KR20240010960A - Electroosmotic pump system and dialysis system - Google Patents

Abstract

The present invention discloses an electroosmotic pump system and a dialysis system. an inlet line through which fluid flows in, an outlet line through which the fluid is discharged, a first pump disposed between the inlet line and the outlet line, and in which a first working fluid is disposed inside the first housing, and the inlet line and a second pump disposed in parallel with the first pump between the outlet line and having a second working fluid disposed inside the second housing, and a power supply for supplying voltage to the first pump and the second pump. The first pump includes a first membrane disposed inside the first housing, a 1A electrode disposed on one side of the first membrane, and a 2A electrode disposed on the other side of the first membrane. And, the second pump includes a second membrane disposed inside the second housing, a 1B electrode disposed on one side of the second membrane, and a 2B electrode disposed on the other side of the second membrane. , the power supplies voltage by alternating polarity to the 1A electrode and the 2A electrode of the first pump, and supplies voltage by alternating polarity to the 1B electrode and the 2B electrode of the second pump. However, different polarities are applied to the 1A electrode of the first pump and the 1B electrode of the second pump.

Description

Electroosmotic pump system and dialysis system {Electroosmotic pump system and dialysis system}

The present invention relates to an electro-osmotic pump and electro-osmotic pump system for drug delivery that can be applied to a patch-type drug delivery device attached to the body or a wearable medical device. Additionally, the present invention relates to a dialysis system for dialyzing blood.

An electroosmotic pump is a pump that utilizes the fluid movement phenomenon that occurs when voltage is applied to both ends of a capillary tube or porous membrane. Electric osmotic pumps can be made much smaller than general mechanical pumps, make no noise, and consume less power.

For example, internationally published patent WO 2011/112723 discloses an electro-osmotic pump comprising a ceramic membrane positioned between a porous silver/silver oxide anode (anode) and a porous silver/silver oxide cathode (cathode), there is.

In the above patent, electrodes are installed on both ends of a porous separator made of ceramic, and when a certain potential is applied, a pressure proportional to the potential is generated. In addition, two electric fluid chambers and a needle for drug injection are used. A drug delivery device using the present invention is disclosed.

However, in the electro-osmotic pump used in the drug delivery device of the above patent, the drug to be delivered and water, the working fluid used to drive the pump, are separated by oil, so unexpected mixing may occur at the interface between the drug and water at any time. It is a structure that can be used.

In an electroosmotic pump, the drug to be delivered and water, the working fluid, must be separated. A drug is a mixture of various substances, and among its constituents, substances that exhibit physiological activity may be oxidized or reduced at a potential for driving an electroosmotic pump. In addition, when the drug is in direct contact with the electrode, polymer substances such as proteins are adsorbed to the electrode and the performance of the pump deteriorates. Therefore, it is preferable that the electrode and the drug are separated from each other.

However, the conventional technology has a problem in that it does not sufficiently satisfy these conditions.

In addition, the power consumption required to drive the pump is a factor that determines its practicality when applied as a patch-type drug delivery device attached to the human body or a wearable medical device, so a small pump that operates at low power is required.

Therefore, the present invention was proposed to solve the above problems, and the purpose of the present invention is to increase marketability through stable operation by separating the working fluid and the drug to be delivered and preventing them from mixing, and to prevent side effects to improve the patient's health. The goal is to provide an electroosmotic pump that maximizes the treatment effect.

In addition, another object of the present invention is to provide an electroosmotic pump that can maximize fluid transfer efficiency relative to power consumption. The present invention provides a drug injection device that operates safely and can accurately deliver drugs.

Another object of the present invention is to provide an electro-osmotic pump system and a dialysis system that can provide continuously pumped fluid by pumping fluid alternately at both ends.

Another object of the present invention is to provide an electroosmotic pump system and a dialysis system that can increase the flow rate pumped by pumps arranged in parallel.

One aspect of the present invention is an inlet line through which a fluid flows in, an outlet line through which the fluid is discharged, and a device disposed between the inlet line and the outlet line and having a first working fluid disposed inside the first housing. 1 pump, a second pump disposed in parallel with the first pump between the inlet line and the outlet line, and having a second working fluid disposed inside a second housing, and the first pump and the second pump It includes a power supply that supplies voltage to the pump, and the first pump includes a first membrane disposed inside the first housing, a 1A electrode disposed on one side of the first membrane, and the other side of the first membrane. It has a 2A electrode disposed in, and the second pump includes a second membrane disposed inside the second housing, a 1B electrode disposed on one side of the second membrane, and a second membrane disposed on the other side of the second membrane. It has a 2B electrode disposed, and the power supply supplies voltage by alternating polarity to the 1A electrode and the 2A electrode of the first pump, and the 1B electrode and the 2B electrode of the second pump. Provides an electro-osmotic pump system that supplies voltage by alternating polarity and applies different polarities to the 1A electrode of the first pump and the 1B electrode of the second pump.

Additionally, the first working fluid of the first pump and the second working fluid of the second pump may move in different directions.

Additionally, the first pump includes a 1A diaphragm disposed to be spaced apart from the 1A electrode, a 1A check valve that moves the fluid from the inlet line to the 1A diaphragm, and a 1A check valve that moves the fluid from the 1A diaphragm to the outlet line. It further includes a 2A check valve for moving the fluid, wherein the second pump includes a 1B diaphragm disposed to be spaced apart from the 1B electrode, and a 1B check valve for moving the fluid from the inlet line to the 1B diaphragm. It may further include a valve, and a 2B check valve that moves the fluid from the 1A diaphragm to the outlet line.

Additionally, the discharge cycle of the fluid discharged from the 2A check valve of the first pump and the discharge cycle of the fluid discharged from the 2B check valve of the second pump may be different from each other.

Additionally, the first pump and the second pump may alternately introduce the fluid into the inlet line and discharge the fluid alternately from the outlet line.

Additionally, the first pump discharges the fluid from the inlet line to the outlet line in a first cycle, and the second pump discharges the fluid from the inlet line to the outlet line in a second cycle different from the first cycle. can do.

Additionally, a third pump is disposed in parallel with the first pump between the inlet line and the outlet line and is disposed in parallel with the second pump, and the power supply alternates polarity to the third pump. While supplying the voltage, the polarity may be applied at a period different from the period of the polarity applied to the first pump and the period of the polarity applied to the second pump.

Additionally, the flow rate of the fluid discharged from the third pump may be different from the flow rate discharged from the first pump or the second pump.

Another aspect of the present invention includes a first line through which one of the blood and the dialysate moves, a second line through which the other of the blood and the dialysate moves, and the first line and the second line pass through, A dialysis device in which the blood is dialyzed using the dialysate, a pump module disposed in at least one of the first line and the second line and moving at least one of the dialysate and the blood passing through the pump module. A dialysis system is provided that includes a power source that supplies power with alternating polarity.

In addition, the pump module is disposed on the first line, a first pump with a working fluid disposed inside the first housing, and a second pump disposed in parallel with the first pump on the first line. It includes a second pump disposed with a working fluid inside the housing, wherein the first pump includes a first membrane disposed inside the first housing, a 1A electrode disposed on one side of the first membrane, and the It has a 2A electrode disposed on the other side of the first membrane, and the second pump includes a second membrane disposed inside the second housing, a 1B electrode disposed on one side of the second membrane, and the first pump. 2 It is provided with a 2B electrode disposed on the other side of the membrane, and the power supply supplies voltage by alternating polarity to the 1A electrode and the 2A electrode of the first pump, and the 1B electrode of the second pump A voltage may be supplied by alternating polarity to the 2B electrode, and the polarity may be applied to the 1A electrode of the first pump and the 1B electrode of the second pump at different cycles.

Additionally, the working fluid of the first pump and the working fluid of the second pump may move in different directions.

