substrate has, on a dry weight basis, at most about 45 milligrams of nicotine per gram of substrate, more preferably at most about 40 milligrams of nicotine per gram of substrate, more preferably at most about 40 milligrams of nicotine per gram of substrate. About 35 milligrams of nicotine, more preferably at most about 30 milligrams of nicotine per gram of substrate, more preferably at most about 25 milligrams of nicotine per gram of substrate, more preferably at most about 20 milligrams of nicotine per gram of substrate. Includes.

For example, an aerosol-generating substrate may comprise, on a dry weight basis, from about 0.1 milligrams to about 50 milligrams of nacotine per gram of substrate, or from about 0.5 milligrams to about 45 milligrams of nacotine per gram of substrate, or per gram of substrate. About 1 milligram to about 40 milligrams of nacotine, or about 2 milligrams to about 35 milligrams of nacotine per gram of substrate, or about 5 milligrams to about 30 milligrams of nacotine per gram of substrate, or about 10 milligrams of nacotine per gram of substrate. It may comprise from milligrams to about 25 milligrams of narcotine, or from about 15 milligrams to about 20 milligrams of narcotine per gram of substrate. In certain preferred embodiments of the invention, the aerosol-generating substrate comprises from about 1 milligram to about 20 milligrams of nicotine per gram of substrate, on a dry weight basis.

The ranges of nicotine content defined for the aerosol-generating substrate include nicotine inherently present in the tobacco material, as well as nicotine optionally added individually to the aerosol-generating substrate, for example in the form of nicotine salts. Includes all forms of nicotine that may be present in the substrate.

In some embodiments, the aerosol-generating substrate is substantially free of nicotine.

Alternatively or additionally to including tobacco particles in the homogenized cumin material of the aerosol-generating substrate according to the invention, the homogenized cumin material may comprise up to 75% by weight of cannabis particles on a dry weight basis. The term “cannabis particles” refers to particles of the cannabis plant, such as Cannabis sativa, Cannabis indica , and Cannabis ruderalis species.

For example, the particulate plant material may comprise from about 40% to about 75% tobacco particles, more preferably from about 45% to about 60% tobacco particles, more preferably from about 50% tobacco particles by weight, on a dry weight basis. % to about 65% by weight tobacco particles.

One or more cannabinoid compounds may optionally be included in the aerosol-generating substrate, but this will be considered a non-cannabis material for the purposes of this invention. As used herein and with reference to the present invention, the term "cannabinoid compound" refers to the cannabis plant - namely Cannabis sativa , Cannabis indica and Cannabis ruderalis. Describes any one of a class of naturally occurring compounds found in some of the species (Cannabis ruderalis ). Cannabinoid compounds are particularly concentrated in the female flower heads and are commonly sold as cannabis oil. Cannabinoid compounds that occur naturally in the cannabis plant include tetrahydrocannabinol (THC) and cannabidiol (CBD). In the context of the present invention, the term “cannabinoid compound” is used to describe both naturally occurring cannabinoid compounds and synthetically prepared cannabinoid compounds.

For example, aerosol-generating substrates include tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannavidic acid (CBDA), cannabinol (CBN), and cannabigerol. (CBG), cannabigerol monomethyl ether (CBGM), cannabivarin (CBV), cannabidivarin (CBDV), tetrahydrocannabivarin (THCV), cannabichromene (CBC), cannabicyclol (CBL), cannabichromevaline (CBCV), cannabigerovarine (CBGV), cannabielsoin (CBE), cannabicitran (CBT), and combinations thereof. You can.

The homogenized cumin material may further comprise proportions of other plant flavor particles (“particulate plant material”) in addition to cumin seed particles or a combination of cumin seed particles and at least one of tobacco particles and cannabis particles.

For the purposes of the present invention, the term “other plant flavor particles” refers to particles of non-cuminous, non-tobacco and non-cannabis plant materials that are capable of producing one or more flavors when heated. This term should be considered to exclude particles of inert plant material, such as cellulose, which do not contribute to the sensory output of the aerosol-generating substrate. The particles may be derived from ground or powdered leaves, fruits, stems, leaf stems, roots, seeds, buds or bark from other plants. Suitable plant flavor particles for inclusion in aerosol-generating substrates according to the present invention will be known to those skilled in the art and include, but are not limited to, clove particles, tea particles, bamboo particles, industrial hemp particles, and combinations thereof.

The composition of the homogenized cumin material can advantageously be adjusted through combining the desired amounts and types of different plant particles. This allows the aerosol-generating substrate to be formed, if desired, from a single homogenized cumin material, without requiring the combination or mixing of different blends, as is the case for example in the manufacture of conventional cut fillers. Accordingly, the manufacture of aerosol-generating substrates can potentially be simplified.

The particulate plant material used in the aerosol-generating substrate of the present invention can be adapted to provide the desired particle size distribution. Particle size distribution is referred to herein as the D-value, whereby the D-value refers to the percentage of particles by number having a diameter less than or equal to a given D-value. For example, in a D95 particle size distribution, 95% of the particles by number have a diameter less than or equal to a given D95 value, and 5% of the particles by number have a diameter greater than a given D95 value. Similarly, in a D5 particle size distribution, 5% of the particles by number have a diameter less than or equal to the D5 value, and 95% of the particles by number have a diameter greater than a given D5 value. Therefore, in combination, the D5 and D95 values provide an indication of the particle size distribution of the particulate plant material.

Particulate plant material may have a D95 value of 50 μm or greater and a D95 value of 400 μm or less. This means that particulate plant material can have a distribution represented by any D95 value within a given range, i.e. D95 can be equal to 50 μm, D95 can be equal to 55 μm, or so on. It may be equal to 400 μm. By providing D95 values within this range, the inclusion of relatively large plant particles into the homogenized cumin material is avoided. This is desirable because the generation of aerosols from these large plant particles is likely to be relatively inefficient. Additionally, the inclusion of large plant particles in the homogenized cumin material can adversely affect the consistency of the material.

Preferably, the particulate plant material may have a D95 value of at least about 50 μm and up to about 350 μm, more preferably at least about 75 μm and up to about 300 μm. Both the particulate cumin material and the particulate tobacco material have a D95 value of at least about 50 μm and a D95 value of up to about 400 μm, preferably a D95 value of at least about 75 μm and a D95 value of up to about 350 μm, more preferably at least about 100 μm. It may have a D95 value of up to about 300 μm.

Preferably, the particulate plant material may have a D5 value of about 10 μm or less to about 50 μm or less, more preferably a D5 value of about 20 μm or less to about 40 μm or less. Providing a D5 value within this range avoids the inclusion of very small dust particles within the homogenized cumin material, which may be desirable from a manufacturing standpoint.

In some embodiments, particulate plant material, including cumin seed particles, can be intentionally ground to form particles with a desired particle size distribution. The use of intentionally ground plant material advantageously improves the homogeneity of the particulate plant material and the consistency of the homogenized cumin material.

The diameter of 100% of the particulate plant material may be about 300 μm or less, more preferably about 275 μm or less. The diameter of 100% of the particulate cumin material and 100% of the particulate tobacco material may be about 300 μm or less, more preferably about 275 μm or less. The particle size range of cumin seed particles allows cumin seed particles to be combined with tobacco particles in a conventional cast leaf process.

The homogenized cumin material comprises, on a dry weight basis, at least about 55% by weight particulate plant material, preferably as described above, comprising cumin seed particles, more preferably at least about 60% by weight particulate plant material, and More preferably it includes at least about 65% by weight particulate plant material. The homogenized cumin material preferably contains, on a dry weight basis, no more than about 95% particulate plant material, more preferably no more than about 90% particulate plant material, more preferably no more than about 85% particulate plant material. contains substances. For example, the homogenized cumin material may contain, on a dry weight basis, from about 55% to about 95% particulate plant material, or from about 60% to about 90% particulate plant material, or from about 65% to about 65% by weight. It may contain 85% by weight particulate plant material. In one particularly preferred embodiment, the homogenized cumin material comprises about 75% by weight particulate plant material on a dry weight basis.

Accordingly, the particulate plant material is typically combined with one or more other ingredients to form a homogenized cumin material.

As defined above, the homogenized cumin material further comprises an aerosol former. Upon evaporation, the aerosol former can deliver other vaporized compounds released from the aerosol-generating substrate upon heating, such as nicotine and flavoring agents, in the aerosol. Aerosolization of a particular compound from an aerosol-generating substrate is not determined solely by its boiling point. The amount of compound aerosolized can be influenced by the physical form of the substrate as well as other components also present within the substrate. The stability of a compound under the temperature and time frame of aerosolization will also affect the amount of compound present in the aerosol.

Suitable aerosol formers for inclusion in the homogenized cumin material are known in the art and include, but are not limited to, polyhydric alcohols such as triethylene glycol, propylene glycol, 1,3-butanediol and glycerol; Esters of polyhydric alcohols such as glycerol mono-, di- or triacetate; and aliphatic esters of mono-, di- or polycarboxylic acids such as dimethyl dodecanedioate and dimethyl tetradecanedioate. The homogenized cumin material may comprise a single aerosol former, or a combination of two or more aerosol formers.

The homogenized cumin material preferably contains from about 5% to about 30% by dry weight, such as from about 10% to about 25% by dry weight, or from about 15% to about 15% by dry weight. It has an aerosol former content of 20% by weight.

For example, if the substrate is intended for use in an aerosol-generating article for an electrically operated aerosol-generating system having a heating element, it preferably comprises an aerosol former content of about 5% to about 30% by weight on a dry weight basis. can do. If the substrate is intended to be used in an aerosol-generating article for an electrically operated aerosol-generating system with a heating element, the aerosol former may preferably be glycerol.

In other embodiments, the homogenized cumin material can have an aerosol former content of from about 1% to about 5% by weight on a dry weight basis. For example, if the substrate is intended for use in an aerosol-generating article in which the aerosol former is maintained in a reservoir separate from the substrate, the substrate may have an aerosol former content of greater than 1% and less than about 5%. In this embodiment, the aerosol former is evaporated upon heating and the stream of aerosol former is contacted with the aerosol-generating substrate to entrain the flavor from the aerosol-generating substrate of the aerosol.

Aerosol formers can act as wetting agents within the aerosol-generating substrate.

Alternatively or additionally, the homogenized cumin material may further comprise an acid. Acids may include carboxylic acids. Carboxylic acids may contain ketone groups. Preferably, the carboxylic acid may contain a ketone group, such as levulinic acid or lactic acid, having less than about 10 carbon atoms, or less than about 6 carbon atoms, or less than about 4 carbon atoms. The inclusion of an acid may be particularly advantageous when the aerosol-generating substrate is in gel form, as described below.

As defined above, the homogenized cumin material may further comprise a binder to modify the mechanical properties of the particulate plant material, wherein the binder is incorporated into the homogenized cumin material as described herein during manufacture. Suitable extrinsic binders are known to those skilled in the art and include, but are not limited to, gums such as guar gum, xanthan gum, gum arabic and locust bean gum; Cellulosic binders such as hydroxypropyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose and ethyl cellulose; polysaccharides such as starch, organic acids such as alginic acid, conjugate base salts of organic acids such as sodium alginate, agar and pectin; and combinations thereof. Preferably, the binder includes guar gum.

Preferably, the binder is present in an amount of about 1% to about 10% by weight, based on the dry weight of the homogenized cumin material, preferably in an amount of about 2% to about 5% by weight, based on the dry weight of the homogenized cumin material. do.

Additionally, the homogenized cumin material may further comprise one or more lipids to facilitate the diffusibility of volatile components (e.g., aerosol formers, (E)-anethole and nicotine), wherein the lipids are added during manufacturing. Included in the homogenized cumin material as described herein. Suitable lipids for inclusion in the homogenized plant material include, but are not limited to, medium chain triglycerides, cocoa butter, palm oil, palm kernel oil, mango oil, shea butter, soybean oil, cottonseed oil, palm oil, hydrogenated palm oil, candelilla wax, Carnauba wax, shellac, sunflower wax, sunflower oil, rice bran, and Revel A; and combinations thereof.

Alternatively or additionally, the homogenized cumin material may further comprise a pH modifier.

Alternatively or additionally, the homogenized cumin material may further comprise fibers to alter the mechanical properties of the homogenized cumin material, wherein reinforcing fibers are included in the homogenized cumin material as described herein during manufacture. . Suitable extrinsic fibers for inclusion in the homogenized cumin material are known in the art and include, but are not limited to, cellulosic fibers; softwood fiber; hardwood fiber; jute fiber; and fibers formed from non-tobacco materials and non-cumin materials, including combinations thereof. Additionally, extrinsic fibers derived from tobacco and/or cumin may be added. Any fibers added to the homogenized cumin material are not considered to form part of the “particulate plant material” as described above. Before inclusion in the homogenized cumin material, the fibers are mechanically pulped; refine; chemical pulping; bleaching; sulfate pulping; and combinations thereof. Fibers typically have a length greater than their width.

Suitable fibers typically have a length greater than 400 μm but less than or equal to 4 mm, preferably in the range from 0.7 mm to 4 mm. Preferably, the fibers are present in an amount of at least about 2% by weight, based on the dry weight of the substrate. The amount of fibers in the homogenized cumin material can vary depending on the type of material and, in particular, the method used to produce the homogenized cumin material. In some embodiments, the fibers may be present in an amount of from about 2% to about 15% by weight, most preferably about 4% by weight, based on the dry weight of the substrate. For example, this level of fiber may be present if the homogenized plant material is in the form of cast leaves. In other embodiments, the fibers may be present in an amount of at least about 30% by weight, or at least about 40% by weight. For example, if the homogenized cumin material is cumin paper formed in a papermaking process, this higher level of fiber is likely to be provided.

In a preferred embodiment of the invention, the homogenized cumin material comprises cumin seed particles, from about 5% to about 30% by weight of aerosol former and from about 1% to about 10% by weight of binder, on a dry weight basis. In this embodiment, the homogenized cumin material preferably further comprises from about 2% to about 15% by weight fibers. Particularly preferably, the binder is guar gum.

