KR20230166220A - Middle East Respiratory Syndrome coronavirus and uses thereof - Google Patents

Abstract

The present invention relates to Middle East Respiratory Syndrome Coronavirus and its uses. Specifically, the present invention relates to selective pressure using four types of neutralizing antibodies against EMC standard strain and domestic isolate (KNIH-002). ) method and relates to a MERS virus produced by subculturing 20 times and a vaccine composition containing the same.

Description

Middle East Respiratory Syndrome coronavirus and uses thereof {Middle East Respiratory Syndrome coronavirus and uses thereof}

The present invention relates to Middle East Respiratory Syndrome Coronavirus (MERS virus) and uses thereof.

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) belongs to the beta-coronavirus genus, which includes SARS-CoV (SARS-CoV), human coronavirus (HCoV-HKU1), and Contains several coronaviruses. It is a single stranded positive-sense RNA virus with a total gene size of approximately 28-30 kb and consists of four structural proteins: Spike (S), Nucleocapsid (N), Membrane (M), and Envelope (E) proteins, ORF3, ORF4a, ORF4b, It is composed of accessory proteins of ORF5 and ORF8a. Among these, the Spike (S) protein is divided into S1 and S2, and the S1 region contains an RBD (Receptor Binding Domain) region that binds to the DPP4 (Dipeptidyl peptidase 4, CD26) receptor of species-specific host cells. Therefore, normal mice (C57BL/6, BALB/c) are not susceptible, and only transgenic mice expressing human DPP4 are susceptible to infection. It has been reported that the Accessory proteins (ORF3, 4a, 4b and 5) of MERS-CoV play an important role in infection and pathogenicity.

A mutant strain with partial deletion of ORF4a and ORF3 was isolated from samples from overseas confirmed patients, and a mutant strain with a specific amino acid change in the RBD region was isolated from samples from domestic confirmed patients, but analysis of the mutations is still insufficient.

Middle East Respiratory Syndrome, which first occurred in Saudi Arabia in 2012, has since spread to 27 countries, mainly in the Middle East, causing 2,578 confirmed cases and 888 deaths worldwide, with a fatality rate of about 35% (WHO, as of August 2021) It reaches. As the MERS virus continues to occur in the Middle East to this day (12 cases in 2021, as of October 6, 2021), there is a high possibility that it will be reintroduced into Korea.

Since the first MERS patient occurred in Korea in May 2015, a total of 186 confirmed cases and 38 deaths (mortality rate 20.4%) occurred in the two months leading up to the end, showing the second highest number of cases after Saudi Arabia. In addition, 16,693 people classified as contacts of confirmed cases were quarantined, which not only threatened the public health of all citizens but also caused great damage to the national economy. The MERS epidemic in Korea was characterized by not only hospital-acquired infections but also hospital-to-hospital transmission, and in September 2018, one case occurred in a Middle East traveler.

Vaccine development research is being conducted on animals based on various platforms such as recombinant S protein, DNA vaccines expressing S protein, and recombinant viruses (adenovirus, vaccinia), but there is no commercialized vaccine to date. Phase 1 clinical trials are underway in the UK and Germany using the chimpanzee adenovirus and vaccinia virus platforms, respectively. The DNA vaccine (GLS-5300) platform jointly developed by Korea's Gene One Life Science and the U.S. (Inovio, Walter Reed Army Institute of Research) has completed phase 1 clinical trials in the U.S. and is currently approved for domestic 1/2a clinical trials. . In addition, various MERS virus vaccine materials are being actively tested on animals using inactivated viruses, protein subunits, nanoparticles, virus-like particles (VLP), and mRNA platforms.

Korean Patent No. 2005685 Korean Patent No. 2047072

Scientific Reports. (2022)12:1260. Plos One. (2020) 15(5):e0232757.

In order to solve the above problems, the purpose of the present invention is to develop a vaccine candidate using an attenuated MERS virus.

In order to achieve the object of the present invention, the present invention provides a Middle East respiratory syndrome coronavirus containing the gene of SEQ ID NO: 2.

In one example of the present invention, the virus may be manufactured by a selective pressure method using a neutralizing antibody against the Middle East respiratory syndrome coronavirus, and the neutralizing antibody is against the spike protein of the Middle East respiratory syndrome coronavirus. It may be a monoclonal antibody, and preferably, the neutralizing antibody may be a 90B2 monoclonal antibody against the spike protein of the Middle East respiratory syndrome coronavirus, but is not limited thereto.

In another example of the present invention, the Middle East respiratory syndrome coronavirus may be prepared by subculturing 20 times in Vero cells.

In addition, the present invention includes the steps of treating a domestic isolate (KNIH-002) with neutralizing antibodies against the Middle East respiratory syndrome coronavirus at a concentration that can meet the selective pressure conditions; Infecting Vero cells; and subculturing; and provides a method of producing Middle East respiratory syndrome coronavirus containing the gene of SEQ ID NO: 2.

In another example of the present invention, the concentration may be 1 μg, and the subculture may be 20 times.

The present invention provides a vaccine composition containing the Middle East respiratory syndrome coronavirus.

In one example of the present invention, the vaccine composition may further include a pharmaceutically acceptable carrier or excipient. Suitable carriers for vaccines are known to those skilled in the art and include, but are not limited to, proteins, sugars, etc. The carrier may be an aqueous or non-aqueous solution, suspension or emulsion. Examples of non-aqueous carriers include propylene glycol, polyethylene glycol, edible oils such as olive oil, and injectable organic esters such as ethyl oleate. Aqueous carriers include water, alcohol/aqueous solutions, emulsions or suspensions including saline and buffered media. Parenteral carriers include sodium chloride solution, Ringer's dextrose, dextrose and sodium chloride, lactated Ringer's or fixed oils. Carriers for intravenous injection include electrolyte supplements, liquid and nutritional supplements, such as those based on Ringer's dextrose. Preservatives and other additives may include, for example, antimicrobial agents, antioxidants, chelating agents, inert gases, etc. Preferred preservatives include formalin, thimerosal, neomycin, polymyxin B and amphotericin B.

In addition, the vaccine composition may additionally include an adjuvant (immune composition, adjuvant) in the form of a diluent.

The adjuvant refers to a compound or mixture that enhances the immune response and/or accelerates the rate of absorption after inoculation and includes an optional absorption-promoting agent. Acceptable adjuvants include Freund's complete adjuvant, Freund's incomplete adjuvant, saponins, mineral gels such as aluminum hydroxide, surfactants such as lysolecithin, pluronic polyols, polyanions, peptides, oil or hydrocarbon emulsions, keyhole limpets. It includes, but is not limited to, hemocyanin, dinitrophenol, etc. A preferred adjuvant is MONTANIDE IMS1313 adjuvant from SEPPIC.

The dosage of the vaccine composition for the purpose of the present invention is not limited as it can be adjusted depending on the condition of the administration subject, the administration route and the form of administration, and those skilled in the art will understand the various ranges depending on the symptoms. However, in the present invention, the experimental effective amount is usually 001 to 1 ml per 1 kg of body weight of the administered subject (10 ^5.0 TCID ₅₀ / ml or more), preferably 001 to 003 ml per 1 kg of body weight continuously or It is believed that intermittent administration is possible.

The vaccine composition of the present invention can be administered through oral, intramuscular, subcutaneous, peritoneal, intravenous, dermal, ocular, intracerebral, etc. administration routes, but is not limited thereto, and is preferably administered through a muscle administration route.

Additionally, the present invention provides a vaccination method against Middle East respiratory syndrome coronavirus comprising administering the vaccine composition to a non-human animal.

The attenuated MERS virus strain of the present invention maintains non-pathogenicity even after continuous subculture, showing potential as an attenuated vaccine candidate, and can be used for future pathogenicity analysis of the MERS virus through genetic analysis results, etc.

Figure 1 shows the survival rate according to infection with a cell passage line (A) and an antibody-evading line (B) in hDDP4 transgenic mice.
Figure 2 shows the results (body weight and survival rate) of a non-pathogenic maintenance experiment for five subcultured strains (20 times).
Figure 3 shows a schematic diagram of animal testing to confirm infection protection against five subculture strains (20 times).
Figure 4 shows the infection defense confirmation results (body weight and survival rate) for five subculture strains (20 times).
Figure 5 shows the results of confirmation of infection protection ability (neutralizing antibody titer) for five subculture strains (20 times).
Figure 6 shows the results of confirmation of infection protection ability (Spike protein-specific antibody titer) for five subcultured strains (20 times).
Figure 7 shows the safety evaluation results of the inoculation dose (body weight change and survival rate) for three subculture strains (20 times).
Figure 8 shows the results of genetic mutation comparison (SNP) of five subcultured strains (20 times) with domestic isolates. * Blue: synonymous, Red: non-synonymous
Figure 9 shows the results of genetic mutation comparison (insertion/deletion) of five subcultured strains (20 times) with domestic isolates.

Hereinafter, the present invention will be described in more detail through examples. However, the following examples are for illustrating the present invention and the scope of the present invention is not limited to the following examples.

<Example 1> Obtaining MERS non-pathogenic virus

go. Securing and confirming the characteristics of MERS cell lines and antibody-evading strains

1) Production of MERS cell lineage (ORF5-del)

- Through prior research, one type of MERS cell passage (ORF5-del) was obtained through continuous cell passage (P5, P10) culture of a domestic isolate (KNIH-002) in Vero cells, and P10 was used in the present invention. The specific manufacturing method is as follows.

- To predict the genetic mutation pattern of MERS virus and investigate related characteristics, domestic isolate (KNIH_002) was continuously subcultured at temperature (33℃, 37℃) and susceptible cells (Vero, Vero E6, Huh-7). It was carried out.

- As a result of comparing the cytopathic effects of domestic isolates, there was no difference in the cytopathic effects depending on temperature conditions, but syncytium was observed in Huh-7 infected cells, unlike Vero and Vero E6 cells (results not submitted).

- After securing the full-length gene base sequences of viruses subcultured for the 5th and 10th times under various conditions for each culture temperature and susceptible cell line, the bases and bases of the wild type virus (accession number: KT029139) were obtained using CLC Main Workbench 7.6.4. Genetic mutations across generations were compared using amino acid sequences.

- As a result, it was confirmed that various mutations can occur in cells susceptible to the virus (Vero, Vero E6, and Huh-7) and temperature (33℃, 37℃) conditions. By cell line, compared to Huh-7 cells, more gene deletion mutations were observed in viruses cultured in Vero and Vero E6 cells. By temperature, many gene deletions between MERS virus genes ORF3 to ORF5 were confirmed at low culture temperatures. By gene, 10 mutations were confirmed in the ORF1a gene, 3 in ORF1b, 8 in S, 2 in ORF4a, 4 in ORF5, 2 in E, and 1 in M (results not shown).

- On the other hand, at the amino acid level, 7 mutations occurred in the ORF1a gene, 1 ORF1b, 4 S, 3 ORF5, 2 E, and 1 M. In particular, the virus subcultured (P5, P10) in Vero cells at 33°C lacked 2 bases in the ORF5 region, and the virus subcultured in Vero E6 cells (P5, P10) at 37°C lacked 12 bases in the terminal region of ORF3. It was confirmed that the entire ORF4ab gene was deficient, with a total of 1,023 bases lacking, from 1 base to 15 bases at the start of ORF5. These gene-deficient mutants showed the same gene deletion pattern even after 20 subcultures (results not shown).

2) Production of MERS neutralizing antibody evasion strain

- Through prior research, we obtained 12 types of antibody-evading strains that evade neutralizing antibodies using the selective pressure method using 4 types of neutralizing antibodies against the EMC standard strain and domestic isolate (KNIH-002) virus. Detailed information about the neutralizing antibody is included in Korean Patent No. 1895228. As a result of analyzing the spike genes of these viruses, it was confirmed that genetic mutations occur not only in the RBD (Receptor Binding Domain) region but also in the non-RBD region. Antibody evasion strains were produced using domestic isolates (KNIH-002) for B antibody (90B2), numbers 6 and 7 (can be confirmed in the amino acid mutation table), and domestic isolates (same) for D antibody (90F2). It is number 9. The specific manufacturing method is as follows.

- MERS virus genes can be mutated under various conditions in addition to subculture in animal cells. Among them, considering the possibility that mutant strains that try to avoid this may be generated even when applying a treatment using a neutralizing antibody in the present invention, we attempted to investigate whether mutations that may occur when applying a neutralizing antibody as a treatment.

- Four A, B, C, and D monoclonal antibodies with excellent neutralizing ability against MERS virus developed in previous research of the present invention were expressed and purified by transfection in 293T cells, and then confirmed through SDS-PAGE that the antibodies were well expressed. (results not submitted).

- In order to induce mutant strains that evade A, B, C, and D antibodies, we attempted to select an antibody concentration that could meet the selection pressure conditions using domestic isolates and standard strains (EMC). For this purpose, 1X10 ⁵ PFU of the virus was mixed with four types of antibodies at various concentrations, infected with Vero cells, and the cytopathic effect was observed at 24-hour intervals.

- Considering the antibody concentration and incubation period, the optimal antibody treatment concentration was selected as 0.1 ㎍ for A antibody in each domestic isolate and standard strain, 1 ㎍ for B and C antibodies, and 10 ㎍ for D antibody. selected.

- As a result of continuously subculturing domestic isolates and standard strains with each antibody at the selected concentration, the cytopathic effect was more than 90% 2 to 3 days after infection, despite treatment with high concentration of antibodies after 4 to 5 subculturing. observed (results not submitted). Therefore, it was expected that evading mutations occurred in each antibody, and 7 to 8 plaques for each condition were isolated and cultured using plaque assay.

- Spike 1 (S1) amino acid mutations of viruses isolated purely from standard strains and domestic isolates subcultured with each antibody were analyzed. After extracting the viral RNA, cDNA was produced using superscript IV, and the amplified PCR product was purified through PCR using this as a template, and then the base and amino acid sequences were analyzed through sequencing.

- As a result, in all 8 domestically prevalent viruses (antibody evading strain No. 4) that were isolated purely for antibody A, amino acid Leucin (L) at position 506 in the RBD region was replaced with Histidine (H), and amino acid leucine at position 530 was substituted with valine. became (002-1EM). No other mutations were confirmed at the S1 position.

- On the other hand, unlike the mutation pattern of domestic isolates, in the case of standard strains, a total of 3 types of mutant strains appeared in 8 pure isolated viruses. In the first type (EMC-1EM), amino acid Leucine (L) at position 506 was replaced by phenylalanine (F), threonine (T) at position 512 by isoleucine (I), and glutamate (E) at position 513 by alanine (A). In the second type (EMC-4EM), Leucine (L) at position 506 was substituted with phenylalanine, arginine (R) at position 511 was substituted with leucine (L), and glutamate (E) at position 513 was substituted with alanine (A). In the third mutant strain (EMC-6EM), arginine (R) at position 511 was replaced with serine (S), and threonine (T) at position 512 was substituted with alanine (A) (results not submitted).

- As a result of amino acid mutation analysis of eight pure domestic isolates for B antibody, two types of mutant strains occurred. In antibody-evading strain No. 7, proline (P) at position 463, belonging to the RBD, was substituted with leucine (L), and leucine (L) at position 530 was substituted with valine (V). Additionally, in S1(NTD) other than RBD, lysine (K) and glycine (G) at positions 32 and 94 were substituted with glutamic acid (E) and arginine (R), respectively.

- In antibody-evading strain No. 6, lysine (K) and glycine (G) at positions 32 and 94 in S1 (NTD) were replaced with glutamic acid (E) and arginine (R), respectively. In the case of standard strains, proline (P) at position 463 was replaced with leucine (L) in the RBD of all eight pure isolated viruses, and serine (S) at positions 65 and 137 in S1 (NTD) were replaced with phenylalanine (F) and arginine, respectively. Replaced with (R).

- Even when analyzing the amino acids of eight pure domestic isolates for C antibodies, two types of mutations occurred. In antibody-evading strain No. 9, leucine (L) at number 506 belonging to RBD was substituted with Phenylalanine (F), and in S1 (NTD), Serine (S) at number 65 was substituted with Phenylalanine (F).

- In the second mutant, Proline (P) and leucine (L) at positions 463 and 506 in RBD were replaced with leucine (L) and Phenylalanine (F), respectively, and in S1 (NTD), Glycine (G) at position 128 was replaced with leucine (L). ) was replaced with . And in the case of the standard strain, all eight pure isolated viruses had Valine (V) replaced by Phenylalanine (F) at position 575 in the RBD.

- As a result of amino acid analysis of pure domestic isolates for D antibody, all eight were aspartic acid at numbers 128, 272, and 314 in S1 (NTD), respectively, as Glycine (G), Aspartic acid (D), and Tyrosine (Y). (D), Glycine (G), and Histidine (H). And in the standard strain, all eight pure isolated viruses had leucine (L) replaced at position 141 for Arginine (R) in S1 (NTD).

- On the other hand, S1 amino acid mutation did not appear in standard strains and domestic isolates subcultured without antibody treatment.

me. Investigation of pathogenicity of cell lines and antibody-evading strains

- To confirm the pathogenicity of the secured cell lines and antibody-evading strains, use a domestic isolate (KNIH-002, wild type) as a positive control and intranasally infect ^DPP4 transgenic mice at a titer of 1 Weight change and survival rate were measured.

- As a result, in the group inoculated with the domestic isolate, body weight began to decrease 7 days after infection and 100% died within 11 days, but 4 types of cell lineage and antibody-evading strains (Escape mutant-4, Escape mutant-6, Escape mutant-7) , Escape mutant-9), body weight change was not significantly reduced in the vaccinated group, and 100% survived, showing no pathogenicity (Figure 1).

<Example 2> Safety confirmation by continuous culture of MERS non-pathogenic virus

- To confirm the safety of one cell strain (ORF5-del) and four antibody-evading strains (Nos. 4, 6, 7, and 9) that were confirmed to be non-pathogenic in hDDP4 transgenic mice, each virus was grown 20 times in Vero cells. Subculture was carried out.

- To confirm the safety of the virus subcultured 20 times, weight change and survival rate were measured daily for 2 weeks after nasal infection in hDPP4 transgenic mice at a titer of 1X10 ⁴ pfu (10LD ₅₀ compared to KNIH-002/wild-type strain).

- In the group inoculated with the domestic isolate (KNIH-002, wild type), body weight began to decrease 7 days after infection and 100% died within 11 days, but 3 types (6, 7, 9) of antibody-evading subculture strains (20 times) (No. 2) showed a 100% survival rate, and one antibody-evading subculture strain (No. 4) and an ORF-5del subculture strain (No. 4) showed an 80% survival rate (Figure 2).

- As a result of the experiment, it was confirmed that the three antibody-evading strains (No. 6, 7, and 9) maintained their non-pathogenicity even after subculturing 20 times.

<Example 3> Confirmation of infection protection ability of MERS subculture strain (No. 20)

- To evaluate the infection protection ability of 5 subculture strains (4, 6, 7, 9, Orf5-del), 10LD ₅₀ (10 ⁴ pfu/30) compared to MERS virus (KNIH-002, wilde type) Immunization was performed by intranasal inoculation at a concentration of ㎕). Two weeks later, MERS virus (KNIH-002) was challenged at a concentration of 100LD ₅₀ (10 ⁵ pfu/30 ㎕), and body weight change and survival rate were measured every day for 2 weeks (FIG. 3).

1) Weight change and survival rate

- In the group (G7, positive) that was not immunized with the subculture strain (No. 20), body weight decreased starting 4 days after MERS virus attack and all died within 9 days, while in the group immunized with the subculture strain, body weight almost decreased. However, a 100% survival rate was observed (Figure 4).

2) Comparison of neutralizing antibody titers

A) Measurement of virus neutralization antibody titer

- To measure neutralizing antibody titer, blood was obtained through orbital blood collection before virus challenge, and serum was separated and insimilated for 30 minutes at 56°C before being used in the neutralization test.

- Serum was diluted in two steps starting from 1/10, then an equal amount of MERS virus (100 TCID ₅₀ ) was added and reacted at 37°C for 1 hour. Afterwards, the virus and serum mixture was added to Vero cells and cultured for 3 to 4 days in an incubator at 37°C with 5% CO2. Then, the cytopathic effect was confirmed and the neutralizing antibody titer was measured.

B) Comparison of measurement results

- As a result of comparing the five subculture strains (No. 20), the neutralizing antibody titers were high in the following order: No. 4 > ORF5-del > No. 9 > No. 6 > No. 7 (Figure 5).

3) Comparison of antibody titers against Spike protein

A) ELISA antibody titer measurement

- In order to measure antibody titers specific to the Spike protein, blood was obtained through orbital blood collection before virus challenge. Afterwards, the serum was separated and serially diluted from 1/1000 to 1/3, and ELISA was measured.

B) Comparison of measurement results

- As a result of comparing 5 types of subculture strains (No. 20), the neutralizing antibodies were the same as the results, and spike protein-specific antibody titers were high in the order of No. 4 > ORF5-del > No. 9 > No. 6 > No. 7 (Figure 6).

<Example 4> Confirmation of safety of inoculation dose of MERS subculture strain (No. 20)

- To confirm the safety according to the inoculation dose for numbers 6, 7, and 9, which showed a 100% survival rate when intranasally inoculated at a concentration of 10LD ₅₀ (10 ⁴ pfu/30 ㎕) among the 5 subculture strains (No. 20), Safety was evaluated by intranasal inoculation at a concentration of 100LD ₅₀ (10 ⁵ pfu/30 ㎕) compared to MERS virus (KNIH-002, wild type) (Table 1).

Groups Mouse number Remarks G1 (No. 6) 5
- mice: hDPP4-Tg (6w, female)
- Virus dose: 10 ⁵ pfu/30ul/mice
- Infection route: IN G2 (No. 7) 5 G3 (No. 9) 5 Gr(NIH002)
-infection positive 5

- As a result, in the case of the group (G4, positive) infected with the MERS virus (KNIH-002, wild type), body weight decreased from the 6th day and all died within 9 days, and the subculture strain (No. 20) No. 9 was immune. In the case of the group (G3, No. 9), body weight decreased from the 7th day, and 4 out of 5 animals (80%) died on the 10th day.

- In the case of the group (G1/2, No. 6/7) immunized with subculture strains (No. 20) No. 6 and No. 7, 100% survived without weight loss of more than 10% (Figure 7).

<Example 5> Full-length genetic analysis of MERS subculture strain (No. 20)

1) Whole-length genetic analysis method

- Next-generation base analysis for genetic characterization of 5 subculture strains (No. 20) (1 cell culture strain (ORF5-del), 4 antibody-evading strains (Nos. 4, 6, 7, and 9)) This was conducted using Next Generation Sequencing (NGS).

2) Full-length genetic analysis

- As a result of NGS genetic analysis of five subcultured strains (No. 20), full-length gene sequences of 30,112bp to 30,118bp were completed (Table 2).

origin Subculture strain (No. 20) Full length gene (bp) MERS antibody-evading strain Number 4 30,118 Number 6 30,112 Number 7 30,118 number 9 30,118 MERS cell culture strain ORF 5-del 30,115

- Full-length genome sequence (No. 4, SEQ ID No. 1)

- Full-length genome sequence (No. 6, SEQ ID No. 2)

- Full-length genome sequence (No. 7, SEQ ID No. 3)

- Full-length genome sequence (No. 9, SEQ ID No. 4)

- Full-length genome sequence (ORF 5-del, SEQ ID NO: 5)

3) Comparative analysis of genetic mutations between subcultured strains (No. 20) and domestic isolates

- As a result of comparing the base and amino acid sequences with the domestically isolated virus (KNIH-002) to analyze the genetic characteristics of five subculture strains (No. 20), a total of 33 genes were identified, including 31 SNPs (single nucleotide polymorphisms) and 2 InDels. The mutation site was confirmed (Figure 8).