In addition, the first pump includes a 1A diaphragm disposed to be spaced apart from the 1A electrode, a 1A check valve for moving the blood or dialysate from the first line to the 1A diaphragm, and a 1A diaphragm in the 1A diaphragm. It further includes a 2A check valve for moving the blood or dialysate to the first line, and the second pump includes a 1B diaphragm disposed to be spaced apart from the 1B electrode, and the 1B diaphragm in the first line. It further includes a 1B check valve for moving the blood or dialysate to the first line, and a 2B check valve for moving the blood or dialysate from the 1A diaphragm to the first line, wherein the 2A pump of the first pump The discharge cycle of the blood or dialysate discharged from the check valve and the discharge cycle of the blood or dialysate discharged from the 2B check valve of the second pump may be different from each other.

Additionally, the first pump may discharge the blood or dialysate into the first line in a first cycle, and the second pump may discharge the blood or dialysate in a second cycle different from the first cycle.

In addition, the first line further includes a third pump disposed in parallel with the first pump and parallel with the second pump, and the power supply supplies voltage to the third pump by alternating polarity. However, the polarity may be applied at a period different from the period of the polarity applied to the first pump and the period of the polarity applied to the second pump.

Additionally, the flow rate of the blood or dialysate discharged from the third pump may be different from the flow rate of the blood or dialysate discharged from the first pump or the second pump.

In addition, the pump module includes at least one pump, where the pump

A driving unit including a housing, a first membrane disposed inside the housing, a first electrode disposed on one side of the first membrane, and a second electrode disposed on the other side of the first membrane, and the driving portion A diaphragm assembly having a first diaphragm disposed on one side and a second diaphragm disposed on the other side of the driving unit, a first check valve mounted to face the first diaphragm and disposed at the inlet end, and a first check valve disposed at the outlet end. A first valve assembly having a second check valve, and a second valve assembly mounted to face the second diaphragm and having a third check valve disposed at the inlet end and a fourth check valve disposed at the outlet end. You can.

In addition, the pump is disposed in the first line, and either the blood or the dialysate alternately flows into the first check valve and the third check valve, and the second check valve and the fourth check valve. Any one of the above can be discharged alternately with the valve.

In addition, the pump may have the first valve assembly disposed in the first line, the second valve assembly disposed in the second line, and any one of the blood and the dialysate discharged from the second check valve. It may be discharged alternately with another one of the blood and the dialysate discharged from the fourth check valve.

In the present invention, the pump operating fluid and the fluid to be delivered, such as a drug, are separated by a flexible diaphragm, which can prevent the active ingredient contained in the fluid to be delivered from being deteriorated by electrochemical reaction due to the voltage applied to the electrode. It works

In addition, the present invention can prevent components contained in the pump operating fluid from being delivered to the drug, allowing various delivery fluids to be applied when designing a patch-type drug delivery device, thereby increasing design freedom. In other words, the present invention enables the design of a patch-type drug delivery device that can be applied to patients suffering from various diseases or by selecting and supplying the optimal drug to patients suffering from a specific disease, such as diabetes.

In addition, the present invention has the effect of improving the marketability of the electro-osmotic pump by applying a check valve with a very low opening pressure to speed up the reaction speed of the check valve, thereby allowing the electro-osmotic pump to operate at low power and high efficiency.

In the present invention, valve assemblies are arranged on both sides of the pump, and alternate polarity is transmitted, so that fluid can be pumped alternately from the valve assemblies on both sides. Thus, the pump can provide continuously pumped fluid to increase flow rate. A dialysis system using the pump can continuously provide high driving force to blood or dialysate, thereby increasing dialysis efficiency.

The present invention can increase the pumped flow rate by arranging pumps in parallel. Since the flow rates discharged from each pump alternately join each other, a large flow rate can be provided continuously.

1 is a perspective view showing the external appearance of an electroosmotic pump to explain an embodiment of the present invention.
Figure 2 is a perspective view of the electro-osmotic pump shown in Figure 1 from another angle.
Figure 3 is an exploded perspective view of Figure 1.
Figure 4 is a cross-sectional view taken along section IV-IV of Figure 1.
Figure 5 is a cross-sectional view taken along section V-V of Figure 1.
FIG. 6 is a diagram illustrating a check valve assembly of one embodiment that can be mounted on the pump of FIG. 1.
Figure 7 is a perspective view showing a modified example of the check valve assembly of Figure 6.
Figure 8 is a cross-sectional view showing a pump according to an embodiment of the present invention.
Figure 9 is a diagram showing a dialysis system according to an embodiment of the present invention.
FIG. 10 is a diagram illustrating a pump module of an embodiment applied to FIG. 9.
FIG. 11 is a graph showing the flow rate of the pump module of FIG. 10.
FIG. 12 is a diagram showing a pump module of another embodiment applied to FIG. 9.
FIG. 13 is a graph showing the flow rate of the pump module of FIG. 12.
FIG. 14 is a graph showing the flow rate of a pump module of another embodiment applied to FIG. 9.
FIG. 15 is a diagram showing a pump module of another embodiment applied to FIG. 9.
Figure 16 is a diagram showing a dialysis system according to another embodiment of the present invention.
FIG. 17 is a diagram illustrating a pump module of an embodiment applied to FIG. 16.
FIG. 18 is a diagram showing a pump module of another embodiment applied to FIG. 16.

Since the present invention can be modified in various ways and can have various embodiments, specific embodiments will be illustrated in the drawings and described in detail in the detailed description. The effects and features of the present invention and methods for achieving them will become clear by referring to the embodiments described in detail below along with the drawings. However, the present invention is not limited to the embodiments disclosed below and may be implemented in various forms.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. When describing with reference to the drawings, identical or corresponding components will be assigned the same reference numerals and redundant description thereof will be omitted. .

In the following examples, singular terms include plural terms unless the context clearly dictates otherwise.

In the following embodiments, terms such as include or have mean that the features or components described in the specification exist, and do not exclude in advance the possibility of adding one or more other features or components.

In cases where an embodiment can be implemented differently, a specific process sequence may be performed differently from the described sequence. For example, two processes described in succession may be performed substantially at the same time, or may be performed in an order opposite to that in which they are described.

In the drawings, the sizes of components may be exaggerated or reduced for convenience of explanation. For example, the size and thickness of each component shown in the drawings are arbitrarily shown for convenience of explanation, so the following embodiments are not necessarily limited to what is shown.

Figures 1 and 2 are perspective views for explaining an embodiment of the present invention, Figure 3 is an exploded perspective view of Figure 1, Figure 4 is a cross-sectional view taken along part IV-IV of Figure 1, and Figure 5 is a view taken along part V-V. A cutaway cross-sectional view showing an electro-osmotic pump.

The electro-osmotic pump of an embodiment of the present invention includes a connector (1), a check valve assembly (3), and a drive unit (5).

The check valve assembly 3 may be coupled to one side of the connector 1, and the drive unit 5 may be coupled to the other side. The connector (1) is provided with a partition (1a) that partitions the check valve assembly (3) and the driving unit (5). The partition 1a is provided with a drug inlet 1b and a drug outlet 1c.

The drug inlet (1b) and the drug outlet (1c) are spaced apart from each other and are disposed to penetrate the partition wall (1a).

The drug inlet 1b may be a passage through which the drug to be introduced into the human body flows in, and the drug outlet 1c may be a passage through which the drug introduced into the drug inlet 1b can be turned around and discharged so that it can be introduced back into the human body.

The check valve assembly 3 may include a valve housing 7, an inlet check valve 9, an outlet check valve 11, a first fixture 13, and a second fixture 15.

The valve housing (7) is provided with a drug inlet extension pipe (7a) and a drug discharge extension pipe (7b). The valve housing 7 may be coupled to one side of the connector 1. And the drug inflow extension pipe (7a) is connected to the drug inlet (1b), and the drug discharge extension pipe (7b) is connected to the drug outlet (1c).

The inflow check valve (9) is disposed in the drug inflow extension pipe (7a). The inflow check valve (9) can block the drug solution being introduced into the human body from passing through the drug inlet (1b) and moving in the reverse direction.