The aerosol-generating substrate homogenized plant material according to the invention may comprise a single type of homogenized plant material or two or more homogenized plant materials having different compositions or morphologies. For example, in one embodiment, the aerosol-generating substrate includes cumin seed particles and tobacco particles or tobacco particles, contained within the same sheet of homogenized plant material. However, in other embodiments, the aerosol-generating substrate may include tobacco particles or cannabis particles and cumin seed particles in different sheets.

The homogenized cumin material is preferably in the form of a solid or gel. However, in some embodiments, the homogenized material may be in solid form rather than a gel. Preferably, the homogenized material is not in the form of a film.

Homogenized plant material may be provided in any suitable form. For example, the homogenized plant material may be in the form of one or more sheets. As used herein in connection with the present invention, the term “sheet” describes a laminated element having a width and length substantially greater than its thickness.

Alternatively or additionally, the homogenized cumin material may be in the form of a plurality of pellets or granules.

Alternatively or additionally, the homogenized cumin material may be in a form that can fill cartridges or shisha consumables or be used in a shisha device. The present invention includes a cartridge or shisha device containing a homogenized cumin material.

Alternatively or additionally, the homogenized cumin material may be in the form of a plurality of strands, strips or shreds. As used herein, the term “strand” describes an elongated element of material having a length substantially greater than its width and thickness. The term “strand” should be considered to include strips, pieces and any other homogenized cumin material having a similar shape. Strands of homogenized cumin material may be formed into sheets of homogenized cumin material, for example by cutting or crushing, or for example by other methods, for example extrusion methods.

In some embodiments, strands may be formed in situ within the aerosol-generating substrate, for example as a result of crimping, splitting or cracking of the sheet of homogenized plant material during formation of the aerosol-generating substrate. The strands of homogenized cumin material within the aerosol-generating substrate may be separate from one another. Alternatively, each strand of homogenized cumin material within the aerosol-generating substrate may be at least partially connected to an adjacent strand or strands along the length of the strand. For example, adjacent strands may be connected by one or more fibers. This may occur, for example, if strands are formed due to the splitting of sheets of homogenized cumin material during the production of the aerosol-generating substrate, as described above.

Preferably, the aerosol-generating substrate is in the form of one or more sheets of homogenized cumin material. In various embodiments of the invention, one or more sheets of homogenized cumin material may be produced by a casting process. In various embodiments of the invention, one or more sheets of homogenized cumin material may be produced by a papermaking process. One or more sheets as described herein may each individually have a thickness of 100 micrometers to 600 micrometers, preferably 150 micrometers to 300 micrometers, and most preferably 200 micrometers to 250 micrometers. Individual thickness refers to the thickness of individual sheets, while combined thickness refers to the total thickness of all sheets that make up the aerosol-generating substrate. For example, if the aerosol-generating substrate is formed from two separate sheets, the combined thickness is the sum of the measured thicknesses of the two individual sheets or the two sheets with the two sheets laminated to the aerosol-generating substrate.

One or more sheets as described herein can each individually have a basis weight of from about 100 g/m ² to about 300 g/m ² .

One or more sheets as described herein each individually weigh about 0.3 g/cm ³ It may have a density of about 1.3 g/cm ³ to about 1.3 g/cm 3 , preferably about 0.7 g/cm ³ to about 1.0 g/cm ³ .

The term “tensile strength” is used throughout this specification to refer to the measure of force required to stretch a sheet of homogenized cumin material until it breaks. More specifically, tensile strength is the maximum tensile force per unit width, measured in the machine direction or cross direction of the sheet material, that the sheet material can withstand before failure. It is expressed in newtons per meter of material (N/m). Tests for measuring the tensile strength of sheet materials are well known. Suitable tests are described in the 2014 publication of International Standard ISO 1924-2 entitled "Paper and board - Determination of tensile properties - Part 2: Constant speed stretching method".

Materials and equipment required to perform testing according to ISO 1924-2 include: universal tensile/compression testing machine, Instron 5566, or equivalent; 100 Newton tensile load cell, Instron, or equivalent; 2 pneumatically operated grips; Steel gauge block 180 ± 0.25 mm long (width: approx. 10 mm, thickness: approx. 3 mm); Double-blade strip cutter, size 15 ± 0.05 x approx. 250 mm, Adamel Lhomargy or equivalent; scalpel; A computer running acquisition software, Merlin, or equivalent; and compressed air.

Before testing, sheets of homogenized cumin material are prepared by primary conditioning at 22 ± 2° C. and 60 ± 5% relative humidity for at least 24 hours. The machine direction or cross direction samples are then cut to approximately 250 x 15 ± 0.1 mm with a double-blade strip cutter. The edges of the specimen must be cut cleanly - do not cut more than three specimens at the same time.

Set up the tensile/compression test machine by installing a tensile load cell of 100 Newtons, turn on the universal tensile/compression test machine and computer switch, and select the measurement method predefined in the software, with the test speed set at 8 mm/min. . The tensile load cell is then calibrated and the pneumatic grips installed. Using a steel gauge block, adjust the test distance between the pneumatically actuated grips to 180 ± 0.5 mm, and set the distance and force to 0.

Place the specimen squarely centered between the grips, avoiding touching the area to be tested with your fingers. Close the upper grip and let the paper strip catch on the open lower grip. The force is set to 0. Then, gently pull the paper strip down and close the lower grip; The starting force should be between 0.05 and 0.20 N. While the upper grip moves upward, slowly increasing force is applied until the specimen fractures. Repeat the same procedure with the remaining specimens. The results are valid when the specimen breaks when the grips are moved a distance of more than 10 mm. Otherwise, reject this result and perform additional measurements.

If the available test specimens of homogenized cumin material are smaller than the samples described in the test according to ISO 1924-2 as described above, the test can be easily scaled down to accommodate the size of the available test specimens.

One or more sheets of the homogenized cumin material described herein may each individually have a tensile strength at the cross-direction peak from 50 N/m to 400 N/m or preferably from 150 N/m to 350 N/m. Given that sheet thickness affects tensile strength, when batches of sheets exhibit variations in thickness, it may be desirable to normalize the values to a specific sheet thickness.

One or more sheets described herein each individually has a tensile strength in the machine direction peak of 100 N/m to 800 N/m or preferably 280 N/m to 620 N/m, normalized to a sheet thickness of 215 μm. You can also have The machine direction refers to the direction in which the sheet material is rolled or unwound into the bobbin and fed into the machine, while the cross direction is perpendicular to the machine direction. These values of tensile strength make the sheets and methods described herein particularly suitable for subsequent operations involving mechanical stresses.

The provision of sheets with a thickness, weight and tensile strength as defined above advantageously optimizes the machinability of the sheets to form an aerosol-generating substrate and ensures that damage such as tearing of the sheets is avoided during high-speed processing of the sheets. .

In embodiments of the invention where the aerosol-generating substrate comprises one or more sheets of homogenized cumin material, the sheets are preferably in the form of one or more corrugated sheets. As used herein, the term "corrugated" refers to a sheet of homogenized cumin material being rolled, folded, or otherwise compressed or retracted substantially transversely to the cylindrical axis of the plug or rod. The step of “crimping” the sheet may be performed by any suitable means that provides the necessary transverse compression of the sheet.

As used herein, the term “longitudinal” refers to the direction corresponding to the major longitudinal axis of the aerosol-generating article extending between the upstream and downstream ends of the aerosol-generating article. During use, air is drawn longitudinally through the aerosol-generating article. The term “transverse” refers to the direction perpendicular to the longitudinal axis. As used herein, the term “length” refers to the longitudinal dimension of a component, and the term “width” refers to the transverse dimension of a component. For example, for a plug or rod with a circular cross-section, the maximum width corresponds to the diameter of the circle.

As used herein, the term “plug” refers to a generally cylindrical element having a substantially polygonal, circular, ovoid, or elliptical cross-section. As used herein, the term “rod” is used to refer to a generally cylindrical element of substantially polygonal cross-section, preferably circular, oval or elliptical cross-section. The rod may have a length longer than that of the plug. Typically, the rod has a length greater than the length of the plug. The rod may comprise one or more plugs, preferably longitudinally aligned.

As used herein, the terms “upstream” and “downstream” describe the relative position of an element or portion of an element of an aerosol-generating article with respect to the direction in which an aerosol is transported through the aerosol-generating article during use. The downstream end of the airflow path is the end at which the aerosol is delivered to the user of the article.

One or more sheets of homogenized cumin material may be gathered transversely about its longitudinal axis and surrounded by a wrapper to form a continuous rod or plug. A continuous rod may be cut into multiple individual rods or plugs. The wrapper may be a paper wrapper or a non-paper wrapper, as described in more detail below.

Alternatively, one or more sheets of homogenized cumin material may be cut into strands as mentioned above. In this embodiment, the aerosol-generating substrate comprises a plurality of strands of homogenized cumin material. The strands can be used to form a plug. Typically, the width of these strands is at least about 0.2 mm, or at least about 0.5 mm. Preferably, the width of these strands is no more than about 5 mm, or about 4 mm, or about 3 mm, or about 1.5 mm. For example, the width of the strand may be from about 0.25 mm to about 5 mm, or from about 0.25 mm to about 3 mm, or from about 0.5 mm to about 1.5 mm.

The length of the strand is preferably greater than about 5 mm, for example between about 5 mm and about 20 mm, or between about 8 mm and about 15 mm, or about 12 mm. Preferably, the strands have substantially the same length as each other. The length of the strand may be determined by the manufacturing process, whereby the rod is cut into shorter plugs and the length of the strand corresponds to the length of the plug. The strands may be brittle, which may lead to fracture, especially during transport. In this case, the length of some strands may be less than the length of the plug.

The plurality of strands extend substantially longitudinally along the length of the aerosol-generating substrate, preferably aligned with the longitudinal axis. Accordingly, it is preferred that the plurality of strands are aligned substantially parallel to each other. The plurality of longitudinal strands of aerosol-generating material are preferably substantially non-coiled.

The strands of homogenized cumin material preferably each have a mass to surface area ratio of at least about 0.02 milligrams per square millimeter, more preferably at least about 0.05 milligrams per square millimeter. Preferably, the strands of homogenized cumin material each have a mass to surface area ratio of less than or equal to about 0.2 milligrams per square millimeter, more preferably less than or equal to about 0.15 milligrams per square millimeter. The mass to surface area ratio is calculated by dividing the mass of the strand of homogenized cumin material in milligrams by the geometric surface area of the strand of homogenized cumin material in square millimeters.

One or more sheets of homogenized cumin material may be textured through crimping, embossing, or perforation. One or more sheets may be textured before being gathered or cut into strands. Preferably, the one or more sheets of homogenized cumin material may be crimped prior to pleating such that the homogenized cumin material is in the form of a crimped sheet, more preferably in the form of a crimped crimped sheet. As used herein, the term “crimped sheet” refers to a sheet having a plurality of substantially parallel ridges or corrugations, usually aligned with the longitudinal axis of the article.

In one embodiment, the aerosol-generating substrate can be in the form of a single plug of aerosol-generating substrate. Preferably, the plug of the aerosol-generating substrate may comprise a plurality of strands of homogenized cumin material. Most preferably, the plug of the aerosol-generating substrate may comprise one or more sheets of homogenized cumin material. Preferably, one or more sheets of homogenized cumin material may be crimped to have a plurality of ridges or corrugations substantially parallel to the cylindrical axis of the plug. This treatment advantageously facilitates the corrugation of the crimped sheet of homogenized cumin material to form a plug. Preferably, one or more sheets of homogenized cumin material may be corrugated. It will be appreciated that the crimped sheet of homogenized cumin material may alternatively or additionally have a plurality of substantially parallel ridges and corrugations disposed at an acute or obtuse angle to the cylindrical axis of the plug. The sheet may be crimped to a degree that the integrity of the sheet is destroyed in a plurality of parallel ridges or corrugations causing separation of the material, resulting in the formation of pieces, strands or strips of homogenized cumin material.

In another embodiment of the aerosol-generating substrate, it comprises a first plug comprising a first homogenized plant material and a second plug comprising a second homogenized plant material, wherein the first homogenized plant material and the second homogenized plant material are different. Levels include cumin seed particles and tobacco particles. For example, the first homogenized plant material may comprise from about 50% to about 75% by weight cumin seed particles on a dry weight basis; The second homogenized plant material comprises from about 50% to about 75% tobacco particles by weight on a dry weight basis. Overall, according to the invention, the homogenized plant material in the aerosol-generating substrate preferably comprises, on a dry weight basis, at least 0.5% by weight of cumin seed particles and at most 74.5% by weight of tobacco particles.

In this arrangement, the first homogenized plant material preferably comprises a first particulate plant material having a higher proportion of cumin seed particles than the second homogenized plant material. The second homogenized plant material may be a homogenized tobacco material substantially free of cumin seed particles.

Preferably, the first homogenized plant material may be in the form of one or more sheets and the second homogenized plant material may be in the form of one or more sheets.

Optionally, the aerosol-generating substrate may include one or more plugs. Preferably, the substrate can comprise a first plug and a second plug, wherein the first homogenized plant material can be positioned within the first plug and the second homogenized plant material can be positioned within the second plug.

Two or more plugs may be combined in an abutting end-to-end relationship and may extend to form a rod. Two plugs can be placed longitudinally with a gap between them, creating a cavity within the rod. The plug may be in any suitable arrangement within the rod.

For example, in a preferred arrangement, a downstream plug containing a major proportion of cumin seed particles may abut an upstream plug containing a major proportion of tobacco particles to form a rod. Alternative configurations in which the upstream and downstream positions of the respective plugs are varied relative to each other are also contemplated. Alternative compositions of the third homogenized plant material containing different proportions of cumin seed particles and tobacco particles and forming a third plug are also contemplated. If two or more plugs are provided, the homogenized plant material may be provided in the same form in each plug or in a different form in each plug, ie, shriveled or shredded. One or more plugs may optionally be wrapped individually or together with a thermally conductive sheet material, as described below.