As the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that these specific techniques are merely preferred embodiments and do not limit the scope of the present invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

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ctgcgcaagt 720 atggccgtgg tggttatcac tacaccccag tcc actatga gcgagacaac acctcttgcc 780 ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta 840 agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa 900 aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg 960 ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc 1020 tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt 1080 ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta 1140 ctcttggatg caaaatttta acgctcaccc cacgcaacaa gt ggagtggc gtttctgact 1200 tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa 1260 cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta 1320 cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg 1380 tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtg ct acttgcccct 1440 ttgctaaggg tgacagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt 1500 acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg 1560 gcgtagctta cgcctacttt ggatgt gagg aaggtactat gtactttgtg cctagagcta 1620 agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca 1680 aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg 1740 gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg 1800 acaaaatacg ccagcttctc aaaggtgtca ccattgacaa gttgcgtgat tatttagctg 1860 actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta 1920 caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt 1980 cctttaagaa agttgcaacc ataccgtaca aggtttgcaa ctctgtta ag gatactctga 2040 cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt 2100 catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt 2160 tagtccgcct cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc 2220 aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact 2280 tcttgtta ga tttggcagga ttgttcagaa tctttcttcg caatgcctat gtgtacactt 2340 cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaaacaa gtgttagact 2400 tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaata tca 2460 gtgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg 2520 tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt 2580 ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg 2640 tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc 2700 ctgatg ttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg 2760 aagaagacgg attcgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct 2820 ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg 288 0 aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac 2940 tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt 3000 ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc 3060 cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg 3120 agggtgatgc atctt ggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg 3180 aggagtgttc tgaagtagag gcttcaggtt tagaagaagg tgaatcagag tgcatttctg 3240 agacttcaac tgaacaagtt gacgtttctc atgaggtttc tgacgacgag tgggctgctg 3300 cagttgatga agcgttcccc ctcgatgaag cagaagatgt tactgaatct gtgcaagaag 3360 aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct 3420 tacaggaaac tcctgttgtg tctgatactg ttgaagtccc accgcaagtg gtgaaacttc 3480 cgtctgaacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg 3540 ataccgaaca gacacagagt gttact gtta aacctaagag gttacgcaaa aagcgtaatg 3600 ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag 3660 gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca 3720 cacatcttaa gcatggcggt ggtatcgctg gtgctattaa tgcggcttca aaaggggctg 3780 tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag 3840 ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc 3900 gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc 3960 ttgtagtcac tcctcttgtt tcaacaggca tatt tggtgt aaaaccagct gtgtcttttg 4020 attatcttat tagagaggct aagactagag ttttagtcgt cgttaattcc caagatgtct 4080 ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac 4140 gtggcgcaat acgtaaagct aaagatta tg gttttactgt ttttgtgtgc acagacaact 4200 ctgctaacac taaagttctt aggaaacaagg gtgttgatta tactaagaag tttcttacag 4260 ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac 4320 aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag 4380 acttaattca agcagggagt gtcgtgcgta gagttaacgt gccctacg tg tgtctcctag 4440 ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag 4500 attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg 4560 aactattggt gcaagactta cgcttaaata agctcctgca ttggt ctgat caaaccatat 4620 gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac 4680 tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct 4740 tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata 4800 gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgatacc attcc tgatg 4860 agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg 4920 cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta 4980 aggctgcagt ccataagtgg aagatggttg tgtgtgataa ggt acgttct ctcaaattga 5040 gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttatg aaggacatta 5100 aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg 5160 acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct 5220 ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt 5280 ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt 5340 gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc 5400 agtgtggtgg tgaacgtcat cggcaaatag tcgaacacac caccccct gg ttgctgctct 5460 caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcgttta 5520 atgtctttca gggcattgaa acggctgttg gccattatgt tcatgcttgc ctgaagggtg 5580 gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg 5640 tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt 5700 ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg 5760 atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg 5820 gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta 5880 ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat 5940 acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt 6000 atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaaca 6060 aagcatctta tgatactaat cttaataagt tcaatagagc tagtttgcgt caaatttttg 6120 acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggcg tccacaccag 6180 ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta 6240 agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgttgat gactcaggta 6300 ctcccgtt gt tgagtatctg tctaaagaag atctacatac attgtatgta gaccctaagt 6360 atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg 6420 agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac 6480 tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg 6540 ctgtaggtag ttgtataaag agtgtagtg c ggcatctagg tgttaactaaa ggcatattga 6600 caggctgttt tagttttgtc aagatgttat ttattcttcc actagcttac tttagtgatt 6660 caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagctggc gttgtgacag 6720 gtaatgttgt aaaacagtg t tgcactgctg ctgttgattt aagtatggat aagttgcgcc 6780 gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt 6840 tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg 6900 aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt 6960 ctgcttgtga cggtcttgct tcagcttata g ggcgaattc atttgatgta cctacattct 7020 gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact 7080 acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt 7140 tgtggtttgc attcgagact ggtttgg cat acatgctcta tacctcggcc ttcaactggt 7200 tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc 7260 ggtcatacaa ttatgctgtg tctagtgcct tctggttatt tacccacatt ccaatggcgg 7320 gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc 7380 atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataaga gg aaccgactta 7440 ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa 7500 atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacattgcag 7560 gtgtggggaa taccttcatc tgtgaagaag tcg caaatga cctcactacc gccctacgca 7620 ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga 7680 ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct 7740 gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta 7800 tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta 7 860 ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa 7920 gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg 7980 ttaatagttt cgtctcgctg tataatgtca cacgcgata a gttggaaaaa cttatctcta 8040 ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg 8100 acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact 8160 ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagttac aataattatg 8220 taccctcata tgttaaacct gatagtgtgt ctaccagtga tttaggtagt ctcattgatt 8280 gtaatgc ggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgtatttgga 8340 acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc 8400 gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct 84 60 tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgtgt 8520 tgcgtgactt tacgttaaag ggttacgttc ttgctaccat tattgtgttt ctgtgtgctg 8580 tactgatgta tttgtgttta cctacatttt ctatggtacc tgttgaattt tatgaagacc 8640 gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata 8700 agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg 8760 tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg 8820 ctcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attt tctttg 8880 tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct 8940 ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg 9000 cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt 9060 acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat 9120 ttcctgaagt agtatt tgaa agtacactta ggattactag aactctgtca actcagtact 9180 gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt 9240 gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta 9300 ttgacattgt cagg cggtta gcagtatcac tgttccagcc tattacttat ttccaattga 9360 ctacctcatt ggtcttgggt ataggtttgt gtgcattcct gactttgctc ttctattata 9420 ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg 9480 ctgctgttct taatagcttg tgcatctgct ttgttgcctc tataccatg tgtatagtac 9540 cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta 9600 tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct 9660 atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac 9720 atg tagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata 9780 tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct 9840 attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag 9900 ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagtgaga 9960 ctggtagtga tcttctttac caaccaccca actgtagcat aacctct ggc gtgttgcaaa 10020 gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta 10080 cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac 10140 acgtaatgtg cccggctgac cag ttgtctg atcctaatta tgatgccttg ttgatttcta 10200 tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg 10260 ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca 10320 ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct 10380 ataatggtcg tccgactggt acattcactg ttgtaatgc g ccctaactac acaattaagg 10440 gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca 10500 atttttgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg 10560 atggtactat gtatggtgcc tttat ggata aacaagtgca ccaagttcag ttaacagaca 10620 aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt 10680 ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc 10740 aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg 10800 ctattgaaca gctgctttat gcgatccaac aactttatac tgggt tccag ggaaagcaaa 10860 tccttggcag tactatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta 10920 tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt 10980 tcgcgaccct tgtttcaacc tatg tgataa tcttacaagc cactaaattt actttgtgga 11040 actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct 11100 tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg 11160 ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc 11220 tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact aca catactg 11280 atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca 11340 acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt 11400 atagcattgg agaagcctca agccccattg cctatctggt tttt gtcact acactcacta 11460 gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca 11520 tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat 11580 tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct tttttgaacc 11640 ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat 11700 t catgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact 11760 ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac 11820 ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag 1 1880 aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgacata ttggcagcaa 11940 cagaccccag tgaggctttc gagaaattcg taagtctctt tgccacttta atgacttttt 12000 ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc 12060 aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga 12120 aagccta tca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc 12180 agaaggctgt taatatagct aaaaacgcct atgagaagga taaggcagtg gcccgtaagt 12240 tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca 12300 agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg 12360 acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg 12420 tcattccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga 12480 atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta 12540 taaacaatgt ggacaatgaa att gttaagt cttcagatgt tgtagacagc aatgaaaatt 12600 taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa 12660 ataatgagat caaaccttca ggtttaaaaa ccatggttgt gtctgcaggt caagagcaaa 12720 ctaactgtaa t actagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga 12780 tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat 12840 ttgttagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg 12900 aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag 12960 ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt 13020 cttcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg 13080 tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta 13140 caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag 13200 cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta 13260 aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt 13320 gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg 13380 actcgcttag gcaagtagca ctgccccaat ctaaagatt c caatttttta aacgagtccg 13440 gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt 13500 ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta 13560 caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta 13620 ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgattt 13680 gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt 13740 taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata 13800 tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagta tgg 13860 ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag 13920 tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt 13980 taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtg ctcacac tagacaacca 14040 ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg 14100 agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg 14160 tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact 14220 tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg 14280 ggatcagac g tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg 14340 tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt 14400 ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggtta tc actacaaaga 14460 attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga 14520 gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga 14580 tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt 14640 gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa 147 00 ggagggctct tcagttacgc tcaaacattt tttctttgct caagatggta atgctgctat 14760 tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt 14820 gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtctta atgc 14880 ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg 14940 caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tctttgccat 15000 gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc 15060 taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca 15120 gtaccatcag aaaat gctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg 15180 tactacaaag ttctatggtg gctgggattt catgcttaaa acattgtaca aagatgttga 15240 taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg 15300 tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga 15360 cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg 15420 tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc 15480 caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc 15540 taatggcaac aagattgtt g acaaagaagt taaagacatg cagtttgatt tgtatgtcaa 15600 tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa 15660 taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta 15720 t gcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa 15780 caatgtcttt atgtctgaag ctaaatgctg ggtgggaaacc gatctgaaga aagggccaca 15840 tgaattttgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc 15900 ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac 15960 tgacggtaca ctcatggtag agcggtttgt g tctttggct atagatgctt accctctcac 16020 aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa 16080 actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga 16140 taattctgct aagttttggg aaga ggcatt ctacagagat ctctatagtt cgcctaccac 16200 tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac 16260 atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc 16320 acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc 16380 agacgttact aagctatatt taggtggtat gagctacttt tgtg tagatc atagacctgt 16440 gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac 16500 aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg 16560 tgattacacc cttgccaata ctacaac aga accactcaaa ctttttgctg ctgagacttt 16620 acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt 16680 tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg 16740 taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta 16800 catcttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtata a 16860 actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc 16920 cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt 16980 acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcagg ttata gtaaatatgt 17040 cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta 17100 ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg 17160 tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc 17220 acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat att tgtttag 17280 tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat 17340 gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta 17400 tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga 17460 accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt 17520 aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa 17580 taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg 17640 caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa 17700 ttttatact gcca atccgg catggagtaa ggcagtcttt atttcgcctt ataattcaca 17760 gaatgctgtg gctcgttcaa tgctgggtct tactactcag actgttgatt cctcacaggg 17820 ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat 17880 taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc 17940 tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca 18000 gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc 18060 tgcttatgca ccaacatacg ttagtgttga tgacaagtat aagacgagtg atgagctttg 18120 cgtgaatctt aatttac ccg caaatatccc atactctcgt gttatttcca ggatgggctt 18180 taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt 18240 aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc 183 00 atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca 18360 gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcccgtcc 18420 tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc 18480 tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta 18540 ctgtacgttt gttt gttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa 18600 gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc 18660 tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt 18720 ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta 18780 ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt 18840 agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc 18900 acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc 18960 tcttcttgcc ggttcatttg a caaagtcta tgatattggc aatcctaaag gaattcctat 19020 tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccagaaaggt 19080 acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt 19140 ttgg aactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg 19200 tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca 19260 cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt 19320 cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat 19380 tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggc gctgt 19440 ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc 19500 atcaggtttc cgcctttggt gttataagac ctttgatatt tataatctct ggtctacttt 19560 tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat 19620 tggtgttgag ggtgaactac ctgtagctgt agtcaatgat aagatcttca ccaagagtgg 19680 cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga 19740 actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca 19800 agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata ttta tggtac 19860 tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg 19920 ttttgacata cgcgataatg gttcattgga gaagttcatg tctactccca atgccatctt 19980 tatttctgat agaaaaatta agaaataccc ttgtattgta ggtcctgatt atgcttactt 20040 caatggtgct atcatccgtg atagtgatgt tgttaaaacaa ccagtgaagt tctacttgta 20100 taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc 20160 ttgtagtgac ttcctacccc tgtctgacat ggagaaagac tttctatctt ttgatagtga 20220 tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga 2 0280 cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca 20340 ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt 20400 tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct 2 0460 tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa 20520 ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca 20580 aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc 20640 cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc 20700 tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta 20760 tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg 20820 ttctgataaa ggtatcgctc ctggtacatc agttttacga cagtggcttc ctacagatgc 20880 cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg 20940 agattgtgta actgtacgtg tcagccaaca agtggatctt gttatattccg acatgtatga 21000 tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct 21060 gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga 21120 acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt 21180 ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg 21240 tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa 21300 ttccactcct atgaatct ga gtacttactc actttttgat ttatccaagt ttcaattaaa 21360 attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc 21420 tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga 21480 tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg 21540 cttgtattaa ggttgat ata caacagactt tctttgataa aacttggcct aggccaattg 21600 atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatattct aacataacta 21660 tcacttatca aggtcttttt ccctatcagg gagaccatgg tgatatgtat gtctactctg 21720 caggacatgc taca ggcaca actccacaaa agttgtttgt agctaactat tctcaggacg 21780 tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactggca 21840 ctgttattat tagcccatct acccgcgcta ctatacgaaa aatttaccct gcttttatgc 21900 tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc 21960 tagttctttt gcccgatgga tgtggcactt t acttagagc tttttatattgt attctagagc 22020 ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca 22080 ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta 22140 aggagtattt taatttac gt aactgcacct ttatgtacac ttataacatt accgaagatg 22200 agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc 22260 ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata 22320 ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag 22380 cttgggctgc cttctacgta tataaacttc aaccg ttaac tttcctgttg gatttttctg 22440 ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact 22500 gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa 22560 aaccttctgg ctcagt tgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc 22620 tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt 22680 ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat 22740 ctccagcagc aattgctagc aactgttatt cttcactgat tttggattat ttttcatacc 22800 cacttagtat gaaatccgat ctcagtgtta gttctgctgg tccaatat cc cagtttaatt 22860 ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta 22920 ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt cttctttctg 22980 atgatcgtac tgaagtacct cagttagtga acgcta atca atactcaccc tgtgtatcca 23040 ttgtcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg 23100 aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga 23160 tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg 23220 aatttgctaa tgacacaaaa attgcctctc aattaggcaa ttgcgtggaa tattccctct 2328 0 atggtgtttc gggccgtggt gtctttcaga attgcacagc tgtaggtgtt cgacagcagc 23340 gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact 23400 actgtttgcg tgcttgtgtt agtgttcctg tttct gtcat ctatgataaa gaaactaaaa 23460 cccacgctac tctatttggt agtgttgcat gtgaacacat ttcctctacc atgtctcaat 23520 actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggt ccccttcaga 23580 cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt 23640 tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca 23700 gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc 23760 aggttgatca acttaatagt agttatttta aattaagtat acctactaat ttttcctttg 23820 gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat t gtaaacagt 23880 acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt 23940 ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt 24000 tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact 24060 ttaatttgac acttctaaaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg 24120 ctattgagga tt tgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt 24180 acgatgattg tatgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg 24240 tggctggtta taaagtatta cctcctctta tggatgttaa tatggaagcc gcgtacactt 24300 catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg 24360 ctattccatt tgcacagagt attttttata ggttaaacgg tgttggcatt actcaacagg 24420 ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc 24480 aaacaggctt cactacaact aatgaagctt ttcggaaggt tcaggatgct gtgaacaaca 24540 atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg 24600 cctctattgg agacatcata caacgtcttg acgttctcga acaggacgcc caaatagaca 24660 gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt 24720 ctgaatcagc t gctctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg 24780 cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa 24840 atgcccctaa tggcctttac tttatgcatg ttggttatta ccctagcaac cacattgagg 24900 ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta 24960 atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct 25020 cgtccttcta tgcacctgag cccatcacct ctcttaatac taagtatgtt gcaccacagg 25080 tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccgaga 25140 ttgacttcca agatgagttg gatgagt ttt tcaaaaatgt tagcaccagt atacctaatt 25200 ttggttctct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc 25260 ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt 25320 atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg 25380 ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggca ca aactgtatgg 25440 gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata 25500 aggttcatgt tcactaatta acgaactatc aatgagagtt caaagaccac ccactctctt 25560 gttagtgttc tcactctctt ttttggtcac tg cattttca aaacctctct atgtacctga 25620 gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga 25680 tacagctggt ctttatacaa attttcgaat tgatgtccca tctgcagaat caactggtac 25740 tcaatcagtt tttgtcgatc gtgagtctac ttcaactcat gatggtctta ccgaacatgt 25800 tactagtgtg aatctttttg acgttggtta ctctgttaat taacgaact c tatggattac 25860 gtgtctctgc ttaatcaaat ttggcagaag taccttaatt caccgtatac tacttgtttg 25920 tatatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg 25980 ctgtggaact gtcagctatc ctttgctggt tat actgaat ctgctgttaa ttctacaaaa 26040 gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga 26100 atccctgacg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa 26160 gaggagtcat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg 26220 ccctgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga 262 80 ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa 26340 accttatggc ggccaacctg tttctgagta tcatattact ctagctttgc taaatctcac 26400 tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcgca atgtcagatt 26460 tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta 26520 ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat 26580 taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat 26640 gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc 26700 atgctttaga acttat cctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc 26760 catacggtct tccaatcagg gtaataaaca aattgttcat tcttacccca ttttacatca 26820 tccaggattt taacgaacta tggctttctc ggcgtcttta tttaaacccg tccagctagt 26880 cccagtt tct cctgcatttc atcgcattga gtctactgac tctattgttt tcacatacat 26940 tcctgctagc ggctatgtag ctgctttagc tgtcaatgtg tgtctcattc ccctattatt 27000 actgctacgt caagatactt gtcgtcgcag cattatcaga actatggttc tctatttcct 27060 tgttctttat aactttttat tagccattgt actagtcaat ggtgtacatt atccaactgg 27120 aagttgcctg atagcct tct tagttatcct cataatactt tggtttgtag atagaattcg 27180 tttctgtctc atgctgaatt cctacattcc actgtttgac atgcgttctc actttattcg 27240 tgttagtaca gtttcttctc atggtatggt ccctgtcata cacaccaaac cattatttat 27300 tagaaacttc gatcagcgtt gcagctgttc tcgttgtttt tatttgcact cttctactta 27360 tatagagtgc acttatatta gccgttttag taagattagc ctagtttctg taact gactt 27420 ctccttaaac ggcaatgttt ccactgtttt cgtgcctgca acgcgcgatt cagttcctct 27480 tcacataatc gccccgagct cgcttatcgt ttaagcagct ctgcgctact atgggtcccg 27540 tgtagaggct aatccattag tctctctttg gacatatgga aaacgaacta tgttaccctt 27600 tgtccaagaa cgaatagggt tgttcatagt aaactttttc atttttaccg tagtatgtgc 27660 tataacactc ttggtgtgta tggctttcct tacggctact agattatgtg tgcaatgtat 27720 gacaggcttc aataccctgt tagttcagcc cgcattatac ttgtataata ctggacgttc 27780 agtctatgta aaattccagg atagtaaacc ccctctacca cctgacgagt gggtttaacg 27840 aactccttca taatgtctaa tatgacgcaa ctcactgagg cgcagattat tgccattatt 27900 aaagactgga actttgcatg gtccctgatc tttctcttaa ttactatcgt actacagtat 27960 ggatacccat cccgtagtat gactgtctat gtctttaaaa tgtttgttt t atggctccta 28020 tggccatctt ccatggcgct atcaatattt agcgccattt atccaattga tctagcttcc 28080 cagataatct ctggcattgt agcagctgtt tcagctatga tgtggatttc ctactttgtg 28140 cagagtatcc ggctgtttat gagaactgga tcatggtggt cattcaatcc tgagactaat 28200 tgccttttga atgttccaat tggtggtaca actgtcgtac gtccactcgt agaggactct 28260 accagtgtaa ctgctgttgt aaccaatggt cacctcaaaa tggctggcat gcatttcggt 28320 gcttgtgact acgacagact tcctaatgaa gtcaccgtgg ccaaacccaa tgtgctgatt 28380 gctttaaaaa tggtgaagcg gcaaagctac ggaactaatt ccggcgttgc cat ttaccat 28440 agatataagg caggtaatta caggagtccg cctattacgg cggatattga acttgcattg 28500 cttcgagctt aggctcttta gtaagagtat cttaattgat tttaacgaat ctcaatttca 28560 ttgttatggc atcccctgct gcacctcgtg ctgtttcctt tgccgataac aatgatataa 28620 caaatacaaa cctgtctcga ggtagaggac gtaatccaaa accacgagct gcaccaaata 28680 acactgtctc ttggt acact gggcttaccc aacacgggaa agtccctctt acctttccac 28740 ctgggcaggg tgtacctctt aatgccaatt ccacccctgc gcaaaatgct gggtattggc 28800 ggagacagga cagaaaaatt aataccggga atggaattaa gcaactggct cccaggtggt 28860 acttctacta cactggaact ggacccgaag cagcactccc attccgggct gttaaggatg 28920 gcatcgtttg ggtccatgaa gatggcgcca ctgatgctcc ttcaactttt gggacgcgga 28980 accctaacaa tgattcagct attgttacac aattcgcgcc cggtactaag cttcctaaaa 29040 acttccacat tgaggggact ggaggcaata gtcaatcatc ttcaagagcc tctagcgtaa 29100 gcagaaactc ttccagatct agttcaca ag gttcaagatc aggaaactct acccgcggca 29160 cttctccagg tccatctgga atcggagcag taggaggtga tctactttac cttgatcttc 29220 tgaacagact acaagccctt gagtctggca aagtaaagca atcgcagcca aaagtaatca 29280 ctaagaaaga tgctgctgct g ctaaaaata agatgcgcca caagcgcact tccaccaaaa 29340 gtttcaacat ggtgcaagct tttggtcttc gcggaccagg agacctccag ggaaactttg 29400 gtgatcttca attgaataaa ctcggcactg aggacccacg ttggccccaa attgctgagc 29460 ttgctcctac agccagtgct tttatgggta tgtcgcaatt taaacttacc catcagaaca 29520 atgatgatca tggcaaccct gtgtacttcc ttc ggtacag tggagccatt aaacttgacc 29580 caaagaatcc caactacaat aagtggttgg agcttcttga gcaaaatatt gatgcctaca 29640 aaaccttccc taagaaggaa aagaaacaaa aggcaccaaa agaagaatca acagaccaaa 29700 tgtctgaacc tccaaaggag cagcgtgtgc a aggtagcat cactcagcgc actcgcaccc 29760 gtccaagtgt tcagcctggt ccaatgattg atgttaacac tgattagtgt cactcaaagt 29820 aacaagatcg cggcaatcgt ttgtgtttgg taaccccatc tcaccatcgc ttgtccactc 29880 ttgcacagaa tggaatcatg ttgtaattac agtgcaataa ggtaattata acccatttaa 29940 ttgatagcta tgctttatta aagtgtgtag ctgtagagag aat gttaaag actgtcacct 30000 ctgcgtgatt gcaagtgaac agtgcccccc gggaagagct ctacagtgtg aaatgtaaat 30060aaaaatagct attattcaat tagattaggc taattagatg atttgcaaaa aaaaaaaa 30118 <210> 2 <211> 30112 <212> DNA <213> Artificial Sequence <220> <223> 6_P20 <400> 2 gatttaagtg aatagcttgg ctatctcacc tcccctcgtt ctcttgcaga actttgattt 60 taacgaactt aaataaaagc cctgttgttt agcgtattgt tgcacttgtc tggtgggatt 120 gtggcattaa gttgcctgct catctaggca gtggacatat gct caacact gggtataatt 180 ctaattgaat actatttttc agttagagcg tcgtgtctct tgtacgtctc ggtcacaata 240 tacggtttcg tccggtgcgt ggcaattcgg ggcacatcat gtctttcgtg gctggtgtga 300 tcgcgcaagg tgcgcgcggt acg tatcgag cagcgctcaa ctctgaaaaa catcaagacc 360 atgtgtctct aactgtgcca ctctgtggtt caggaaacct ggttgaaaaa ctttcaccat 420 ggttcatgga tggcgaaaat gcctatgaag tggtgaaggc catgttactt aaaaaagagc 480 cacttctcta tgtgcccatc cggctggctg gacacactag acacctccca ggtcctcgtg 540 tgtacctggt tgagaggctc attgcttgt g aaaatccatt catggttaac caattggctt 600 atagctctag tgcaaatggc agcctggttg gcacaacttt gcagggcaag cctattggta 660 tgttcttccc ttatgacatc gaacttgtca caggaaagca aaatattctc ctgcgcaagt 