The discharge check valve 11 is disposed in the drug discharge extension pipe 7b. The discharge check valve 11 can allow the drug that has passed through the drug inlet 1b to pass in the direction of injection into the human body, and can block it from moving in the reverse direction.

The inlet check valve (9) and the discharge check valve (11) may be duckbill valves that are flexible and have a low opening pressure. These inlet check valves (9) and discharge check valves (11) have increased fluid transfer efficiency compared to power consumption and can operate for a long time, thereby increasing marketability.

The first fixture 13 may be inserted into the drug inflow extension pipe 7a and serve to secure the inflow check valve 9. The second fixture 15 may be inserted into the drug discharge extension pipe 7b and serve to fix the discharge check valve 11.

In addition, it is preferable that the first fixture 13 and the second fixture 15 have a conduit through which the drug can pass.

In the embodiment of the present invention, an example in which the inlet check valve 9 and the discharge check valve 11 are combined with the valve housing 7 is shown and described, but the drug provided in the connector 1 is not limited thereto. It is also possible that the inlet check valve 9 and the discharge check valve 11 are respectively coupled to the inlet 1b and the drug outlet 1c. This other example can be manufactured in a simpler structure by integrating the valve housing (7) with the connector (1). Another example of this embodiment of the present invention can further reduce manufacturing costs by reducing the number of parts and can be manufactured compactly.

The driving unit 5 is coupled to one side of the connector 1. The driving unit 5 is preferably disposed on the opposite side to which the check valve assembly 3 is coupled. It is preferable that the driving unit 5 is arranged to be isolated from the drug passing through the check valve assembly 3. The driving unit 5 serves to apply pressure to the drug passing through the check valve assembly 3 so that the drug passes through the drug outlet 1c.

The driving unit 5 includes a first diaphragm 17, a first housing 19, a first power supply line 21, a first electrode 23, a membrane 25, a second electrode 27, and a second power supply line. (29), a second housing (31), and a second diaphragm (33).

The first diaphragm 17 is coupled to one side of the connector 1. The first diaphragm 17 and the connector 1 are provided with a space therebetween. That is, the first diaphragm 17 is coupled to the connector 1 while maintaining a certain space in the connector 1. Therefore, the drug on the check valve assembly (3) side does not move to the driving unit (5) side by the first diaphragm (17) and remains isolated.

The surface of the first diaphragm 17 can repeatedly move a certain section in the axial direction by pressure generated from the driving unit 5. In some cases, the first diaphragm 17 may be provided with wrinkles that allow the surface to move smoothly in the axial direction (x-axis direction with respect to FIG. 1).

The first diaphragm 17 described above is coupled to one side of the first housing 19. The first housing 19 is provided with a space 19a penetrating along the axial direction. Accordingly, one side of the space 19a of the first housing 19 may be closed by the first diaphragm 17.

The first electrode 23 is coupled to the other side of the first housing 19 to close the space 19a formed by the first housing 19. And the first housing 19 can accommodate a working fluid such as water in the space 19a provided therein.

The first housing 19 may be provided with a hole 19b for fluid injection on its outer circumference. This hole 19b can be sealed after the working fluid is injected into the first housing 19. Accordingly, the working fluid of the driving unit (5) can be isolated from the chemical liquid on the check valve assembly (3) side.

The first power supply line 21 may supply power to the first electrode 23. The first power supply line 21 is arranged along the edge of the first housing 19 and may be fixed in contact with the first electrode 23. The first power supply line 21 is preferably disposed between the first housing 19 and the first electrode 23. However, as another example of an embodiment of the present invention, the first power supply line 21 may be disposed between the first electrode 23 and the membrane 25 as long as it can only supply power to the first electrode 23.

The first electrode 23 is formed in a plate shape and can close the space 19a of the first housing 19. That is, the first housing 19 may form a space 19a by the first diaphragm 17 and the first electrode 23. And a working fluid such as water is accommodated in the space 19a of the first housing 19.

The membrane 25 may be made of a porous material through which working fluid and ions move. The membrane 25 is preferably made of an insulating material such as ceramic. When the membrane 25 is made of a non-conductor, the electroosmotic pump of the present invention is operated for a long time so that the electrochemical reactive material used in the first electrode 23 and the second electrode 27 is consumed or desorbed, making the membrane porous. (25) Even if exposed, side reactions such as electrolysis of water that occur due to exposure of carbon paper or carbon fabric do not occur when using conventional carbon paper or carbon fabric. Therefore, unnecessary power consumption due to side reactions can be prevented. Therefore, the present invention has safe driving characteristics and can improve durability.

The membrane 25 can be used by processing a flexible material such as non-conductive polymer resin, rubber, urethane, or plastic film into a thin film.

The second electrode 27 is disposed on the other side of the membrane 25. That is, the membrane 25 is preferably disposed between the first electrode 23 and the second electrode 27. The second power supply line 29 can supply external power to the second electrode 27. The second power supply line 29 may be coupled to the edge of the second housing 31. However, the second power supply line 29 can have any arrangement as long as it can supply power to the second electrode 27.

The second housing 31 has the same or similar shape and shape as the first housing 19. The second housing 31 is provided with another space 31a penetrating therein in the axial direction. Like the first housing 19, the second housing 31 may be provided with a hole 31b penetrating the internal space 31a. The hole 31b of the second housing 31 may be sealed with a sealant or filled by fusion, etc. after the working fluid is injected.

The second diaphragm 33 may be coupled to one side of the second housing 31 to close the space 31a provided in the second housing 31.

That is, the second housing 31 can close the space 31a by the second electrode 27 and the second diaphragm 33, which are formed in a plate shape.

A wrinkle portion 33a may be formed on the surface of the second diaphragm 33. The wrinkles 33a formed in the second diaphragm 33 may have irregularities that protrude in the axial direction when viewed in cross section. The corrugated portion 33a of the second diaphragm 33 can serve to increase pumping performance by sufficiently moving the surface of the second diaphragm 33 in the axial direction.

In the embodiment of the present invention, an example in which the wrinkles 33a are formed in the second diaphragm 33 is shown and described, but in some cases, the wrinkles may also be formed in the first diaphragm 17. In addition, the wrinkles that can be formed in the first diaphragm 17 or the second diaphragm 33 serve to maximize the deformation of the first diaphragm 17 and the second diaphragm 33 even with a small amount of energy, thereby reducing energy consumption. You can. In other words, there is an advantage that the driving unit 5 can be driven for a long time even with a small external power source.

4 and 5, the above-described first housing 19, first power supply line 21, first electrode 23, membrane 25, second electrode 27, and second power supply The supply line 29 and the second housing 31 can be kept airtight from the outside by the sealant S. That is, the first power supply line 21, the first electrode 23, the membrane 25, the second electrode 27, and the second power supply line 29 are connected to the first housing 19 and the second housing 31. ) is small compared to the size of the assembled state, and a sealant is applied to the circumferential portion (the portion exposed to the outside and forming a groove or space based on the cross section) between the first housing 19 and the second housing 31. (S) can be placed. This encapsulant (S) can form an airtight layer that maintains airtightness from the outside.

These encapsulants may be hot melt-based, epoxy-based, polyurethane-based, or cyanoacrylate-based adhesives. However, the encapsulant is not limited to these examples, and any material that can be hardened to prevent the outflow of working fluid and deformation of the external shape of the component can be used.

The operating process of this embodiment of the present invention will be described in detail as follows.

First, when power is supplied to the first power supply line 21 and the second power supply line 29 with different voltage polarities, a voltage difference occurs between the first electrode 23 and the second electrode 27. Due to this voltage difference, positive ions are generated as a result of an electrode reaction at the oxidizing electrode. Cations generated in the above reaction move to the cathode, drag the working fluid with them, and pass through the membrane 25 to generate pressure (pumping force).

That is, this electrochemical reaction allows ions and working fluid to pass through the membrane 25 and move into the space 19a of the first housing 19 or the space 31a of the second housing 31.