The first plug may include one or more sheets of first homogenized plant material and the second plug may include one or more sheets of second homogenized plant material. The sum of the lengths of the plugs may be about 10 mm to about 40 mm, preferably about 10 mm to about 15 mm, more preferably about 12 mm. The first plug and the second plug may have the same length, or may have different lengths. When the first plug and the second plug have the same length, the length of each plug may preferably be from about 6 mm to about 20 mm. Preferably, the second plug can be longer than the first plug to provide the desired ratio of tobacco particles to cumin seed particles in the substrate. Overall, the substrate preferably contains, on a dry weight basis, 0 to 75% by weight of tobacco particles and 2.5 to 75% by weight of cumin seed particles. Preferably, the second plug is at least 40% to 50% longer than the first plug.

If the first homogenized plant material and the second homogenized plant material are in the form of one or more sheets, preferably the one or more sheets of the first homogenized plant material and the second homogenized plant material may be corrugated sheets. Preferably, the one or more sheets of first homogenized plant material and second homogenized plant material may be crimped sheets. It will be understood that all other physical properties described with reference to embodiments in which a single homogenized plant material is present are equally applicable to embodiments in which a first homogenized plant material and a second homogenized plant material are present. Additionally, the description of additives (such as binders, lipids, fibers, aerosol formers, wetting agents, plasticizers, flavoring agents, fillers, aqueous and non-aqueous solvents and combinations thereof) with reference to embodiments in which a single homogenized plant material is present. It will be understood that the same applies to embodiments in which there is a first homogenized plant material and a second homogenized plant material.

In another embodiment of the aerosol-generating substrate, the first homogenized plant material is in the form of a first sheet, the second homogenized plant material is in the form of a second sheet, and the second sheet at least partially overlies the first sheet.

The first sheet may be a textured sheet, and the second sheet may be a non-textured sheet.

Both the first and second sheets may be textured sheets.

The first sheet may be a textured sheet that is textured in a different way than the second sheet. For example, the first sheet can be crimped and the second sheet can be perforated. Alternatively, the first sheet may be perforated and the second sheet may be crimped.

Both the first and second sheets may be crimped sheets that are morphologically different from each other. For example, the second sheet may be crimped with a different number of crimps per unit width of the sheet compared to the first sheet.

The sheet may be wrinkled to form a plug. Sheets gathered together to form a plug can have different physical dimensions. The width and thickness of the sheet can be varied.

It may be desirable to bring together two sheets, each having a different thickness or each having a different width. This may change the physical properties of the plug. This can facilitate the formation of blended plugs of aerosol-generating substrates from sheets of different chemical compositions.

The first sheet may have a first thickness, and the second sheet may have a second thickness that is a multiple of the first thickness, for example, the second sheet may be 2 or 3 times the first thickness. It can also be twice as thick.

The first sheet may have a first width, and the second sheet may have a second width that is different from the first width.

The first sheet and the second sheet may be placed in an overlapping relationship before being pleated together, or at the point at which they are pleated together. The sheets may have the same width and thickness. Sheets may have different thicknesses. The sheets may have different widths. The sheets may have different textures.

If it is desirable for both the first sheet and the second sheet to be textured, the sheets may be textured simultaneously before being wrinkled. For example, the sheets may be brought into overlapping relationship and passed through a texturing means, such as a pair of crimp rollers. A suitable device and process for co-crimping is explained with reference to Figure 2 of WO-A-2013/178766. In a preferred embodiment, a second sheet of second homogenized plant material is laid over a first sheet of first homogenized plant material and the combined sheets are gathered to form a plug of the aerosol-generating substrate. Optionally, the sheets may be crimped together prior to pleating to facilitate pleating.

Alternatively, each sheet can be individually textured and then brought together and pleated into a plug. For example, if the two sheets have different thicknesses, it may be desirable to crimp the first sheet differently relative to the second sheet.

It will be understood that all other physical properties described with reference to embodiments in which a single homogenized plant material is present are equally applicable to embodiments in which a first homogenized plant material and a second homogenized plant material are present. Additionally, the description of additives (such as binders, lipids, fibers, aerosol formers, wetting agents, plasticizers, flavoring agents, fillers, aqueous and non-aqueous solvents and combinations thereof) with reference to embodiments in which a single homogenized plant material is present. It will be understood that the same applies to embodiments in which there is a first homogenized plant material and a second homogenized plant material.

Homogenized plant material for use in aerosol-generating substrates according to the present invention may be prepared by a variety of methods, including papermaking, casting, dough recycling, extrusion, or any other suitable process.

Preferably, the homogenized tobacco material is in the form of “cast leaves”. As used herein, the term “cast leaf” refers to a slurry containing plant particles (e.g., in the form of cumin seed particles, or a mixture of tobacco particles and cumin seed particles) and a binder (e.g., guar gum), which is conveyed on a belt conveyor. refers to a sheet product produced by a casting process, which is based on casting on a support surface, drying the slurry, and removing the dried sheet from the support surface. Examples of casting or cast leaf processes are described, for example, in US-A-5,724,998 for making cast leaf cigarettes. In the cast leaf process, particulate plant material is mixed with liquid ingredients, typically water, to form a slurry. Other components added in the slurry may include fibers, binders, and aerosol formers. Particulate plant material can clump up in the presence of binders. The slurry is cast onto a support surface and dried to form a sheet of homogenized cumin material.

In certain preferred embodiments, the homogenized cumin material used in the articles according to the invention is produced by casting. Cumin materials manufactured by casting processes generally contain agglomerated particulate plant material.

In the cast leaf process, most of the flavor is advantageously preserved because substantially all of the soluble fraction is retained within the plant material. Additionally, energy-intensive papermaking steps are avoided.

In one preferred embodiment of the invention, a mixture comprising particulate plant material, water, binder and aerosol former is formed to form the homogenized cumin material. After the sheet is formed from the mixture, the sheet is dried. Preferably, the mixture is an aqueous mixture. As used herein, “dry weight” refers to the weight of a particular non-water component relative to the sum of the weights of all non-water components in the mixture, expressed as a percentage. The composition of the aqueous mixture may be referred to as “dry weight percent.” It refers to the weight of the non-water component relative to the total weight of the aqueous mixture, expressed as a percentage.

The mixture may be a slurry. As used herein, “slurry” is a homogenized aqueous mixture that has a relatively low dry weight. The slurry used in the method herein may preferably have a dry weight of 5% to 60%.

Alternatively, the mixture may be a dough. As used herein, “dough” is an aqueous mixture that has a relatively high dry weight. Dough as used in the methods herein may preferably have a dry weight of at least 60%, more preferably at least 70%.

Slurry and doughs comprising greater than 30% dry weight may be desirable in certain embodiments of the method.

The step of mixing the particulate plant material, water and other optional ingredients may be performed by any suitable means. For low viscosity mixtures, i.e. some slurries, it is desirable to carry out mixing using a high energy mixer or a high shear mixer. Such mixing homogeneously breaks up and distributes the mixture of various phases. For higher viscosity mixtures, i.e. for some doughs, a kneading process can be used to homogeneously distribute the mixture of various phases.

The method according to the invention may further include the step of vibrating the mixture to distribute the various components. Vibrating the mixture, for example vibrating the tank or silo in which the homogenized mixture is located, can assist in homogenizing the mixture, especially if the mixture is a low viscosity mixture, i.e. partially a slurry. If vibration as well as mixing is performed, less mixing time may be required to homogenize the mixture to the optimal target for casting.

If the mixture is a slurry, the web of homogenized cumin material is preferably formed by a casting process comprising casting the slurry onto a support surface, such as a belt conveyor. A method of producing homogenized cumin material includes drying the cast web to form a sheet. The cast web may be dried for a suitable time at room temperature, or at an ambient temperature of at least about 60°C, more preferably at least about 80°C. Preferably, the cast web is dried at an ambient temperature of less than or equal to 200°C, more preferably less than or equal to about 160°C. For example, the cast web can be dried at a temperature of about 60°C to about 200°C, or about 80°C to about 160°C. Preferably, the moisture content of the sheet after drying is about 5% to about 15% based on the total weight of the sheet. The sheet can then be removed from the support surface after drying. The cast sheet has tensile strength that allows it to be mechanically manipulated and wound or unwound from the bobbin without breaking or deforming.

If the mixture is a dough, the dough may be extruded into the form of sheets, strands or strips prior to drying the extruded mixture. Preferably, the dough may be extruded in the form of a sheet. The extruded mixture may be dried for a suitable time at room temperature, or at a temperature of at least about 60°C, more preferably at least about 80°C. Preferably, the extruded mixture is dried at an ambient temperature of less than or equal to 200°C, more preferably less than or equal to about 160°C. For example, the extruded mixture can be dried at a temperature of about 60°C to about 200°C, or about 80°C to about 160°C. Preferably, the moisture content of the extruded mixture after drying is from about 5% to about 15% based on the total weight of the sheet. Sheets formed from dough require less drying time and/or lower drying temperatures due to their significantly lower water content compared to webs formed from slurry.

After the sheet has dried, the method may optionally include coating a nicotine salt on the sheet, preferably together with an aerosol former, as described in the disclosure of WO-A-2015/082652.

After the sheet has dried, the method according to the invention may optionally include cutting the sheet into strands, shreds or strips for the formation of an aerosol-generating substrate as described above. Strands, shreds, or strips can be joined to form a rod of aerosol-generating substrate using any suitable means. In a formed rod of an aerosol-generating substrate, the strands, shreds, or strips may be substantially aligned, for example, along the length of the rod. Alternatively, the strands, shreds, or strips may be randomly oriented in the rod.

The method according to the invention may optionally further comprise, after the drying step, winding the sheet onto a bobbin.

The present invention further provides an alternative papermaking method for producing sheets of homogenized plant material in the form of plant “paper”. Plant paper refers to reconstituted plant sheets formed by a process of extracting plant feedstock with a solvent to produce an extract of soluble plant compounds and an insoluble residue of fibrous plant material, the extract being recombined with the insoluble residue. The extract may be selectively concentrated or further processed before being recombined with the insoluble residue. The insoluble residue can optionally be purified and combined with additional plant fiber before being recombined with the extract. In the process according to the invention, the plant feedstock will optionally comprise particles of cumin combined with particles of tobacco.

More specifically, the method includes a first step of mixing plant material and water to form a dilute suspension. The dilute suspension mainly contains separate cellulose fibers. The suspension has a lower viscosity and higher moisture content than the slurry produced from the casting process. This first step may involve soaking, optionally in the presence of an alkali such as sodium hydroxide, and optionally applying heat.

The method further comprises a second step of separating the suspension into an insoluble portion containing insoluble residues of fibrous plant material and a liquid or aqueous extract comprising soluble plant compounds. The water remaining in the insoluble residue of the fibrous plant material can be drained through a screen that acts as a sieve, allowing a web of randomly woven fibers to lie underneath. Water can be further removed from this web by pressing with rollers, sometimes assisted by suction or vacuum.

After removal of the aqueous portion and water, the insoluble residue is formed into a sheet. Preferably, a generally flat, uniform sheet of plant fiber is formed.

Preferably, the method further comprises concentrating the extract of soluble plant compounds removed from the sheet, and adding the concentrated extract into the sheet of insoluble residue of fibrous plant material to form a sheet of homogenized plant material. Includes. Alternatively or additionally, soluble or concentrated plant material from other processes may be added to the sheet. The extract or concentrated extract may be derived from different varieties of plants of the same species, or from different species of plants.

This process has been used with tobacco to make reconstituted tobacco products, also known as cigarette paper, as described in US-A-3,860,012. The same process can also be used with one or more plants to produce paper-like sheet materials, such as cumin paper sheets.

In certain preferred embodiments, the homogenized plant material used in the article according to the invention is produced by a papermaking process as defined above. In this embodiment, the homogenized cumin material is in the form of cumin paper.

Homogenized tobacco material or homogenized cumin material produced by this process is referred to as tobacco paper or cumin paper. Homogenized plant material produced by the papermaking process is distinguished by the presence of a plurality of fibers throughout the material, which are visible to the eye or under a light microscope, especially when the paper is wetted with water. In contrast, homogenized plant material produced by the casting process contains fewer fibers than paper and tends to dissociate into a slurry when wet. Blended tobacco cumin paper refers to homogenized plant material produced by this process using a mixture of tobacco and cumin materials.

In embodiments where the aerosol-generating substrate includes a combination of cumin seed particles and tobacco particles, the aerosol-generating substrate may include one or more cumin paper sheets and one or more tobacco paper sheets. Sheets of cumin paper and tobacco paper may be interlocked or stacked together before being crimped to form rods. Optionally, the sheet may be crimped. Alternatively, sheets of cumin paper and tobacco paper can be cut into strands, strips or strips and then combined to form rods. The relative amounts of tobacco and cumin in the aerosol-generating substrate can be adjusted by varying the respective numbers of tobacco and cumin sheets or the respective amounts of cumin and tobacco strands, strips or pieces in the load.

For example, the number or amount of tobacco and cumin sheets or strands can be adjusted to provide a ratio of cumin to tobacco of about 1:4, or about 1:9, or about 1:30.

Other known processes that can be applied to prepare homogenized plant material include, for example, dough reconstitution processes of the type described in US-A-3,894,544; and extrusion processes of the type described, for example, in GB-A-983,928. Typically, the density of homogenized plant material produced by extrusion processes and dough reconstitution processes is greater than the density of homogenized plant material produced by casting processes.

In an alternative embodiment of the invention, the homogenized cumin material is in the form of a gel composition formed with cumin seed particles, an aerosol former and a binder.

Preferably, when the homogenized cumin material is in the form of a gel composition containing cumin seed particles, the binder comprises a cellulose ether such as carboxymethyl cellulose. The binder may be present in an amount of from about 1% to about 5% by weight, based on the total weight of the gel. For example, the gel composition may include 1.5% to 3.5% by weight sodium carboxymethyl cellulose.

Preferably, the gel composition includes at least about 60% by weight of an aerosol former, such as glycerin, based on the total weight of the gel. For example, the gel composition may include 65% to 85% glycerin by weight.

Optionally, the gel composition may further include an acid such as lactic acid. The acid may be present in an amount of up to about 6% by weight, based on the total weight of the gel composition. Optionally, the gel composition may include up to about 5% nicotine by weight, based on the total weight of the gel composition. Optionally, the gel composition comprises from about 10% to about 30% water by weight, based on the total weight of the gel composition.