720 atggccgtgg tggttatcac tacaccccag tcc actatga gcgagacaac acctcttgcc 780 ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta 840 agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa 900 aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg 960 ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc 1020 tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt 1080 ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta 1140 ctcttggatg caaaatttta acgctcaccc cacgcaacaa gt ggagtggc gtttctgact 1200 tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa 1260 cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta 1320 cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg 1380 tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtg ct acttgcccct 1440 ttgctaaggg tgacagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt 1500 acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg 1560 gcgtagctta cgcctacttt ggatgt gagg aaggtactat gtactttgtg cctagagcta 1620 agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca 1680 aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg 1740 gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg 1800 acaaaatacg ccagcttctc aaaggtgtca ccattgacaa gttgcgtgat tatttagctg 1860 actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta 1920 caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt 1980 cctttaagaa agttgcaacc ataccgtaca aggtttgcaa ctctgtta ag gatactctga 2040 cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt 2100 catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt 2160 tagtccgcct cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc 2220 aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact 2280 tcttgtta ga tttggcagga ttgttcagaa tctttcttcg caatgcctat gtgtacactt 2340 cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaaacaa gtgttagact 2400 tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaata tca 2460 gtgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg 2520 tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt 2580 ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg 2640 tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc 2700 ctgatg ttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg 2760 aagaagacgg attcgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct 2820 ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg 288 0 aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac 2940 tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt 3000 ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc 3060 cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg 3120 agggtgatgc atctt ggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg 3180 aggagtgttc tgaagtagag gcttcaggtt tagaagaagg tgaatcagag tgcatttctg 3240 agacttcaac tgaacaagtt gacgtttctc atgaggtttc tgacgacgag tgggctgctg 3300 cagttgatga agcgttcccc ctcgatgaag cagaagatgt tactgaatct gtgcaagaag 3360 aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct 3420 tacaggaaac tcctgttgtg tctgatactg ttgaagtccc accgcaagtg gtgaaacttc 3480 cgtctgaacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg 3540 ataccgaaca gacacagagt gttact gtta aacctaagag gttacgcaaa aagcgtaatg 3600 ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag 3660 gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca 3720 cacatcttaa gcatggcggt ggtatcgctg gtgctattaa tgcggcttca aaaggggctg 3780 tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag 3840 ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc 3900 gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc 3960 ttgtagtcac tcctcttgtt tcaacaggca tatt tggtgt aaaaccagct gtgtcttttg 4020 attatcttat tagagaggct aagactagag ttttagtcgt cgttaattcc caagatgtct 4080 ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac 4140 gtggcgcaat acgtaaagct aaagatta tg gttttactgt ttttgtgtgc acagacaact 4200 ctgctaacac taaagttctt aggaaacaagg gtgttgatta tactaagaag tttcttacag 4260 ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac 4320 aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag 4380 acttaattca agcagggagt gtcgtgcgta gagttaacgt gccctacg tg tgtctcctag 4440 ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag 4500 attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg 4560 aactattggt gcaagactta cgcttaaata agctcctgca ttggt ctgat caaaccatat 4620 gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac 4680 tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct 4740 tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata 4800 gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgatacc attcc tgatg 4860 agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg 4920 cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta 4980 aggctgcagt ccataagtgg aagatggttg tgtgtgataa ggt acgttcg ctcaaattga 5040 gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttatg aaggacatta 5100 aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg 5160 acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct 5220 ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt 5280 ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt 5340 gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc 5400 agtgtggtgg tgaacgtcat cggcaaatag tcgaacacac caccccct gg ttgctgctct 5460 caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcgttta 5520 atgtctttca gggcattgaa acggctgttg gccattatgt tcatgcttgc ctgaagggtg 5580 gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg 5640 tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt 5700 ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg 5760 atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg 5820 gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta 5880 ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat 5940 acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt 6000 atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaaca 6060 aagcatctta tgatactaat cttaataagt tcaatagagc tagtttgcgt caaatttttg 6120 acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggcg tccacaccag 6180 ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta 6240 agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgttgat gactcaggta 6300 ctcccgtt gt tgagtatctg tctaaagaag atctacatac attgtatgta gaccctaagt 6360 atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg 6420 agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac 6480 tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg 6540 ctgtaggtag ttgtataaag agtgtagtg c ggcatctagg tgttaactaaa ggcatattga 6600 caggctgttt tagttttgtc aagatgttat ttattcttcc actagcttac tttagtgatt 6660 caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagctggc gttgtgacag 6720 gtaatgttgt aaaacagtg t tgcactgctg ctgttgattt aagtatggat aagttgcgcc 6780 gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt 6840 tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg 6900 aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt 6960 ctgcttgtga cggtcttgct tcagcttata g ggcgaattc atttgatgta cctacattct 7020 gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact 7080 acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt 7140 tgtggtttgc attcgagact ggtttgg cat acatgctcta tacctcggcc ttcaactggt 7200 tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc 7260 ggtcatacaa ttatgctgtg tctagtgcct tctggttatt tacccacatt ccaatggcgg 7320 gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc 7380 atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataaga gg aaccgactta 7440 ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa 7500 atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacattgcag 7560 gtgtggggaa taccttcatc tgtgaagaag tcg caaatga cctcactacc gccctacgca 7620 ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga 7680 ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct 7740 gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta 7800 tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta 7 860 ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa 7920 gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg 7980 ttaatagttt cgtctcgctg tataatgtca cacgcgata a gttggaaaaa cttatctcta 8040 ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg 8100 acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact 8160 ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagttac aataattatg 8220 taccctcata tgttaaacct gatagtgtgt ctaccagtga tttaggtagt ctcattgatt 8280 gtaatgc ggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgtatttgga 8340 acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc 8400 gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct 84 60 tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgtgt 8520 tgcgtgactt tacgttaaag ggttacgttc ttgctaccat tattgtgttt ctgtgtgctg 8580 tactgatgta tttgtgttta cctacatttt ctatggtacc tgttgaattt tatgaagacc 8640 gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata 8700 agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg 8760 tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg 8820 ctcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attt tctttg 8880 tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct 8940 ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg 9000 cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt 9060 acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat 9120 ttcctgaagt agtatt tgaa agtacactta ggattactag aactctgtca actcagtact 9180 gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt 9240 gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta 9300 ttgacattgt cagg cggtta gcagtatcac tgttccagcc tattacttat ttccaattga 9360 ctacctcatt ggtcttgggt ataggtttgt gtgcattcct gactttgctc ttctattata 9420 ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg 9480 ctgctgttct taatagcttg tgcatctgct ttgttgcctc tataccatg tgtatagtac 9540 cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta 9600 tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct 9660 atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac 9720 atg tagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata 9780 tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct 9840 attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag 9900 ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagtgaga 9960 ctggtagtga tcttctttac caaccaccca actgtagcat aacctct ggc gtgttgcaaa 10020 gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta 10080 cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac 10140 acgtaatgtg cccggctgac cag ttgtctg atcctaatta tgatgccttg ttgatttcta 10200 tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg 10260 ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca 10320 ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct 10380 ataatggtcg tccgactggt acattcactg ttgtaatgc g ccctaactac acaattaagg 10440 gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca 10500 atttttgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg 10560 atggtactat gtatggtgcc tttat ggata aacaagtgca ccaagttcag ttaacagaca 10620 aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt 10680 ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc 10740 aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg 10800 ctattgaaca gctgctttat gcgatccaac aactttatac tgggt tccag ggaaagcaaa 10860 tccttggcag tactatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta 10920 tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt 10980 tcgcgaccct tgtttcaacc tatg tgataa tcttacaagc cactaaattt actttgtgga 11040 actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct 11100 tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg 11160 ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc 11220 tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact aca catactg 11280 atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca 11340 acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt 11400 atagcattgg agaagcctca agccccattg cctatctggt tttt gtcact acactcacta 11460 gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca 11520 tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat 11580 tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct tttttgaacc 11640 ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat 11700 t catgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact 11760 ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac 11820 ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag 1 1880 aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgacata ttggcagcaa 11940 cagaccccag tgaggctttc gagaaattcg taagtctctt tgccacttta atgacttttt 12000 ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc 12060 aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga 12120 aagccta tca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc 12180 agaaggctgt taatatagct aaaaacgcct atgagaaaga taaggcagtg gcccgtaagt 12240 tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca 12300 agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg 12360 acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg 12420 tcattccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga 12480 atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta 12540 taaacaatgt ggacaatgaa att gttaagt cttcagatgt tgtagacagc aatgaaaatt 12600 taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa 12660 ataatgagat caaaccttca ggtttaaaaa ccatggttgt gtctgcaggt caagagcaaa 12720 ctaactgtaa t actagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga 12780 tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat 12840 ttgttagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg 12900 aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag 12960 ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt 13020 cttcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg 13080 tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta 13140 caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag 13200 cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta 13260 aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt 13320 gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg 13380 actcgcttag gcaagtagca ctgccccaat ctaaagatt c caatttttta aacgagtccg 13440 gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt 13500 ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta 13560 caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta 13620 ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgattt 13680 gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt 13740 taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata 13800 tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagta tgg 13860 ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag 13920 tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt 13980 taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtg ctcacac tagacaacca 14040 ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg 14100 agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg 14160 tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact 14220 tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg 14280 ggatcagac g tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg 14340 tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt 14400 ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggtta tc actacaaaga 14460 attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga 14520 gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga 14580 tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt 14640 gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa 147 00 ggagggctct tcagttacgc tcaaacattt tttctttgct caagatggta atgctgctat 14760 tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt 14820 gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtctta atgc 14880 ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg 14940 caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tctttgccat 15000 gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc 15060 taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca 15120 gtaccatcag aaaat gctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg 15180 tactacaaag ttctatggtg gctgggattt catgcttaaa acattgtaca aagatgttga 15240 taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg 15300 tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga 15360 cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg 15420 tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc 15480 caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc 15540 taatggcaac aagattgtt g acaaagaagt taaagacatg cagtttgatt tgtatgtcaa 15600 tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa 15660 taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta 15720 t gcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa 15780 caatgtcttt atgtctgaag ctaaatgctg ggtgggaaacc gatctgaaga aagggccaca 15840 tgaattctgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc 15900 ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac 15960 tgacggtaca ctcatggtag agcggtttgt gt ctttggct atagatgctt accctctcac 16020 aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa 16080 actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga 16140 taattctgct aagttttggg aagagg catt ctacagagat ctctatagtt cgcctaccac 16200 tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac 16260 atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc 16320 acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc 16380 agacgttact aagctatatt taggtggtat gagctacttt tgtg tagatc atagacctgt 16440 gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac 16500 aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg 16560 tgattacacc cttgccaata ctacaac aga accactcaaa ctttttgctg ctgagacttt 16620 acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt 16680 tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg 16740 taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta 16800 catcttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtata a 16860 actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc 16920 cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt 16980 acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcagg ttata gtaaatatgt 17040 cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta 17100 ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg 17160 tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc 17220 acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat att tgtttag 17280 tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat 17340 gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta 17400 tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga 17460 accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt 17520 aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa 17580 taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg 17640 caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa 17700 ttttatact gcca atccgg catggagtaa ggcagtcttt atttcgcctt ataattcaca 17760 gaatgctgtg gctcgttcaa tgctgggtct tactactcag actgttgatt cctcacaggg 17820 ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat 17880 taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc 17940 tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca 18000 gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc 18060 tgcttatgca ccaacatacg ttagtgttga tgacaagtat aagacgagtg atgagctttg 18120 cgtgaatctt aatttac ccg caaatatccc atactctcgt gttatttcca ggatgggctt 18180 taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt 18240 aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc 183 00 atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca 18360 gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcccgtcc 18420 tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc 18480 tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta 18540 ctgtacgttt gttt gttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa 18600 gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc 18660 tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt 18720 ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta 18780 ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt 18840 agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc 18900 acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc 18960 tcttcttgcc ggttcatttg a caaagtcta tgatattggc aatcctaaag gaattcctat 19020 tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccagaaaggt 19080 acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt 19140 ttgg aactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg 19200 tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca 19260 cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt 19320 cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat 19380 tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggc gctgt 19440 ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc 19500 atcaggtttc cgcctttggt gttataagac ctttgatatt tataatctct ggtctacttt 19560 tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat 19620 tggtgttgag ggtgaactac ctgtagctgt agtcaatgat aagatcttca ccaagagtgg 19680 cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga 19740 actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca 19800 agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata ttta tggtac 19860 tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg 19920 ttttgacata cgcgataatg gttcattgga gaagttcatg tctactccca atgccatctt 19980 tatttctgat agaaaaatta agaaataccc ttgtattgta ggtcctgatt atgcttactt 20040 caatggtgct atcatccgtg atagtgatgt tgttaaaacaa ccagtgaagt tctacttgta 20100 taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc 20160 ttgtagtgac ttcctacccc tgtctgacat ggagaaagac tttctatctt ttgatagtga 20220 tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga 2 0280 cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca 20340 ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt 20400 tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct 2 0460 tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa 20520 ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca 20580 aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc 20640 cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc 20700 tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta 20760 tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg 20820 ttctgataaa ggtatcgctc ctggtacatc agttttacga cagtggcttc ctacagatgc 20880 cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg 20940 agattgtgta actgtacgtg tcagccaaca agtggatctt gttatattccg acatgtatga 21000 tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct 21060 gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga 21120 acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt 21180 ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg 21240 tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa 21300 ttccactcct atgaatct ga gtacttactc actttttgat ttatccaagt ttcaattaaa 21360 attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc 21420 tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga 21480 tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg 21540 cttgtattaa ggttgat ata caacagactt tctttgataa aacttggcct aggccaattg 21600 atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatatttt aacataacta 21660 tcacttatca aggtcttttt ccctatcagg gagaccatgg tgatatgtat gtctactctg 21720 caggacatgc ta caggcaca actccacaaa agttgtttgt agctaactat tctcaggacg 21780 tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactggca 21840 ctgttattat tagcccatct acccgcgcta ctatacgaaa aatttaccct gcttttatgc 21900 tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc 21960 tagttctttt gcccgatgga tgtggcactt t acttagagc tttttatattgt attctagagc 22020 ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca 22080 ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta 22140 aggagtattt taatttac gt aactgcacct ttatgtacac ttataacatt accgaagatg 22200 agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc 22260 ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata 22320 ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag 22380 cttgggctgc cttctacgta tataaacttc aaccg ttaac tttcctgttg gatttttctg 22440 ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact 22500 gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa 22560 aaccttctgg ctcagt tgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc 22620 tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt 22680 ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat 22740 ctccagcagc aattgctagc aactgttatt cttcactgat tttggattat ttttcatacc 22800 cacttagtat gaaatccgat ctcagtgtta gttctgctgg tctaatat cc cagtttaatt 22860 ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta 22920 ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt cttctttctg 22980 atgatcgtac tgaagtacct cagttagtga acgcta atca atactcaccc tgtgtatcca 23040 ttctcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg 23100 aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga 23160 tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg 23220 aatttgctaa tgacacaaaa attgcctctc aattaggcaa ttgcgtggaa tattccctct 2328 0 atggtgtttc gggccgtggt gtctttcaga attgcacagc tgtaggtgtt cgacagcagc 23340 gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact 23400 actgtttgcg tgcttgtgtt agtgttcctg tttct gtcat ctatgataaa gaaactaaaa 23460 cccacgctac tctatttggt agtgttgcat gtgaacacat ttcctctacc atgtctcaat 23520 actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggt ccccttcaga 23580 cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt 23640 tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca 23700 gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc 23760 aggttgatca acttaatagt agttatttta aattaagtat acctactaat ttttcctttg 23820 gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat t gtaaacagt 23880 acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt 23940 ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt 24000 tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact 24060 ttaatttgac acttctaaaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg 24120 ctattgagga tt tgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt 24180 acgatgattg tatgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg 24240 tggctggtta taaagtatta cctcctctta tggatgttaa tatggaagcc gcgtacactt 24300 catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg 24360 ctattccatt tgcacagagt attttttata ggttaaacgg tgttggcatt actcaacagg 24420 ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc 24480 aaacaggctt cactacaact aatgaagctt ttcggaaggt tcaggatgct gtgaacaaca 24540 atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg 24600 cctctattgg agacatcata caacgtcttg acgttctcga acaggacgcc caaatagaca 24660 gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt 24720 ctgaatcagc t gctctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg 24780 cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa 24840 atgcccctaa tggcctttac tttatgcatg ttggttatta ccctagcaac cacattgagg 24900 ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta 24960 atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct 25020 cgtccttcta tgcacctgag cccatcacct ctcttaatac taagtatgtt gcaccacagg 25080 tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccggga 25140 ttgacttcca agatgagttg gatgagt ttt tcaaaaatgt tagcaccagt atacctaatt 25200 ttggttctct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc 25260 ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt 25320 atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg 25380 ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggca ca aactgtatgg 25440 gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata 25500 aggttcatgt tcactaatta acgaactatc aatgagagtt caaagaccac ccactctctt 25560 gttagtgttc tcactctctt ttttggtcac tg cattttca aaacctctct atgtacctga 25620 gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga 25680 tacagctggt ctttatacaa attttcgaat tgatgtccca tctgcagaat caactggtac 25740 tcaatcagtt tctgtcgatc gtgagtctac ttcaactcat gatggtctta ccgaacatgt 25800 tactagtgtg aatctttttg acgttggtta ctcagttaat taacgaactc tatggattac 25860 gtgtctctgc ttaatcaaat ttggcagaag taccttaatt caccgtatac tacttgtttg 25920 tatatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg 25980 ctgtggaact gtcagctatc ctttgctggt tatact gaat ctgctgttaa ttctacaaaa 26040 gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga 26100 atccctgacg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa 26160 gaggagtcat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg 26220 ccctgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga 262 80 ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa 26340 accttatggc ggccaacctg tttctgagta ctatattact ctagctttgc taaatctcac 26400 tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcg ca atgtcagatt 26460 tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta 26520 ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat 26580 taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat 26640 gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc 26700 atgctttaga acttat cctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc 26760 catacggtct tccaatcagg gtaataaaca aattgttcat tcttacccca ttttacatca 26820 tccaggattt taacgaacta tggctttctc ggcgtcttta cccgtccagc tagtcccagt 26880 ttctcc tgca tttcatcgca ttgagtctac tgactctatt gttttcacat acattcctgc 26940 tagcggctat gtagctgctt tagctgtcaa tgtgtgtctc attcccctat tattactgct 27000 acgtcaagat acttgtcgtc gcagcattat cagaactatg gttctctatt tccttgttct 27060 ttataacttt ttattagcca ttgtactagt caatggtgta cattatccaa ctggaagttg 27120 cctgatagcc t tcttagtta tcctcataat actttggttt gtacatagaa ttcgtttctg 27180 tctcatgctg aattcctaca ttccactgtt tgacatgcgt tctcacttta ttcgtgttag 27240 tacagtttct tctcatggta tggtccctgt catacacacc aaaccattat ttattagaaa 27300 cttcgatcag cgttgcagct gttctcgttg tttttatttg cactcttcta cttatataga 27360 gtgcacttat attagccgtt ttagtaagat tagcctagtt tctgtaactg acttct cctt 27420 aaacggcaat gtttccactg ttttcgtgcc tgcaacgcgc gattcagttc ctcttcacat 27480 aatcgccccg agctcgctta tcgtttaagc agctctgcgc tactatgggt cccgtgtaga 27540 ggctaatcca ttagtctctc tttgg acata tggaaaacga actatgttac cctttgtcca 27600 agaacgaata gggttgttca tagtaaactt tttcattttt accgtagtat gtgctataac 27660 actcttggtg tgtatggctt tccttacggc tactagatta tgtgtgcaat gtatgacagg 27720 cttcaatacc ctgttagttc agcccgcatt atacttgtat aatactggac gttcagtcta 27780 tgtaaaattc caggatagta aaccccctct accacctgac gagtgggttt aacgaactcc 278 40 ttcataatgt ctaatatgac gcaactcact gaggcgcaga ttattgccat tattaaagac 27900 tggaactttg catggtccct gatctttctc ttaattacta tcgtactaca gtatggatac 27960 ccatcccgta gtatgactgt ctatgtcttt aaaatgtttg ttttatggct cctat ggcca 28020 tcttccatgg cgctatcaat atttagcgcc atttatccaa ttgatctagc ttcccagata 28080 atctctggca ttgtagcagc tgtttcagct atgatgtgga tttcctactt tgtgcagagt 28140 atccggctgt ttatgagaac tggatcatgg tggtcattca atcctgagac taattgcctt 28200 ttgaatgttc caattggtgg tacaactgtc gtacgtccac tcgtagagga ctctaccagt 28260 g taactgctg ttgtaaccaa tggtcacctc aaaatggctg gcatgcattt cggtgcttgt 28320 gactacgaca gacttcctaa tgaagtcacc gtggccaaac ccaatgtgct gattgcttta 28380 aaaatggtga agcggcaaag ctacggaact aattccggcg ttgccattta ccatagatat 2 8440 aaggcaggta attacaggag tccgcctatt acggcggata ttgaacttgc attgcttcga 28500 gcttaggctc tttagtaaga gtatcttaat tgattttaac gaatctcaat ttcattgtta 28560 tggcatcccc tgctgcacct cgtgctgttt cctttgccga taacaatgat ataacaaata 28620 caaacctgtc tcgaggtaga ggacgtaatc caaaaccacg agctgcacca aataacactg 28680 tctcttggta cactgggctt acccaacacg ggaaagtccc tcttaccttt ccacctgggc 28740 agggtgtacc tcttaatgcc aattccaccc ctgcgcaaaa tgctgggtat tggcggagac 28800 aggacagaaa aattaatacc gggaatggaa ttaagcaact ggctcccagg tggtacttct 28860 actacactgg aactgg accc gaagcagcac tcccattccg ggctgttaag gatggcatcg 28920 tttgggtcca tgaagatggc gccactgatg ctccttcaac ttttgggacg cggaacccta 28980 acaatgattc agctattgtt acacaattcg cgcccggtac taagcttcct aaaaacttcc 29040 acattgaggg gactggaggc aatagtcaat catcttcaag agcctctagc gtaagcagaa 29100 actcttccag atctagttca caaggtt caa gatcaggaaa ctctacccgc ggcacttctc 29160 caggtccatc tggaatcgga gcagtaggag gtgatctact ttaccttgat cttctgaaca 29220 gactacaagc ccttgagtct ggcaaagtaa agcaatcgca gccaaaagta atcactaaga 29280 aagatgctg c tgctgctaaa aataagatgc gccacaagcg cacttccacc aaaagtttca 29340 acatggtgca agcttttggt cttcgcggac caggagacct ccagggaaac tttggtgatc 29400 ttcaattgaa taaactcggc actgaggacc cacgttggcc ccaaattgct gagcttgctc 29460 ctacagccag tgcttttatg ggtatgtcgc aatttaaact tacccatcag aacaatgatg 29520 atcatggcaa ccctgtgtac ttccttcggt acagtggagc cattaaactt gacccaaaga 29580 atcccaacta caataagtgg ttggagcttc ttgagcaaaa tattgatgcc tacaaaacct 29640 tccctaagaa ggaaaagaaa caaaaggcac caaaagaaga atcaacagac caaatgtctg 29700 aacctccaaa ggagcagcgt gtgcaa ggta gcatcactca gcgcactcgc acccgtccaa 29760 gtgttcagcc tggtccaatg attgatgtta acactgatta gtgtcactca aagtaacaag 29820 atcgcggcaa tcgtttgtgt ttggtaaccc catctcacca tcgcttgtcc actcttgcac 29880 agaatggaat catgttgtaa ttacagtgca ataaggtaat tataacccat ttaattgata 29940 gctatgcttt attaaagtgt gtagctgtag agagaatgtt aa agactgtc acctctgcgt 30000 gattgcaagt gaacagtgcc ccccgggaag agctctacag tgtgaaatgt aaataaaaat 30060agctattatt caattagatt aggctaatta gatgatttgc aaaaaaaaaa aa 30112 <210> 3 <211> 30118 <212> DNA <213> Artificial Sequence <220> <223> 7_P20 <400> 3 gatttaagtg aatagcttgg ctatctcacc tcccctcgtt ctcttgcaga actttgattt 60 taacgaactt aaataaaagc cctgttgttt agcgtattgt tgcacttgtc tggtgggatt 120 gtggcattaa tttgcctgct catctaggca gtggacatat gct caacact gggtataatt 180 ctaattgaat actatttttc agttagagcg tcgtgtctct tgtacgtctc ggtcacaata 240 tacggtttcg tccggtgcgt ggcaattcgg ggcacatcat gtctttcgtg gctggtgtga 300 tcgcgcaagg tgcgcgcggt acg tatcgag cagcgctcaa ctctgaaaaa catcaagacc 360 atgtgtctct aactgtgcca ctctgtggtt caggaaacct ggttgaaaaa ctttcaccat 420 ggttcatgga tggcgaaaat gcctatgaag tggtgaaggc catgttactt aaaaaagagc 480 cacttctcta tgtgcccatc cggctggctg gacacactag acacctccca ggtcctcgtg 540 tgtacctggt tgagaggctc attgcttgt g aaaatccatt catggttaac caattggctt 600 atagctctag tgcaaatggc agcctggttg gcacaacttt gcagggcaag cctattggta 660 tgttcttccc ttatgacatc gaacttgtca caggaaagca aaatattctc ctgcgcaagt 720 atggccgtgg tggttatcac tacaccccag tcc actatga gcgagacaac acctcttgcc 780 ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta 840 agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa 900 aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg 960 ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc 1020 tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt 1080 ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta 1140 ctcttggatg caaaatttta acgctcaccc cacgcaacaa gt ggagtggc gtttctgact 1200 tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa 1260 cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta 1320 cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg 1380 tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtg ct acttgcccct 1440 ttgctaaggg tgacagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt 1500 acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg 1560 gcgtagctta cgcctacttt ggatgt gagg aaggtactat gtactttgtg cctagagcta 1620 agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca 1680 aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg 1740 gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg 1800 acaaaatacg ccagcttctc aaaggtgtca ccattgacaa gttgcgtgat tatttagctg 1860 actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta 1920 caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt 1980 cctttaagaa agttgcaacc ataccgtaca aggtttgcaa ctctgtta ag gatactctga 2040 cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt 2100 catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt 2160 tagtccgcct cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc 2220 aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact 2280 tcttgtta ga tttggcagga ttgttcagaa tctttcttcg caatgcctat gtgtacactt 2340 cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaaacaa gtgttagact 2400 tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaata tca 2460 gtgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg 2520 tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt 2580 ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg 2640 tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc 2700 ctgatg ttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg 2760 aagaagacgg attcgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct 2820 ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg 288 0 aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac 2940 tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt 3000 ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc 3060 cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg 3120 agggtgatgc atctt ggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg 3180 aggagtgttc tgaagtagag gcttcaggtt tagaagaagg tgaatcagag tgcatttctg 3240 agacttcaac tgaacaagtt gacgtttctc atgaggtttc tgacgacgag tgggctgctg 3300 cagttgatga agcgttcccc ctcgatgaag cagaagatgt tactgaatct gtgcaagaag 3360 aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct 3420 tacaggaaac tcctgttgtg tctgatactg ttgaagtccc accgcaagtg gtgaaacttc 3480 cgtctgaacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg 3540 ataccgaaca gacacagagt gttact gtta aacctaagag gttacgcaaa aagcgtaatg 3600 ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag 3660 gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca 3720 cacatcttaa gcatggcggt ggtatcgctg gtgctattaa tgcggcttca aaaggggctg 3780 tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag 3840 ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc 3900 gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc 3960 ttgtagtcac tcctcttgtt tcaacaggca tatt tggtgt aaaaccagct gtgtcttttg 4020 attatcttat tagagaggct aagactagag ttttagtcgt cgttaattcc caagatgtct 4080 ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac 4140 gtggcgcaat acgtaaagct aaagatta tg gttttactgt ttttgtgtgc acagacaact 4200 ctgctaacac taaagttctt aggaaacaagg gtgttgatta tactaagaag tttcttacag 4260 ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac 4320 aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag 4380 acttaattca agcagggagt gtcgtgcgta gagttaacgt gccctacg tg tgtctcctag 4440 ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag 4500 attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg 4560 aactattggt gcaagactta cgcttaaata agctcctgca ttggt ctgat caaaccatat 4620 gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac 4680 tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct 4740 tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata 4800 gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgatacc attcc tgatg 4860 agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg 4920 cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta 4980 aggctgcagt ccataagtgg aagatggttg tgtgtgataa ggt acgttcg ctcaaattga 5040 gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttatg aaggacatta 5100 aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg 5160 acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct 5220 ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt 5280 ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt 5340 gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc 5400 agtgtggtgg tgaacgtcat cggcaaatag tcgaacacac caccccct gg ttgctgctct 5460 caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcgttta 5520 atgtctttca gggcattgaa acggctgttg gccattatgt tcatgcttgc ctgaagggtg 5580 gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg 5640 tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt 5700 ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg 5760 atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg 5820 gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta 5880 ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat 5940 acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt 6000 atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaaca 6060 aagcatctta tgatactaat cttaataagt tcaatagagc tagtttgcgt caaatttttg 6120 acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggcg tccacaccag 6180 ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta 6240 agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgttgat gactcaggta 6300 ctcccgtt gt tgagtatctg tctaaagaag atctacatac attgtatgta gaccctaagt 6360 atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg 6420 agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac 6480 tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg 6540 ctgtaggtag ttgtataaag agtgtagtg c ggcatctagg tgttaactaaa ggcatattga 6600 caggctgttt tagttttgtc aagatgttat ttattcttcc actagcttac tttagtgatt 6660 caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagctggc gttgtgacag 6720 gtaatgttgt aaaacagtg t tgcactgctg ctgttgattt aagtatggat aagttgcgcc 6780 gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt 6840 tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg 6900 aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt 6960 ctgcttgtga cggtcttgct tcagcttata g ggcgaattc atttgatgta cctacattct 7020 gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact 7080 acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt 7140 tgtggtttgc attcgagact ggtttgg cat acatgctcta tacctcggcc ttcaactggt 7200 tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc 7260 ggtcatacaa ttatgctgtg tctagtgcct tctggttatt tacccacatt ccaatggcgg 7320 gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc 7380 atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataaga gg aaccgactta 7440 ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa 7500 atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacattgcag 7560 gtgtggggaa taccttcatc tgtgaagaag tcg caaatga cctcactacc gccctacgca 7620 ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga 7680 ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct 7740 gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta 7800 tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta 7 860 ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa 7920 gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg 7980 ttaatagttt cgtctcgctg tataatgtca cacgcgata a gttggaaaaa cttatctcta 8040 ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg 8100 acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact 8160 ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagttac aataattatg 8220 taccctcata tgttaaacct gatagtgtgt ctaccagtga tttaggtagt ctcattgatt 8280 gtaatgc ggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgtatttgga 8340 acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc 8400 gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct 84 60 tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgtgt 8520 tgcgtgactt tacgttaaag ggttacgttc ttgctaccat tattgtgttt ctgtgtgctg 8580 tactgatgta tttgtgttta cctacatttt ctatggtacc tgttgaattt tatgaagacc 8640 gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata 8700 agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg 8760 tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg 8820 ctcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attt tctttg 8880 tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct 8940 ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg 9000 cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt 9060 acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat 9120 ttcctgaagt agtatt tgaa agtacactta ggattactag aactctgtca actcagtact 9180 gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt 9240 gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta 9300 ttgacattgt cagg cggtta gcagtatcac tgttccagcc tattacttat ttccaattga 9360 ctacctcatt ggtcttgggt ataggtttgt gtgcattcct gactttgctc ttctattata 9420 ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg 9480 ctgctgttct taatagcttg tgcatctgct ttgttgcctc tataccatg tgtatagtac 9540 cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta 9600 tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct 9660 atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac 9720 atg tagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata 9780 tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct 9840 attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag 9900 ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagtgaga 9960 ctggtagtga tcttctttac caaccaccca actgtagcat aacctct ggc gtgttgcaaa 10020 gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta 10080 cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac 10140 acgtaatgtg cccggctgac cag ttgtctg atcctaatta tgatgccttg ttgatttcta 10200 tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg 10260 ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca 10320 ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct 10380 ataatggtcg tccgactggt acattcactg ttgtaatgc g ccctaactac acaattaagg 10440 gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca 10500 atttttgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg 10560 atggtactat gtatggtgcc tttat ggata aacaagtgca ccaagttcag ttaacagaca 10620 aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt 10680 ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc 10740 aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg 10800 ctattgaaca gctgctttat gcgatccaac aactttatac tgggt tccag ggaaagcaaa 10860 tccttggcag tactatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta 10920 tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt 10980 tcgcgaccct tgtttcaacc tatg tgataa tcttacaagc cactaaattt actttgtgga 11040 actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct 11100 tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg 11160 ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc 11220 tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact aca catactg 11280 atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca 11340 acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt 11400 atagcattgg agaagcctca agccccattg cctatctggt tttt gtcact acactcacta 11460 gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca 11520 tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat 11580 tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct tttttgaacc 11640 ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat 11700 t catgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact 11760 ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac 11820 ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag 1 1880 aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgacata ttggcagcaa 11940 cagaccccag tgaggctttc gagaaattcg taagtctctt tgccacttta atgacttttt 12000 ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc 12060 aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga 12120 aagccta tca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc 12180 agaaggctgt taatatagct aaaaacgcct atgagaagga taaggcagtg gcccgtaagt 12240 tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca 12300 agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg 12360 acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg 12420 tcattccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga 12480 atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta 12540 taaacaatgt ggacaatgaa att gttaagt cttcagatgt tgtagacagc aatgaaaatt 12600 taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa 12660 ataatgagat caaaccttca ggtttaaaaa ccatggttgt gtctgcaggt caagagcaaa 12720 ctaactgtaa t actagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga 12780 tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat 12840 ttgttagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg 12900 aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag 12960 ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt 13020 cttcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg 13080 tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta 13140 caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag 13200 cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta 13260 aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt 13320 gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg 13380 actcgcttag gcaagtagca ctgccccaat ctaaagatt c caatttttta aacgagtccg 13440 gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt 13500 ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta 13560 caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta 13620 ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgattt 13680 gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt 13740 taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata 13800 tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagta tgg 13860 ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag 13920 tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt 13980 taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtg ctcacac tagacaacca 14040 ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg 14100 agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg 14160 tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact 14220 tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg 14280 ggatcagac g tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg 14340 tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt 14400 ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggtta tc actacaaaga 14460 attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga 14520 gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga 14580 tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt 14640 gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa 147 00 ggagggctct tcagttacgc tcaaacattt tttctttgct caagatggta atgctgctat 14760 tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt 14820 gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtctta atgc 14880 ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg 14940 caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tctttgccat 15000 gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc 15060 taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca 15120 gtaccatcag aaaat gctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg 15180 tactacaaag ttctatggtg gctgggattt catgcttaaa acattgtaca aagatgttga 15240 taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg 15300 tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga 15360 cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg 15420 tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc 15480 caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc 15540 taatggcaac aagattgtt g acaaagaagt taaagacatg cagtttgatt tgtatgtcaa 15600 tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa 15660 taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta 15720 t gcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa 15780 caatgtcttt atgtctgaag ctaaatgctg ggtgggaaacc gatctgaaga aagggccaca 15840 tgaattctgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc 15900 ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac 15960 tgacggtaca ctcatggtag agcggtttgt gt ctttggct atagatgctt accctctcac 16020 aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa 16080 actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga 16140 taattctgct aagttttggg aagagg catt ctacagagat ctctatagtt cgcctaccac 16200 tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac 16260 atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc 16320 acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc 16380 agacgttact aagctatatt taggtggtat gagctacttt tgtg tagatc atagacctgt 16440 gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac 16500 aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg 16560 tgattacacc cttgccaata ctacaac aga accactcaaa ctttttgctg ctgagacttt 16620 acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt 16680 tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg 16740 taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta 16800 catcttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtata a 16860 actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc 16920 cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt 16980 acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcagg ttata gtaaatatgt 17040 cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta 17100 ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg 17160 tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc 17220 acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat att tgtttag 17280 tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat 17340 gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta 17400 tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga 17460 accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt 17520 aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa 17580 taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg 17640 caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa 17700 ttttatact gcca atccgg catggagtaa ggcagtcttt atttcgcctt ataattcaca 17760 gaatgctgtg gctcgttcaa tgctgggtct tactactcag actgttgatt cctcacaggg 17820 ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat 17880 taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc 17940 tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca 18000 gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc 18060 tgcttatgca ccaacatacg ttagtgttga tgacaagtat aagacgagtg atgagctttg 18120 cgtgaatctt aatttac ccg caaatatccc atactctcgt gttatttcca ggatgggctt 18180 taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt 18240 aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc 183 00 atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca 18360 gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcccgtcc 18420 tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc 18480 tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta 18540 ctgtacgttt gttt gttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa 18600 gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc 18660 tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt 18720 ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta 18780 ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt 18840 agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc 18900 acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc 18960 tcttcttgcc ggttcatttg a caaagtcta tgatattggc aatcctaaag gaattcctat 19020 tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccagaaaggt 19080 acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt 19140 ttgg aactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg 19200 tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca 19260 cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt 19320 cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat 19380 tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggc gctgt 19440 ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc 19500 atcaggtttc cgcctttggt gttataagac ctttgatatt tataatctct ggtctacttt 19560 tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat 19620 tggtgttgag ggtgaactac ctgtagctgt agtcaatgat aagatcttca ccaagagtgg 19680 cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga 19740 actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca 19800 agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata ttta tggtac 19860 tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg 19920 ttttgacata cgcgataatg gttcattgga gaagttcatg tctactccca atgccatctt 19980 tatttctgat agaaaaatta agaaataccc ttgtattgta ggtcctgatt atgcttactt 20040 caatggtgct atcatccgtg atagtgatgt tgttaaaacaa ccagtgaagt tctacttgta 20100 taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc 20160 ttgtagtgac ttcctacccc tgtctgacat ggagaaagac tttctatctt ttgatagtga 20220 tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga 2 0280 cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca 20340 ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt 20400 tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct 2 0460 tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa 20520 ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca 20580 aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc 20640 cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc 20700 tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta 20760 tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg 20820 ttctgataaa ggtatcgctc ctggtacatc agttttacga cagtggcttc ctacagatgc 20880 cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg 20940 agattgtgta actgtacgtg tcagccaaca agtggatctt gttatattccg acatgtatga 21000 tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct 21060 gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga 21120 acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt 21180 ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg 21240 tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa 21300 ttccactcct atgaatct ga gtacttactc actttttgat ttatccaagt ttcaattaaa 21360 attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc 21420 tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga 21480 tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg 21540 cttgtattaa ggttgat ata caacagactt tctttgataa aacttggcct aggccaattg 21600 atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatatttt aacataacta 21660 tcacttatca aggtcttttt ccctatcagg gagaccatgg tgatatgtat gtctactctg 21720 caggacatgc ta caggcaca actccacaaa agttgtttgt agctaactat tctcaggacg 21780 tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactggca 21840 ctgttattat tagcccatct acccgcgcta ctatacgaaa aatttaccct gcttttatgc 21900 tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc 21960 tagttctttt gcccgatgga tgtggcactt t acttagagc tttttatattgt attctagagc 22020 ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca 22080 ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta 22140 aggagtattt taatttac gt aactgcacct ttatgtacac ttataacatt accgaagatg 22200 agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc 22260 ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata 22320 ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag 22380 cttgggctgc cttctacgta tataaacttc aaccg ttaac tttcctgttg gatttttctg 22440 ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact 22500 gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa 22560 aaccttctgg ctcagt tgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc 22620 tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt 22680 ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat 22740 ctccagcagc aattgctagc aactgttatt cttcactgat tttggattat ttttcatacc 22800 cacttagtat gaaatccgat ctcagtgtta gttctgctgg tctaatat cc cagtttaatt 22860 ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta 22920 ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt cttctttctg 22980 atgatcgtac tgaagtacct cagttagtga acgcta atca atactcaccc tgtgtatcca 23040 ttctcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg 23100 aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga 23160 tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg 23220 aatttgctaa tgacacaaaa attgcctctc aattaggcaa ttgcgtggaa tattccctct 2328 0 atggtgtttc gggccgtggt gtctttcaga attgcacagc tgtaggtgtt cgacagcagc 23340 gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact 23400 actgtttgcg tgcttgtgtt agtgttcctg tttct gtcat ctatgataaa gaaactaaaa 23460 cccacgctac tctatttggt agtgttgcat gtgaacacat ttcctctacc atgtctcaat 23520 actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggt ccccttcaga 23580 cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt 23640 tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca 23700 gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc 23760 aggttgatca acttaatagt agttatttta aattaagtat acctactaat ttttcctttg 23820 gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat t gtaaacagt 23880 acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt 23940 ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt 24000 tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact 24060 ttaatttgac acttctaaaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg 24120 ctattgagga tt tgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt 24180 acgatgattg tatgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg 24240 tggctggtta taaagtatta cctcctctta tggatgttaa tatggaagcc gcgtatactt 24300 catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg 24360 ctattccatt tgcacagagt attttttata ggttaaacgg tgttggcatt actcaacagg 24420 ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc 24480 aaacaggctt cactacaact aatgaagctt ttcggaaggt tcaggatgct gtgaacaaca 24540 atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg 24600 cctctattgg agacatcata caacgtcttg acgttctcga acaggacgcc caaatagaca 24660 gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt 24720 ctgaatcagc t gatctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg 24780 cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa 24840 atgcccctaa tggcctttac tttatgcatg ttggttatta ccctagcaac cacattgagg 24900 ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta 24960 atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct 25020 cgtccttcta tgcacctgag cccatcacct ctcttaatac taagtatgtt gcaccacagg 25080 tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccggga 25140 ttgacttcca agatgagttg gatgagt ttt tcaaaaatgt tagcaccagt atacctaatt 25200 ttggttctct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc 25260 ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt 25320 atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg 25380 ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggca ca aactgtatgg 25440 gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata 25500 aggttcatgt tcactaatta acgaactatc aatgagagtt caaagaccac ccactctctt 25560 gttagtgttc tcactctctt ttttggtcac tg cattttca aaacctctct atgtacctga 25620 gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga 25680 tacagctggt ctttatacaa attttcgaat tgatgtccca tctgcagaat caactggtac 25740 tcaatcagtt tctgtcgatc gtgagtctac ttcaactcat gatggtctta ccgaacatgt 25800 tactagtgtg aatctttttg acgttggtta ctcagttaat taacgaactc tatggattac 25860 gtgtctctgc ttaatcaaat ttggcagaag taccttaatt caccgtatac tacttgtttg 25920 tatatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg 25980 ctgtggaact gtcagctatc ctttgctggt tatact gaat ctgctgttaa ttctacaaaa 26040 gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga 26100 atccctgacg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa 26160 gaggagtcat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg 26220 ccctgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga 262 80 ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa 26340 accttatggc ggccaacctg tttctgagta ctatattact ctagctttgc taaatctcac 26400 tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcg ca atgtcagatt 26460 tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta 26520 ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat 26580 taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat 26640 gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc 26700 atgctttaga acttat cctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc 26760 catacggtct tccaatcagg gtaataaaca aattgttcat tcttacccca ttttacatca 26820 tccaggattt taaccaacta tggctttctc ggcgtcttta tttaaacccg tccagctagt 26880 cccagttt ct cctgcatttc atcgcattga gtctactgac tctattgttt tcacatacat 26940 tcctgctagc ggctatgtag ctgctttagc tgtcaatgtg tgtctcattc ccctattatt 27000 actgctacgt caagatactt gtcgtcgcag cattatcaga actatggttc tctatttcct 27060 tgttctttat aactttttat tagccattgt actagtcaat ggtgtacatt atccaactgg 27120 aagttgcctg atagcct tct tagttatcct cataatactt tggtttgtag atagaattcg 27180 tttctgtctc atgctgaatt cctacattcc actgtttgac atgcgttctc actttattcg 27240 tgttagtaca gtttcttctc atggtatggt ccctgtcata cacaccaaac cattatttat 27300 tagaaacttc gatcagcgtt gcagctgttc tcgttgtttt tatttgcact cttctactta 27360 tatagagtgc acttatatta gccgttttag taagattagc ctagtttctg taact gactt 27420 ctccttaaac ggcaatgttt ccactgtttt cgtgcctgca acgcgcgatt cagttcctct 27480 tcacataatc gccccgagct cgcttatcgt ttaagcagct ctgcgctact atgggtcccg 27540 tgtagaggct aatccattag tctctctttg gacatatgga aaacgaacta tgttaccctt 27600 tgtccaagaa cgaatagggt tgttcatagt aaactttttc atttttaccg tagtatgtgc 27660 tataacactc ttggtgtgta tggctttcct tacggctact agattatgtg tgcaatgtat 27720 gacaggcttc aataccctgt tagttcagcc cgcattatac ttgtataata ctggacgttc 27780 agtctatgta aaattccagg atagtaaacc ccctctacca cctgacgagt gggtttaacg 27840 aactccttca taatgtctaa tatgacgcaa ctcactgagg cgcagattat tgccattatt 27900 aaagactgga actttgcatg gtccctgatc tttctcttaa ttactatcgt actacagtat 27960 ggatacccat cccgtagtat gactgtctat gtctttaaaa tgtttgttt t atggctccta 28020 tggccatctt ccatggcgct atcaatattt agcgccattt atccaattga tctagcttcc 28080 cagataatct ctggcattgt agcagctgtt tcagctatga tgtggatttc ctactttgtg 28140 cagagtatcc ggctgtttat gagaactgga tcatggtggt cattcaatcc tgagactaat 28200 tgccttttga atgttccaat tggtggtaca actgtcgtac gtccactcgt agaggactct 28260 accagtgtaa ctgctgttgt aaccaatggt cacctcaaaa tggctggcat gcatttcggt 28320 gcttgtgact acgacagact tcctaatgaa gtcaccgtgg ccaaacccaa tgtgctgatt 28380 gctttaaaaa tggtgaagcg gcaaagctac ggaactaatt ccggcgttgc cat ttaccat 28440 agatataagg caggtaatta caggagtccg cctattacgg cggatattga acttgcattg 28500 cttcgagctt aggctcttta gtaagagtat cttaattgat tttaacgaat ctcaatttca 28560 ttgttatggc atcccctgct gcacctcgtg ctgtttcctt tgccgataac aatgatataa 28620 caaatacaaa cctgtctcga ggtagaggac gtaatccaaa accacgagct gcaccaaata 28680 acactgtctc ttggt acact gggcttaccc aacacgggaa agtccctctt acctttccac 28740 ctgggcaggg tgtacctctt aatgccaatt ccacccctgc gcaaaatgct gggtattggc 28800 ggagacagga cagaaaaatt aataccggga atggaattaa gcaactggct cccaggtggt 28860 acttctacta cactggaact ggacccgaag cagcactccc attccgggct gttaaggatg 28920 gcatcgtttg ggtccatgaa gatggcgcca ctgatgctcc ttcaactttt gggacgcgga 28980 accctaacaa tgattcagct attgttacac aattcgcgcc cggtactaag cttcctaaaa 29040 acttccacat tgaggggact ggaggcaata gtcaatcatc ttcaagagcc tctagcgtaa 29100 gcagaaactc ttccagatct agttcaca ag gttcaagatc aggaaactct acccgcggca 29160 cttctccagg tccatctgga atcggagcag taggaggtga tctactttac cttgatcttc 29220 tgaacagact acaagccctt gagtctggca aagtaaagca atcgcagcca aaagtaatca 29280 ctaagaaaga tgctgctgct g ctaaaaata agatgcgcca caagcgcact tccaccaaaa 29340 gtttcaacat ggtgcaagct tttggtcttc gcggaccagg agacctccag ggaaactttg 29400 gtgatcttca attgaataaa ctcggcactg aggacccacg ttggccccaa attgctgagc 29460 ttgctcctac agccagtgct tttatgggta tgtcgcaatt taaacttacc catcagaaca 29520 atgatgatca tggcaaccct gtgtacttcc ttc ggtacag tggagccatt aaacttgacc 29580 caaagaatcc caactacaat aagtggttgg agcttcttga gcaaaatatt gatgcctaca 29640 aaaccttccc taagaaggaa aagaaacaaa aggcaccaaa agaagaatca acagaccaaa 29700 tgtctgaacc tccaaaggag cagcgtgtgc a aggtagcat cactcagcgc actcgcaccc 29760 gtccaagtgt tcagcctggt ccaatgattg atgttaacac tgattagtgt cactcaaagt 29820 aacaagatcg cggcaatcgt ttgtgtttgg taaccccatc tcaccatcgc ttgtccactc 29880 ttgcacagaa tggaatcatg ttgtaattac agtgcaataa ggtaattata acccatttaa 29940 ttgatagcta tgctttatta aagtgtgtag ctgtagagag aat gttaaag actgtcacct 30000 ctgcgtgatt gcaagtgaac agtgcccccc gggaagagct ctacagtgtg aaatgtaaat 30060aaaaatagct attattcaat tagattaggc taattagatg atttgcaaaa aaaaaaaa 30118 <210> 4 <211> 30118 <212> DNA <213> Artificial Sequence <220> <223> 9_P20 <400> 4 gatttaagtg aatagcttgg ctatctcact tcccctcgtt ctcttgcaga actttgattt 60 taacgaactt aaataaaagc cctgttgttt agcgtattgt tgcacttgtc tggtgggatt 120 gtggcattaa tttgcctgct catctaggca gtggacatat gct caacact gggtataatt 180 ctaattgaat actatttttc agttagagcg tcgtgtctct tgtacgtctc ggtcacaata 240 tacggtttcg tccggtgcgt ggcaattcgg ggcacatcat gtctttcgtg gctggtgtga 300 tcgcgcaagg tgcgcgcggt acg tatcgag cagcgctcaa ctctgaaaaa catcaagacc 360 atgtgtctct aactgtgcca ctctgtggtt caggaaacct ggttgaaaaa ctttcaccat 420 ggttcatgga tggcgaaaat gcctatgaag tggtgaaggc catgttactt aaaaaagagc 480 cacttctcta tgtgcccatc cggctggctg gacacactag acacctccca ggtcctcgtg 540 tgtacctggt tgagaggctc attgcttgt g aaaatccatt catggttaac caattggctt 600 atagctctag tgcaaatggc agcctggttg gcacaacttt gcagggcaag cctattggta 660 tgttcttccc ttatgacatc gaacttgtca caggaaagca aaatattctc ctgcgcaagt 720 atggccgtgg tggttatcac tacaccccag tcc actatga gcgagacaac acctcttgcc 780 ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta 840 agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa 900 aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg 960 ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc 1020 tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt 1080 ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta 1140 ctcttggatg caaaatttta acgctcaccc cacgcaacaa gt ggagtggc gtttctgact 1200 tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa 1260 cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta 1320 cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg 1380 tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtg ct acttgcccct 1440 ttgctaaggg tgacagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt 1500 acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg 1560 gcgtagctta cgcctacttt ggatgt gagg aaggtactat gtactttgtg cctagagcta 1620 agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca 1680 aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg 1740 gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg 1800 acaaaatacg ccagcttctc aaaggtgtca ccattgacaa gttgcgtgat tatttagctg 1860 actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta 1920 caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt 1980 cctttaagaa agttgcaacc ataccgtaca aggtttgcaa ctctgtta ag gatactctga 2040 cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt 2100 catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt 2160 tagtccgcct cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc 2220 aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact 2280 tcttgtta ga tttggcagga ttgttcagaa tctttcttcg caatgcctat gtgtacactt 2340 cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaaacaa gtgttagact 2400 tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaata tca 2460 gtgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg 2520 tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt 2580 ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg 2640 tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc 2700 ctgatg ttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg 2760 aagaagacgg attcgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct 2820 ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg 288 0 aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac 2940 tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt 3000 ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc 3060 cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg 3120 agggtgatgc atctt ggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg 3180 aggagtgttc tgaagtagag gcttcaggtt tagaagaagg tgaatcagag tgcatttctg 3240 agacttcaac tgaacaagtt gacgtttctc atgaggtttc tgacgacgag tgggctgctg 3300 cagttgatga agcgttcccc ctcgatgaag cagaagatgt tactgaatct gtgcaagaag 3360 aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct 3420 tacaggaaac tcctgttgtg tctgatactg ttgaagtccc accgcaagtg gtgaaacttc 3480 cgtctgaacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg 3540 ataccgaaca gacacagagt gttact gtta aacctaagag gttacgcaaa aagcgtaatg 3600 ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag 3660 gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca 3720 cacatcttaa gcatggcggt ggcatcgctg gtgctattaa tgcggcttca aaaggggctg 3780 tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag 3840 ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc 3900 gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc 3960 ttgtagtcac tcctcttgtt tcaacaggca tatt tggtgt aaaaccagct gtgtcttttg 4020 attatcttat tagagaggct aagactagag ttttagtcgt cgttaattcc caagatgtct 4080 ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac 4140 gtggcgcaat acgtaaagct aaagatta tg gttttactgt ttttgtgtgc acagacaact 4200 ctgctaacac taaagttctt aggaaacaagg gtgttgatta tactaagaag tttcttacag 4260 ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac 4320 aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag 4380 acttaattca agcagggagt gtcgtgcgta gagttaacgt gccctacg tg tgtctcctag 4440 ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag 4500 attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg 4560 aactattggt gcaagactta cgcttaaata agctcctgca ttggt ctgat caaaccatat 4620 gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac 4680 tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct 4740 tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata 4800 gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgatacc attcc tgatg 4860 agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg 4920 cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta 4980 aggctgcagt ccataagtgg aagatggttg tgtgtgataa ggt acgttcg ctcaaattga 5040 gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttatg aaggacatta 5100 aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg 5160 acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct 5220 ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt 5280 ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt 5340 gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc 5400 agtgtggtgg tgaacgtcat cggcaaatag tcgaacacac caccccct gg ttgctgctct 5460 caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcgttta 5520 atgtctttca gggcattgaa acggctgttg gccattatgt tcatgcttgc ctgaagggtg 5580 gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg 5640 tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt 5700 ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg 5760 atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg 5820 gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta 5880 ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat 5940 acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt 6000 atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaaca 6060 aagcatctta tgatactaat cttaataagt tcaatagagt tagtttgcgt caaatttttg 6120 acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggcg tccacaccag 6180 ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta 6240 agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgttgat gactcaggta 6300 ctcccgtt gt tgagtatctg tctaaagaag atctacatac attgtatgta gaccctaagt 6360 atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg 6420 agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac 6480 tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg 6540 ctgtaggtag ttgtataaag agtgtagtg c ggcatctagg tgttaactaaa ggcatattga 6600 caggctgttt tagttttgtc aagatgttat ttattcttcc actagcttac tttagtgatt 6660 caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagctggc gttgtgacag 6720 gtaatgttgt aaaacagtg t tgcactgctg ctgttgattt aagtatggat aagttgcgcc 6780 gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt 6840 tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg 6900 aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt 6960 ctgcttgtga cggtcttgct tcagcttata g ggcgaattc atttgatgta cctacattct 7020 gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact 7080 acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt 7140 tgtggtttgc attcgagact ggtttgg cat acatgctcta tacctcggcc ttcaactggt 7200 tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc 7260 ggtcatacaa ttatgctgtg tctagtgcct tctggttatt tacccacatt ccaatggcgg 7320 gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc 7380 atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataaga gg aaccgactta 7440 ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa 7500 atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacattgcag 7560 gtgtggggaa taccttcatc tgtgaagaag tcg caaatga cctcactacc gccctacgca 7620 ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga 7680 ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct 7740 gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta 7800 tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta 7 860 ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa 7920 gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg 7980 ttaatagttt cgtctcgctg tataatgtca cacgcgata a gttggaaaaa cttatctcta 8040 ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg 8100 acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact 8160 ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagttac aataattatg 8220 taccctcata tgttaaacct gatagtgtgt ctaccagtga tttaggtagt ctcattgatt 8280 gtaatgc ggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgtatttgga 8340 acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc 8400 gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct 84 60 tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgtgt 8520 tgcgtgactt tacgttaaag ggttacgttc ttgctaccat tattgtgttt ctgtgtgctg 8580 tactgatgta tttgtgttta cctacatttt ctatggtacc tgttgaattt tatgaagacc 8640 gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata 8700 agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg 8760 tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg 8820 ctcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attt tctttg 8880 tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct 8940 ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg 9000 cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt 9060 acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat 9120 ttcctgaagt agtatt tgaa agtacactta ggattactag aactctgtca actcagtact 9180 gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt 9240 gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta 9300 ttgacattgt cagg cggtta gcagtatcac tgttccagcc tattacttat ttccaattga 9360 ctacctcatt ggtcttgggt ataggtttgt gtgcattcct gactttgctc ttctattata 9420 ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg 9480 ctgctgttct taatagcttg tgcatctgct ttgttgcctc tataccatg tgtatagtac 9540 cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta 9600 tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct 9660 atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac 9720 atg tagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata 9780 tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct 9840 attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag 9900 ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagtgaga 9960 ctggtagtga tcttctttac caaccaccca actgtagcat aacctct ggc gtgttgcaaa 10020 gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta 10080 cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac 10140 acgtaatgtg cccggctgac cag ttgtctg atcctaatta tgatgccttg ttgatttcta 10200 tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg 10260 ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca 10320 ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct 10380 ataatggtcg tccgactggt acattcactg ttgtaatgc g ccctaactac acaattaagg 10440 gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca 10500 atttttgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg 10560 atggtactat gtatggtgcc tttat ggata aacaagtgca ccaagttcag ttaacagaca 10620 aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt 10680 ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc 10740 aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg 10800 ctattgaaca gctgctttat gcgatccaac aactttatac tgggt tccag ggaaagcaaa 10860 tccttggcag tactatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta 10920 tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt 10980 tcgcgaccct tgtttcaacc tatg tgataa tcttacaagc cactaaattt actttgtgga 11040 actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct 11100 tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg 11160 ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc 11220 tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact aca catactg 11280 atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca 11340 acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt 11400 atagcattgg agaagcctca agccccattg cctatctggt tttt gtcact acactcacta 11460 gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca 11520 tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat 11580 tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct tttttgaacc 11640 ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat 11700 t catgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact 11760 ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac 11820 ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag 1 1880 aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgacata ttggcagcaa 11940 cagaccccag tgaggctttc gagaaattcg taagtctctt tgccacttta atgacttttt 12000 ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc 12060 aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga 12120 aagccta tca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc 12180 agaaggctgt taatatagct aaaaacgcct atgagaagga taaggcagtg gcccgtaagt 12240 tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca 12300 agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg 12360 acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg 12420 tcattccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga 12480 atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta 12540 taaacaatgt ggacaatgaa att gttaagt cttcagatgt tgtagacagc aatgaaaatt 12600 taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa 12660 ataatgagat caaaccttca ggtttaaaaa ccatggttgt gtctgcaggt caagagcaaa 12720 ctaactgtaa t actagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga 12780 tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat 12840 ttgttagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg 12900 aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag 12960 ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt 13020 cttcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg 13080 tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta 13140 caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag 13200 cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta 13260 aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt 13320 gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg 13380 actcgcttag gcaagtagca ctgccccaat ctaaagatt c caatttttta aacgagtccg 13440 gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt 13500 ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta 13560 caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta 13620 ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgattt 13680 gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt 13740 taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata 13800 tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagta tgg 13860 ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag 13920 tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt 13980 taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtg ctcacac tagacaacca 14040 ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg 14100 agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg 14160 tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact 14220 tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg 14280 ggatcagac g tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg 14340 tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt 14400 ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggtta tc actacaaaga 14460 attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga 14520 gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga 14580 tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt 14640 gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa 147 00 ggagggctct tcagttacgc tcaaacattt tttctttgct caagatggta atgctgctat 14760 tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt 14820 gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtctta atgc 14880 ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg 14940 caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tctttgccat 15000 gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc 15060 taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca 15120 gtaccatcag aaaat gctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg 15180 tactacaaag ttctatggtg gctgggattt catgcttaaa acattgtaca aagatgttga 15240 taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg 15300 tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga 15360 cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg 15420 tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc 15480 caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc 15540 taatggcaac aagattgtt g acaaagaagt taaagacatg cagtttgatt tgtatgtcaa 15600 tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa 15660 taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta 15720 t gcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa 15780 caatgtcttt atgtctgaag ctaaatgctg ggtgggaaacc gatctgaaga aagggccaca 15840 tgaattctgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc 15900 ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac 15960 tgacggtaca ctcatggtag agcggtttgt gt ctttggct atagatgctt accctctcac 16020 aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa 16080 actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga 16140 taattctgct aagttttggg aagagg catt ctacagagat ctctatagtt cgcctaccac 16200 tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac 16260 atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc 16320 acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc 16380 agacgttact aagctatatt taggtggtat gagctacttt tgtg tagatc atagacctgt 16440 gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac 16500 aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg 16560 tgattacacc cttgccaata ctacaac aga accactcaaa ctttttgctg ctgagacttt 16620 acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt 16680 tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg 16740 taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta 16800 catcttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtata a 16860 actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc 16920 cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt 16980 acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcagg ttata gtaaatatgt 17040 cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta 17100 ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg 17160 tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc 17220 acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat att tgtttag 17280 tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat 17340 gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta 17400 tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga 17460 accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt 17520 aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa 17580 taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg 17640 caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa 17700 ttttatact gcca atccgg catggagtaa ggcagtcttt atttcgcctt ataattcaca 17760 gaatgctgtg gctcgttcaa tgctgggtct tactactcag actgttgatt cctcacaggg 17820 ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat 17880 taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc 17940 tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca 18000 gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc 18060 tgcttatgca ccaacatacg ttagtgttga tgacaagtat aagacgagtg atgagctttg 18120 cgtgaatctt aatttac ccg caaatatccc atactctcgt gttatttcca ggatgggctt 18180 taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt 18240 aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc 183 00 atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca 18360 gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcccgtcc 18420 tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc 18480 tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta 18540 ctgtacgttt gttt gttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa 18600 gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc 18660 tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt 18720 ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta 18780 ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt 18840 agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc 18900 acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc 18960 tcttcttgcc ggttcatttg a caaagtcta tgatattggc aatcctaaag gaattcctat 19020 tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccagaaaggt 19080 acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt 19140 ttgg aactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg 19200 tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca 19260 cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt 19320 cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat 19380 tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggc gctgt 19440 ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc 19500 atcaggtttc cgtctttggt gttataagac ctttgatatt tataatctct ggtctacttt 19560 tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat 19620 tggtgttgag ggtgaactac ctgtagctgt agtcaatgat aagatcttca ccaagagtgg 19680 cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga 19740 actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca 19800 agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata ttta tggtac 19860 tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg 19920 ttttgacata cgcgataatg gttcattgga gaagttcatg tctactccca atgccatctt 19980 tatttctgat agaaaaatta agaaataccc ttgtattgta ggtcctgatt atgcttactt 20040 caatggtgct atcatccgtg atagtgatgt tgttaaaacaa ccagtgaagt tctacttgta 20100 taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc 20160 ttgtagtgac ttcctacccc tgtctgacat ggagaaagac tttctatctt ttgatagtga 20220 tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga 2 0280 cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca 20340 ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt 20400 tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct 2 0460 tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa 20520 ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca 20580 aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc 20640 cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc 20700 tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta 20760 tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg 20820 ttctgataaa ggtatcgctc ctggtacatc agttttacga cagtggcttc ctacagatgc 20880 cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg 20940 agattgtgta actgtacgtg tcagccaaca agtggatctt gttatattccg acatgtatga 21000 tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct 21060 gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga 21120 acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt 21180 ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg 21240 tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa 21300 ttccactcct atgaatct ga gtacttactc actttttgat ttatccaagt ttcaattaaa 21360 attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc 21420 tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga 21480 tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg 21540 cttgtattaa ggttgat ata caacagactt tctttgataa aacttggcct aggccaattg 21600 atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatattct aacataacta 21660 tcacttatca cggtcttttt ccctatcagg gagaccatgg tgatatgtat gtctactctg 21720 caggacatgc taca ggcaca actccacaaa agttgtttgt agctaactat tctcaggacg 21780 tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactgaca 21840 ctgttattat tagcccatct acccgcgcta ctatacgaaa aatttaccct gcttttatgc 21900 tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc 21960 tagttctttt gcccgatgga tgtggcactt t acttagagc tttttatattgt attctagagc 22020 ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca 22080 ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta 22140 aggagtattt taatttac gt aactgcacct ttatgtacac ttataacatt accgaagatg 22200 agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc 22260 ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata 22320 ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag 22380 cttgggctgc cttctacgta tataaacttc aaccg ttaac tttcctgttg gatttttctg 22440 ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact 22500 gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa 22560 aaccttctgg ctcagt tgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc 22620 tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt 22680 ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat 22740 ctccagcagc aattgctagc aactgttatt cttcactgat tttggattat ttttcatacc 22800 cacttagtat gaaatccgat ctcagtgtta gttctgctgg tctaatat cc cagtttaatt 22860 ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta 22920 ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt tttctttctg 22980 atgatcgtac tgaagtacct cagttagtga acgcta atca atactcaccc tgtgtatcca 23040 ttctcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg 23100 aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga 23160 tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg 23220 aatttgctaa tgacacaaaa attgcctctc aattaggcaa ttgcgtggaa tattccctct 2328 0 atggtgtttc gggccgtggt gtctttcaga attgcacagc tgtaggtgtt cgacagcagc 23340 gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact 23400 actgtttgcg tgcttgtgtt agtgttcctg tttct gtcat ctatgataaa gaaactaaaa 23460 cccacgctac tctatttggt agtgttgcat gtgaacacat ttcctctacc atgtctcaat 23520 actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggt ccccttcaga 23580 cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt 23640 tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca 23700 gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc 23760 aggttgatca acttaatagt agttatttta aattaagtat acctactaat ttttcctttg 23820 gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat t gtaaacagt 23880 acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt 23940 ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt 24000 tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact 24060 ttaatttgac acttctaaaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg 24120 ctattgagga tt tgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt 24180 acgatgattg tatgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg 24240 tggctggtta taaagtatta cctcctctta tggatgttaa tatggaagcc gcgtacactt 24300 catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg 24360 ctattccatt tgcacagagt attttttata ggttaaacgg tgttggcatt actcaacagg 24420 ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc 24480 aaacaggctt cactacaact aatgaagctt ttcggaaggt tcaggatgct gtgaacaaca 24540 atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg 24600 cctctattgg agacatcata caacgtcttg acgttctcga acaggacgcc caaatagaca 24660 gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt 24720 ctgaatcagc t gctctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg 24780 cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa 24840 atgcccctaa tggcctttac tttatgcatg ttggttatta ccctagcaac cacattgagg 24900 ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta 24960 atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct 25020 cgtccttcta tgcacctgag cccatcacct ctcttaatac taagtatgtt gcaccacagg 25080 tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccggga 25140 ttgacttcca agatgagttg gatgagt ttt tcaaaaatgt tagcaccagt atacctaatt 25200 ttggttttct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc 25260 ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt 25320 atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg 25380 ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggca ca aactgtatgg 25440 gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata 25500 aggttcatgt tcactaatta acgaactatc aatgagagtt caaagaccac ccactctctt 25560 gttagtgttc tcactctctt ttttggtcac tg cattttca aaacctctct atgtacctga 25620 gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga 25680 tacagctggt ctttatacaa attttcgaat tgatgtccca tctgcagaat caactggtac 25740 tcaatcagtt tctgtcgatc gtgagtctac ttcaactcat gatggtctta ccgaacatgt 25800 tactagtgtg aatctttttg acgttggtta ctcagttaat taacgaactc tatggattac 25860 gtgtctctgc ttaatcaaat ttggcagaag taccttaatt caccgtatac tacttgtttg 25920 tatatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg 25980 ctgtggaact gtcagctatc ctttgctggt tatact gaat ctgctgttaa ttctacaaaa 26040 gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga 26100 atccctgacg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa 26160 gaggagtcat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg 26220 ccctgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga 262 80 ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa 26340 accttatggc ggccaacctg tttctgagta ctatattact ctagctttgc taaatctcac 26400 tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcg ca atgtcagatt 26460 tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta 26520 ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat 26580 taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat 26640 gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc 26700 atgctttaga acttat cctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc 26760 catacggtct tccaatcagg gtaataaaca aattgttcat tcttacccca ttttacatca 26820 tccaggattt taacgaacta tggctttctc ggcgtcttta tttaaacccg tccagctagt 26880 cccagtt tct cctgcatttc atcgcattga gtctactgac tctattgttt tcacatacat 26940 tcctgctagc ggctatgtag ctgctttagc tgtcaatgtg tgtctcattc ccctattatt 27000 actgctacgt caagatactt gtcgtcgcag cattatcaga actatggttc tctatttcct 27060 tgttctttat aactttttat tagccattgt actagtcaat ggtgtacatt atccaactgg 27120 aagttgcctg atagcct tct tagttatcct cataatactt tggtttgtag atagaattcg 27180 tttctgtctc atgctgaatt cctacattcc actgtttgac atgcgttctc actttattcg 27240 tgttagtaca gtttcttctc atggtatggt ccctgtcata cacaccaaac cattatttat 27300 tagaaacttc gatcagcgtt gcagctgttc tcgttgtttt tatttgcact cttctactta 27360 tatagagtgc acttatatta gccgttttag taagattagc ctagtttctg taact gactt 27420 ctccttaaac ggcaatgttt ccactgtttt cgtgcctgca acgcgcgatt cagttcctct 27480 tcacataatc gccccgagct cgcttatcgt ttaagcagct ctgcgctact atgggtcccg 27540 tgtagaggct aatccattag tctctctttg gacatatgga aaacgaacta tgttaccctt 27600 tgtccaagaa cgaatagggt tgttcatagt aaactttttc atttttaccg tagtatgtgc 27660 tataacactc ttggtgtgta tggctttcct tacggctact agattatgtg tgcaatgtat 27720 gacaggcttc aataccctgt tagttcagcc cgcattatac ttgtataata ctggacgttc 27780 agtctatgta aaattccagg atagtaaacc ccctctacca cctgacgagt gggtttaacg 27840 aactccttca taatgtctaa tatgacgcaa ctcactgagg cgcagattat tgccattatt 27900 aaagactgga actttgcatg gtccctgatc tttctcttaa ttactatcgt actacagtat 27960 ggatacccat cccgtagtat gactgtctat gtctttaaaa tgtttgttt t atggctccta 28020 tggccatctt ccatggcgct atcaatattt agcgccattt atccaattga tctagcttcc 28080 cagataatct ctggcattgt agcagctgtt tcagctatga tgtggatttc ctactttgtg 28140 cagagtatcc ggctgtttat gagaactgga tcatggtggt cattcaatcc tgagactaat 28200 tgccttttga atgttccaat tggtggtaca actgtcgtac gtccactcgt agaggactct 28260 accagtgtaa ctgctgttgt aaccaatggt cacctcaaaa tggctggcat gcatttcggt 28320 gcttgtgact acgacagact tcctaatgaa gtcaccgtgg ccaaacccaa tgtgctgatt 28380 gctttaaaaa tggtgaagcg gcaaagctac ggaactaatt ccggcgttgc cat ttaccat 28440 agatataagg caggtaatta caggagtccg cctattacgg cggatattga acttgcattg 28500 cttcgagctt aggctcttta gtaagagtat cttaattgat tttaacgaat ctcaatttca 28560 ttgttatggc atcccctgct gcacctcgtg ctgtttcctt tgccgataac aatgatataa 28620 caaatacaaa cctgtctcga ggtagaggac gtaatccaaa accacgagct gcaccaaata 28680 acactgtctc ttggt acact gggcttaccc aacacgggaa agtccctctt acctttccac 28740 ctgggcaggg tgtacctctt aatgccaatt ccacccctgc gcaaaatgct gggtattggc 28800 ggagacagga cagaaaaatt aataccggga atggaattaa gcaactggct cccaggtggt 28860 acttctacta cactggaact ggacccgaag cagcactccc attccgggct gttaaggatg 28920 gcatcgtttg ggtccatgaa gatggcgcca ctgatgctcc ttcaactttt gggacgcgga 28980 accctaacaa tgattcagct attgttacac aattcgcgcc cggtactaag cttcctaaaa 29040 acttccacat tgaggggact ggaggcaata gtcaatcatc ttcaagagcc tctagcgtaa 29100 gcagaaactc ttccagatct agttcaca ag gttcaagatc aggaaactct acccgcggca 29160 cttctccagg tccatctgga atcggagcag taggaggtga tctactttac cttgatcttc 29220 tgaacagact acaagccctt gagtctggca aagtaaagca atcgcagcca aaagtaatca 29280 ctaagaaaga tgctgctgct g ctaaaaata agatgcgcca caagcgcact tccaccaaaa 29340 gtttcaacat ggtgcaagct tttggtcttc gcggaccagg agacctccag ggaaactttg 29400 gtgatcttca attgaataaa ctcggcactg aggacccacg ttggccccaa attgctgagc 29460 ttgctcctac agccagtgct tttatgggta tgtcgcaatt taaacttacc catcagaaca 29520 atgatgatca tggcaaccct gtgtacttcc ttc ggtacag tggagccatt aaacttgacc 29580 caaagaatcc caactacaat aagtggttgg agcttcttga gcaaaatatt gatgcctaca 29640 aaaccttccc taagaaggaa aagaaacaaa aggcaccaaa agaagaatca acagaccaaa 29700 tgtctgaacc tccaaaggag cagcgtgtgc a aggtagcat cactcagcgc actcgcaccc 29760 gtccaagtgt tcagcctggt ccaatgattg atgttaacac tgattagtgt cactcaaagt 29820 aacaagatcg cggcaatcgt ttgtgtttgg taaccccatc tcaccatcgc ttgtccactc 29880 ttgcacagaa tggaatcatg ttgtaattac agtgcaataa ggtaattata acccatttaa 29940 ttgatagcta tgctttatta aagtgtgtag ctgtagagag aat gttaaag actgtcacct 30000 ctgcgtgatt gcaagtgaac agtgcccccc gggaagagct ctacagtgtg aaatgtaaat 30060aaaaatagct attattcaat tagattaggc taattagatg atttgcaaaa aaaaaaag 30118 <210> 5 <211> 30115 <212> DNA <213> Artificial Sequence <220> <223> ORFs_pel_P20 <400> 5 gatttaagtg aatagcttgg ctatctcgct tcccctcgtt ctcttgcaga actttgattt 60 taacgaactt aaataaaagc cctgttgttt agcgtattgt tgcacttgtc tggtgggatt 120 gtggcattaa tttgcctgct catctaggca gtggacatat g ctcaacact gggtataatt 180 ctaattgaat actatttttc agttagagcg tcgtgtctct tgtacgtctc ggtcacaata 240 tacggtttcg tccggtgcgt ggcaattcgg ggcacatcat gtctttcgtg gctggtgtga 300 tcgcgcaagg tgcgcgcggt ac gtatcgag cagcgctcaa ctctgaaaaa catcaagacc 360 atgtgtctct aactgtgcca ctctgtggtt caggaaacct ggttgaaaaa ctttcaccat 420 ggttcatgga tggcgaaaat gcctatgaag tggtgaaggc catgttactt aaaaaagagc 480 cacttctcta tgtgcccatc cggctggctg gacacactag acacctccca ggtcctcgtg 540 tgtacctggt tgagaggctc attgcttgt g aaaatccatt catggttaac caattggctt 600 atagctctag tgcaaatggc agcctggttg gcacaacttt gcagggcaag cctattggta 660 tgttcttccc ttatgacatc gaacttgtca caggaaagca aaatattctc ctgcgcaagt 720 atggccgtgg tggttatcac tacaccccag tcc actatga gcgagacaac acctcttgcc 780 ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta 840 agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa 900 aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg 960 ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc 1020 tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt 1080 ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta 1140 ctcttggatg caaaatttta acgctcaccc cacgcaacaa gt ggagtggc gtttctgact 1200 tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa 1260 cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta 1320 cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg 1380 tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtg ct acttgcccct 1440 ttgctaaggg tgacagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt 1500 acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg 1560 gcgtagctta cgcctacttt ggatgt gagg aaggtactat gtactttgtg cctagagcta 1620 agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca 1680 aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg 1740 gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg 1800 acaaaatacg ccagcttctc aaaggtgtca ccattgacaa gttgcgtgat tatttagctg 1860 actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta 1920 caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt 1980 cctttaagaa agttgcaacc ataccgtaca aggtttgcaa ctctgtta ag gatactctga 2040 cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt 2100 catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt 2160 tagtccgcct cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc 2220 aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact 2280 tcttgtta ga tttggcagga ttgttcagaa tctttcttcg caatgcctat gtgtacactt 2340 cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaaacaa gtgttagact 2400 tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaata tca 2460 gtgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg 2520 tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt 2580 ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg 2640 tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc 2700 ctgatg ttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg 2760 aagaagacgg attcgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct 2820 ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg 288 0 aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac 2940 tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt 3000 ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc 3060 cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg 3120 agggtgatgc atctt ggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg 3180 aggagtgttc tgaagtagag gcttcaggtt tagaagaagg tgaatcagag tgcatttctg 3240 agacttcaac tgaacaagtt gacgtttctc atgaggtttc tgacgacgag tgggctgctg 3300 cagttgatga agcgttcccc ctcgatgaag cagaagatgt tactgaatct gtgcaagaag 3360 aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct 3420 tacaggaaac tcctgttgtg tctgatactg ttgaagtccc accgcaagtg gtgaaacttc 3480 cgtctgaacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg 3540 ataccgaaca gacacagagt gttact gtta aacctaagag gttacgcaaa aagcgtaatg 3600 ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag 3660 gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca 3720 cacatcttaa gcatggcggt ggtatcgctg gtgctattaa tgcggcttca aaaggggctg 3780 tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag 3840 ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc 3900 gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc 3960 ttgtagtcac tcctcttgtt tcaacaggca tatt tggtgt aaaaccagct gtgtcttttg 4020 attatcttat tagagaggct aagactagag ttttagtcgt cgttaattcc caagatgtct 4080 ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac 4140 gtggcgcaat acgtaaagct aaagatta tg gttttactgt ttttgtgtgc acagacaact 4200 ctgctaacac taaagttctt aggaaacaagg gtgttgatta tactaagaag tttcttacag 4260 ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac 4320 aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag 4380 acttaattca agcagggagt gtcgtgcgta gagttaacgt gccctacg tg tgtctcctag 4440 ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag 4500 attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg 4560 aactattggt gcaagactta cgcttaaata agctcctgca ttggt ctgat caaaccatat 4620 gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac 4680 tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct 4740 tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata 4800 gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgatacc attcc tgatg 4860 agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg 4920 cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta 4980 aggctgcagt ccataagtgg aagatggttg tgtgtgataa ggt acgttct ctcaaattga 5040 gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttatg aaggacatta 5100 aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg 5160 acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct 5220 ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt 5280 ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt 5340 gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc 5400 agtgtggtgg tgaacgtcat cggcaaatag tcgaacacac caccccct gg ttgctgctct 5460 caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcgttta 5520 atgtctttca gggcattgaa acggctgttg gccattatgt tcatgcttgc ctgaagggtg 5580 gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg 5640 tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt 5700 ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg 5760 atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg 5820 gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta 5880 ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat 5940 acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt 6000 atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaaca 6060 aagcatctta tgatactaat cttaataagt tcaatagagc tagtttgcgt caaatttttg 6120 acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggcg tccacaccag 6180 ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta 6240 agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgttgat gactcaggta 6300 ctcccgtt gt tgagtatctg tctaaagaag atctacatac attgtatgta gaccctaagt 6360 atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg 6420 agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac 6480 tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg 6540 ctgtaggtag ttgtataaag agtgtagtg c ggcatctagg tgttaactaaa ggcatattga 6600 caggctgttt tagttttgtc aagatgttat ttattcttcc actagcttac tttagtgatt 6660 caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagctggc gttgtgacag 6720 gtaatgttgt aaaacagtg t tgcactgctg ctgttgattt aagtatggat aagttgcgcc 6780 gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt 6840 tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg 6900 aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt 6960 ctgcttgtga cggtcttgct tcagcttata g ggcgaattc atttgatgta cctacattct 7020 gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact 7080 acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt 7140 tgtggtttgc attcgagact ggtttgg cat acatgctcta tacctcggcc ttcaactggt 7200 tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc 7260 ggtcatacaa ttatgctgtg tctagtgcct tctggttatt tacccacatt ccaatggcgg 7320 gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc 7380 atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataaga gg aaccgactta 7440 ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa 7500 atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacattgcag 7560 gtgtggggaa taccttcatc tgtgaagaag tcg caaatga cctcactacc gccctacgca 7620 ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga 7680 ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct 7740 gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta 7800 tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta 7 860 ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa 7920 gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg 7980 ttaatagttt cgtctcgctg tataatgtca cacgcgata a gttggaaaaa cttatctcta 8040 ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg 8100 acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact 8160 ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagttac aataattatg 8220 taccctcata tgttaaacct gatagtgtgt ctaccagtga tttaggtagt ctcattgatt 8280 gtaatgc ggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgtatttgga 8340 acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc 8400 gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct 84 60 tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgtgt 8520 tgcgtgactt tacgttaaag ggttacgttc ttgctaccat tattgtgttt ctgtgtgctg 8580 tactgatgta tttgtgttta cctacatttt ctatggtacc tgttgaattt tatgaagacc 8640 gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata 8700 agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg 8760 tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg 8820 cgcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attt tctttg 8880 tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct 8940 ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg 9000 cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt 9060 acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat 9120 ttcctgaagt agtatt tgaa agtacactta ggattactag aactctgtca actcagtact 9180 gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt 9240 gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta 9300 ttgacattgt cagg cggtta gcagtatcac tgttccagcc tattacttat ttccaattga 9360 ctacctcatt ggtcttgggt ataggtttgt gtgcattcct gactttgctc ttctattata 9420 ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg 9480 ctgctgttct taatagcttg tgcatctgct ttgttgcctc tataccatg tgtatagtac 9540 cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta 9600 tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct 9660 atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac 9720 atg tagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata 9780 tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct 9840 attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag 9900 ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagtgaga 9960 ctggtagtga tcttctttac caaccaccca actgtagcat aacctct ggc gtgttgcaaa 10020 gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta 10080 cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac 10140 acgtaatgtg cccggctgac cag ttgtctg atcctaatta tgatgccttg ttgatttcta 10200 tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg 10260 ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca 10320 ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct 10380 ataatggtcg tccgactggt acattcactg ttgtaatgc g ccctaactac acaattaagg 10440 gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca 10500 atttttgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg 10560 atggtactat gtatggtgcc tttat ggata aacaagtgca ccaagttcag ttaacagaca 10620 aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt 10680 ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc 10740 aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg 10800 ctattgaaca gctgctttat gcgatccaac aactttatac tgggt tccag ggaaagcaaa 10860 tccttggcag tactatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta 10920 tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt 10980 tcgcgaccct tgtttcaacc tatg tgataa tcttacaagc cactaaattt actttgtgga 11040 actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct 11100 tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg 11160 ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc 11220 tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact aca catactg 11280 atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca 11340 acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt 11400 atagcattgg agaagcctca agccccattg cctatctggt tttt gtcact acactcacta 11460 gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca 11520 tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat 11580 tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct tttttgaacc 11640 ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat 11700 t catgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact 11760 ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac 11820 ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag 1 1880 aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgacata ttggcagcaa 11940 cagaccccag tgaggctttc gggaaattcg taagtctctt tgccacttta atgacttttt 12000 ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc 12060 aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga 12120 aagccta tca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc 12180 agaaggctgt taatatagct aaaaacgcct atgagaagga taaggcagtg gcccgtaagt 12240 tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca 12300 agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg 12360 acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg 12420 tcattccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga 12480 atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta 12540 taaacaatgt ggacaatgaa att gttaagt cttcagatgt tgtagacagc aatgaaaatt 12600 taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa 12660 ataatgagat caaaccttca ggtttaaaaa ccatggttgt gtctgcaggt caagagcaaa 12720 ctaactgtaa t actagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga 12780 tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat 12840 ttgttagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg 12900 aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag 12960 ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt 13020 cttcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg 13080 tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta 13140 caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag 13200 cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta 13260 aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt 13320 gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg 13380 actcgcttag gcaagtagca ctgccccaat ctaaagatt c caatttttta aacgagtccg 13440 gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt 13500 ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta 13560 caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta 13620 ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgattt 13680 gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt 13740 taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata 13800 tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagta tgg 13860 ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag 13920 tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt 13980 taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtg ctcacac tagacaacca 14040 ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg 14100 agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg 14160 tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact 14220 tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg 14280 ggatcagac g tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg 14340 tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt 14400 ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggtta tc actacaaaga 14460 attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga 14520 gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga 14580 tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt 14640 gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa 147 00 ggagggctct tcagttacgc tcaaacattt tttctttgct caagatggta atgctgctat 14760 tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt 14820 gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtctta atgc 14880 ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg 14940 caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tctttgccat 15000 gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc 15060 taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca 15120 gtaccatcag aaaat gctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg 15180 tactacaaag ttctatggtg gctgggattt catgcttaaa acattgtaca aagatgttga 15240 taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg 15300 tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga 15360 cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg 15420 tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc 15480 caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc 15540 taatggcaac aagattgtt g acaaagaagt taaagacatg cagtttgatt tgtatgtcaa 15600 tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa 15660 taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta 15720 t gcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa 15780 caatgtcttt atgtctgaag ctaaatgctg ggtgggaaacc gatctgaaga aagggccaca 15840 tgaattctgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc 15900 ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac 15960 tgacggtaca ctcatggtag agcggtttgt gt ctttggct atagatgctt accctctcac 16020 aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa 16080 actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga 16140 taattctgct aagttttggg aagagg catt ctacagagat ctctatagtt cgcctaccac 16200 tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac 16260 atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc 16320 acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc 16380 agacgttact aagctatatt taggtggtat gagctacttt tgtg tagatc atagacctgt 16440 gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac 16500 aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg 16560 tgattacacc cttgccaata ctacaac aga accactcaaa ctttttgctg ctgagacttt 16620 acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt 16680 tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg 16740 taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta 16800 catcttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtata a 16860 actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc 16920 cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt 16980 acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcagg ttata gtaaatatgt 17040 cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta 17100 ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg 17160 tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc 17220 acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat att tgtttag 17280 tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat 17340 gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta 17400 tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga 17460 accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt 17520 aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa 17580 taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg 17640 caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa 17700 ttttatact gcca atccgg catggagtaa ggcagtcttt atttcgcctt ataattcaca 17760 gaatgctgtg gctcgttcaa tgctgggtct tactactcag actgttgatt cctcacaggg 17820 ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat 17880 taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc 17940 tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca 18000 gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc 18060 tgcttatgca ccaacatacg ttagtgttga tgacaagtat aagacgagtg atgagctttg 18120 cgtgaatctt aatttac ccg caaatatccc atactctcgt gttatttcca ggatgggctt 18180 taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt 18240 aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc 183 00 atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca 18360 gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcccgtcc 18420 tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc 18480 tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta 18540 ctgtacgttt gttt gttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa 18600 gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc 18660 tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt 18720 ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta 18780 ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt 18840 agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc 18900 acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc 18960 tcttcttgcc ggttcatttg a caaagtcta tgatattggc aatcctaaag gaattcctat 19020 tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccagaaaggt 19080 acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt 19140 ttgg aactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg 19200 tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca 19260 cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt 19320 cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat 19380 tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggc gctgt 19440 ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc 19500 atcaggtttc cgcctttggt gttataagac ctttgatatt tataatctct ggtctacttt 19560 tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat 19620 tggtgttgag ggtgaactac ctgtagcttt agtcaatgat aagatcttca ccaagagtgg 19680 cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga 19740 actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca 19800 agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata ttta tggtac 19860 tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg 19920 ttttgacata cgcgataatg gttcattgga gaagttcatg tctactccca atgccatctt 19980 tatttctgat agaaaaatta agaaataccc ttgtattgta ggtcctgatt atgcttactt 20040 caatggtgct atcatccgtg atagtgatgt tgttaaaacaa ccagtgaagt tctacttgta 20100 taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc 20160 ttgtagtgac ttcctacccc tgtctgacat ggagaaagac tttctatctt ttgatagtga 20220 tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga 2 0280 cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca 20340 ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt 20400 tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct 2 0460 tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa 20520 ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca 20580 aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc 20640 cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc 20700 tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta 20760 tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg 20820 ttctgataaa ggtatcgctc ctggtacatc agttttacga cagtggcttc ctacagatgc 20880 cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg 20940 agattgtgta actgtacgtg tcagccaaca agtggatctt gttatattccg acatgtatga 21000 tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct 21060 gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga 21120 acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt 21180 ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg 21240 tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa 21300 ttccactcct atgaatct ga gtacttactc actttttgat ttatccaagt ttcaattaaa 21360 attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc 21420 tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga 21480 tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg 21540 cttgtattga ggttgat ata caacagactt tctttgataa aacttggcct aggccaattg 21600 atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatattct aacataacta 21660 tcacttatca aggtcttttt ccctatcagg gagaccatgg tgatatgtat gtctactctg 21720 caggacatgc taca ggcaca actccacaaa agttgtttgt agctaactat tctcaggacg 21780 tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactggca 21840 ctgttattat tagcccatct acccgcgcta ctatacgaaa aatttaccct gcttttatgc 21900 tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc 21960 tagttctttt gcccgatgga tgtggcactt t acttagagc tttttatattgt attctagagc 22020 ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca 22080 ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta 22140 aggagtattt taatttac gt aactgcacct ttatgtacac ttataacatt accgaagatg 22200 agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc 22260 ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata 22320 ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag 22380 cttgggctgc cttctacgta tataaacttc aaccg ttaac tttcctgttg gatttttctg 22440 ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact 22500 gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa 22560 aaccttctgg ctcagt tgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc 22620 tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt 22680 ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat 22740 ctccagcagc aattgctagc aactgttatt cttcactgat tttggattat ttttcatacc 22800 cacttagtat gaaatccgat ctcagtgtta gttctgctgg tccaatat cc cagtttaatt 22860 ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta 22920 ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt cttctttctg 22980 atgatcgtac tgaagtacct cagttagtga acgcta atca atactcaccc tgtgtatcca 23040 ttctcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg 23100 aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga 23160 tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg 23220 aatttgctaa tgacacaaaa attgcctttc aattaggcaa ttgcgtggaa tattccctct 232 80 atggtgtttc gggccgtggt gtctttcaga attgcacagc tgtaggtgtt cgacagcagc 23340 gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact 23400 actgtttgcg tgcttgtgtt agtgttcctg ttt ctgtcat ctatgataaa gaaactaaaa 23460 cccacgctac tctatttggt agtgttgcat gtgaacacat ttcctctacc atgtctcaat 23520 actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggt ccccttcaga 23580 cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt 23640 tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca 23700 gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc 23760 aggttgatca acttaatagt agttatttta aattaagtat acctactaat ttttcctttg 23820 gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat t gtaaacagt 23880 acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt 23940 ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt 24000 tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact 24060 ttaatttgac acttctaaaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg 24120 ctattgagga tt tgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt 24180 acgatgattg tatgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg 24240 tggctggtta taaagtatta cctcctctta tggatgttaa tatggaagcc gcgtacactt 24300 catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg 24360 ctattccatt tgcacagagt attttttata ggttaaacgg tgttggcatt actcaacagg 24420 ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc 24480 aaacaggctt cactacaact aatgaagctt ttcggaaggt tcaggatgct gtgaacaaca 24540 atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg 24600 cctctattgg agacatcata caacgtcttg acgttctcga acaggacgcc caaatagaca 24660 gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt 24720 ctgaatcagc t gctctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg 24780 cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa 24840 atgcccctaa tggcctttac tttatgcatg ttggttatta ccctagcaac cacattgagg 24900 ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta 24960 atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct 25020 cgtccttcta tgcacctgag cccatcacct ctcttaatac taagtatgtt gcaccacagg 25080 tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccggga 25140 ttgacttcca agatgagttg gatgagt ttt tcaaaaatgt tagcaccagt atacctaatt 25200 ttggttttct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc 25260 ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt 25320 atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg 25380 ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggca ca aactgtatgg 25440 gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata 25500 aggttcatgt tcactaatta acgaactatc aatgagagtt caaagaccac ccactctctt 25560 gttagtgttc tcactctctt ttttggtcac tg cattttca aaacctctct atgtacctga 25620 gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga 25680 tacagctggt ctttatacaa attttcgaat tgatgtccca tctgcagaat caactggtac 25740 tcaatcagtt tctgtcgatc gtgagtctac ttcaactcat gatggtctta ccgaacatgt 25800 tactagtgtg aatctttttg acgttggtta ctcagttaat taacgaactc tatggattac 25860 gtgtctctgc ttaatcaaat ttggcagaag taccttaatt caccgtatac tacttgtttg 25920 tatatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg 25980 ctgtggaact gtcagctatc ctttgctggt tatact gaat ctgctgttaa ttctacaaaa 26040 gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga 26100 atccctgacg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa 26160 gaggagtcat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg 26220 ccctgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga 262 80 ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa 26340 accttatggc ggccaacctg tttctgagta ccatattact ctagctttgc taaatctcac 26400 tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcgca atgtcagatt 26460 tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta 26520 ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat 26580 taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat 26640 gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc 26700 atgctttaga acttat cctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc 26760 catacggtct tccaatcagg gtaataaaca aattgttcat tcttacccca ttttacatca 26820 tccaggattt taacgaacta tggctttctc ggcgtctttt aaacccgtcc agctagtccc 26880 a gtttctcct gcatttcatc gcattgagtc tactgactct attgttttca catacattcc 26940 tgctagcggc tatgtagctg ctttagctgt caatgtgtgt ctcattcccc tattattact 27000 gctacgtcaa gatacttgtc gtcgcagcat tatcagaact atggttctct atttccttgt 27060 tctttataac tttttattag ccattgtact agtcaatggt gtacattatc caactggaag 27120 ttgcctgata gcctt cttag ttatcctcat aatactttgg tttgtagata gaattcgttt 27180 ctgtctcatg ctgaattcct acattccact gtttgacatg cgttctcact ttaattcgtgt 27240 tagtacagtt tcttctcatg gtatggtccc tgtcatacac accaaaccat tatttattag 27300 aaacttcgat cagcgttgca gctgttctcg ttgtttttat ttgcactctt ctacttatat 27360 agagtgcact tatattagcc gttttagtaa gattagccta gtttctgta a ctgacttctc 27420 cttaaacggc aatgtttcca ctgttttcgt gcctgcaacg cgcgattcag ttcctcttca 27480 cataatcgcc ccgagctcgc ttatcgttta agcagctctg cgctactatg ggtcccgtgt 27540 agaggctaat ccattag tct ctctttggac atatggaaaa cgaactatgt taccctttgt 27600 ccaagaacga atagggttgt tcatagtaaa ctttttcatt tttaccgtag tatgtgctac 27660 aacactcttg gtgtgtatgg ctttccttac ggctactaga ttatgtgtgc aatgtatgac 27720 aggcttcaat accctgttag ttcagcccgc attatacttg tataatactg gacgttcagt 27780 ctatgtaaaa ttccaggata gtaaaccccc tctaccacct gacgagtggg tttaacga ac 27840 tccttcataa tgtctaatat gacgcaactc actgaggcgc agattatgc cattattaaa 27900 gactggaact ttgcatggtc cctgatcttt ctcttaatta ctatcgtact acagtatgga 27960 tacccatccc gtagtatgac tgtctatgtc tttaaaatgt ttgtttta tg gctcctatgg 28020 ccatcttcca tggcgctatc aatatttagc gccatttatc caattgatct agcttcccag 28080 ataatctctg gcattgtagc agctgtttca gctatgatgt ggatttccta ctttgtgcag 28140 agtatccggc tgtttatgag aactggatca tggtggtcat tcaatcctga gactaattgc 28200 cttttgaatg ttccaattgg tggtacaact gtcgtacgtc cactcgtaga ggactctacc 28 260 agtgtaactg ctgttgtaac caatggtcac ctcaaaatgg ctggcatgca tttcggtgct 28320 tgtgactacg acagacttcc taatgaagtc accgtggcca aacccaatgt gctgattgct 28380 ttaaaaatgg tgaagcggca aagctacgga actaattccg gcgtt gccat ttaccataga 28440 tataaggcag gtaattacag gagtccgcct attacggcgg atattgaact tgcattgctt 28500 cgagcttagg ctctttagta agagtatctt aattgatttt aacgaatctc aatttcattg 28560 ttatggcatc ccctgctgca cctcgtgctg tttcctttgc cgataacaat gatataacaa 28620 atacaaacct gtctcgaggt agaggacgta atccaaaacc acgagctgca ccaaataaca 28680 ctgtctcttg g tacactggg cttacccaac acgggaaagt ccctcttacc tttccacctg 28740 ggcagggtgt acctcttaat gccaattcca cccctgcgca aaatgctggg tattggcgga 28800 gacaggacag aaaaattaat accgggaatg gaattaagca actggctccc aggtggtact 28860 tct actacac tggaactgga cccgaagcag cactcccatt ccgggctgtt aaggatggca 28920 tcgtttgggt ccatgaagat ggcgccactg atgctccttc aacttttggg acgcggaacc 28980 ctaacaatga ttcagctatt gttacacaat tcgcgcccgg tactaagctt cctaaaaact 29040 tccacattga ggggactgga ggcaatagtc aatcatcttc aagagcctct agcgtaagca 29100 gaaactcttc cagatctagt tcaca aggtt caagatcagg aaactctacc cgcggcactt 29160 ctccaggtcc atctggaatc ggagcagtag gaggtgatct actttacctt gatcttctga 29220 acagactaca agcccttgag tctggcaaag taaagcaatc gcagccaaaa gtaatcacta 29280 agaaagatgc tgct gctgct aaaaataaga tgcgccacaa gcgcacttcc accaaaagtt 29340 tcaacatggt gcaagctttt ggtcttcgcg gaccaggaga cctccaggga aactttggtg 29400 atcttcaatt gaataaactc ggcactgagg acccacgttg gccccaaatt gctgagcttg 29460 ctcctacagc cagtgctttt atgggtatgt cgcaatttaa acttacccat cagaacaatg 29520 atgatcatgg caaccctgtg tacttccttc ggt acagtgg agccattaaa cttgacccaa 29580 agaatcccaa ctacaataag tggttggagc ttcttgagca aaatattgat gcctacaaaa 29640 ccttccctaa gaaggaaaag aaacaaaagg caccaaaaga agaatcaaca gaccaaatgt 29700 ctgaacctcc aaaggagcag cgtgtg caag gtagcatcac tcagcgcact cgcacccgtc 29760 caagtgttca gcctggtcca atgattgatg ttaacactga ttagtgtcac tcaaagtaac 29820 aagatcgcgg caatcgtttg tgtttggtaa ccccatctca ccatcgcttg tccactcttg 29880 cacagaatgg aatcatgttg taattacagt gcaataaggt aattataacc catttaattg 29940 atagctatgc tttattaaag tgtgtagctg tagagagaat gttaaagact gtcacc tctg 30000 cgtgattgca agtgaacagt gccccccggg aagagctcta cagtgtgaaa tgtaaataaa 30060aatagctatt attcaattag attaggctaa ttagatgatt tgcaaaaaaa aaaaa 30115 <210> 6 <211> 30108 <212> DNA <213> Artificial Sequence <220> <223> MT387202 <400> 6 gatttaagtg aatagcttgg ctatctcact tcccctcgtt ctcttgcagr actttgattt 60 taacgaactt aaataaaagc cctgttgttt agcgtattgt tgcacttgtc tggtgggatt 120 gtggcattaa tttgcctgct catctaggca gtggacatat g ctcaacact gggtataatt 180 ctaattgaat actatttttc agttagagcg tcgtgtctct tgtacgtctc ggtcacaata 240 tacggtttcg tccggtgcgt ggcaattcgg ggcacatcat gtctttcgtg gctggtgtga 300 tcgcgcaagg tgcgcgcggt ac gtatcgag cagcgctcaa ctctgaaaaa catcaagacc 360 atgtgtctct aactgtgcca ctctgtggtt caggaaacct ggttgaaaaa ctttcaccat 420 ggttcatgga tggcgaaaat gcctatgaag tggtgaaggc catgttactt aaaaaagagc 480 cacttctcta tgtgcccatc cggctggctg gacacactag acacctccca ggtcctcgtg 540 tgtacctggt tgagaggctc attgcttgt g aaaatccatt catggttaac caattggctt 600 atagctctag tgcaaatggc agcctggttg gcacaacttt gcagggcaag cctattggta 660 tgttcttccc ttatgacatc gaacttgtca caggaaagca aaatattctc ctgcgcaagt 720 atggccgtgg tggttatcac tacaccccag tcc actatga gcgagacaac acctcttgcc 780 ctgagtggat ggacgatttt gaggcggatc ctaaaggcaa atatgcccag aatctgctta 840 agaagttgat tggcggtgat gtcactccag ttgaccaata catgtgtggc gttgatggaa 900 aacccattag tgcctacgca tttttaatgg ccaaggatgg aataaccaaa ctggctgatg 960 ttgaagcgga cgtcgcagca cgtgctgatg acgaaggctt catcacatta aagaacaatc 1020 tatatagatt ggtttggcat gttgagcgta aagacgttcc atatcctaag caatctattt 1080 ttactattaa tagtgtggtc caaaaggatg gtgttgaaaa cactcctcct cactatttta 1140 ctcttggatg caaaatttta acgctcaccc cacgcaacaa gt ggagtggc gtttctgact 1200 tgtccctcaa acaaaaactc ctttacacct tctatggtaa ggagtcactt gagaacccaa 1260 cctacattta ccactccgca ttcattgagt gtggaagttg tggtaatgat tcctggctta 1320 cagggaatgc tatccaaggg tttgcctgtg gatgtggggc atcatataca gctaatgatg 1380 tcgaagtcca atcatctggc atgattaagc caaatgctct tctttgtg ct acttgcccct 1440 ttgctaaggg tgacagctgt tcttctaatt gcaaacattc agttgctcag ttggttagtt 1500 acctttctga acgctgtaat gttattgctg attctaagtc cttcacactt atctttggtg 1560 gcgtagctta cgcctacttt ggatgt gagg aaggtactat gtactttgtg cctagagcta 1620 agtctgttgt ctcaaggatt ggagactcca tctttacagg ctgtactggc