When the polarity of power is alternately supplied to the first electrode 23 and the second electrode 27 through the first power supply line 21 and the second power supply line 29, the first housing ( The working fluid may repeatedly move to the space 19a of 19) and the space 31a of the second housing 31.

In other words, if the electrode that was playing the role of the oxidizing electrode changes to playing the role of the reducing electrode due to the alternation of voltage polarity, the electrochemical reactants consumed when used as the oxidizing electrode can be recovered when used as the reducing electrode. The reverse case is also done in the same way, allowing continuous operation of the electric osmotic pump.

Then, the first diaphragm 17 and the second diaphragm 33 are deformed to generate pressure. This pressure acts on the space between the connector 1 and the first diaphragm 17.

Then, the drug is introduced into the drug inlet (1b) through the drug inflow extension pipe (7a) by the pressure generated from above. And the drug moved in this way can be injected into the human body while being discharged through the drug outlet (1c) and the drug discharge extension pipe (7b).

At this time, the inlet check valve (9) and the discharge check valve (11) serve to move the drug in only one direction. Therefore, the battery osmosis pump of the embodiment of the present invention can stably inject drugs into the human body while using low power.

In particular, in the present invention, since the working fluid of the driving unit 5 and the drug are separated from each other, it is possible to prevent the active ingredient contained in the drug from being deteriorated due to electrochemical reaction.

In addition, the present invention can be applied to a wider range of drugs or working fluids by blocking the components contained in the working fluid of the driving unit 5 from being transferred to the drug.

The present invention uses a check valve with a very low opening pressure, so that the reaction speed of the check valve is very fast, and as a result, the overall pump can be operated with low power and high efficiency.

The electro-osmotic pump of the present invention can be applied to the electro-osmotic pump system or dialysis system described later.

FIG. 6 is a diagram illustrating a check valve assembly of one embodiment that can be mounted on the pump of FIG. 1.

Referring to FIG. 6, the check valve assembly may be mounted on the electro-osmotic pump of the above-described embodiment or the valve assembly of the pump 100 described later. The check valve assembly may include a valve housing 7A, a first check valve 9A, and a second check valve 11A.

The check valve assembly is mounted to face the first diaphragm (17A) and can be mounted on a housing in which a driving unit (not shown) is installed with a connector (1A).

The valve housing 7A may have a first check valve 9A and a second check valve 11A disposed therein to allow movement of fluid in different directions.

The first check valve 9A may be disposed between the first space S1 and the second space S2 of the valve housing 7A. The first check valve 9A can allow fluid from the outside to pass through the first space S1 and the second space S2 and move to the first diaphragm 17A. The fluid passes through the 1-1 opening (71A-1) and moves from the outside into the first space (S1), and passes through the 1-2 opening (71A-2) into the first diaphragm in the second space (S2). You can move to (17A).

The first check valve 9A may have a first shaft 91A and a first head 92A. The first shaft 91A may be placed in the first space S1, and the first head 92A may be placed in the second space S2. The first shaft 91A is inserted into the first partition 73A dividing the first space S1 and the second space S2, and the first head 92A is disposed on the first partition 73A. 1 The through hole (7A-1) can be opened and closed selectively.

The second check valve 11A may be disposed between the third space S3 and the fourth space S4 of the valve housing 7A. The second check valve 11A may allow fluid to pass through the third space S3 and the fourth space S4 in the first diaphragm 17A and move outward. The fluid passes through the 2-1 opening (72A-1) and moves from the first diaphragm (17A) to the third space (S3), and passes through the 2-2 opening (72A-2) into the fourth space (S4). ) can be moved to the outside.

The second check valve 11A may have a second shaft 111A and a second head 112A. The second shaft 111A may be placed in the third space S3, and the second head 112A may be placed in the fourth space S4. The second shaft 111A is inserted into the second partition 74A dividing the third space S3 and the fourth space S4, and the second head 112A is disposed on the second partition 74A. 2 The through hole (7A-2) can be opened and closed selectively.

When the pressure of the space between the first diaphragm (17A) and the valve housing (7A) is lowered, fluid flows into the first space (S1) through the 1-1 opening (71A-1). Since the first space (S1) has a higher pressure than the second space (S2), the first head (92A) opens the first through hole (7A-1), and the third space (S3) opens the fourth space ( Since the pressure is lower than S4), the second head 112A closes the second through hole 7A-2. The fluid passes through the first through hole (7A-1) and moves to the second space (S2), and then passes through the first-2 opening (71A-2) to the first diaphragm (17A) and the valve housing (7A). Move to the space in between.

When the pressure in the space between the first diaphragm 17A and the valve housing 7A increases, fluid is discharged to the outside through the 2-2 opening 72A-2. Since the first space (S1) has a lower pressure than the second space (S2), the first head (92A) closes the first through hole (7A-1), and the third space (S3) closes the fourth space ( Since the pressure is higher than S4), the second head 112A opens the second through hole 7A-2. The fluid moves from the first diaphragm (17A) to the third space (S3) through the 2-1 opening (72A-1) and to the fourth space (S4) through the second through hole (7A-2). It moves, and then passes through the 2-2 opening (72A-2) and is discharged to the outside.

Figure 7 is a perspective view showing a modified example of the check valve assembly of Figure 6.

Referring to Figure 7, the check valve assembly (9B) may include a tube (91B), a body (92B), a seal (93B), and an elastic member (94B). The check valve assembly 9B may be installed on the first check valve 9A and the second check valve 11A in FIG. 6.

The body 92B is inserted into the tube 91B and can be divided into a first space 911B and a second space 912B. The first space 911B and the second space 912B may be distinguished by a neck where the inner diameter of the tube 91B is narrowed. The shaft 922B of the body 92B may be disposed in the first space 911B, and the head 921B of the body 92B may be disposed in the second space 912B. The check valve assembly 9B allows fluid to move from the first space 911B to the second space 912B of the tube 91B.

The body 92B may have a head 921B, a shaft 922B, a flange 923B, and a groove 924B. The shaft 922B, the flange 923B, and the groove 924B may be disposed in the first space 911B, and the head 921B may be disposed in the second space 912B.

The head 921B may be inserted into the second space 912B, and the seal 93B may be inserted. Flow may be blocked from the second space 912B to the first space 911B by the seal 93B.

The shaft 922B extends from the head 921B and may be inserted into the first space 911B. A flange 923B may be disposed at the end of the head 921B.

The flange 923B can move the shaft 922B by receiving pressure from the fluid. Additionally, the elastic member 94B is inserted into the flange 923B, so that the elastic member 94B can be compressed when subjected to fluid pressure.

If the pressure of the fluid in the first space 911B is higher than the fluid in the second space 912B, the fluid in the first space 911B may pressurize the rear end of the flange 923B. At this time, the groove 924B is disposed on one side of the flange 923B, so that fluid can pass through the groove 924B and move to the shaft 922B.

Since the check valve assembly (9B) has a flange (923B) that receives the pressure of the fluid so that the body (92B) moves, and a groove (924B) that allows the movement of the fluid, the check valve assembly (9B) responds to the pressure of the fluid. Accordingly, opening and closing are simple and fluid can move when opened.

Figure 8 is a cross-sectional view showing a pump according to an embodiment of the present invention.

Referring to FIG. 8, the pump 100 may be driven by electro-osmosis. The pump 100 has diaphragms disposed at both ends and can pump fluid alternately and continuously.

The pump 100 may include a housing 110, a driving unit 120, a diaphragm unit 130, a first valve assembly 140, and a second valve assembly 150.

The housing 110 may store a working fluid therein. A driving unit 120 may be placed inside the housing 110, and a diaphragm unit 130 may be placed at the end.

The driver 120 may include a membrane 121, a first electrode 122, a second electrode 123, a first electrode tab 124, and a second electrode tab 125.

The membrane 121 may have a porous material through which working fluid and ions move. The membrane 121 may be substantially the same as the membrane 25 described above.