In embodiments where the homogenized cumin material is in the form of a gel composition, the aerosol-generating substrate preferably comprises a porous medium loaded with the gel composition. The term “porous” is used herein to refer to a material that provides a plurality of pores or openings that allow passage of air through the material.

The porous medium can be any suitable porous material capable of retaining or retaining the gel composition. Ideally, a porous medium is capable of allowing the gel composition to move within it. In certain embodiments, the porous media includes natural materials, synthetic materials, or semi-synthetic materials, or combinations thereof. In certain embodiments, the porous medium is a sheet material, foam, or fiber, such as loose fiber; or a combination thereof. In certain embodiments, the porous media includes woven, non-woven, or extruded materials, or combinations thereof. Preferably, the porous medium includes cotton, paper, viscose, PLA, or cellulose acetate, or a combination thereof. Preferably, the porous medium comprises a sheet material, such as cotton or cellulose acetate. In a particularly preferred embodiment, the porous medium comprises a sheet made of cotton fibers.

The porous media used in the present invention may be crimped or shredded. In a preferred embodiment, the porous medium is crimped. In an alternative embodiment, the porous media includes shredded porous media. The crimping or shredding process may occur before or after the gel composition is loaded.

Preferably, when the homogenized cumin material is in the form of a gel composition loaded onto a porous medium, the aerosol-generating substrate comprises an elongated susceptor element extending longitudinally through or adjacent to the porous medium.

Preferably, the aerosol-generating substrate of the aerosol-generating article according to the invention comprises at least about 150 milligrams of homogenized cumin material, more preferably at least about 175 milligrams of homogenized cumin material, more preferably at least about 200 milligrams of homogenized cumin material. Includes.

An aerosol-generating article according to the invention comprises a rod comprising an aerosol-generating substrate in one or more plugs. The rod of aerosol-generating substrate can have a length of about 5 mm to about 120 mm. For example, the rod may preferably have a length of about 10 to about 45 mm, more preferably about 10 mm to 15 mm, and most preferably about 12 mm. In an alternative embodiment, the rod preferably has a length of about 30 mm to about 45 mm, or about 33 mm to about 41 mm. If the rod is formed from a single plug of aerosol-generating substrate, the plug has the same length as the rod.

Rods of aerosol-generating substrate can have an outer diameter of about 5 mm to about 10 mm, depending on their intended use. For example, in some embodiments, the rod can have an outer diameter of about 5.5 mm to about 8 mm, or about 6.5 mm to about 8 mm. The outer diameter of the rod of the aerosol-generating substrate corresponds to the diameter of the rod containing any wrapper.

The rod of aerosol-generating substrate of the aerosol-generating article according to the invention is preferably surrounded by one or more wrappers along at least part of its length. The one or more wrappers may include a paper wrapper or a non-paper wrapper, or both. Suitable paper wrappers for use in certain embodiments of the invention are known in the art and include cigarette paper; and filter plug wraps. Suitable non-paper wrappers for use in certain embodiments of the invention are known in the art and include, but are not limited to, sheets of homogenized tobacco material. Homogenized tobacco wrappers include wherein the aerosol-generating substrate comprises one or more sheets of homogenized cumin material formed of particulate plant material, wherein the particulate plant material has a low weight percent, such as 20% to 0% tobacco particles, on a dry weight basis. It is particularly suitable for use in embodiments containing cumin seed particles in combination with tobacco particles.

In certain embodiments of the invention, the aerosol-generating substrate is surrounded along at least part of its length by a thermally conductive sheet material, for example a metallic foil such as aluminum foil or metallized paper. Metallic foil or metallized paper serves the purpose of quickly conducting heat throughout the aerosol-generating substrate. Additionally, metallic foil or metallized paper can serve to prevent ignition of the aerosol-generating substrate if the consumer attempts to light it. Additionally, during use, the metallic foil or metallized paper can prevent odors produced upon heating of the outer wrapper from entering aerosols generated from the aerosol-generating substrate. For example, this may be a problem for aerosol-generating articles having an aerosol-generating substrate that is externally heated during use to generate an aerosol. Alternatively or additionally, a metalized wrapper may be used to facilitate detection or recognition of the aerosol-generating article when inserted into the aerosol-generating device during use. Metallic foil or metallized paper may contain metal particles, such as iron particles.

The one or more wrappers surrounding the aerosol-generating substrate preferably have a total thickness of about 0.1 mm to about 0.9 mm.

The internal diameter of the rod of the aerosol-generating substrate is preferably between about 3 mm and about 9.5 mm, more preferably between about 4 mm and about 7.5 mm, and even more preferably between about 5 mm and about 7.5 mm. “Inside diameter” corresponds to the diameter of the rod of the aerosol-generating substrate, not including the thickness of the wrapper, but is measured with the wrapper still in place. Aerosol-generating articles according to the present invention also include, but are not limited to, cartridges or shisha consumables.

The aerosol-generating article according to the invention may optionally comprise a support element comprising at least one hollow tube immediately downstream of the aerosol-generating substrate. One function of the tube is to position the aerosol-generating substrate toward the distal end of the aerosol-generating article so that it can be brought into contact with a heating element. When the heating element is inserted into the aerosol-generating substrate, the tube serves to prevent the aerosol-generating substrate from being pushed along the aerosol-generating article toward other downstream elements. The tube also serves as a spacer element to separate the downstream element from the aerosol-generating substrate. The tube may be made of any material such as cellulose acetate, polymer, cardboard or paper.

Alternatively or additionally, the aerosol-generating article according to the invention optionally comprises an aerosol cooling element downstream of the aerosol-generating substrate and immediately downstream of the hollow tube forming the support element. In use, the aerosol formed by the volatile compounds released from the aerosol-generating substrate passes through and is cooled by the aerosol cooling element before being inhaled by the user. Low temperatures allow vapors to condense into aerosols. The aerosol cooling element may be a hollow tube, such as a hollow cellulose acetate tube or a cardboard tube, which may be similar to a support element immediately downstream of the aerosol-generating substrate. The aerosol cooling element is a hollow tube of the same outer diameter, but may have a smaller or larger inner diameter compared to the hollow tube forming the support element. In one embodiment, the paper-wrapped aerosol cooling element is one or more made of any suitable material, such as metallic foil, paper laminated with foil, polymeric sheets, preferably made of synthetic polymers, and substantially non-porous paper or cardboard. Contains longitudinal channels. In some embodiments, the paper-wrapped aerosol cooling element is made of polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyethylene terephthalate (PET), polylactic acid (PLA), cellulose acetate (CA), and paper laminated with polymer sheets, and aluminum foil. Alternatively, the aerosol cooling element is selected from the group consisting of polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyethylene terephthalate (PET), polylactic acid (PLA), and cellulose acetate (CA). The material may be made from woven or non-woven filaments. In a preferred embodiment, the aerosol cooling element is a crimped and corrugated sheet of polylactic acid wrapped in filter paper. In another preferred embodiment, the aerosol cooling element comprises longitudinal channels and is made of woven filaments of a synthetic polymer, such as polylactic acid filaments, wrapped in paper.

One or more additional hollow tubes may be provided downstream of the aerosol cooling element.

Aerosol-generating articles according to the invention may further comprise a filter or mouthpiece downstream of the aerosol-generating substrate and, if present, the support element and the aerosol cooling element. The filter may include one or more filtration materials for removing particulate components, gaseous components, or combinations thereof. Suitable filtration materials are known in the art and include, but are not limited to, fibrous filtration materials such as cellulose acetate tow and paper; Adsorbents such as activated alumina, zeolites, molecular sieves and silica gel; Biodegradable polymers, including, for example, polylactic acid (PLA), Mater-Bi®, hydrophobic viscose fibers, and bioplastics; and combinations thereof. The filter may be located at the downstream end of the aerosol-generating article. The filter may be a cellulose acetate filter plug. The filter is about 7 mm long in one embodiment, but may have a length of about 5 mm to about 10 mm.

Aerosol-generating articles according to the invention may include a mouth end cavity at the downstream end of the article. The mouth end cavity may be defined by one or more wrappers extending downstream from the filter or mouthpiece. Alternatively, the mouth end cavity may be defined by a separate tubular element provided at the downstream end of the aerosol-generating article.

The aerosol-generating article according to the invention preferably further comprises a ventilation zone provided at a location along the aerosol-generating article. For example, the aerosol-generating article may be provided in a position along a hollow tube provided downstream of the aerosol-generating substrate.

Aerosol-generating articles according to the invention may optionally further comprise an upstream element at the upstream end of the aerosol-generating substrate. The upstream element may be a porous plug element, such as a plug of fibrous filtration material such as cellulose acetate.

In a preferred embodiment of the invention, the aerosol-generating article comprises an aerosol-generating substrate, at least one hollow tube downstream of the aerosol-generating substrate and a filter downstream of the at least one hollow tube. Optionally, the aerosol-generating article further comprises a mouth end cavity at the downstream end of the filter. Preferably, the ventilation zone is provided at a location along the at least one hollow pipe.

In a particularly preferred embodiment with this arrangement, the aerosol-generating article comprises an aerosol-generating substrate, an upstream element at the upstream end of the aerosol-generating substrate, a support element downstream of the aerosol-generating substrate, an aerosol cooling element downstream of the support element, and a filter downstream of the aerosol cooling element. Preferably, both the support element and the aerosol cooling element are in the form of hollow tubes. Preferably, the aerosol-generating substrate comprises an elongated susceptor element extending longitudinally therethrough.

In a particularly preferred example, the aerosol-generating substrate has a length of about 33 mm and an outer diameter of about 5.5 mm to 6.7 mm, wherein the aerosol-generating substrate comprises about 340 mg of homogenized cumin material in the form of a plurality of strands, The material contains about 14% glycerol by weight on a dry weight basis. In this embodiment, the aerosol-generating article has a total length of about 74 mm and has a mouth end cavity defined by a hollow tube having a length of about 6 to 7 mm as well as a cellulose acetate tow filter with a length of about 10 mm. Includes. The aerosol-generating article includes a hollow tube downstream of the aerosol-generating substrate, the hollow tube having a length of about 25 mm and having a ventilation zone.

Aerosol-generating articles according to the invention may have a total length of at least about 30 mm, or at least about 40 mm. The total length of the aerosol-generating article may be less than 90 mm, or less than about 80 mm.

In one embodiment, the aerosol-generating article has a total length of about 40 mm to about 50 mm, preferably about 45 mm. In another embodiment, the aerosol-generating article has a total length of about 70 mm to about 90 mm, preferably about 80 mm to about 85 mm. In another embodiment, the aerosol-generating article has a total length of about 72 mm to about 76 mm, preferably about 74 mm.

The aerosol-generating article may have an outer diameter of about 5 mm to about 8 mm, preferably about 6 mm to about 8 mm. In one embodiment, the aerosol-generating article has an outer diameter of about 7.3 mm.

Aerosol-generating articles according to the invention may further comprise one or more aerosol modifying elements. The aerosol modifying element may provide an aerosol modifier. As used herein, the term aerosol modifier is used to describe any agent that, when used, modifies one or more characteristics or properties of an aerosol that passes through a filter. Suitable aerosol modifiers include, but are not limited to, agents that impart taste or flavor to the aerosol that passes through the filter in use, or agents that remove flavor from the aerosol that passes through the filter in use.

The aerosol modifier may be one or more of water or liquid flavoring agents. Water or moisture can modify the user's sensory experience, for example by moistening the generated aerosol, which can provide a cooling effect to the aerosol and reduce the perception of harshness experienced by the user. The aerosol modifying element may be in the form of a flavor delivery element to deliver one or more liquid flavors. Alternatively, the liquid flavoring agent may be added directly to the homogenized cumin material, for example, by adding flavoring to the slurry or feedstock during manufacture of the homogenized cumin material, or by spraying the liquid flavoring agent onto the surface of the homogenized cumin material. You can.

The one or more liquid flavoring agents may include any flavor compound or plant extract suitable for releasable disposition in liquid form within the flavor delivery member to enhance the taste of the aerosol generated during use of the aerosol-generating article. Flavoring agents, liquids or solids, can also be placed directly into the material forming the filter, such as cellulose acetate tow. Suitable flavors or flavors include, but are not limited to, menthol, mint such as peppermint and spearmint, chocolate, licorice, citrus and other fruit flavors, gamma octalactone, vanillin, ethyl vanillin, mouthwash flavors, spice flavors such as cinnamon, and methyl salicylate. , linalool, eugenol, bergamot oil, geranium oil, lemon oil, cannabis oil, and tobacco flavor. Other suitable flavors may include flavor compounds selected from the group consisting of acids, alcohols, esters, aldehydes, ketones, pyrazines, combinations or blends thereof, etc.

In certain embodiments of the invention, the aerosol modifier may be an essential oil derived from one or more plants. For example, the homogenized cumin material may include cumin oil, such as cumin seed essential oil, to further enhance the cumin flavor transmitted to the consumer when heated.

In certain embodiments of the invention, the aerosol-generating substrate may include a homogenized cumin material comprising particulate plant material, such as tea particles, in combination with cumin seed oil.

The aerosol modifier may be an adsorbent material, such as activated carbon, that modifies the flavor and aroma of the aerosol by removing certain components of the aerosol as it passes through the filter.

One or more aerosol modification elements may be located downstream of or within the aerosol-generating substrate. The aerosol-generating substrate may include a homogenized cumin material and an aerosol modifying element. In various embodiments, the aerosol modifying element may be placed adjacent to or embedded in the homogenized cumin material. Typically, the aerosol reforming element is located downstream of the aerosol-generating substrate, most typically within an aerosol cooling element, within a filter of the aerosol-generating article, such as within a filter plug or within a cavity, preferably within a cavity between filter plugs. can do. The one or more aerosol modification elements may be in the form of one or more threads, capsules, microcapsules, beads, or polymeric matrix materials, or combinations thereof.

If the aerosol modifying element is in the form of a thread as described in WO-A-2011/060961, the thread may be formed from paper, such as a filter plug wrap, the thread carrying at least one aerosol modifier and positioned within the body of the filter. can do. Other materials that can be used to form threads include cellulose acetate and cotton.