tcttggaaca 1680 aggtcactca aattgctaac atgttcttgg aacagactca gcattccctt aactttgtgg 1740 gagagttcgt tgtcaacgat gttgtcctcg caattctctc tggaaccaca actaatgttg 1800 acaaaatacg ccagcttctc aaaggtgtca ccattgacaa gttgcgtgat tatttagctg 1860 actatgacgt agcagtcact gccggcccat tcatggataa tgctattaat gttggtggta 1920 caggattaca gtatgccgcc attactgcac cttatgtagt tctcactggc ttaggtgagt 1980 cctttaagaa agttgcaacc ataccgtaca aggtttgcaa ctctgtta ag gatactctga 2040 cttattatgc tcacagcgtg ttgtacagag tttttcctta tgacatggat tctggtgtgt 2100 catcctttag tgaactactt tttgattgcg ttgatctttc agtagcttct acctattttt 2160 tagtccgcct cttgcaagat aagactggcg actttatgtc tacaattatt acttcctgcc 2220 aaactgctgt tagtaagctt ctagatacat gttttgaagc tacagaagca acatttaact 2280 tcttgtta ga tttggcagga ttgttcagaa tctttcttcg caatgcctat gtgtacactt 2340 cacaagggtt tgtggtggtc aatggcaaag tttctacact tgtcaaaacaa gtgttagact 2400 tgcttaataa gggtatgcaa cttttgcata caaaggtctc ctgggctggt tctaata tca 2460 gtgctgttat ctacagcggc agggagtctc taatattccc atcgggaacc tattactgtg 2520 tcaccactaa ggctaagtcc gttcaacaag atcttgacgt tattttgcct ggtgagtttt 2580 ccaagaagca gttaggactg ctccaaccta ctgacaattc tacaactgtt agtgttactg 2640 tatccagtaa catggttgaa actgttgtgg gtcaacttga gcaaactaat atgcatagtc 2700 ctgatg ttat agtaggtgac tatgtcatta ttagtgaaaa attgtttgtg cgtagtaagg 2760 aagaagacgg attcgccttc taccctgctt gcactaatgg tcatgctgta ccgactctct 2820 ttagacttaa gggaggtgca cctgtaaaaa aagtagcctt tggcggtgat caagtacatg 288 0 aggttgctgc tgtaagaagt gttactgtcg agtacaacat tcatgctgta ttagacacac 2940 tacttgcttc ttctagtctt agaacctttg ttgtagataa gtctttgtca attgaggagt 3000 ttgctgacgt agtaaaggaa caagtctcag acttgcttgt taaattactg cgtggaatgc 3060 cgattccaga ttttgattta gacgatttta ttgacgcacc atgctattgc tttaacgctg 3120 agggtgatgc atctt ggtct tctactatga tcttctctct tcaccccgtc gagtgtgacg 3180 aggagtgttc tgaagtagag gcttcaggtt tagaagaagg tgaatcagag tgcatttctg 3240 agacttcaac tgaacaagtt gacgtttctc atgaggtttc tgacgacgag tgggctgctg 3300 cagttgatga agcgttcccc ctcgatgaag cagaagatgt tactgaatct gtgcaagaag 3360 aagcacaacc agtagaagta cctgttgaag atattgcgca ggttgtcata gctgacacct 3420 tacaggaaac tcctgttgtg tctgatactg ttgaagtccc accgcaagtg gtgaaacttc 3480 cgtctgaacc tcagactatc cagcccgagg taaaagaagt tgcacctgtc tatgaggctg 3540 ataccgaaca gacacagagt gttact gtta aacctaagag gttacgcaaa aagcgtaatg 3600 ttgacccttt gtccaatttt gaacataagg ttattacaga gtgcgttacc atagttttag 3660 gtgacgcaat tcaagtagcc aagtgctatg gggagtctgt gttagttaat gctgctaaca 3720 cacatcttaa gcatggcggt ggtatcgctg gtgctattaa tgcggcttca aaaggggctg 3780 tccaaaaaga gtcagatgag tatattctgg ctaaagggcc gttacaagta ggagattcag 3840 ttctcttgca aggccattct ctagctaaga atatcctgca tgtcgtaggc ccagatgccc 3900 gcgctaaaca ggatgtttct ctccttagta agtgctataa ggctatgaat gcatatcctc 3960 ttgtagtcac tcctcttgtt tcaacaggca tatt tggtgt aaaaccagct gtgtcttttg 4020 attatcttat tagagaggct aagactagag ttttagtcgt cgttaattcc caagatgtct 4080 ataagagtct taccatagtt gacattccac agagtttgac tttttcatat gatgggttac 4140 gtggcgcaat acgtaaagct aaagatta tg gttttactgt ttttgtgtgc acagacaact 4200 ctgctaacac taaagttctt aggaaacaagg gtgttgatta tactaagaag tttcttacag 4260 ttgacggtgt gcaatattat tgctacacgt ctaaggacac tttagatgat atcttacaac 4320 aggctaataa gtctgttggt attatatcta tgcctttggg atatgtgtct catggtttag 4380 acttaattca agcagggagt gtcgtgcgta gagttaacgt gccctacg tg tgtctcctag 4440 ctaataaaga gcaagaagct attttgatgt ctgaagacgt taagttaaac ccttcagaag 4500 attttataaa gcacgtccgc actaatggtg gttacaattc ttggcattta gtcgagggtg 4560 aactattggt gcaagactta cgcttaaata agctcctgca ttggt ctgat caaaccatat 4620 gctacaagga tagtgtgttt tatgttgtaa agaatagtac agcttttcca tttgaaacac 4680 tttcagcatg tcgtgcgtat ttggattcac gcacgacaca gcagttaaca atcgaagtct 4740 tagtgactgt cgatggtgta aattttagaa cagtcgttct aaataataag aacacttata 4800 gatcacagct tggatgcgtt ttctttaatg gtgctgatat ttctgatacc attcc tgatg 4860 agaaacagaa tggtcacagt ttatatctag cagacaattt gactgctgat gaaacaaagg 4920 cgcttaaaga gttatatggc cccgttgatc ctactttctt acacagattc tattcactta 4980 aggctgcagt ccataagtgg aagatggttg tgtgtgataa ggt acgttct ctcaaattga 5040 gtgataataa ttgttatctt aatgcagtta ttatgacact tgatttatg aaggacatta 5100 aatttgttat acctgctcta cagcatgcat ttatgaaaca taagggcggt gattcaactg 5160 acttcatagc cctcattatg gcttatggca attgcacatt tggtgctcca gatgatgcct 5220 ctcggttact tcataccgtg cttgcaaagg ctgagttatg ctgttctgca cgcatggttt 5280 ggagagagtg gtgcaatgtc tgtggcataa aagatgttgt tctacaaggc ttaaaagctt 5340 gttgttacgt gggtgtgcaa actgttgaag atctgcgtgc tcgcatgaca tatgtatgcc 5400 agtgtggtgg tgaacgtcat cggcaaatag tcgaacacac caccccct gg ttgctgctct 5460 caggcacacc aaatgaaaaa ttggtgacaa cctccacggc gcctgatttt gtagcgttta 5520 atgtctttca gggcattgaa acggctgttg gccattatgt tcatgcttgc ctgaagggtg 5580 gtcttatttt aaagtttgac tctggcaccg ttagcaagac ttcagactgg aagtgcaagg 5640 tgacagatgt acttttcccc ggccaaaaat acagtagcga ttgtaatgtc gtacggtatt 5700 ctttggacgg taatttcaga acagaggttg atcccgacct atctgctttc tatgttaagg 5760 atggtaaata ctttacaagt gaaccacccg taacatattc accagctaca attttagctg 5820 gtagtgtcta cactaatagc tgccttgtat cgtctgatgg acaacctggc ggtgatgcta 5880 ttagtttgag ttttaataac cttttagggt ttgattctag taaaccagtc actaagaaat 5940 acacttactc cttcttgcct aaagaagacg gcgatgtgtt gttggctgag tttgacactt 6000 atgaccctat ttataagaat ggtgccatgt ataaaggcaa accaattctt tgggtcaaca 6060 aagcatctta tgatactaat cttaataagt tcaatagagc tagtttgcgt caaatttttg 6120 acgtagcccc cattgaactc gaaaataaat tcacaccttt gagtgtggcg tccacaccag 6180 ttgaacctcc aactgtagat gtggtagcac ttcaacagga aatgacaatt gtcaaatgta 6240 agggtttaaa taaacctttc gtgaaggaca atgtcagttt cgttgttgat gactcaggta 6300 ctcccgtt gt tgagtatctg tctaaagaag atctacatac attgtatgta gaccctaagt 6360 atcaagtcat tgtcttaaaa gacaatgtac tttcttctat gcttagattg cacaccgttg 6420 agtcaggtga tattaacgtt gttgcagctt ccggatcttt gacacgtaaa gtgaagttac 6480 tatttagggc ttcattttat ttcaaagaat ttgctacccg cactttcact gctaccactg 6540 ctgtaggtag ttgtataaag agtgtagtg c ggcatctagg tgttaactaaa ggcatattga 6600 caggctgttt tagttttgtc aagatgttat ttattcttcc actagcttac tttagtgatt 6660 caaaactcgg caccacagag gttaaagtga gtgctttgaa aacagctggc gttgtgacag 6720 gtaatgttgt aaaacagtg t tgcactgctg ctgttgattt aagtatggat aagttgcgcc 6780 gtgtggattg gaaatcaacc ctacggttgt tacttatgtt atgcacaact atggtattgt 6840 tgtcttctgt gtatcacttg tatgtcttca atcaggtctt atcaagtgat gttatgtttg 6900 aagatgccca aggtttgaaa aagttctaca aagaagttag agcttaccta ggaatctctt 6960 ctgcttgtga cggtcttgct tcagcttata g ggcgaattc atttgatgta cctacattct 7020 gcgcaaaccg ttctgcaatg tgtaattggt gcttgattag ccaagattcc ataactcact 7080 acccagctct taagatggtt caaacacatc ttagccacta tgttcttaac atagattggt 7140 tgtggtttgc attcgagact ggtttgg cat acatgctcta tacctcggcc ttcaactggt 7200 tgttgttggc aggtacattg cattatttct ttgcacagac ttccatattt gtagactggc 7260 ggtcatacaa ttatgctgtg tctagtgcct tctggttatt tacccacatt ccaatggcgg 7320 gtttggtacg aatgtataat ttgttagcat gcctttggct tttacgcaag ttttatcagc 7380 atgtaatcaa tggttgcaaa gatacggcat gcttgctctg ctataaga gg aaccgactta 7440 ctagagttga agcttctacc gttgtctgtg gtggaaaacg tacgttttat atcacagcaa 7500 atggcggtat ttcattctgt cgtaggcata attggaattg tgtggattgt gacattgcag 7560 gtgtggggaa taccttcatc tgtgaagaag tcg caaatga cctcactacc gccctacgca 7620 ggcctattaa cgctacggat agatcacatt attatgtgga ttccgttaca gttaaagaga 7680 ctgttgttca gtttaattat cgtagagacg gtcaaccatt ctacgagcgg tttcccctct 7740 gcgcttttac aaatctagat aagttgaagt tcaaagaggt ctgtaaaact actactggta 7800 tacctgaata caactttatc atctacgact catcagatcg tggccaggaa agtttagcta 7 860 ggtctgcatg tgtttattat tctcaagtct tgtgtaaatc aattcttttg gttgactcaa 7920 gtttggttac ttctgttggt gattctagtg aaatcgccac taaaatgttt gattcctttg 7980 ttaatagttt cgtctcgctg tataatgtca cacgcgata a gttggaaaaa cttatctcta 8040 ctgctcgtga tggcgtaagg cgaggcgata acttccatag tgtcttaaca acattcattg 8100 acgcagcacg aggccccgca ggtgtggagt ctgatgttga gaccaatgaa attgttgact 8160 ctgtgcagta tgctcataaa catgacatac aaattactaa tgagagttac aataattatg 8220 taccctcata tgttaaacct gatagtgtgt ctaccagtga tttaggtagt ctcattgatt 8280 gtaatgc ggc ttcagttaac caaattgtct tgcgtaattc taatggtgct tgtatttgga 8340 acgctgctgc atatatgaaa ctctcggatg cacttaaacg acagattcgc attgcatgcc 8400 gtaagtgtaa tttagctttc cggttaacca cctcaaagct acgcgctaat gataatatct 84 60 tatcagttag attcactgct aacaaaattg ttggtggtgc tcctacatgg tttaatgtgt 8520 tgcgtgactt tacgttaaag ggttacgttc ttgctaccat tattgtgttt ctgtgtgctg 8580 tactgatgta tttgtgttta cctacatttt ctatggtacc tgttgaattt tatgaagacc 8640 gcatcttgga ctttaaagtt cttgataatg gtatcattag ggatgtaaat cctgatgata 8700 agtgctttgc taataagcac cggtccttca cacaatggta tcatgagcat gttggtggtg 8760 tctatgacaa ctctatcaca tgcccattga cagttgcagt aattgctgga gttgctggtg 8820 ctcgcattcc agacgtacct actacattgg cttgggtgaa caatcagata attt tctttg 8880 tttctcgagt ctttgctaat acaggcagtg tttgctacac tcctatagat gagataccct 8940 ataagagttt ctctgatagt ggttgcattc ttccatctga gtgcactatg tttagggatg 9000 cagagggccg tatgacacca tactgccatg atcctactgt tttgcctggg gcttttgcgt 9060 acagtcagat gaggcctcat gttcgttacg acttgtatga tggtaacatg tttattaaat 9120 ttcctgaagt agtatt tgaa agtacactta ggattactag aactctgtca actcagtact 9180 gccggttcgg tagttgtgag tatgcacaag agggtgtttg tattaccaca aatggctcgt 9240 gggccatttt taatgaccac catcttaata gacctggtgt ctattgtggc tctgatttta 9300 ttgacattgt cagg cggtta gcagtatcac tgttccagcc tattacttat ttccaattga 9360 ctacctcatt ggtcttgggt ataggtttgt gtgcattcct gactttgctc ttctattata 9420 ttaataaagt aaaacgtgct tttgcagatt acacccagtg tgctgtaatt gctgttgttg 9480 ctgctgttct taatagcttg tgcatctgct ttgttgcctc tataccatg tgtatagtac 9540 cttacactgc attgtactat tatgctacat tctattttac taatgagcct gcatttatta 9600 tgcatgtttc ttggtacatt atgttcgggc ctatcgttcc catatggatg acctgcgtct 9660 atacagttgc aatgtgcttt agacacttct tctgggtttt agcttatttt agtaagaaac 9720 atg tagaagt ttttactgat ggtaagctta attgtagttt ccaggacgct gcctctaata 9780 tctttgttat taacaaggac acttatgcag ctcttagaaa ctctttaact aatgatgcct 9840 attcacgatt tttggggttg tttaacaagt ataagtactt ctctggtgct atggaaacag 9900 ccgcttatcg tgaagctgca gcatgtcatc ttgctaaagc cttacaaaca tacagtgaga 9960 ctggtagtga tcttctttac caaccaccca actgtagcat aacctct ggc gtgttgcaaa 10020 gcggtttggt gaaaatgtca catcccagtg gagatgttga ggcttgtatg gttcaggtta 10080 cctgcggtag catgactctt aatggtcttt ggcttgacaa cacagtctgg tgcccacgac 10140 acgtaatgtg cccggctgac cag ttgtctg atcctaatta tgatgccttg ttgatttcta 10200 tgactaatca tagtttcagt gtgcaaaaac acattggcgc tccagcaaac ttgcgtgttg 10260 ttggtcatgc catgcaaggc actcttttga agttgactgt cgatgttgct aaccctagca 10320 ctccagccta cacttttaca acagtgaaac ctggcgcagc atttagtgtg ttagcatgct 10380 ataatggtcg tccgactggt acattcactg ttgtaatgc g ccctaactac acaattaagg 10440 gttcctttct gtgtggttct tgtggtagtg ttggttacac caaggagggt agtgtgatca 10500 atttttgtta catgcatcaa atggaacttg ctaatggtac acataccggt tcagcatttg 10560 atggtactat gtatggtgcc tttat ggata aacaagtgca ccaagttcag ttaacagaca 10620 aatactgcag tgttaatgta gtagcttggc tttacgcagc aatacttaat ggttgcgctt 10680 ggtttgtaaa acctaatcgc actagtgttg tttcttttaa tgaatgggct cttgccaacc 10740 aattcactga atttgttggc actcaatccg ttgacatgtt agctgtcaaa acaggcgttg 10800 ctattgaaca gctgctttat gcgatccaac aactttatac tgggt tccag ggaaagcaaa 10860 tccttggcag tactatgttg gaagatgaat tcacacctga ggatgttaat atgcagatta 10920 tgggtgtggt tatgcagagt ggtgtgagaa aagttacata tggtactgcg cattggttgt 10980 tcgcgaccct tgtttcaacc tatg tgataa tcttacaagc cactaaattt actttgtgga 11040 actacttgtt tgagactatt cccacacagt tgttcccact cttatttgtg actatggcct 11100 tcgttatgtt gttggttaaa cacaaacaca cctttttgac acttttcttg ttgcctgtgg 11160 ctatttgttt gacttatgca aacatagtct acgagcccac tactcccatt tcgtcagcgc 11220 tgattgcagt tgcaaattgg cttgccccca ctaatgctta tatgcgcact aca catactg 11280 atattggtgt ctacattagt atgtcacttg tattagtcat tgtagtgaag agattgtaca 11340 acccatcact ttctaacttt gcgttagcat tgtgcagtgg tgtaatgtgg ttgtacactt 11400 atagcattgg agaagcctca agccccattg cctatctggt tttt gtcact acactcacta 11460 gtgattatac gattacagtc tttgttactg tcaaccttgc aaaagtttgc acttatgcca 11520 tctttgctta ctcaccacag cttacacttg tgtttccgga agtgaagatg atacttttat 11580 tatacacatg tttaggtttc atgtgtactt gctattttgg tgtcttctct tttttgaacc 11640 ttaagcttag agcacctatg ggtgtctatg actttaaggt ctcaacacaa gagttcagat 11700 t catgactgc taacaatcta actgcaccta gaaattcttg ggaggctatg gctctgaact 11760 ttaagttaat aggtattggc ggtacacctt gtataaaggt tgctgctatg cagtctaaac 11820 ttacagatct taaatgcaca tctgtggttc tcctctctgt gctccaacag ttacacttag 1 1880 aggctaatag tagggcctgg gctttctgtg ttaaatgcca taatgacata ttggcagcaa 11940 cagaccccag tgaggctttc gagaaattcg taagtctctt tgccacttta atgacttttt 12000 ctggtaatgt agatcttgat gcgttagcta gtgatatttt tgacactcct agcgtacttc 12060 aagctactct ttctgagttt tcacacttag ctacctttgc tgagttggaa gctgcgcaga 12120 aagccta tca ggaagctatg gactctggtg acacctcacc acaagttctt aaggctttgc 12180 agaaggctgt taatatagct aaaaacgcct atgagaagga taaggcagtg gcccgtaagt 12240 tagaacgtat ggctgatcag gctatgactt ctatgtataa gcaagcacgt gctgaagaca 12300 agaaagcaaa aattgtcagt gctatgcaaa ctatgttgtt tggtatgatt aagaagctcg 12360 acaacgatgt tcttaatggt atcatttcta acgctaggaa tggttgtata cctcttagtg 12420 tcattccact gtgtgcttca aataaacttc gcgttgtaat tcctgacttc accgtctgga 12480 atcaggtagt cacatatccc tcgcttaact acgctggggc tttgtgggac attacagtta 12540 taaacaatgt ggacaatgaa att gttaagt cttcagatgt tgtagacagc aatgaaaatt 12600 taacatggcc acttgtttta gaatgcacta gggcatccac ttctgccgtt aagttgcaaa 12660 ataatgagat caaaccttca ggtttaaaaa ccatggttgt gtctgcaggt caagagcaaa 12720 ctaactgtaa t actagttcc ttagcttatt acgaacctgt gcagggtcgt aaaatgctga 12780 tggctcttct ttctgataat gcctatctca aatgggcgcg tgttgaaggt aaggacggat 12840 ttgttagtgt agagctacaa cctccttgca aattcttgat tgcgggacca aaaggacctg 12900 aaatccgata tctctatttt gttaaaaatc ttaacaacct tcatcgcggg caagtgttag 12960 ggcacattgc tgcgactgtt agattgcaag ctggttctaa caccgagttt gcctctaatt 13020 cttcggtgtt gtcacttgtt aacttcaccg ttgatcctca aaaagcttat ctcgatttcg 13080 tcaatgcggg aggtgcccca ttgacaaatt gtgttaagat gcttactcct aaaactggta 13140 caggtatagc tatatctgtt aaaccagaga gtacagctga tcaagagact tatggtggag 13200 cttcagtgtg tctctattgc cgtgcgcata tagaacatcc tgatgtctct ggtgtttgta 13260 aatataaggg taagtttgtc caaatccctg ctcagtgtgt ccgtgaccct gtgggatttt 13320 gtttgtcaaa taccccctgt aatgtctgtc aatattggat tggatatggg tgcaattgtg 13380 actcgcttag gcaagtagca ctgccccaat ctaaagatt c caatttttta aacgagtccg 13440 gggttctatt gtaaatgccc gaatagaacc ctgttcaagt ggtttgtcca ctgatgtcgt 13500 ctttagggca tttgacatct gcaactataa ggctaaggtt gctggtattg gaaaatacta 13560 caagactaat acttgtaggt ttgtagaatt agatgaccaa gggcatcatt tagactccta 13620 ttttgtcgtt aagaggcata ctatggagaa ttatgaacta gagaagcact gttacgattt 13680 gttacgtgac tgtgatgctg tagctcccca tgatttcttc atctttgatg tagacaaagt 13740 taaaacacct catattgtac gtcagcgttt aactgagtac actatgatgg atcttgtata 13800 tgccctgagg cactttgatc aaaatagcga agtgcttaag gctatcttag tgaagta tgg 13860 ttgctgtgat gttacctact ttgaaaataa actctggttt gattttgttg aaaatcccag 13920 tgttattggt gtttatcata aacttggaga acgtgtacgc caagctatct taaacactgt 13980 taaattttgt gaccacatgg tcaaggctgg tttagtcggt gtg ctcacac tagacaacca 14040 ggaccttaat ggcaagtggt atgattttgg tgacttcgta atcactcaac ctggttcagg 14100 agtagctata gttgatagct actattctta tttgatgcct gtgctctcaa tgaccgattg 14160 tctggccgct gagacacata gggattgtga ttttaataaa ccactcattg agtggccact 14220 tactgagtat gattttactg attataaggt acaactcttt gagaagtact ttaaatattg 14280 ggatcagac g tatcacgcaa attgcgttaa ttgtactgat gaccgttgtg tgttacattg 14340 tgctaatttc aatgtattgt ttgctatgac catgcctaag acttgtttcg gacccatagt 14400 ccgaaagatc tttgttgatg gcgtgccatt tgtagtatct tgtggtta tc actacaaaga 14460 attaggttta gtcatgaata tggatgttag tctccataga cataggctct ctcttaagga 14520 gttgatgatg tatgccgctg atccagccat gcacattgcc tcctctaacg cttttcttga 14580 tttgaggaca tcatgtttta gtgtcgctgc acttacaact ggtttgactt ttcaaactgt 14640 gcggcctggc aattttaacc aagacttcta tgatttcgtg gtatctaaag gtttctttaa 147 00 ggagggctct tcagttacgc tcaaacattt tttctttgct caagatggta atgctgctat 14760 tacagattat aattactatt cttataatct gcctactatg tgtgacatca aacaaatgtt 14820 gttctgcatg gaagttgtaa acaagtactt cgaaatctat gacggtggtt gtctta atgc 14880 ttctgaagtg gttgttaata atttagacaa gagtgctggc catcctttta ataagtttgg 14940 caaagctcgt gtctattatg agagcatgtc ttaccaggag caagatgaac tctttgccat 15000 gacaaagcgt aacgtcattc ctaccatgac tcaaatgaat ctaaaatatg ctattagtgc 15060 taagaataga gctcgcactg ttgcaggcgt gtccatactt agcacaatga ctaatcgcca 15120 gtaccatcag aaaat gctta agtccatggc tgcaactcgt ggagcgactt gcgtcattgg 15180 tactacaaag ttctatggtg gctgggattt catgcttaaa acattgtaca aagatgttga 15240 taatccgcat cttatgggtt gggattaccc taagtgtgat agagctatgc ctaatatgtg 15300 tagaatcttc gcttcactca tattagctcg taaacatggc acttgttgta ctacaaggga 15360 cagattttat cgcttggcaa atgagtgtgc tcaggtgcta agcgaatatg ttctatgtgg 15420 tggtggttac tacgtcaaac ctggaggtac cagtagcgga gatgccacca ctgcatatgc 15480 caatagtgtc tttaacattt tgcaggcgac aactgctaat gtcagtgcac ttatgggtgc 15540 taatggcaac aagattgtt g acaaagaagt taaagacatg cagtttgatt tgtatgtcaa 15600 tgtttacagg agcactagcc cagaccccaa atttgttgat aaatactatg cttttcttaa 15660 taagcacttt tctatgatga tactgtctga tgacggtgtc gtttgctata atagtgatta 15720 t gcagctaag ggttacattg ctggaataca gaattttaag gaaacgctgt attatcagaa 15780 caatgtcttt atgtctgaag ctaaatgctg ggtgggaaacc gatctgaaga aagggccaca 15840 tgaattctgt tcacagcata cgctttatat taaggatggc gacgatggtt acttccttcc 15900 ttatccagac ccttcaagaa ttttgtctgc cggttgcttt gtagatgata tcgttaagac 15960 tgacggtaca ctcatggtag agcggtttgt gt ctttggct atagatgctt accctctcac 16020 aaagcatgaa gatatagaat accagaatgt attctgggtc tacttacagt atatagaaaa 16080 actgtataaa gaccttacag gacacatgct tgacagttat tctgtcatgc tatgtggtga 16140 taattctgct aagttttggg aagagg catt ctacagagat ctctatagtt cgcctaccac 16200 tttgcaggct gtcggttcat gcgttgtatg ccattcacag acttccctac gctgtgggac 16260 atgcatccgt agaccatttc tctgctgtaa atgctgctat gatcatgtta tagcaactcc 16320 acataagatg gttttgtctg tttctcctta cgtttgtaat gcccctggtt gtggcgtttc 16380 agacgttact aagctatatt taggtggtat gagctacttt tgtg tagatc atagacctgt 16440 gtgtagtttt ccactttgcg ctaatggtct tgtattcggc ttatacaaga atatgtgcac 16500 aggtagtcct tctatagttg aatttaatag gttggctacc tgtgactgga ctgaaagtgg 16560 tgattacacc cttgccaata ctacaac aga accactcaaa ctttttgctg ctgagacttt 16620 acgtgccact gaagaggcgt ctaagcagtc ttatgctatt gccaccatca aagaaattgt 16680 tggtgagcgc caactattac ttgtgtggga ggctggcaag tccaaaccac cactcaatcg 16740 taattatgtt tttactggtt atcatataac caaaaatagt aaagtgcagc tcggtgagta 16800 catcttcgag cgcattgatt atagtgatgc tgtatcctac aagtctagta caacgtata a 16860 actgactgta ggtgacatct tcgtacttac ctctcactct gtggctacct tgacggcgcc 16920 cacaattgtg aatcaagaga ggtatgttaa aattactggg ttgtacccaa ccattacggt 16980 acctgaagag ttcgcaagtc atgttgccaa cttccaaaaa tcagg ttata gtaaatatgt 17040 cactgttcag ggaccacctg gcactggcaa aagtcatttt gctatagggt tagcgattta 17100 ctaccctaca gcacgtgttg tttatacagc atgttcacac gcagctgttg atgctttgtg 17160 tgaaaaagct tttaaatatt tgaacattgc taaatgttcc cgtatcattc ctgcaaaggc 17220 acgtgttgag tgctatgaca ggtttaaagt taatgagaca aattctcaat att tgtttag 17280 tactattaat gctctaccag aaacttctgc cgatattctg gtggttgatg aggttagtat 17340 gtgcactaat tatgatcttt caattattaa tgcacgtatt aaagctaagc acattgtcta 17400 tgtaggagat ccagcacagt tgccagctcc taggactttg ttgactagag gcacattgga 17460 accagaaaat ttcaatagtg tcactagatt gatgtgtaac ttaggtcctg acatattttt 17520 aagtatgtgc tacaggtgtc ctaaggaaat agtaagcact gtgagcgctc ttgtctacaa 17580 taataaattg ttagccaaga aggagctttc aggccagtgc tttaaaatac tctataaggg 17640 caatgtgacg catgatgcta gctctgccat taatagacca caactcacat ttgtgaagaa 17700 ttttatact gcca atccgg catggagtaa ggcagtcttt atttcgcctt ataattcaca 17760 gaatgctgtg gctcgttcaa tgctgggtct tactactcag actgttgatt cctcacaggg 17820 ttcagaatac cagtacgtta tcttctgtca aacagcagat acggcacatg ctaacaacat 17880 taacagattt aatgttgcaa tcactcgtgc ccaaaaaggt attctttgtg ttatgacatc 17940 tcaggcactc tttgagtcct tagagtttac tgaattgtct tttactaatt acaagctcca 18000 gtctcagatt gtaactggcc tttttaaaga ttgctctaga gaaacttctg gcctctcacc 18060 tgcttatgca ccaacatacg ttagtgttga tgacaagtat aagacgagtg atgagctttg 18120 cgtgaatctt aatttac ccg caaatatccc atactctcgt gttatttcca ggatgggctt 18180 taaactcgat gcaacagttc ctggatatcc taagcttttc attactcgtg aagaggctgt 18240 aaggcaagtt cgaagctgga taggcttcga tgttgagggt gctcatgctt cccgtaatgc 183 00 atgtggcacc aatgtgcctc tacaattagg attttcaact ggtgtgaact ttgttgttca 18360 gccagttggt gttgtagaca ctgagtgggg taacatgtta acgggcattg ctgcccgtcc 18420 tccaccaggt gaacagttta agcacctcgt gcctcttatg cataaggggg ctgcgtggcc 18480 tattgttaga cgacgtatag tgcaaatgtt gtcagacact ttagacaaat tgtctgatta 18540 ctgtacgttt gttt gttggg ctcatggctt tgaattaacg tctgcatcat acttttgcaa 18600 gataggtaag gaacagaagt gttgcatgtg caatagacgc gctgcagcgt actcttcacc 18660 tctgcaatct tatgcctgct ggactcattc ctgcggttat gattatgtct acaacccttt 18720 ctttgtcgat gttcaacagt ggggttatgt aggcaatctt gctactaatc acgatcgtta 18780 ttgctctgtc catcaaggag ctcatgtggc ttctaatgat gcaataatga ctcgttgttt 18840 agctattcat tcttgtttta tagaacgtgt ggattgggat atagagtatc cttatatctc 18900 acatgaaaag aaattgaatt cctgttgtag aatcgttgag cgcaacgtcg tacgtgctgc 18960 tcttcttgcc ggttcatttg a caaagtcta tgatattggc aatcctaaag gaattcctat 19020 tgttgatgac cctgtggttg attggcatta ttttgatgca cagcccttga ccagaaaggt 19080 acaacagctt ttctatacag aggacatggc ctcaagattt gctgatgggc tctgcttatt 19140 ttgg aactgt aatgtaccaa aatatcctaa taatgcaatt gtatgcaggt ttgacacacg 19200 tgtgcattct gagttcaatt tgccaggttg tgatggcggt agtttgtatg ttaacaagca 19260 cgcttttcat acaccagcat atgatgtgag tgcattccgt gatctgaaac ctttaccatt 19320 cttttattat tctactacac catgtgaagt gcatggtaat ggtagtatga tagaggatat 19380 tgattatgta cccctaaaat ctgcagtctg tattacagct tgtaatttag ggggc gctgt 19440 ttgtaggaag catgctacag agtacagaga gtatatggaa gcatataatc ttgtctctgc 19500 atcaggtttc cgcctttggt gttataagac ctttgatatt tataatctct ggtctacttt 19560 tacaaaagtt caaggtttgg aaaacattgc ttttaatgtt gttaaacaag gccattttat 19620 tggtgttgag ggtgaactac ctgtagctgt agtcaatgat aagatcttca ccaagagtgg 19680 cgttaatgac atttgtatgt ttgagaataa aaccactttg cctactaata tagcttttga 19740 actctatgct aagcgtgctg tacgctcgca tcccgatttc aaattgctac acaatttaca 19800 agcagacatt tgctacaagt tcgtcctttg ggattatgaa cgtagcaata ttta tggtac 19860 tgctactatt ggtgtatgta agtacactga tattgatgtt aattcagctt tgaatatatg 19920 ttttgacata cgcgataatg gttcattgga gaagttcatg tctactccca atgccatctt 19980 tatttctgat agaaaaatta agaaataccc ttgtattgta ggtcctgatt atgcttactt 20040 caatggtgct atcatccgtg atagtgatgt tgttaaaacaa ccagtgaagt tctacttgta 20100 taagaaagtc aataatgagt ttattgatcc tactgagtgt atttacactc agagtcgctc 20160 ttgtagtgac ttcctacccc tgtctgacat ggagaaagac tttctatctt ttgatagtga 20220 tgttttcatt aagaagtatg gcttggaaaa ctatgctttt gagcacgtag tctatggaga 2 0280 cttctctcat actacgttag gcggtcttca cttgcttatt ggtttataca agaagcaaca 20340 ggaaggtcat attattatgg aagaaatgct aaaaggtagc tcaactattc ataactattt 20400 tattactgag actaacacag cggcttttaa ggcggtgtgt tctgttatag atttaaagct 2 0460 tgacgacttt gttatgattt taaagagtca agaccttggc gtagtatcca aggttgtcaa 20520 ggttcctatt gacttaacaa tgattgagtt tatgttatgg tgtaaggatg gacaggttca 20580 aaccttctac cctcgactcc aggcttctgc agattggaaa cctggtcatg caatgccatc 20640 cctctttaaa gttcaaaatg taaaccttga acgttgtgag cttgctaatt acaagcaatc 20700 tattcctatg cctcgcggtg tgcacatgaa catcgctaaa tatatgcaat tgtgccagta 20760 tttaaatact tgcacattag ccgtgcctgc caatatgcgt gttatacatt ttggcgctgg 20820 ttctgataaa ggtatcgctc ctggtacatc agttttacga cagtggcttc ctacagatgc 20880 cattattata gataatgatt taaatgagtt cgtgtcagat gctgacataa ctttatttgg 20940 agattgtgta actgtacgtg tcagccaaca agtggatctt gttatattccg acatgtatga 21000 tcctactact aagaatgtaa caggtagtaa tgagtcaaag gctttattct ttacttacct 21060 gtgtaacctc attaataata atcttgctct tggtgggtct gttgctatta aaataacaga 21120 acactcttgg agcgttgaac tttatgaact tatgggaaaa tttgcttggt ggactgtttt 21180 ctgcaccaat gcaaatgcat cctcatctga aggattcctc ttaggtatta attacttggg 21240 tactattaaa gaaaatatag atggtggtgc tatgcacgcc aactatatat tttggagaaa 21300 ttccactcct atgaatct ga gtacttactc actttttgat ttatccaagt ttcaattaaa 21360 attaaaagga acaccagttc ttcaattaaa ggagagtcaa attaacgaac tcgtaatatc 21420 tctcctgtcg cagggtaagt tacttatccg tgacaatgat acactcagtg tttctactga 21480 tgttcttgtt aacacctaca gaaagttacg ttgatgtagg gccagattct gttaagtctg 21540 cttgtattaa ggttgat ata caacagactt tctttgataa aacttggcct aggccaattg 21600 atgtttctaa ggctgacggt attatatacc ctcaaggccg tacatattct aacataacta 21660 tcacttatca aggtcttttt ccctatcagg gagaccatgg tgatatgtat gtctactctg 21720 caggacatgc taca ggcaca actccacaaa agttgtttgt agctaactat tctcaggacg 21780 tcaaacagtt tgctaatggg tttgtcgtcc gtataggagc agctgccaat tccactggca 21840 ctgttattat tagcccatct acccgcgcta ctatacgaaa aatttaccct gcttttatgc 21900 tgggttcttc agttggtaat ttctcagatg gtaaaatggg ccgcttcttc aatcatactc 21960 tagttctttt gcccgatgga tgtggcactt t acttagagc tttttatattgt attctagagc 22020 ctcgctctgg aaatcattgt cctgctggca attcctatac ttcttttgcc acttatcaca 22080 ctcctgcaac agattgttct gatggcaatt acaatcgtaa tgccagtctg aactctttta 22140 aggagtattt taatttac gt aactgcacct ttatgtacac ttataacatt accgaagatg 22200 agattttaga gtggtttggc attacacaaa ctgctcaagg tgttcacctc ttctcatctc 22260 ggtatgttga tttgtacggc ggcaatatgt ttcaatttgc caccttgcct gtttatgata 22320 ctattaagta ttattctatc attcctcaca gtattcgttc tatccaaagt gatagaaaag 22380 cttgggctgc cttctacgta tataaacttc aaccg ttaac tttcctgttg gatttttctg 22440 ttgatggtta tatacgcaga gctatagact gtggttttaa tgatttgtca caactccact 22500 gctcatatga atccttcgat gttgaatctg gagtttattc agtttcgtct ttcgaagcaa 22560 aaccttctgg ctcagt tgtg gaacaggctg aaggtgttga atgtgatttt tcacctcttc 22620 tgtctggcac acctcctcag gtttataatt tcaagcgttt ggtttttacc aattgcaatt 22680 ataatcttac caaattgctt tcactttttt ctgtgaatga ttttacttgt agtcaaatat 22740 ctccagcagc aattgctagc aactgttatt cttcactgat tttggattat ttttcatacc 22800 cacttagtat gaaatccgat ctcagtgtta gttctgctgg tccaatat cc cagtttaatt 22860 ataaacagtc cttttctaat cccacatgtt tgattttagc gactgttcct cataacctta 22920 ctactattac taagcctctt aagtacagct atattaacaa gtgctctcgt cttctttctg 22980 atgatcgtac tgaagtacct cagttagtga acgcta atca atactcaccc tgtgtatcca 23040 ttctcccatc cactgtgtgg gaagacggtg attattatag gaaacaacta tctccacttg 23100 aaggtggtgg ctggcttgtt gctagtggct caactgttgc catgactgag caattacaga 23160 tgggctttgg tattacagtt caatatggta cagacaccaa tagtgtttgc cccaagcttg 23220 aatttgctaa tgacacaaaa attgcctytc aattaggcaa ttgcgtggaa tattccctct 2328 0 atggtgtttc gggccgtggt gtctttcaga attgcacagc tgtaggtgtt cgacagcagc 23340 gctttgttta tgatgcgtac cagaatttag ttggctatta ttctgatgat ggcaactact 23400 actgtttgcg tgcttgtgtt agtgttcctg tttct gtcat ctatgataaa gaaactaaaa 23460 cccacgctac tctatttggt agtgttgcat gtgaacacat ttcctctacc atgtctcaat 23520 actcccgttc tacgcgatca atgcttaaac ggcgagattc tacatatggt ccccttcaga 23580 cacctgttgg ttgtgtccta ggacttgtta attcctcttt gttcgtagag gactgcaagt 23640 tgcctcttgg tcaatctctc tgtgctcttc ctgacacacc tagtactctc acacctcgca 23700 gtgtgcgctc tgttccaggt gaaatgcgct tggcatccat tgcttttaat catcctattc 23760 aggttgatca acttaatagt agttatttta aattaagtat acctactaat ttttcctttg 23820 gtgtgactca ggagtacatt cagacaacca ttcagaaagt tactgttgat t gtaaacagt 23880 acgtttgcaa tggtttccag aagtgtgagc aattactgcg cgagtatggc cagttttgtt 23940 ccaaaataaa ccaggctctc catggtgcca atttacgcca ggatgattct gtacgtaatt 24000 tgtttgcgag cgtgaaaagc tctcaatcat ctcctatcat accaggtttt ggaggtgact 24060 ttaatttgac acttctaaaa cctgtttcta tatctactgg cagtcgtagt gcacgtagtg 24120 ctattgagga tt tgctattt gacaaagtca ctatagctga tcctggttat atgcaaggtt 24180 acgatgattg tatgcagcaa ggtccagcat cagctcgtga tcttatttgt gctcaatatg 24240 tggctggtta taaagtatta cctcctctta tggatgttaa tatggaagcc gcgtacactt 24300 catctttgct tggcagcata gcaggtgttg gctggactgc tggcttatcc tcctttgctg 24360 ctattccatt tgcacagagt attttttata ggttaaacgg tgttggcatt actcaacagg 24420 ttctttcaga gaaccaaaag cttattgcca ataagtttaa tcaggctctg ggagctatgc 24480 aaacaggctt cactacaact aatgaagctt ttcggaaggt tcaggatgct gtgaacaaca 24540 atgcacaggc tctatccaaa ttagctagcg agctatctaa tacttttggt gctatttccg 24600 cctctattgg agacatcata caacgtcttg acgttctcga acaggacgcc caaatagaca 24660 gacttattaa tggccgtttg acaacactaa atgcttttgt tgcacagcag cttgttcgtt 24720 ctgaatcagc t gctctttcc gctcaattgg ctaaagataa agtcaatgag tgtgtcaagg 24780 cacaatccaa gcgttctgga ttttgcggtc aaggcacaca tatagtgtcc tttgttgtaa 24840 atgcccctaa tggcctttac tttatgcatg ttggttatta ccctagcaac cacattgagg 24900 ttgtttctgc ttatggtctt tgcgatgcag ctaaccctac taattgtata gcccctgtta 24960 atggctactt tattaaaact aataacacta ggattgttga tgagtggtca tatactggct 25020 cgtccttcta tgcacctgag cccatcacct ctcttaatac taagtatgtt gcaccacagg 25080 tgacatacca aaacatttct actaacctcc ctcctcctct tctcggcaat tccaccggga 25140 ttgacttcca agatgagttg gatgagt ttt tcaaaaatgt tagcaccagt atacctaatt 25200 ttggttctct aacacagatt aatactacat tactcgatct tacctacgag atgttgtctc 25260 ttcaacaagt tgttaaagcc cttaatgagt cttacataga ccttaaagag cttggcaatt 25320 atacttatta caacaaatgg ccgtggtaca tttggcttgg tttcattgct gggcttgttg 25380 ccttagctct atgcgtcttc ttcatactgt gctgcactgg ttgtggca ca aactgtatgg 25440 gaaaacttaa gtgtaatcgt tgttgtgata gatacgagga atacgacctc gagccgcata 25500 aggttcatgt tcactaatta acgaactatc aatgagagtt caaagaccac ccactctctt 25560 gttagtgttc tcactctctt ttttggtcac tg cattttca aaacctctct atgtacctga 25620 gcattgtcag aattattctg gttgcatgct tagggcttgt attaaaactg cccaagctga 25680 tacagctggt ctttatacaa attttcgaat tgatgtccca tctgcagaat caactggtac 25740 tcaatcagtt tctgtcgatc gtgagtctac ttcaactcat gatggtctta ccgaacatgt 25800 tactagtgtg aatctttttg acgttggtta ctcagttaat taacgaactc tatggattac 25860 gtgtctctgc ttaatcaaat ttggcagaag taccttaatt caccgtatac tacttgtttg 25920 tatatcccta aacccacagc taagtataca cctttagttg gcacttcatt gcaccctgtg 25980 ctgtggaact gtcagctatc ctttgctggt tatact gaat ctgctgttaa ttctacaaaa 26040 gctttggcca aacaggacgc agctcagcga atcgcttggt tgctacataa ggatggagga 26100 atccctgacg gatgttccct ctacctccgg cactcaagtt tattcgcgca aagcgaggaa 26160 gaggagtcat tctccaacta agaaactgcg ctacgttaag cgtagatttt ctcttctgcg 26220 ccctgaagac cttagtgtta ttgtccaacc aacacactat gtcagggtta cattttcaga 262 80 ccccaacatg tggtatctac gttcgggtca tcatttacac tcagttcaca attggcttaa 26340 accttatggc ggccaacctg tttctgagta ccatattact ctagctttgc taaatctcac 26400 tgatgaagat ttagctagag atttttcacc cattgcgctc tttttgcgca atgtcagatt 26460 tgagctacat gagttcgcct tgctgcgcaa aactcttgtt cttaatgcat cagagatcta 26520 ctgtgctaac atacatagat ttaagcctgt gtatagagtt aacacggcaa tccctactat 26580 taaggattgg cttctcgttc agggattttc cctttaccat agtggcctcc ctttacatat 26640 gtcaatctct aaattgcatg cactggatga tgttactcgc aattacatca ttacaatgcc 26700 atgctttaga acttat cctc aacaaatgtt tgttactcct ttggccgtag atgttgtctc 26760 catacggtct tccaatcagg gtaataaaca aattgttcat tcttacccca ttttacatca 26820 tccaggattt taacgaacta tggctttctc ggcgtcttta tttaaacccg tccagctagt 26880 cccagtt tct cctgcatttc atcgcattga gtctactgac tctattgttt tcacatacat 26940 tcctgctagc ggctatgtag ctgctttagc tgtcaatgtg tgtctcattc ccctattatt 27000 actgctacgt caagatactt gtcgtcgcag cattatcaga actatggttc tctatttcct 27060 tgttctttat aactttttat tagccattgt actagtcaat ggtgtacatt atccaactgg 27120 aagttgcctg atagcct tct tagttatcct cataatactt tggtttgtag atagaattcg 27180 tttctgtctc atgctgaatt cctacattcc actgtttgac atgcgttctc actttattcg 27240 tgttagtaca gtttcttctc atggtatggt ccctgtcata cacaccaaac cattatttat 27300 tagaaacttc gatcagcgtt gcagctgttc tcgttgtttt tatttgcact cttctactta 27360 tatagagtgc acttatatta gccgttttag taagattagc ctagtttctg taact gactt 27420 ctccttaaac ggcaatgttt ccactgtttt cgtgcctgca acgcgcgatt cagttcctct 27480 tcacataatc gccccgagct cgcttatcgt ttaagcagct ctgcgctact atgggtcccg 27540 tgtagaggct aatccattag tctctctttg gacatatgga aaacgaacta tgttaccctt 27600 tgtccaagaa cgaatagggt tgttcatagt aaactttttc atttttaccg tagtatgtgc 27660 tataacactc ttggtgtgta tggctttcct tacggctact agattatgtg tgcaatgtat 27720 gacaggcttc aataccctgt tagttcagcc cgcattatac ttgtataata ctggacgttc 27780 agtctatgta aaattccagg atagtaaacc ccctctacca cctgacgagt gggtttaacg 27840 aactccttca taatgtctaa tatgacgcaa ctcactgagg cgcagattat tgccattatt 27900 aaagactgga actttgcatg gtccctgatc tttctcttaa ttactatcgt actacagtat 27960 ggatacccat cccgtagtat gactgtctat gtctttaaaa tgtttgttt t atggctccta 28020 tggccatctt ccatggcgct atcaatattt agcgccattt atccaattga tctagcttcc 28080 cagataatct ctggcattgt agcagctgtt tcagctatga tgtggatttc ctactttgtg 28140 cagagtatcc ggctgtttat gagaactgga tcatggtggt cattcaatcc tgagactaat 28200 tgccttttga atgttccaat tggtggtaca actgtcgtac gtccactcgt agaggactct 28260 accagtgtaa ctgctgttgt aaccaatggt cacctcaaaa tggctggcat gcatttcggt 28320 gcttgtgact acgacagact tcctaatgaa gtcaccgtgg ccaaacccaa tgtgctgatt 28380 gctttaaaaa tggtgaagcg gcaaagctac ggaactaatt ccggcgttgc cat ttaccat 28440 agatataagg caggtaatta caggagtccg cctattacgg cggatattga acttgcattg 28500 cttcgagctt aggctcttta gtaagagtat cttaattgat tttaacgaat ctcaatttca 28560 ttgttatggc atcccctgct gcacctcgtg ctgtttcctt tgccgataac aatgatataa 28620 caaatacaaa cctgtctcga ggtagaggac gtaatccaaa accacgagct gcaccaaata 28680 acactgtctc ttggt acact gggcttaccc aacacgggaa agtccctctt acctttccac 28740 ctgggcaggg tgtacctctt aatgccaatt ccacccctgc gcaaaatgct gggtattggc 28800 ggagacagga cagaaaaatt aataccggga atggaattaa gcaactggct cccaggtggt 28860 acttctacta cactggaact ggacccgaag cagcactccc attccgggct gttaaggatg 28920 gcatcgtttg ggtccatgaa gatggcgcca ctgatgctcc ttcaactttt gggacgcgga 28980 accctaacaa tgattcagct attgttacac aattcgcgcc cggtactaag cttcctaaaa 29040 acttccacat tgaggggact ggaggcaata gtcaatcatc ttcaagagcc tctagcgtaa 29100 gcagaaactc ttccagatct agttcaca ag gttcaagatc aggaaactct acccgcggca 29160 cttctccagg tccatctgga atcggagcag taggaggtga tctactttac cttgatcttc 29220 tgaacagact acaagccctt gagtctggca aagtaaagca atcgcagcca aaagtaatca 29280 ctaagaaaga tgctgctgct g ctaaaaata agatgcgcca caagcgcact tccaccaaaa 29340 gtttcaacat ggtgcaagct tttggtcttc gcggaccagg agacctccag ggaaactttg 29400 gtgatcttca attgaataaa ctcggcactg aggacccacg ttggccccaa attgctgagc 29460 ttgctcctac agccagtgct tttatgggta tgtcgcaatt taaacttacc catcagaaca 29520 atgatgatca tggcaaccct gtgtacttcc ttc ggtacag tggagccatt aaacttgacc 29580 caaagaatcc caactacaat aagtggttgg agcttcttga gcaaaatatt gatgcctaca 29640 aaaccttccc taagaaggaa aagaaacaaa aggcaccaaa agaagaatca acagaccaaa 29700 tgtctgaacc tccaaaggag cagcgtgtgc a aggtagcat cactcagcgc actcgcaccc 29760 gtccaagtgt tcagcctggt ccaatgattg atgttaacac tgattagtgt cactcaaagt 29820 aacaagatcg cggcaatcgt ttgtgtttgg taaccccatc tcaccatcgc ttgtccactc 29880 ttgcacagaa tggaatcatg ttgtaattac agtgcaataa ggtaattata acccatttaa 29940 ttgatagcta tgctttatta aagtgtgtag ctgtagagag aat gttaaag actgtcacct 30000 ctgcgtgatt gcaagtgaac agtgcccccc gggaagagct ctacagtgtg aaatgtaaat 30060aaaaaatagc tattattcaa ttagattagg ctaattagat gatttgca 30108