The first electrode 122 may be placed on one side of the membrane 121, and the second electrode 123 may be placed on the other side of the membrane 121. The first electrode 122 may be electrically connected to the power source PW of FIG. 9 through the first electrode tab 124. The second electrode 123 may be electrically connected to the power source (PW) by the second electrode tab 125.

The diaphragm unit 130 may have a first diaphragm 131 and a second diaphragm 132. The diaphragm unit 130 may allow movement of the working fluid inside the housing 110.

The first diaphragm 131 covers one side of the housing 110 and may be disposed adjacent to the first valve assembly 140. The housing 110 may have a first space V1 whose one end is covered by the first diaphragm 131 and the first electrode 122.

The second diaphragm 132 covers the other side of the housing 110 and may be disposed adjacent to the second valve assembly 150. The housing 110 may have a second space V2 whose other end is covered by the second diaphragm 132 and the second electrode 123.

The first valve assembly 140 is mounted on one end of the housing 110 and may be arranged to face the first diaphragm 131. The first valve assembly 140 may be mounted on the housing 110 by the first connector 111.

In one embodiment, the first valve assembly 140 may have a first valve housing 141, a first check valve 142, and a second check valve 143. The first valve housing 141, the first check valve 142, and the second check valve 143 may be the above-described valve housing 7, the inlet check valve 9, and the discharge check valve 11, respectively. there is.

In an alternative embodiment, first valve assembly 140 may include a first fixture 144 and a second fixture 145. The first fixture 144 and the second fixture 145 may be the first fixture 13 and the second fixture 15 described above.

The second valve assembly 150 is mounted on the other end of the housing 110 and may be arranged to face the second diaphragm 132. The second valve assembly 150 may be mounted to the housing 110 by a second connector 112.

In one embodiment, the second valve assembly 150 may have a second valve housing 151, a third check valve 152, and a fourth check valve 153. The second valve housing 151, the third check valve 152, and the fourth check valve 153 may be the aforementioned valve housing 7, the inlet check valve 9, and the discharge check valve 11, respectively. there is.

In an alternative embodiment, the second valve assembly 150 may include a third fixture 154 and a fourth fixture 155. The third fixture 154 and the fourth fixture 155 may be the first fixture 13 and the second fixture 15 described above.

The power source (PW) may alternately supply voltages with different polarities to the first electrode 122 and the second electrode 123. When voltages with different polarities are alternately supplied to the first electrode 122 and the second electrode 123, a voltage difference occurs between the first electrode 122 and the second electrode 123. Due to the above voltage difference, cations are generated at the anode through an electrode reaction, and the generated cations move to the cathode, dragging the working fluid with them and passing through the membrane 121, thereby generating pressure.

Since polarity is applied alternately to the first electrode 122 and the second electrode 123, the working fluid flows from the first space (V1) to the second space (V2) and from the second space (V2) to the first space ( With V1), the flow direction can be changed alternately.

When the working fluid moves from the first space (V1) to the second space (V2), the first diaphragm 131 moves toward the driving unit 120, the first check valve 142 opens, and the second check valve 142 opens. (143) is closed. At the same time, the second diaphragm 132 moves away from the driving unit 120, the third check valve 152 is closed and the fourth check valve 153 is opened. That is, the inlet of the first valve assembly 140 is open and the outlet is closed, but the inlet of the second valve assembly 150 is closed and the outlet is open.

When the working fluid moves from the second space (V2) to the first space (V1), the first diaphragm 131 moves away from the driving unit 120, the first check valve 142 is closed, and the second check valve ( 143) is open. At the same time, the second diaphragm 132 moves toward the driving unit 120, the third check valve 152 opens and the fourth check valve 153 closes. That is, the inlet of the first valve assembly 140 is closed and the outlet is open, but the second valve assembly 150 has an open inlet and a closed outlet.

The pump 100 may have the first valve assembly 140 and the second valve assembly 150 alternately introduce fluid, and alternately discharge the pumped fluid. The cycle of fluid inflow and discharge from the first valve assembly 140 and the cycle of fluid inflow and discharge from the second valve assembly 150 are set differently.

In detail, since the first electrode 122 and the second electrode 123 of the driving unit 120 are alternately applied to apply polarity, the fluid inflow and discharge cycle of the first valve assembly 140 is determined by the second valve assembly 150. It may be the exact opposite of the fluid inflow and outflow cycle.

In one embodiment, the pump 100 may continuously pump fluid by injecting and discharging the same fluid into the first valve assembly 140 and the second valve assembly 150. The pump 100 alternately flows fluid into the first valve assembly 140 and the second valve assembly 150, and then alternately flows into the first valve assembly 140 and the second valve assembly 150. The fluid is discharged, and the pump 100 can continuously pump the fluid within a preset deviation range.

In one embodiment, the pump 100 may pump different fluids by injecting and discharging different fluids into the first valve assembly 140 and the second valve assembly 150, respectively. The pump 100 allows the first fluid to flow into the first valve assembly 140 and be discharged from the first valve assembly 140, and the second fluid to flow into the second valve assembly 150 and the second valve assembly 150. ) can be discharged from. At this time, the first valve assembly 140 and the second valve assembly 150 may alternately pump different fluids simultaneously.

The pump 100 has diaphragms disposed on both sides of the driving unit 120, and the first valve assembly 140 and the second valve assembly 150 are driven in conjunction with each other, thereby improving efficiency.

Figure 9 is a diagram showing a dialysis system according to an embodiment of the present invention.

Referring to FIG. 9, the dialysis system 1000 may have a first line through which blood moves and a second line through which dialysate moves. The first line and the second line pass through a dialysis device (DI), where the blood can be dialyzed.

The dialysis system 1000 may be equipped with a pump system for pumping blood or dialysate. In one embodiment, the pump system may be an electroosmotic pump system. Hereinafter, the pump module may be replaced by a pump system or an electro-osmotic pump system.

The first pump module PM1 is disposed in the first line and can move blood. The second pump module (PM2) may be disposed in the second line to move dialysate. The electro-osmotic pump of FIG. 1 described above or the pump 100 of FIG. 8 described above may be disposed in the first pump module (PM1) and the second pump module (PM2).

The first line includes a 1A line (L1) extending from the patient to the first pump module (PM1), a 1B line (L2) extending from the first pump module (PM1) to the dialysis device (DI), and a dialysis device. It may have a first C line (L3) extending from (DI) to the patient.

In an optional embodiment, a first pressure gauge (P1) is disposed on the 1A line (L1) to measure the blood pressure flowing into the first pump module (PM1). A second pressure gauge (P2) is disposed on the 1B line to measure the blood pressure pumped from the first pump module (PM1). A third pressure gauge P3 is disposed on the first C line L3 to measure the blood pressure that passes through the dialysis device DI and returns to the patient.

In an alternative embodiment, a drug injector (IJ) may be placed in the first line. A drug injector (IJ) may be placed in the first B line (L2), and an anticoagulant such as heparin may be injected from the drug injector (IJ). As an example, the drug injector (IJ) may be placed between the first pump module (PM1) and the second pressure gauge (P2).

In an optional embodiment, an air trap (AT) may be placed in the first line. An air trap (AT) can remove air from dialyzed blood or detect air excessively contained in the blood. The air trap (AT) may be placed in the first C line (L3).

The second line extends from the first reservoir (not shown) to the dialysis device (DI), the 2A line (C1) through which the dialysate moves before being dialyzed, and extends from the dialysis device (DI) to the second reservoir (not shown). It may have a second B line (C2) through which the dialysed solution moves.

The second pump module (PM2) may be arranged so that the 2A line (C1) and the 2B line (C2) pass through. With this arrangement, the second pump module PM2 can pump the dialysate moving to the dialysis device DI and the dialysate discharged from the dialysis device DI, thereby transmitting a driving force for moving the dialysate.