If the aerosol modification element is in the form of a capsule as described in WO-A-2007/010407, WO-A-2013/068100 and WO-A-2014/154887, the capsule may be a destructible capsule located within the filter, the interior of the capsule The core contains an aerosol modifier that can be released upon destruction of the outer shell of the capsule when the filter is subjected to an external force. The capsule can be positioned within the filter plug or within the cavity, preferably within the cavity between the filter plugs.

If the aerosol modification element is in the form of a polymeric matrix material, the polymeric matrix material may produce aerosols, for example when the polymeric matrix is heated to a temperature above the melting point of the polymeric matrix material described in WO-A-2013/034488. When the article is heated, it releases flavoring agents. Typically, these polymeric matrix materials may be positioned within beads within an aerosol-generating substrate. Alternatively or additionally, the flavoring agent may be entrapped within domains of the polymeric matrix material and capable of being released from the polymeric matrix material upon compression of the polymeric matrix material. Preferably, the flavoring agent is released when the polymeric matrix material is compressed with a force of about 15 N. These flavor modifying elements can provide sustained release of liquid flavor over a force range of at least 5 N, such as 5 N to 20 N, as described in WO2013/068304. Typically, these polymeric matrix materials may be located within beads within the filter.

The aerosol-generating article may include a combustible heat source and an aerosol-generating substrate downstream of the combustible heat source, the aerosol-generating substrate being as described above for the first aspect of the invention.

For example, a substrate as described herein can be used in a heated aerosol-generating article of the type disclosed in WO-A-2009/022232, which comprises a combustible carbon-based heat source, an aerosol-generating substrate downstream of the combustible heat source, and a combustible and a heat-conducting element around and in contact with a rear portion of the carbon-based heat source and an adjacent front portion of the aerosol-generating substrate. However, it will be appreciated that substrates as described herein may also be used in heated aerosol-generating articles comprising combustible heat sources having other configurations.

The present invention provides an aerosol-generating system comprising an aerosol-generating device comprising a heating element, and an aerosol-generating article for use with the aerosol-generating device, the aerosol-generating article comprising an aerosol-generating substrate as described above.

In another embodiment, an aerosol-generating substrate as described herein can be used in a heated aerosol-generating article for use in an electrically operated aerosol-generating system, wherein the aerosol-generating substrate of the heated aerosol-generating article is heated by an electrical heat source. .

For example, aerosol-generating substrates as described herein can be used in heated aerosol-generating articles of the type disclosed in EP-A-0 822 760.

The heating element of such aerosol-generating device may have any suitable shape for conducting heat. Heating of the aerosol-generating substrate can be accomplished internally, externally, or both. The heating element may preferably be a heater blade or fin configured to be inserted into the substrate, so that the substrate is heated from the inside. Alternatively, the heating element may partially or fully surround the substrate and heat the substrate circumferentially from the outside.

The aerosol-generating system may be an electrically operated aerosol-generating system comprising an induction heating device. The induction heating device generally comprises an induction source configured to be coupled to a susceptor, which may be provided externally to the aerosol-generating substrate or may be provided internally to the aerosol-generating substrate. The induction source generates an alternating electromagnetic field, which induces magnetization or eddy currents within the susceptor. The susceptor may heat as a result of hysteresis losses or induced eddy currents that heat the susceptor through ohmic or resistive heating.

An electrically operated aerosol-generating system comprising an induction heating device also includes an aerosol-generating article having an aerosol-generating substrate and a susceptor in thermal proximity to the aerosol-generating substrate. Typically, the susceptor is in direct contact with the aerosol-generating substrate, and heat is transferred from the susceptor to the aerosol-generating substrate primarily by conduction. Examples of electrically operated aerosol-generating systems with induction heating devices and aerosol-generating articles with susceptors are described in WO-A1-95/27411 and WO-A1-2015/177255.

The susceptor may be a plurality of susceptor particles that may be deposited on or embedded within an aerosol-generating substrate. When the aerosol-generating substrate is in the form of one or more sheets, a plurality of susceptor particles may be deposited on or embedded within one or more sheets. The susceptor particles are fixed by the substrate, for example in the form of a sheet, and maintained in the initial position. Preferably, the susceptor particles can be homogeneously distributed in the homogenized cumin material of the aerosol-generating substrate. Because of the particulate nature of the susceptor, heat is generated depending on the distribution of particles within the sheet of homogenized cumin material of the substrate. Alternatively, susceptors in the form of one or more sheets, strips, pieces or rods may be placed next to or used embedded in the homogenized cumin material. In one embodiment, the aerosol-forming substrate includes one or more susceptor strips. For example, a rod of an aerosol-generating substrate may include an elongated susceptor element extending longitudinally therethrough. In some embodiments, the susceptor is present within an aerosol-generating device.

The susceptor may have a heat loss exceeding 0.05 J/kg, preferably exceeding 0.1 J/kg. Heat loss is the capacity of a susceptor to transfer heat to the surrounding material. Preferably, since the susceptor particles are homogeneously distributed in the aerosol-generating substrate, uniform heat loss from the susceptor particles is achieved, creating a uniform heat distribution in the aerosol-generating substrate and a uniform temperature distribution within the aerosol-generating article. can cause It has been discovered that a certain minimum heat loss of 0.05 J/kg in the susceptor particles enables aerosol generation by heating the aerosol-generating substrate to a substantially uniform temperature. Preferably, the average temperature achieved within the aerosol-generating substrate in this embodiment is from about 200°C to about 240°C.

Reducing the risk of overheating the aerosol-generating substrate can be supported by the use of susceptor materials with a Curie temperature, which allow the heating process due to hysteresis losses only up to a certain maximum temperature. The susceptor may have a Curie temperature of about 200°C to about 450°C, preferably about 240°C to about 400°C, for example about 280°C. When a susceptor material reaches its Curie temperature, its magnetic properties change. At the Curie temperature, the susceptor material changes from a ferromagnetic phase to a paramagnetic phase. At this point, heating stops based on energy loss due to orientation of the ferromagnetic domains. Furthermore, the heating is then carried out primarily on the basis of eddy current formation such that the heating process is automatically reduced upon reaching the Curie temperature of the susceptor material. Preferably, the susceptor material and its Curie temperature are tailored to the composition of the aerosol-generating substrate to achieve optimal temperature and temperature distribution within the aerosol-generating substrate for optimal aerosol generation.

In some preferred embodiments of the aerosol-generating article according to the invention, the susceptor consists of ferrite. Ferrite is a ferromagnetic material with high magnetic permeability and is particularly suitable as a susceptor material. The main component of ferrite is iron. Other metallic components, such as zinc, nickel, manganese, or non-metallic components, such as silicon, may be present in varying amounts. Ferrite is a relatively inexpensive, commercially available material. Ferrite is available in particle form in the size range of particles used in the particulate plant material forming the homogenized plant material according to the invention. Preferably, the particles are fully calcined ferrite powders, for example FP160, FP215, FP350 by PPT, Indiana, USA.

In certain embodiments of the invention, an aerosol-generating system comprises an aerosol-generating article comprising an aerosol-generating substrate as defined above, a source of an aerosol former, and vaporizing the aerosol former, preferably a heating element as defined above. Includes means. The source of aerosol former may be a reservoir, which may be refillable or replaceable, present on the aerosol-generating device. While the reservoir is physically separated from the aerosol-generating article, the generated vapor is directed through the aerosol-generating article. The vapor forms contact with an aerosol-generating substrate, releasing volatile compounds such as nicotine and flavoring agents in the particulate plant material, forming an aerosol. Optionally, to assist volatilization of the compounds within the aerosol-generating substrate, the aerosol-generating system may further comprise a heating element that heats the aerosol-generating substrate, preferably in a cooperative manner with the aerosol former. However, in certain embodiments, the heating element used to heat the aerosol-generating article is separate from the heater that heats the aerosol former.

As defined above, the present invention further provides an aerosol generated upon heating of an aerosol-generating substrate, wherein the aerosol comprises certain amounts and proportions of the characteristic compounds derived from cumin seed particles as defined above, there is.

According to the present invention, the aerosol contains: proccumenol in an amount of at least 0.5 micrograms per aerosol puff; Cuminaldehyde in an amount of at least 0.05 micrograms per aerosol puff; and isothymol in an amount of at least 0.01 micrograms per aerosol puff, wherein the aerosol puff has a volume of 55 milliliters as generated by the smoking machine. For the purposes of the present invention, a “puff” is defined as the volume of aerosol released from an aerosol-generating substrate upon heating and collected for analysis, where a puff of aerosol has a puff volume of 55 milliliters when generated by a smoking machine. Accordingly, any reference herein to an aerosol “puff” should be understood to refer to a 55 milliliter puff unless otherwise noted.

The indicated ranges define the total amount of each component measured in a 55 milliliter puff of aerosol. Aerosols can be generated from an aerosol-generating substrate using any suitable means and captured and analyzed as described above to identify and quantify characteristic compounds within the aerosol. For example, a “puff” may correspond to a 55 milliliter puff taken from a smoking machine such as that used in the Health Canada test method described herein.

Preferably, the aerosol according to the present invention contains at least about 5 micrograms of procumenol per aerosol puff, more preferably at least about 10 micrograms of procumenol per aerosol puff. Alternatively or additionally, the aerosol generated from the aerosol-generating substrate may contain up to about 60 micrograms of proccumenol per aerosol puff, preferably at most about 50 micrograms of proccumenol per aerosol puff, more preferably per aerosol puff. Contains up to about 40 micrograms of procumenol per serving. For example, an aerosol generated from an aerosol-generating substrate may contain about 0.5 micrograms to about 60 micrograms of proccumenol per aerosol puff, or about 5 micrograms to 50 micrograms of proccumenol per aerosol puff, or per aerosol puff. It may contain from about 10 micrograms to about 40 micrograms of procumenol.

Preferably, aerosols according to the present invention contain at least about 0.5 micrograms of cuminaldehyde per puff of aerosol, more preferably at least about 1 microgram of cuminaldehyde per puff of aerosol. Alternatively, or additionally, the aerosol generated from the aerosol-generating substrate preferably contains at most about 8 micrograms of cuminaldehyde per puff of aerosol, more preferably at most about 6 micrograms of cuminaldehyde per puff of aerosol, and even more. Preferably, the aerosol contains up to about 4 micrograms of cuminaldehyde per puff. For example, an aerosol generated from an aerosol-generating substrate may contain about 0.05 micrograms to about 8 micrograms of cuminaldehyde per puff of aerosol, or about 0.5 micrograms to about 6 micrograms of cuminaldehyde per puff of aerosol, or It may contain from about 1 microgram to about 4 micrograms of cuminaldehyde per puff.

Preferably, aerosols according to the present invention contain at least about 0.1 micrograms of isothymol per puff of aerosol, more preferably at least about 0.5 micrograms of isothymol per puff of aerosol. Alternatively, or additionally, the aerosol generated from the aerosol-generating substrate preferably contains at most about 3 micrograms of isothymol per puff of aerosol, more preferably at most about 2.5 micrograms of isothymol per puff of aerosol, and even more. Preferably the aerosol contains up to about 2 micrograms of isothymol per puff. For example, the aerosol generated from an aerosol-generating substrate may contain from about 0.01 micrograms to about 3 micrograms isothymol per aerosol puff, or from about 0.1 micrograms to about 2.5 micrograms isothymol per aerosol puff, or from about It may contain from 0.5 micrograms to about 2 micrograms of isothymol.

According to the invention, the aerosol composition is such that the amount of proccumenol per puff of aerosol is preferably at least five times the amount of cuminaldehyde per puff of aerosol. Accordingly, the ratio of proccumenol to cuminaldehyde in the aerosol is preferably at least about 5:1. Preferably, the aerosol composition is such that the amount of proccumenol per puff of aerosol is at least 7.5 times the amount of cuminaldehyde per puff of aerosol.

According to the invention, the aerosol composition is such that the amount of proccumenol per puff of aerosol is preferably at least 15 times the amount of isothymol per puff of aerosol. Accordingly, the ratio of proccumenol to isothymol in the aerosol is preferably at least about 15:1. Preferably, the aerosol composition has the amount of proccumenol per puff of aerosol at least about 20 times the amount of isothymol per puff of aerosol.

A defined ratio of proccumenol to cuminaldehyde and isothymol characterizes the aerosol derived from cumin seed particles. In contrast, in aerosols generated from cumin essential oil, the ratio of cuminaldehyde to proccumenol will be significantly different.

Preferably, aerosols according to the present invention contain at least about 0.1 milligrams of aerosol former per aerosol puff, more preferably at least about 0.2 milligrams of aerosol former per aerosol puff, more preferably at least about 0.3 milligrams per aerosol puff. It further includes an aerosol former. Preferably, the aerosol comprises at most 0.6 milligrams of aerosol former per aerosol puff, more preferably at most 0.5 milligrams of aerosol former per aerosol puff, more preferably at most 0.4 milligrams of aerosol former per aerosol puff. . For example, the aerosol may contain from about 0.1 milligrams to about 0.6 milligrams of aerosol former per aerosol puff, or from about 0.2 milligrams to about 0.5 milligrams of aerosol former per aerosol puff, or from about 0.3 milligrams to about 0.4 milligrams per aerosol puff. May contain aerosol formers. These values are based on a puff volume of 55 milliliters as defined above.

Suitable aerosol formers for use in the present invention are specified above.

Preferably, the aerosol generated from the aerosol-generating substrate according to the invention is. It further comprises at least about 2 micrograms of nicotine per aerosol puff, more preferably at least about 20 micrograms of nicotine per aerosol puff, and more preferably at least about 40 micrograms of nicotine per aerosol puff. Preferably, the aerosol further contains at most about 200 micrograms of nicotine per aerosol puff, more preferably at most about 150 micrograms of nicotine per aerosol puff, and more preferably at most about 75 micrograms of nicotine per aerosol puff. Includes. For example, the aerosol may contain from about 2 micrograms to about 200 micrograms of nicotine per puff of the aerosol, or from about 20 micrograms to about 150 micrograms of nicotine per puff of the aerosol, or from about 40 micrograms to about 75 micrograms of nicotine per puff of the aerosol. May contain micrograms of nicotine. These values are based on a puff volume of 55 milliliters as defined above. In some embodiments of the invention, the aerosol may contain 0 micrograms of nicotine.