Claims (13)

Middle East respiratory syndrome coronavirus containing the gene of SEQ ID NO: 2. The Middle East respiratory syndrome coronavirus according to claim 1, wherein the virus is produced by a selective pressure method using neutralizing antibodies against the Middle East respiratory syndrome coronavirus. The Middle East respiratory syndrome coronavirus according to claim 2, wherein the neutralizing antibody is a monoclonal antibody against the spike protein of the Middle East respiratory syndrome coronavirus. The Middle East respiratory syndrome coronavirus according to claim 2, wherein the neutralizing antibody is a 90B2 monoclonal antibody against the spike protein of the Middle East respiratory syndrome coronavirus. The Middle East respiratory syndrome coronavirus according to claim 1, wherein the Middle East respiratory syndrome coronavirus is produced by subculturing 20 times in Vero cells. Processing the domestic isolate (KNIH-002) with neutralizing antibodies against the Middle East respiratory syndrome coronavirus at a concentration that can meet the selective pressure conditions;
Infecting Vero cells; and
A method of producing Middle East respiratory syndrome coronavirus comprising the gene of SEQ ID NO: 2, including the step of subculturing. The method of claim 6, wherein the neutralizing antibody is a monoclonal antibody against the spike protein of the Middle East respiratory syndrome coronavirus. The method of claim 6, wherein the neutralizing antibody is a 90B2 monoclonal antibody against the spike protein of the Middle East respiratory syndrome coronavirus. The method of producing Middle East respiratory syndrome coronavirus containing the gene of SEQ ID NO: 2 according to claim 6, wherein the concentration is 1 μg. The method of producing the Middle East respiratory syndrome coronavirus containing the gene of SEQ ID NO: 2 according to claim 6, wherein the subculture is performed 20 times. A vaccine composition containing the Middle East respiratory syndrome coronavirus of any one of claims 1 to 5 The vaccine composition according to claim 11, further comprising a pharmaceutically acceptable carrier or excipient. A method of vaccinating against Middle East respiratory syndrome coronavirus comprising administering the vaccine composition of claim 11 to a non-human animal.