In one embodiment, the above-described pump 100 may be applied to the second pump module PM2. When the 2A line (C1) is disposed in the first valve assembly 140 and the 2B line (C2) is disposed in the second valve assembly 150, the 2A line (C1) is connected by driving the pump 100. And in the second B line (C2), each dialysate can move by receiving a driving force. The second pump module (PM2) transmits driving force to both the dialysate flowing into the dialysis device (DI) and the dialysate discharged from the dialysis device (DI), increasing the circulation speed of the dialysate and improving the dialysis efficiency of the dialysis system 1000. It can be raised.

In an alternative embodiment, the second line may be equipped with an air removal pump (RM1). An air removal pump (RM1) may be disposed in the 2A line (C1). The air removal pump RM1 may remove air contained in the dialysate before it flows into the dialysis device DI.

In an alternative embodiment, the second line may be equipped with a heater (HT). A heater HT may be placed in the 2A line C1. The heater HT may set the temperature of the dialysate to a preset range before it flows into the dialysis device DI. For example, the heater HT may set the temperature of the dialysate to be substantially the same as the temperature of the blood. Since the dialysate maintains a preset temperature by the heater (HT), temperature changes in blood passing through the dialysis device (DI) can be minimized.

In an alternative embodiment, the second line may be equipped with a moisture removal pump (RM2). A moisture removal pump (RM2) may be disposed in the 2B line (C2). The moisture removal pump RM2 can remove moisture from the dialysate discharged from the dialysis device DI. In one embodiment, the moisture removal pump (RM2) may be disposed in a branch line branched from the 2B line (C2). One end of the branch line may be connected between the second pump module (PM2) and the dialysis device (DI), and the other end of the branch line may be connected to the discharge end of the second pump module (PM2).

In an alternative embodiment, the second line may have a detector (SE). A detector (SE) is placed in the second B line (C2) to detect blood contained in the dialysate.

FIG. 10 is a diagram showing a pump module of an embodiment applied to FIG. 9, and FIG. 11 is a graph showing the flow rate of the pump module of FIG. 10. The pump module (PM) of FIG. 10 may be applied to the first pump module (PM1) or the second pump module (PM2) of FIG. 9.

Referring to FIG. 10, the pump module (PM) may include a plurality of pumps. The drawing shows an embodiment in which the pump module (PM) includes a first pump (PU1) and a second pump (PU2), but is not limited to this and may be provided with three or more pumps. However, for convenience of explanation, the following description will focus on an embodiment equipped with two pumps.

The first pump (PU1) and the second pump (PU2) may be the electro-osmosis pump of FIG. 1 described above or the pump 100 of FIG. 8 described above.

The inlet line (IL) allows fluid to flow in, and the outlet line (OL) allows fluid to discharge. In the inlet line IL, the inlet of the first pump PU1 and the inlet of the second pump PU2 may be connected in parallel. In the outlet line OL, the outlet of the first pump PU1 and the outlet of the second pump PU2 may be connected in parallel.

A first pressure gauge (P1) may be disposed at the inlet line (IL), and a second pressure gauge (P2) may be disposed at the outlet line (OL). Pressure data sensed from the first pressure gauge (P1) and the second pressure gauge (P2) may be transmitted to the controller (CON).

The controller (CON) can control the operation of the power source (PW). The controller (CON) can control the polarity of the voltage applied to the first pump (PU1) and the second pump (PU2). Additionally, the controller (CON) can control the changing cycle of the polarity applied to the first pump (PU1) and the second pump (PU2).

The first pump PU1 is disposed between the inlet line IL and the outlet line OL, and the first working fluid may be disposed inside the first housing.

The first pump PU1 includes a first housing, a first membrane disposed inside the first housing, a 1A electrode disposed on one side of the first membrane, a 2A electrode disposed on the other side of the first membrane, and a first membrane. It may be provided with a 1A diaphragm disposed to be spaced apart from the 1A electrode, a 1A check valve for moving the fluid from the inlet line to the 1A diaphragm, and a 2A check valve for moving the fluid from the 1A diaphragm to the outlet line. .

In the first pump PU1, the 1A electrode tab TA1A may be connected to the 1A electrode, and the 2A electrode tab TA2A may be connected to the 2A electrode.

The second pump PU2 is disposed in parallel with the first pump PU1 between the inlet line IL and the outlet line OL, and a second working fluid may be disposed inside the second housing.

The second pump PU2 includes a second housing, a second membrane disposed inside the second housing, a 1B electrode disposed on one side of the second membrane, a 2B electrode disposed on the other side of the second membrane, and a 1B electrode. It may be provided with a 1B diaphragm disposed spaced apart from the other, a 1B check valve for moving the fluid from the inlet line to the 1B diaphragm, and a 2B check valve for moving the fluid from the 1A diaphragm to the outlet line.

In the second pump PU2, the 1B electrode tab TA1B may be connected to the 1B electrode, and the 2B electrode tab TA2B may be connected to the 2A electrode.

The power source (PW) may supply power to the first pump (PU1) and the second pump (PU2). The power source (PW) can supply voltages of different polarities to the pump module (PM).

The power source PW may provide voltages of different polarities to the 1A electrode tab TA1A and the 2A electrode tab TA2A of the first pump PU1. The power source PW may supply voltage by alternating polarity to the 1st A electrode and the 2A electrode of the first pump PU1.

The power source PW may provide voltages of different polarities to the 1B electrode tab TA1B and the 2B electrode tab TA2B of the second pump PU2. The power source (PW) may provide voltage by alternating polarity to the first and second electrodes of the second pump (PU2).

The 1A electrode of the first pump PU1 and the 1B electrode of the second pump PU2 may be applied with different polarities. The 1A electrode and the 2B electrode may have one polarity, and the 1B electrode and the 2A electrode may have a different polarity.

The first working fluid and the second working fluid of the first pump (PU1) may move to different “ports.” The first pump (PU1) and the second pump (PU2) may move the fluid in the inlet line (IL). may alternately flow in, and the fluid may be alternately discharged from the outlet line OL. When fluid is sucked in from the first pump PU1, the pumped fluid may be discharged from the second pump PU2. .

Referring to FIG. 11, the pump module (PM) can continuously pump fluid by a plurality of pumps arranged in parallel. When different polarities are applied to the electro-osmotic first pump (PU1) and the second pump (PU2), the first pump (PU1) and the second pump (PU2) alternately discharge the pumped fluid. Thus, the pump module (PM) can continuously discharge the pumped flow rate within a preset range.

The power source (PW) may apply voltage polarity to the first pump (PU1) and the second pump (PU2) at different cycles. The discharge cycle of the fluid discharged from the 2A check valve of the first pump (PU1) and the discharge cycle of the fluid discharged from the 2B check valve of the second pump (PU2) may be different from each other.

In detail, the first pump (PU1) discharges the fluid from the inlet line (IL) to the outlet line (OL) in a first cycle, and the second pump (PU2) discharges the fluid from the inlet line (IL) to the outlet line (OL). The fluid may be discharged in a second cycle that is different from the first cycle.

In one embodiment, the first cycle and the second cycle may be opposite cycles, as shown in FIG. 11 .

In another embodiment, although not shown in the graph, at least a portion of the first cycle and the second cycle may overlap. Therefore, since the first pump (PU1) and the second pump (PU2) periodically have time to discharge fluid together, the flow rate discharged from the pump module (PM) can be precisely controlled.

FIG. 12 is a diagram showing a pump module of another embodiment applied to FIG. 9, and FIG. 13 is a graph showing the flow rate of the pump module of FIG. 12.

Referring to FIG. 12, the pump module (PM) may be equipped with three pumps. The first pump (PU1) and the second pump (PU2) may be substantially the same as the pump module described in FIG. 10.

The third pump PU3 may be disposed between the inlet line IL and the outlet line OL. The third pump (PU3) may be arranged in parallel with the first pump (PU1) and in parallel with the second pump (PU2).

The power source (PW) supplies voltage with alternating polarity to the third pump (PU3), but the polarity cycle is different from the cycle of the polarity applied to the first pump (PU1) and the cycle of the polarity applied to the second pump (PU2). can be approved.