Alternatively or additionally, the aerosol according to the present invention may optionally contain at least about 0.5 milligrams of a cannabinoid compound per aerosol puff, more preferably at least about 1 milligram of a cannabinoid compound per aerosol puff, more preferably at least about 2 per aerosol puff. It may additionally contain milligrams of cannabinoid compounds. Preferably, the aerosol contains up to about 5 milligrams of cannabinoid compounds per aerosol puff, more preferably at most about 4 milligrams of cannabinoid compounds per aerosol puff, more preferably at most about 3 milligrams of cannabinoid compounds per aerosol puff. For example, the aerosol may contain from about 0.5 milligrams to about 5 milligrams of a cannabinoid compound per aerosol puff, or from about 1 milligram to about 4 milligrams of a cannabinoid compound per aerosol puff, or from about 2 milligrams to about 3 milligrams of a cannabinoid compound per aerosol puff. It can be included. In some embodiments of the invention, the aerosol may contain 0 micrograms of cannabinoid compounds. These values are based on a puff volume of 55 milliliters as defined above.

Preferably, the cannabinoid compound is selected from CBD and THC. More preferably, the cannabinoid compound is CBD.

Carbon monoxide may also be present in aerosols according to the invention and can be measured and used to further characterize the aerosol. Oxides of nitrogen, such as nitrogen oxides and nitrogen dioxide, can also be present in aerosols and can be measured and used to further characterize aerosols.

Aerosols according to the invention containing characteristic compounds from cumin seed particles can be formed from particles having a mass median aerodynamic diameter (MMAD) ranging from about 0.01 to 200 microns, or about 1 to 100 microns. Preferably, when the aerosol contains nicotine as described above, the aerosol includes particles having an MMAD in the range of about 0.1 to about 3 microns to optimize delivery of nicotine from the aerosol.

The mass median aerodynamic diameter (MMAD) of an aerosol refers to the aerodynamic diameter at which half of the particulate mass of an aerosol is contributed by particles with an aerodynamic diameter greater than the MMAD and by particles with an aerodynamic diameter less than the MMAD. do. The aerodynamic diameter is defined as the diameter of a spherical particle with a density of 1 g/cm ³ and a settling velocity equal to that for which the particle is characterized.

The mass median aerodynamic diameter of the aerosol according to the present invention is determined by Schaller et al., "Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity and physical properties of the aerosol," Regul. Toxicol. and Pharmacol., 81 (2016) S27-S47.

As defined above, the present invention further provides an aerosol-generating article comprising an aerosol-generating substrate, said aerosol-generating substrate comprising a homogenized cumin material, wherein upon heating the aerosol-generating substrate according to Test Method A: The aerosol generated from the aerosol-generating substrate may contain procumenol in an amount of at least 0.5 micrograms per puff of aerosol; Cuminaldehyde in an amount of at least about 0.05 micrograms per puff of aerosol; and isothymol in an amount of at least 0.01 micrograms per puff of aerosol, wherein the puff of aerosol has a volume of 55 milliliters as produced by a smoking machine.

For the purposes of the present invention, a “puff” is defined as the volume of aerosol released from an aerosol-generating substrate upon heating and collected for analysis, where a puff of aerosol has a puff volume of 55 milliliters when generated by a smoking machine. Accordingly, any reference herein to an aerosol “puff” should be understood to refer to a 55 milliliter puff unless otherwise noted. The indicated ranges define the total amount of each component measured in a 55 milliliter puff of aerosol. Aerosols can be generated from an aerosol-generating substrate using any suitable means and captured and analyzed as described above to identify and quantify characteristic compounds within the aerosol. For example, a “puff” may correspond to a 55 milliliter puff taken from a smoking machine such as that used in the Health Canada test method described herein.

Preferably, the amount of proccumenol per puff of aerosol is at least 5 times the amount of cuminaldehyde per puff of aerosol, more preferably at least 7.5 times the amount of cuminaldehyde per puff of aerosol.

Preferably, the amount of proccumenol per puff of aerosol is at least 15 times the amount of isothymol per puff of aerosol, more preferably at least 20 times the amount of isothymol per puff of aerosol.

As defined above, the present invention also provides an aerosol-generating substrate formed from homogenized plant material comprising cumin seed particles, an aerosol former and a binder, wherein the aerosol-generating substrate contains at least 15 microns per gram of substrate on a dry weight basis. gram of prockumenol; at least 20 micrograms of cumin aldehyde per gram of substrate on a dry weight basis; and at least 10 micrograms of isothymol per gram of substrate on a dry weight basis.

A non-exhaustive list of non-limiting examples is provided below. Any one or more features of these embodiments may be combined with any one or more features of other embodiments, implementations, or aspects described herein.

EX1. An aerosol-generating article comprising an aerosol-generating substrate, the aerosol-generating substrate comprising a homogenized cumin material, the homogenized cumin material comprising cumin seed particles, an aerosol former and a binder, the aerosol-generating substrate comprising:

At least 15 micrograms of procumenol per gram of said substrate, on a dry weight basis;

At least 20 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and

An aerosol-generating article comprising at least 10 micrograms of isothymol per gram of said substrate, on a dry weight basis.

EX2. The aerosol-generating article of Example EX1, wherein the amount of cuminaldehyde per gram of said substrate is at least equal to the amount of proccumenol per gram of said substrate.

EX3. The aerosol-generating article of Example EX1 or EX2, wherein the amount of proccumenol per gram of said substrate is at least equal to the amount of isothymol per gram of said substrate.

EX4. The aerosol-generating article of Example EX1, EX2 or EX3, wherein the aerosol-generating substrate comprises from 15 micrograms to 1800 micrograms of procumenol per gram of the substrate, on a dry weight basis.

EX5. The aerosol-generating article of any one of Examples EX1-EX4, wherein the aerosol-generating substrate comprises from 20 micrograms to 2500 micrograms of cuminaldehyde per gram of the substrate on a dry weight basis.

EX6. The aerosol-generating article of any one of Examples EX1-EX5, wherein the aerogenerating substrate comprises from 10 micrograms to 1200 micrograms of isothymol per gram of the substrate on a dry weight basis.

EX7. In any one of Examples EX1 to EX6, when heating the aerosol-generating substrate according to Test Method A, the aerosol generated is:

At least 25 micrograms of procumenol per gram of said substrate, on a dry weight basis;

At least 2 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and

An aerosol-generating article comprising at least 1 microgram of isothymol per gram of said substrate, on a dry weight basis.

EX8. The aerosol-generating article of Example EX7, wherein upon heating the aerosol-generating substrate according to Test Method A, an aerosol is generated comprising up to 3500 micrograms of procumenol per gram of the substrate, on a dry weight basis.

EX9. The aerosol-generating article of Example EX7 or EX8, wherein upon heating the aerosol-generating substrate according to Test Method A, an aerosol is generated comprising up to 500 micrograms of cuminaldehyde per gram of substrate, on a dry weight basis.

EX10. The aerosol-generating article of Example EX7, EX8 or EX9, wherein upon heating the aerosol-generating substrate according to Test Method A, an aerosol is generated comprising up to 200 micrograms of isothymol per gram of substrate, on a dry weight basis.

EX11. The aerosol-generating article of any of Examples 7-10, wherein upon heating the aerosol-generating substrate according to Test Method A, an aerosol comprising 0 micrograms of nicotine per gram of the substrate is generated.

EX12. According to any one of Examples EX1 to EX6, when heating the aerosol-generating substrate in a THS2.2 holder under Health Canada mechanical smoking prescription, the aerosol generated is:

At least 25 micrograms of procumenol per gram of said substrate, on a dry weight basis;

At least 2 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and

An aerosol-generating article comprising at least 1 microgram of isothymol per gram of said substrate, on a dry weight basis.

EX13. The aerosol-generating article of any one of Examples EX1-EX12, wherein the homogenized cumin material comprises at least 2.5% by weight cumin seed particles on a dry weight basis.

EX14. The aerosol-generating article of any one of Examples EX1-EX13, wherein the homogenized cumin material comprises up to 50% by weight cumin seed particles on a dry weight basis.

EX15. The aerosol-generating article of any one of Examples EX1 to EX14, wherein the homogenized cumin material further comprises up to 75% by weight tobacco particles, on a dry weight basis.

EX16. The aerosol-generating article of any one of Examples EX1-EX15, wherein the homogenized cumin material further comprises tobacco particles, wherein the weight ratio of cumin seed particles to tobacco particles is less than or equal to 1:4.

EX17. The aerosol-generating article of either Example EX15 or EX16, wherein the homogenized cumin material comprises 5% to 20% cumin seed particles and 55% to 70% tobacco particles, by weight, on a dry weight basis. .

EX18. The aerosol-generating article of any of Examples EX1-EX17, wherein the homogenized cumin material comprises substantially zero nicotine.

EX19. The aerosol-generating article of any one of Examples EX1-EX17, wherein the aerosol-generating substrate further comprises at least 0.1 milligrams of nicotine per gram of the substrate, on a dry weight basis.

EX20. The aerosol-generating article of Example EX19, wherein the aerosol-generating substrate comprises from 1 milligram to 20 milligrams of nicotine per gram of the substrate, on a dry weight basis.

EX21. The aerosol-generating article of any of Examples EX1-EX20, wherein the cumin seed particles have a D95 value of greater than or equal to about 50 microns and less than or equal to about 400 microns.

EX22. The aerosol-generating article of any of Examples EX1-EX21, wherein the cumin seed particles have a D5 value of greater than or equal to about 10 microns and less than or equal to about 50 microns.

EX23. The aerosol-generating article of any of Examples EX1-EX22, wherein the cumin seed particles are intentionally ground.

EX24. The aerosol-generating article of any of Examples EX1-EX23, wherein 100% of the cumin seed particles have a diameter of 300 microns or less.

EX25. The aerosol-generating article of any one of Examples EX1 to EX24, wherein the homogenized cumin material comprises up to 75% by weight particulate plant material, wherein the particulate plant material comprises the cumin seed particles.

EX26. The aerosol-generating article of any one of Examples EX1-EX25, wherein the homogenized cumin material has an aerosol former content of from 5% to about 30% by weight on a dry weight basis.

EX27. The method of any one of Examples EX1 to EX26, wherein the binder is selected from gums such as, for example, guar gum, xanthan gum, gum Arabic, and locust bean gum; cellulose binders such as, for example, hydroxypropyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose and ethyl cellulose; polysaccharides such as starch, organic acids such as alginic acid, conjugate base salts of organic acids such as sodium alginate, agar and pectin; and combinations thereof.

EX28. The aerosol-generating article of any of Examples EX1-EX27, wherein the binder comprises guar gum.

EX29. The aerosol-generating article of any of Examples EX1 to EX28, wherein the homogenized cumin material comprises from 1% to 10% by weight binder, on a dry weight basis.

EX30. The aerosol-generating article of any of Examples EX1-EX29, wherein the homogenized cumin material further comprises fibers.

EX31. The aerosol-generating article of Example EX30, wherein the fibers have a length greater than 400 micrometers.

EX32. The aerosol-generating article of Example EX30 or EX31, wherein the fibers are present in an amount of from about 2% to about 15% by weight, based on the dry weight of the aerosol-generating substrate.

EX33. The aerosol-generating article of Example EX30 or EX31, wherein the fibers are present in an amount of at least 30% by weight, based on the dry weight of the aerosol-generating substrate.

EX34. The method of any one of Examples EX1 to EX33, wherein the homogenized cumin material comprises cumin seed particles, from about 5% to about 30% by weight of an aerosol former, and from about 1% to about 10% by weight on a dry weight basis. % by weight binder.

EX35. The aerosol-generating article of Example EX34, wherein the homogenized cumin material further comprises from about 2% to about 15% by weight fibers.

EX36. The aerosol-generating article of Example EX34 or EX35, wherein the binder is guar gum.

EX37. The aerosol-generating article of any of Examples EX1 to EX36, wherein the homogenized cumin material is in the form of one or more sheets.

EX38. The aerosol-generating article of Example EX37, wherein each of the one or more sheets has a thickness of 100 micrometers to 600 micrometers.

EX39. The aerosol-generating article of Example EX38, wherein each of the one or more sheets has a basis weight of from 100 g/m ² to 300 g/m ² .

EX40. The aerosol-generating article of Example EX38 or EX39, wherein each of the one or more sheets has a density of from 0.3 g/cm ³ to 1.3 g/cm ³ .

EX41. The aerosol-generating article of Example EX38, EX39 or EX40, wherein each of the one or more sheets has a tensile strength at the peak in the cross direction from 50 N/m to 400 N/m.

EX42. The aerosol-generating article of any one of Examples EX38 to EX40, wherein each of the one or more sheets has a peak tensile strength in the machine direction of from 100 N/m to 800 N/m.

EX43. The aerosol-generating article according to any one of Examples EX38 to EX42, wherein the one or more sheets are in the form of one or more corrugated sheets.

EX44. The aerosol-generating article of any of Examples EX1-EX36, wherein the homogenized cumin material is in the form of a plurality of strands.

EX45. The aerosol-generating article of Example EX44, wherein the strands have a width of at least 0.2 millimeters.

EX46. The aerosol-generating article of Example EX44 or EX45, wherein the plurality of strands extend substantially longitudinally along the length of the aerosol-generating substrate, aligned with the longitudinal axis.

EX47. The aerosol-generating article of Example EX44, EX45 or EX46, wherein the plurality of strands each have a mass to surface area ratio of at least 0.02 mg/mm ² .

EX48. The aerosol-generating article of any of Examples EX1-EX47, wherein the homogenized cumin material in the aerosol-generating substrate is in the form of cast leaves.

EX49. The aerosol-generating article of any of Examples EX1-EX47, wherein the homogenized cumin material in the aerosol-generating substrate is in the form of cumin paper.

EX50. According to any one of Examples EX1 to EX49, when heating the aerosol-generating substrate according to Test Method A, the aerosol generated from the aerosol-generating substrate is:

Proccumenol in an amount of at least 0.5 micrograms per puff of aerosol;

Cuminaldehyde in an amount of at least 0.05 micrograms per puff of aerosol; and

Containing isothymol in an amount of at least 0.01 micrograms per puff of the aerosol,

A puff of aerosol has a volume of 55 milliliters as produced by a smoking machine, and the amount of proccumenol per puff of said aerosol is at least five times the amount of cumylaldehyde per puff of said aerosol, and the amount of proccumenol per puff of said aerosol is wherein the amount is at least 15 times the amount of isothymol per puff of said aerosol.

EX51. An aerosol-generating article comprising an aerosol-generating substrate, the aerosol-generating substrate comprising cumin seed particles, about 5% to about 30% by weight of an aerosol former and about 1% to about 10% by weight of a binder, on a dry weight basis. An aerosol-generating article comprising a homogenized cumin material comprising.

EX52. The aerosol-generating article of Example EX51, wherein the homogenized cumin material further comprises essential oil, preferably cumin seed essential oil.

EX53. The aerosol-generating article of Example EX51 or EX52, wherein the homogenized cumin material further comprises tobacco particles.

EX54. The aerosol-generating article of any of Examples EX51-EX53, wherein the homogenized cumin material comprises at least 2.5% by weight cumin seed particles on a dry weight basis.

EX55. An aerosol-generating substrate comprising a homogenized cumin material comprising cumin seed particles, an aerosol former and a binder, the aerosol-generating substrate comprising:

At least 15 micrograms of procumenol per gram of said substrate, on a dry weight basis;

At least 20 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and

An aerosol-generating article comprising at least 10 micrograms of isothymol per gram of said substrate, on a dry weight basis.

EX56. An aerosol generating system, comprising:

An aerosol-generating device comprising a heating element; and

An aerosol-generating system comprising an aerosol-generating article according to any one of Examples EX1 to EX54.

EX57. The aerosol-generating system of Example EX56, wherein the heating element is a heater blade configured to be inserted into the aerosol-generating substrate.

EX57. An aerosol generated upon heating of the aerosol-generating substrate according to Example EX55, wherein the aerosol is,

Proccumenol in an amount of at least 0.5 micrograms per puff of aerosol;

Cuminaldehyde in an amount of at least 0.05 micrograms per puff of aerosol; and

Containing isothymol in an amount of at least 0.01 micrograms per puff of the aerosol,

A puff of aerosol has a volume of 55 milliliters as produced by a smoking machine, and the amount of proccumenol per puff of said aerosol is at least five times the amount of cumylaldehyde per puff of said aerosol, and the amount of proccumenol per puff of said aerosol is wherein the amount of isothymol is at least 15 times the amount of isothymol per puff of the aerosol.

EX58. A method for producing an aerosol-generating substrate, the method comprising:

forming a slurry comprising cumin seed particles, water, an aerosol former, a binder, and optionally tobacco particles;

Casting or extruding the slurry into the form of a sheet or strand; and

Drying the sheet or strand at 80°C to 160°C.

EX59. The method of Example EX58, wherein the slurry is cast onto a support surface and dried to form a sheet of cast leaves.

EX60. A method for producing an aerosol-generating substrate, the method comprising:

forming a dilute suspension comprising cumin seed particles, water and optionally tobacco particles;

separating the suspension into an insoluble portion and a liquid extract;

forming the insoluble portion into a sheet;

Concentrating the liquid extract and adding the concentrated liquid extract to the sheet to form cumin paper.

Specific embodiments will be further described for purposes of illustration only with reference to the accompanying drawings, wherein:
1 illustrates a first embodiment of a description of an aerosol-generating article as described herein.
Figure 2 illustrates an aerosol-generating system comprising an aerosol-generating article and an aerosol-generating device comprising an electrical heating element.
Figure 3 illustrates an aerosol-generating system comprising an aerosol-generating article and an aerosol-generating device comprising a combustible heating element.
4A and 4B illustrate a second embodiment of a substrate of an aerosol-generating article as described herein.
Figure 5 illustrates a third embodiment of a description of an aerosol-generating article as described herein.
6A, 6B and 6C each show a cross-sectional view of a filter 1050 further comprising an aerosol modification element, wherein
Figure 6a shows aerosol reforming elements in the form of spherical capsules or beads within a filter plug.
Figure 6b shows an aerosol modification element in the form of a thread in a filter plug.
Figure 6c shows an aerosol reforming element in the form of a spherical capsule within a cavity inside the filter.
Figure 7 is a cross-sectional view of a plug of aerosol-generating substrate 1020 further comprising an elongated susceptor element.
Figure 8 depicts the experimental setup for collecting aerosol samples to be analyzed to determine characteristic compounds.

1 illustrates a heated aerosol-generating article 1000 comprising a substrate as described herein. Article 1000 includes four elements: an aerosol-generating substrate 1020, a hollow cellulose acetate tube 1030, a spacer element 1040, and a mouthpiece filter 1050. These four elements are sequentially arranged in coaxial alignment and assembled by the cigarette paper 1060 to form the aerosol-generating article 1000. The article 1000 has a mouth end 1012 that a user inserts into his or her mouth during use, and a distal end 1013 located at an opposite end of the article to the mouth end 1012. The embodiment of the aerosol-generating article shown in Figure 1 is particularly suitable for use in electrically operated aerosol-generating devices that include a heater for heating the aerosol-generating substrate.

When assembled, article 1000 is about 45 millimeters long, has an outer diameter of about 7.2 millimeters and an inner diameter of about 6.9 millimeters.

The aerosol-generating substrate 1020 includes a plug formed from a sheet of homogenized cumin material containing cumin seed particles, alone or in combination with tobacco particles.

A number of examples of suitable homogenized cumin materials for forming the aerosol-generating substrate 1020 are shown in Table 1 below (see Samples B-D). The sheet is pleated, crimped and wrapped in filter paper (not shown) to form a plug. The sheets contain additives including glycerol as an aerosol former.

As shown in Figure 1, the aerosol-generating article 1000 is designed to engage with an aerosol-generating device for consumption. This aerosol-generating device includes means for heating the aerosol-generating substrate 1020 to a temperature sufficient to form an aerosol. Typically, an aerosol-generating device may include a heating element surrounding the aerosol-generating article 1000 adjacent to the aerosol-generating substrate 1020, or a heating element inserted within the aerosol-generating substrate 1020.

Once engaged with the aerosol-generating device, the user draws on the mouth end 1012 of the smoking article 1000 and the aerosol-generating substrate 1020 is heated to a temperature of approximately 375°C. At this temperature, volatile compounds are released from the aerosol-generating substrate 1020. This compound condenses to form an aerosol. The aerosol is drawn through filter 1050 and into the user's mouth.

2 illustrates a portion of an electrically operated aerosol-generating system 2000 that utilizes heating blades 2100 to heat the aerosol-generating substrate 1020 of the aerosol-generating article 1000. Heated blades are mounted within the aerosol product containment chamber of the electrically operated aerosol generating device 2010. The aerosol-generating device defines a plurality of air holes 2050 to allow air to flow into the aerosol-generating article 1000. Air flow is indicated by arrows in Figure 2. The aerosol-generating device includes a power supply and electronics, not illustrated in FIG. 2 . The aerosol-generating article 1000 of FIG. 2 is as described with respect to FIG. 1 .

In an alternative configuration shown in Figure 3, the aerosol generating system is shown with a combustible heating element. While the article 1000 of FIG. 1 is intended for consumption with an aerosol-generating device, the article 1001 of FIG. 3 is a combustible heat source that can ignite and transfer heat to the aerosol-generating substrate 1020 to form an inhalable aerosol. Includes (1080). The combustible heat source 80 is a charcoal element assembled in close proximity to the aerosol-generating substrate at the distal end 13 of the rod 11. Elements that are essentially the same as those in Figure 1 are given the same numbers.

Figures 4A and 4B depict a second embodiment of a heated aerosol-generating article 4000a, 4000b. The aerosol-generating substrate 4020a, 4020b includes a first downstream plug 4021 formed from particulate plant material comprising cumin seed particles, and a second upstream plug 4022 formed from particulate plant material primarily comprising tobacco particles. . One of Samples A through D in Table 1 below represents a suitable homogenized cumin material for use in the first downstream plug. Table 1 below shows suitable homogenized tobacco material for use in the second upstream plug as Sample E. Sample E contains only tobacco particles and is included for comparative purposes only.

In each plug, the homogenized plant material is in the form of a sheet that is crimped and wrapped with filter paper (not shown). The sheets all contain additives including glycerol as an aerosol former. In the embodiment shown in Figure 4A, the plugs are combined in an abutting end-to-end relationship to form a rod and each has an equal length of about 6 mm. In a more preferred embodiment (not shown), the second plug is preferably longer than the first plug, for example preferably 2 mm longer, more preferably 3 mm longer, so that the tobacco stem within the substrate is longer. To provide the desired proportion of cumin seeds, the length of the second plug is 7 or 7.5 mm while the length of the first plug is 5 or 4.5 mm. In Figure 4b, the cellulose acetate tube support element 1030 is omitted.

Articles 4000a, 4000b, similar to article 1000 of FIG. 1, are particularly suitable for use with electrically operated aerosol generating system 2000 comprising the heater shown in FIG. 2. Elements that are essentially the same as those in Figure 1 are given the same numbers. Alternatively, it will be appreciated by those skilled in the art that a combustible heat source (not shown) in place of an electric heating element may be used with the second embodiment, in a configuration similar to that of article 1001 of FIG. 3 that includes combustible heat source 1080. It can be expected by .

Figure 5 shows a third embodiment of a heated aerosol-generating article 5000. The aerosol-generating substrate 5020 includes a rod formed of a first sheet of homogenized cumin material formed from particulate plant material comprising a percentage of cumin seed particles, and a second sheet of homogenized tobacco material comprising primarily cast leaf tobacco. Contains.

One of Samples A-D in Table 1 below represents a suitable homogenized cumin material for use as the first sheet. Sample E in Table 1 below represents suitable homogenized tobacco material for use as the second sheet. Sample E contains only tobacco particles and is included for comparative purposes only.

A second sheet is placed on top of the first sheet, and the combined sheets are crimped, corrugated and wrapped at least partially with filter paper (not shown) to form a plug that is part of the rod. Both sheets contain additives including glycerol as an aerosol former. Similar to article 1000 of FIG. 1, article 5000 is particularly suitable for use with electrically operated aerosol-generating system 2000 comprising a heater shown in FIG. 2. Elements that are essentially the same as those in Figure 1 are given the same numbers. Alternatively, it will be understood by those skilled in the art that a combustible heat source (not shown) in place of an electric heating element may be used with the third embodiment, in a configuration similar to that of article 1001 of FIG. 3 that includes combustible heat source 1080. It can be expected by .

Figures 6A, 6B and 6C are each a cross-sectional view of a filter 1050 further comprising an aerosol modification element. In Figure 6A, filter 1050 further comprises an aerosol reforming element in the form of a spherical capsule or bead 605.

In the embodiment of Figure 6A, the capsule or bead 605 is embedded within the filter portion 601 and is surrounded on all sides by filter material 603. In this embodiment, the capsule comprises an outer shell and an inner core, with the inner core containing the liquid flavour. The liquid flavorant is intended to provide flavor to the aerosol during use of the aerosol-generating article provided with the filter. Capsule 605 releases at least a portion of the liquid flavor when the filter is subjected to an external force, for example by being squeezed by a consumer. In the depicted embodiment, the capsule is typically spherical in shape and has a substantially continuous outer shell containing the liquid flavour.

In the embodiment of FIG. 6B , filter segment 601 has a plug of filter material 603 and a central flavoring section that extends axially through the plug of filter material 603 parallel to the longitudinal axis of filter 1050. Contains thread 607. The central flavor-containing thread 607 has substantially the same length as the plug of filter material 603, and the end of the central flavor-containing thread 607 is visible at the end of the filter segment 601. In Figure 6B, filter material 603 is cellulose acetate tow. A central flavor-containing thread 607 is formed from a twisted filter plug wrap and carries an aerosol modifier.

In the implementation of Figure 6C, filter segment 601 includes more than one plug of filter material 603, 603'. Preferably, the plug of filter material 603, 603' is formed from cellulose acetate and is thus capable of filtering aerosols provided by the aerosol-generating article. The wrapper 609 wraps around and connects the filter plugs 603 and 603'. Inside the cavity 611 is a capsule 605 containing an outer shell and an inner core containing the liquid flavour. Otherwise the capsule is similar to the embodiment of Figure 6A.

Figure 7 is a cross-sectional view of the aerosol-generating substrate 1020 further comprising an elongated susceptor strip 705. The aerosol-generating substrate 1020 includes a plug 703 formed from a sheet of homogenized cumin seed material containing tobacco particles and cumin seed particles. An elongated susceptor strip 705 is embedded within the plug 703 and extends longitudinally between the upstream and downstream ends of the plug 703. During use, the elongated susceptor strip 705 heats the homogenized cumin material by induction heating as described above.

Example

As described above with reference to the figures, different samples of homogenized plant material for use in aerosol-generating substrates according to the invention can be prepared from an aqueous slurry having the composition shown in Table 1. Sample A contains only cumin seed particles according to the invention and no tobacco particles. Samples B and C contain cumin seed particles and tobacco particles according to the invention. Sample D contains only tobacco particles and is included for comparative purposes only.

Particulate plant material in all samples A-D comprised approximately 75% of the dry weight of the homogenized plant material, with glycerol, guar gum and cellulose fibers accounting for approximately the remaining 25% of the dry weight of the homogenized plant material. Samples are prepared from an aqueous slurry containing 78-79 kg of water per 100 kg of slurry.

In the table below, % DWB stands for “dry weight basis”, in this case the % by weight calculated relative to the dry weight of the homogenized plant material. Cumin powder can be formed from dried cumin seeds, which can be ground by triple impact milling to a final D95 = 175 microns.