In detail, looking at FIG. 13, fluid is discharged alternately from the first pump (PU1) and the second pump (PU2), and the third pump (PU3) is between the first pump (PU1) and the second pump (PU2). ), the pumped fluid can be discharged. The third pump (PU3) discharges the pumped fluid in the section where the suction and discharge of the fluid are switched in the first pump (PU1) and the section where the suction and discharge of the fluid is switched in the second pump (PU2), so the outlet The flow rate deviation of fluids joined in the line (OL) can be reduced.

In one embodiment, the flow rate of the fluid discharged from the third pump (PU3) may be different from the flow rate discharged from the first pump (PU1) or the second pump (PU2). For example, the flow rate discharged from the third pump (PU3) may be smaller than the flow rate discharged from the first pump (PU1) or the second pump (PU2). Since the flow rate discharged from the third pump (PU3) is relatively less than that of the first pump (PU1) or the second pump (PU2), the flow rate of the fluid joining the outlet line (OL) can be maintained.

FIG. 14 is a graph showing the flow rate of a pump module of another embodiment applied to FIG. 9.

Referring to FIG. 14, the pump module (PM) may be equipped with four pumps. The first pump (PU1), the second pump (PU2), the third pump (PU3), and the fourth pump (PU4) discharge the pumped fluid at different intervals to compensate for the deviation of the flow rate discharged to the outlet line (OL). It can be minimized.

FIG. 15 is a diagram showing a pump module of another embodiment applied to FIG. 9.

Referring to FIG. 15, the above-described pump 100 can be applied to a pump module.

The pump 100 may include a housing 110, a driving unit 120, a first diaphragm 131, a second diaphragm 132, a first valve assembly 140, and a second valve assembly 150. The first valve assembly 140 has a first check valve (CV1) and a second check valve (CV2), and the second valve assembly 150 has a third check valve (CV3) and a fourth check valve (CV4). You can have it.

The pump 100 is disposed in the first line, and either blood or dialysate alternately flows into the first check valve (CV1) and the third check valve (CV3), and the second check valve (CV2) and the second check valve (CV2). 4 Any one of the above can be discharged alternately with the check valve (CV4).

In one embodiment, the pump 100 has a 1A line (L1) connected to the first check valve (CV1) and the third check valve (CV3), so that blood can flow in. Additionally, the pump 100 may discharge blood by connecting the 1B line (L2) to the second check valve (CV2) and the fourth check valve (CV4).

In one embodiment, although not shown in the drawing, the pump 100 has a 2A line (C1) connected to the first check valve (CV1) and the third check valve (CV3), so that dialysate can flow in. In addition, the pump 100 may discharge dialysate by connecting the 2B line (C2) to the second check valve (CV2) and the fourth check valve (CV4).

Since voltages of different polarities are alternately applied to the pump 100 from the power source (PW), the movement of the working fluid is switched. The pump 100 changes the volume of the first space (V1) and the second space (V2) by the movement of the working fluid.

In detail, when the first check valve (CV1) is opened, the fourth check valve (CV4) is opened, and the second check valve (CV2) and the third check valve (CV3) are closed. Additionally, when the second check valve (CV2) is opened, the third check valve (CV3) is opened, and the first check valve (CV1) and the fourth check valve (CV4) are closed.

When a fluid such as blood or dialysate flows into the first valve assembly 140, the pumped fluid is discharged from the second valve assembly 150, and when fluid flows into the second valve assembly 150, the first valve assembly 150 is discharged. The pumped fluid is discharged at 140. Thus, the pump 100 allows fluid to flow substantially continuously from the 1A line (L1) or 2A line (C1), and the pumped fluid flows substantially continuously from the 1B line (L2) or 2B line (C2). ) can be discharged.

FIG. 16 is a diagram illustrating a dialysis system according to another embodiment of the present invention, and FIG. 17 is a diagram illustrating a pump module of an embodiment applied to FIG. 16.

16 and 17, the dialysis system 2000 has a 1A line (L1), a 1B line (L2), and a 1C line (L3) through which blood moves, and a 2A line through which dialysis fluid moves ( C1) and a second B line (C2). Additionally, the dialysis system 2000 may include a pump module (PM) and a dialysis device (DI).

In an optional embodiment, the dialysis system 2000 includes a first pressure gauge (P1), a second pressure gauge (P2), a third pressure gauge (P3), a drug injector (IJ), an air trap (AT), and an air removal pump (RM1). ), a heater (HT), a moisture removal pump (RM2), and a detector (SE).

Compared to the above-described dialysis system 1000, the dialysis system 2000 is characterized by the arrangement of the pump module (PM), and the following will focus on this. The pump module (PM) may include the pump 100 described above.

In the pump 100, the first valve assembly 140 may be disposed in a first line, and the second valve assembly 150 may be disposed in a second line. One of the blood and dialysate discharged from the second check valve (CV2) may be discharged alternately with the other one of the blood and dialysate discharged from the fourth check valve (CV4).

In detail, blood can pass through the first valve assembly 140, and dialysate can pass through the second valve assembly 150. By driving the driving unit 120, the first check valve (CV1) of the first valve assembly (140) is opened and the second check valve (CV2) is closed, and blood flows into the first valve assembly (140). . At the same time, the third check valve (CV3) of the second valve assembly (150) is closed and the fourth check valve (CV4) is opened, and the pumped dialysate is discharged from the second valve assembly (150). Afterwards, the first check valve (CV1) of the first valve assembly (140) is closed and the second check valve (CV2) is opened, and the pumped blood is discharged from the first valve assembly (140). At the same time, the third check valve (CV3) of the second valve assembly (150) is opened and the fourth check valve (CV4) is closed, and dialysate flows into the second valve assembly (150).

In the dialysis system 2000 of the present invention, a pump module (PM) driven by electroosmosis can pump blood and dialysate together. In particular, blood and dialysate are alternately pumped by driving the pump module (PM), thereby increasing the efficiency of the dialysis system 2000.

FIG. 18 is a diagram showing a pump module of another embodiment applied to FIG. 16.

Referring to FIG. 18, the pump module (PM) may have a plurality of pumps arranged in parallel. The drawing shows an embodiment in which two pumps are arranged in parallel, but the pump is not limited to this and three or more pumps may be arranged.

The first pump PU1 may have a first valve assembly and a second valve assembly. The first valve assembly may include a first check valve (CV1) disposed at the inlet end and a second check valve (CV2) disposed at the outlet end. The second valve assembly may include a third check valve (CV3) disposed at the inlet end and a fourth check valve (CV4) disposed at the outlet end.

The second pump PU2 may have a 1A valve assembly and a 2A valve assembly. The 1A valve assembly may have a 1A check valve (CV1A) disposed at the inlet end and a 2A check valve (CV2A) may be disposed at the outlet end. The 2A valve assembly may have a 3A check valve (CV3A) disposed at the inlet end and a 4A check valve (CV4A) may be disposed at the outlet end.

The first valve assembly and the 1A valve assembly may be disposed on a first line through which blood moves, and the second valve assembly and the 2A valve assembly may be disposed on a second line through which dialysate moves.

The first check valve (CV1) and the 1A check valve (CV1A) are connected to the 1A line (L1), so that blood can flow into the first pump (PU1) and the second pump (PU2). The second check valve (CV2) and the second A check valve (CV2A) are connected to the first B line (L2), so that blood can be discharged from the first pump (PU1) and the second pump (PU2).

The third check valve (CV3) and the 3A check valve (CV3A) are connected to the 2A line (C1), so that dialysate can flow into the first pump (PU1) and the second pump (PU2). The fourth check valve (CV4) and the 4A check valve (CV4A) are connected to the 2B line (C2), so that the dialysate can be discharged from the first pump (PU1) and the second pump (PU2).

The first electrode of the first pump PU1 is connected to the 1A electrode tab TA1A, and the second electrode is connected to the 2A electrode tab TA2A. The 1A electrode of the second pump PU2 is connected to the 1B electrode tab TA1B, and the 2A electrode is connected to the 2B electrode tab TA2B.