The slurry was cast using a casting bar (0.6 mm) onto a glass plate and dried in an oven at 140°C for 7 minutes and then in a second oven at 120°C for 30 seconds.

For each sample A to D of homogenized plant material, a plug can be created from a single continuous sheet of homogenized plant material, the sheets each having a width of 100 mm to 125 mm. The individual sheets preferably have a thickness of about 220 microns and a basis weight of about 194 g/m ² _. The cutting width of each sheet is approximately 80 mm. The sheets can be crimped to a height of 165 microns to 170 microns, rolled into plugs about 12 mm long and about 7 mm in diameter, and surrounded by a paper wrapper. The weight of homogenized plant material in each plug is approximately 188 mg, and the total weight of each plug is approximately 192.1 mg.

For each plug, from the downstream end: mouth end cellulose acetate filter (about 7 mm long), aerosol spacer comprising a crimped sheet of polylactic acid polymer (about 18 mm long), hollow acetate tube (about 8 mm long). , and a plug of an aerosol-generating substrate, with an overall length of about 45 mm having a structure as shown in Figure 3.

For Sample A of homogenized plant material in which cumin seed particles comprised 100% of the particulate plant material, methanol was used to extract characteristic compounds from the plug of homogenized plant material as described above. The extract was analyzed as described above to confirm the presence of characteristic compounds and to determine the amount of characteristic compounds. The results of this analysis are shown in Table 2 below, where the amounts indicated correspond to the amounts per aerosol-generating article, and the aerosol-generating substrate of the aerosol-generating article contained 188 milligrams of Sample A of the homogenized plant material.

For comparison, the amounts of characteristic compounds present in the particulate plant material (cumin seed particles) used to form sample A are also indicated. For particulate matter, the amount indicated corresponds to the amount of the characteristic compound in a sample of particulate plant matter with a weight corresponding to the total weight of particulate plant matter in the aerosol-generating article containing 188 milligrams of sample A.

For each of samples B and C containing a proportion of cumin seed particles, the amount of the characteristic compound can be estimated based on the values in Table 2 by assuming that the amount is present in proportion to the weight of cumin seed particles. .

Mainstream aerosols of aerosol-generating articles comprising aerosol-generating substrates formed from samples A to D of homogenized plant material can be generated according to Test Method A, as described above. For each sample, the resulting aerosol can be captured and analyzed.

As described above, according to Test Method A, aerosol-generating articles can be tested using the IQOS® Heated-Non-Combustion Device Tobacco Heating System 2.2 Holder (THS2.2 Holder) available from Philip Morris Products SA. The aerosol-generating article is heated under the Health Canada mechanical smoking regimen (as described in ISO/TR 19478-1:2014) over 30 puffs with a puff volume of 55 ml, puff duration of 2 seconds, and puff interval of 30 seconds.

Aerosols generated during the smoking test are collected on a Cambridge filter pad and extracted with a liquid solvent. Figure 10 shows a suitable device for generating and collecting aerosols from aerosol-generating articles.

The aerosol generating device 111 shown in Figure 10 is a commercially available tobacco heating device (IQOS). The contents of mainstream aerosols generated during the Health Canada smoking test as described above are collected in an aerosol collection chamber (113) on an aerosol collection line (120). The glass fiber filter pad 140 is a 44 mm Cambridge Glass Fiber Filter Pad (CFP) according to ISO 4387 and ISO 3308.

LC-HRAM-MS analysis :

Extraction solvents 170, 170a - in this case methanol and internal standard (ISTD) solution - are present in a volume of 10 mL in each micro-impinger 160, 160a. Cold baths 161 and 161a each contain dry ice-isopropyl ether to maintain micro-impingers 160 and 160a at approximately -60°C, respectively. The gas-vapor phase is captured in the extraction solvent (170, 170a) as aerosol bubbles through micro-impingers (160, 160a). The combined solution from the two micro-impingers is separated in step 181 as the impinger-trapped gas-vapor phase solution 180.

The CFP and impinger-entrapped gas-vapor phase solution 180 are combined in a clean Pyrex® tube in step 190. In step 200, by shaking thoroughly (to disintegrate the CFP), vortexing for 5 minutes and finally centrifuging (4500 g, 5 minutes, 10° C.), the total particulate matter was transferred to the impinger-entrapped gas-vapor phase solution ( 180) (containing methanol as solvent) is used to extract from CFP. An aliquot (300 μL) of the reconstituted total aerosol extract 220 was transferred to a silanized chromatography vial and mixed with methanol (700 μL) since the extraction solvent 170, 170a already contained the internal standard (ISTD) solution. diluted. The vial was closed and mixed for 5 minutes using an Eppendorf ThermoMixer (5°C, 2000 rpm).

Aliquots (1.5 μL) of the diluted extract were injected and analyzed by LC-HRAM-MS in both full scan mode and data-dependent fragmentation mode for compound identification.

GCxGC-TOFMS analysis:

As discussed above, once samples for GCxGC-TOFMS experiments are prepared, different solvents are suitable for extracting and analyzing polar, nonpolar, and volatile compounds separated from the total aerosol. The experimental setup is identical to that described regarding sample collection for LC-HRAM-MS with the exceptions indicated below.

Nonpolar & Polar

The extraction solvent (171,171a) is in a volume of 10 mL and is an 80:20 v/v mixture of dichloromethane and methanol, also containing a retention-index marker (RIM) compound and a stable isotope labeled internal standard (ISTD). . Cold baths 162 and 162a each contain a dry ice-isopropanol mixture to maintain micro-impingers 160 and 160a at approximately -78°C, respectively. The gas-vapor phase is captured in the extraction solvent (171, 171a) as aerosol bubbles via micro-impingers (160, 160a). The combined solution from the two micro-impingers is separated in step 182 as the impinger-trapped gas-vapor phase solution 210.

nonpolar

In step 190 the CFP and impinger-entrapped gas-vapor phase solution 210 are combined in a clean Pyrex® tube. In step 200, by shaking thoroughly (to disintegrate the CFP), vortexing for 5 minutes and finally centrifuging (4500 g, 5 minutes, 10° C.), the total particulate matter was transferred to the impinger-entrapped gas-vapor phase solution ( 210) (containing dichloromethane and methanol as solvents) is used to separate the polar and non-polar components of the total aerosol extract 230.

In step 250, a 10 mL aliquot (240) of the total aerosol extract (230) was taken. In step 260, a 10 mL aliquot of water is added, and the entire sample is shaken and centrifuged. The nonpolar fraction (270) was separated, dried over sodium sulfate, and analyzed by GCxGC-TOFMS in full scan mode.

polarity

ISTD and RIM compounds were added to the polar fraction (280) and then analyzed directly by GCxGC-TOFMS in full scan mode.

Each smoking replicate (n = 3) contains a captured and reconstituted non-polar fraction (270) and a polar fraction (280) accumulated for each sample.

Volatile ingredients

Two micro-impingers (160, 160a) were used in series to capture the entire aerosol. In this case, the extraction solvents 172, 172a containing a retention-index marker (RIM) compound, which is N,N-dimethylformamide (DMF), and a stable isotope labeled internal standard (ISTD), are each micro- It is present in a volume of 10 mL in pins 160 and 160a. Cold baths 161 and 161a each contain dry ice-isopropyl ether to maintain micro-impingers 160 and 160a at approximately -60°C, respectively. The gas-vapor phase is captured in the extraction solvent (170, 170a) as aerosol bubbles via micro-impingers (160, 160a). The combined solution from the two micro-impingers is separated into a volatile-containing phase (211) in step (183). The volatile-containing phase 211 is analyzed separately from the other phases and injected directly into the GCxGC-TOFMS using cool-on-column injection without additional preparation.

Table 3 below shows the levels of compounds characteristic of cumin seed particles in aerosols generated from aerosol-generating articles containing sample B of homogenized plant material, including cumin seed particles only. For comparison, Table 3 also shows the levels of characteristic compounds in aerosols generated from aerosol-generating articles comprising sample E of homogenized plant material containing only tobacco particles (and therefore not in accordance with the present invention).

In the aerosol generated from sample A, relatively high levels of characteristic compounds were measured. The ratio of cuminaldehyde to proccumenol exceeded 1, and the ratio of proccumenol to isothymol also exceeded 1. Therefore, the levels of characteristic compounds were indicative of the presence of cumin seed particles in the sample. In contrast, for tobacco-only sample D, which contained virtually no cumin seed particles, the levels of the characteristic compounds were found to be at or close to zero.

For each of Samples B and C containing cumin seed particles, the amount of the characteristic compound in the aerosol is given in Table 3 by assuming that the amount is present in proportion to the weight of the cumin seed particle in the aerosol-generating substrate from which the aerosol is generated. It can be estimated based on the value.

Table 4 below compares the phenol levels in aerosols generated from aerosol-generating articles containing Sample B (1:10 ratio of cumin to tobacco) with aerosols generated from Sample D of tobacco alone. The reduction shown is the reduction provided by replacing 10% of the tobacco particles in the homogenized material of Sample D with cumin seed particles.

As shown in Table 4, the aerosol generated from Sample B containing 10% by weight of cumin seed particles based on the dry weight of particulate plant material was 100% by weight of tobacco based on the dry weight of particulate plant material. This results in reduced levels of phenol when compared to the level of the same compound in the aerosol generated from Sample D.

In most cases, the reduction provided in the levels of these undesirable aerosol compounds is significantly greater than the proportional reduction expected as a result of 20% substitution of tobacco particles for cumin seed particles. Therefore, including cumin seed particles in combination with tobacco particles provides an unexpectedly high level of reduction in the levels of these compounds. Accordingly, inclusion of cumin seed particles can provide aerosols with improved organoleptic properties while reducing the levels of certain undesirable compounds in the aerosol.

Claims (15)

An aerosol-generating article comprising an aerosol-generating substrate, the aerosol-generating substrate comprising a homogenized cumin material, the homogenized cumin material comprising cumin seed particles, an aerosol former and a binder, the aerosol-generating substrate comprising:
At least 15 micrograms of procumenol per gram of said substrate, on a dry weight basis;
At least 20 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and
An aerosol-generating article comprising at least 10 micrograms of isothymol per gram of said substrate, on a dry weight basis. 2. The method of claim 1, wherein the amount of cuminaldehyde per gram of said substrate is at least equal to the amount of proccumenol per gram of said substrate, and the amount of proccumenol per gram of said substrate is at least equal to the amount of isothymol per gram of said substrate. Aerosol-generating articles. 3. An aerosol-generating article according to claim 1 or 2, wherein the aerosol-generating substrate further comprises from 1 milligram to 20 milligrams of nicotine per gram of the substrate, on a dry weight basis. 4. The method of any one of claims 1 to 3, wherein the homogenized cumin material comprises, on a dry weight basis, 5% to 30% by weight of aerosol former, and 1% to 10% by weight of binder. Aerosol-generating articles. 5. An aerosol-generating article according to any preceding claim, wherein the binder comprises guar gum. 6. An aerosol-generating article according to any preceding claim, wherein the homogenized cumin material comprises at least 2.5% by weight of cumin seed particles on a dry weight basis. 7. An aerosol-generating article according to any preceding claim, wherein the homogenized cumin material further comprises tobacco particles, wherein the weight ratio of cumin seed particles to tobacco particles is less than or equal to 1:4. 8. An aerosol-generating article according to any preceding claim, wherein the homogenized cumin material in the aerosol-generating substrate is in the form of cast leaves. 8. An aerosol-generating article according to any preceding claim, wherein the homogenized cumin material of the aerosol-generating substrate is in the form of cumin paper. 10. The method according to any one of claims 1 to 9, wherein upon heating the aerosol-generating substrate according to test method A, the aerosol generated is:
At least 25 micrograms of procumenol per gram of said substrate, on a dry weight basis;
At least 2 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and
An aerosol-generating article comprising at least 1 microgram of isothymol per gram of said substrate, on a dry weight basis. 11. The method according to any one of claims 1 to 10, wherein upon heating the aerosol-generating substrate according to Test Method A, the aerosol generated from the aerosol-generating substrate is:
Proccumenol in an amount of at least 0.5 micrograms per puff of aerosol;
Cuminaldehyde in an amount of at least 0.05 micrograms per puff of aerosol; and
Containing isothymol in an amount of at least 0.01 micrograms per puff of the aerosol,
A puff of aerosol has a volume of 55 milliliters as produced by a smoking machine, and the amount of proccumenol per puff of said aerosol is at least five times the amount of cumylaldehyde per puff of said aerosol, and the amount of proccumenol per puff of said aerosol is wherein the amount is at least 15 times the amount of isothymol per puff of said aerosol. An aerosol-generating substrate comprising a homogenized cumin material comprising cumin seed particles, an aerosol former and a binder, the aerosol-generating substrate comprising:
At least 15 micrograms of procumenol per gram of said substrate, on a dry weight basis;
At least 20 micrograms of cuminaldehyde per gram of said substrate, on a dry weight basis; and
An aerosol-generating substrate comprising at least 10 micrograms of isothymol per gram of the substrate, on a dry weight basis. An aerosol generating system, comprising:
An aerosol-generating device comprising a heating element; and
An aerosol-generating system comprising an aerosol-generating article according to any one of claims 1 to 12. An aerosol generated upon heating the aerosol-generating substrate according to claim 12, wherein the aerosol is,
Proccumenol in an amount of at least 0.5 micrograms per puff of aerosol;
Cuminaldehyde in an amount of at least 0.05 micrograms per puff of aerosol; and
Containing isothymol in an amount of at least 0.01 micrograms per puff of the aerosol,
A puff of aerosol has a volume of 55 milliliters as produced by a smoking machine, and the amount of proccumenol per puff of said aerosol is at least five times the amount of cumylaldehyde per puff of said aerosol, and the amount of proccumenol per puff of said aerosol is wherein the amount of isothymol is at least 15 times the amount of isothymol per puff of the aerosol. A method for producing an aerosol-generating substrate, the method comprising:
forming a slurry comprising cumin seed particles, water, an aerosol former, a binder, and optionally tobacco particles;
Casting or extruding the slurry into the form of a sheet or strand; and
Drying the sheet or strand at 80°C to 160°C.