The power source (PW) supplies voltage by alternating polarity to the 1A electrode tab (TA1A) and the 2A electrode tab (TA2A) of the first pump (PU1), and the 1B electrode tab (TA1B) of the second pump (PU2). ) and the second B electrode tab (TA2B) can be supplied with voltage by alternating polarity.

The power source (PW) may supply voltages of different polarities to the first pump (PU1) and the second pump (PU2). For example, the 1A electrode tab TA1A and the 1B electrode tab TA1B may have different polarities, and the 2A electrode tab TA2A and the 2B electrode tab TA2B may have different polarities.

In the pump module, the flow direction of the first working fluid of the first pump (PU1) and the flow direction of the second working fluid of the second pump (PU2) are set in opposite directions.

Blood may flow into and out of the pump module substantially continuously along the first line. Additionally, dialysate may flow into and out of the pump module substantially continuously along the second line.

Although the preferred embodiments of the present invention have been described above, the present invention is not limited thereto, and can be implemented with various modifications within the scope of the claims, the detailed description of the invention, and the accompanying drawings. It is natural that it falls within the scope of the invention.

100: pump
110: housing
120: driving unit
130: Diaphragm unit
140: first valve assembly
150: second valve assembly
1000, 2000: Dialysis system

Claims (18)

an inlet line through which fluid enters;
an outlet line through which the fluid is discharged;
a first pump disposed between the inlet line and the outlet line and having a first working fluid disposed inside the first housing;
a second pump disposed in parallel with the first pump between the inlet line and the outlet line, and having a second working fluid disposed inside the second housing; and
Includes; a power supply that supplies voltage to the first pump and the second pump,
The first pump is
a first membrane disposed inside the first housing;
a 1A electrode disposed on one side of the first membrane; and
A 2A electrode disposed on the other side of the first membrane,
The second pump is
a second membrane disposed internally to the second housing;
A 1B electrode disposed on one side of the second membrane; and
A 2B electrode disposed on the other side of the second membrane,
The power source is
A voltage is supplied by alternating polarity to the 1A electrode and the 2A electrode of the first pump, and a voltage is supplied by alternating polarity to the 1B electrode and the 2B electrode of the second pump. An electro-osmotic pump system in which different polarities are applied to the 1A electrode of one pump and the 1B electrode of the second pump. According to claim 1,
The electro-osmotic pump system wherein the first working fluid of the first pump and the second working fluid of the second pump move in different directions. According to claim 1,
The first pump is
A 1A diaphragm disposed to be spaced apart from the 1A electrode;
a 1A check valve moving the fluid from the inlet line to the 1A diaphragm; and
Further comprising a 2A check valve that moves the fluid from the 1A diaphragm to the outlet line,
The second pump is
A 1B diaphragm disposed to be spaced apart from the 1B electrode;
a 1B check valve that moves the fluid from the inlet line to the 1B diaphragm; and
An electro-osmotic pump system further comprising a 2B check valve that moves the fluid from the 1A diaphragm to the outlet line. According to clause 3,
The discharge cycle of the fluid discharged from the 2A check valve of the first pump and the discharge cycle of the fluid discharged from the 2B check valve of the second pump are different from each other. According to clause 3,
The first pump and the second pump are
An electro-osmotic pump system, wherein the fluids are alternately introduced into the inlet line and the fluids are alternately discharged from the outlet line. According to claim 1,
the first pump discharges the fluid from the inlet line to the outlet line in a first cycle,
wherein the second pump discharges the fluid from the inlet line to the outlet line in a second cycle different from the first cycle. According to claim 1,
A third pump is disposed in parallel with the first pump between the inlet line and the outlet line and is disposed in parallel with the second pump,
The power source is
An electro-osmotic pump system in which voltage is supplied by alternating polarity to the third pump, but the polarity is applied at a period different from the period of polarity applied to the first pump and the period of polarity applied to the second pump. According to clause 7,
The third pump is
An electro-osmotic pump system, wherein the flow rate of the fluid discharged is different from the flow rate discharged from the first pump or the second pump. a first line through which either blood or dialysate moves;
a second line through which the other one of the blood and the dialysate moves;
a dialysis device through which the first line and the second line pass, and through which the blood is dialyzed using the dialysate;
a pump module disposed in at least one of the first line and the second line, and moving at least one of the dialysate and the blood passing therethrough; and
A power supply that supplies power to the pump module by alternating polarity. According to clause 9,
The pump module is
A first pump disposed on the first line and having a working fluid disposed inside the first housing; and
A second pump is disposed in parallel with the first pump on the first line and has a working fluid disposed inside the second housing,
The first pump is
a first membrane disposed inside the first housing;
a 1A electrode disposed on one side of the first membrane; and
A 2A electrode disposed on the other side of the first membrane,
The second pump is
a second membrane disposed internally to the second housing;
A 1B electrode disposed on one side of the second membrane; and
A 2B electrode disposed on the other side of the second membrane,
The power source is
A voltage is supplied by alternating polarity to the 1A electrode and the 2A electrode of the first pump, and a voltage is supplied by alternating polarity to the 1B electrode and the 2B electrode of the second pump. A dialysis system in which polarity is applied to the first electrode of one pump and the first electrode of the second pump at different intervals. According to claim 10,
The dialysis system wherein the working fluid of the first pump and the working fluid of the second pump move in different directions. According to claim 10,
The first pump is
A 1A diaphragm disposed to be spaced apart from the 1A electrode;
a 1A check valve that moves the blood or dialysate from the first line to the 1A diaphragm; and
Further comprising a 2A check valve that moves the blood or dialysate from the 1A diaphragm to the first line,
The second pump is
A 1B diaphragm disposed to be spaced apart from the 1B electrode;
A 1B check valve that moves the blood or dialysate from the first line to the 1B diaphragm; and
It further includes a 2B check valve that moves the blood or dialysate from the 1A diaphragm to the first line,
A dialysis system wherein the discharge cycle of the blood or dialysate discharged from the 2A check valve of the first pump and the discharge cycle of the blood or dialysate discharged from the 2B check valve of the second pump are different from each other. According to claim 10,
The first pump discharges the blood or dialysate into the first line in a first cycle,
The second pump discharges the blood or dialysate in a second cycle different from the first cycle. According to claim 10,
A third pump is disposed in parallel with the first pump in the first line and is disposed in parallel with the second pump,
The power source is
A dialysis system wherein a voltage is supplied with alternating polarity to the third pump, and the polarity is applied at a cycle different from the cycle of the polarity applied to the first pump and the cycle of the polarity applied to the second pump. According to claim 14,
The third pump is
A dialysis system, wherein the flow rate of the blood or dialysate discharged is different from the flow rate of the blood or dialysate discharged from the first pump or the second pump. According to clause 9,
The pump module includes at least one pump,
The pump is
housing;
a driving unit including a first membrane disposed inside the housing, a first electrode disposed on one side of the first membrane, and a second electrode disposed on the other side of the first membrane;
a diaphragm assembly having a first diaphragm disposed on one side of the driving unit and a second diaphragm disposed on the other side of the driving unit;
a first valve assembly mounted to face the first diaphragm and having a first check valve disposed at an inlet end and a second check valve disposed at an outlet end; and
A dialysis system comprising: a second valve assembly mounted to face the second diaphragm and having a third check valve disposed at an inlet end and a fourth check valve disposed at an outlet end. According to claim 16,
The pump is
It is placed on the first line,
Either the blood or the dialysate alternately flows into the first check valve and the third check valve,
A dialysis system wherein any one of the second check valves and the fourth check valves are alternately discharged. According to clause 16,
The pump is
the first valve assembly is disposed in the first line, the second valve assembly is disposed in the second line,
A dialysis system, wherein one of the blood and the dialysate discharged from the second check valve is discharged alternately with the other one of the blood and the dialysate discharged from the fourth check valve.

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