KR20230153216A - Drug injection apparatus and method - Google Patents

Abstract

The drug injection device according to the present invention includes a drug injector that electrochemically drives an electroosmotic pump to inhale drug from a drug source and discharges the inhaled drug to the injection target; And for the drug injector, a control unit that outputs a control signal corresponding to an injection sequence defining driving of the electro-osmotic pump, wherein the injection sequence defines a voltage pulse or current pulse to be applied to the electro-osmotic pump. Comprising at least one pulse block, each of the pulse blocks defines a pair of pulse signals including a forward pulse and a reverse pulse that are applied to the electroosmosis pump to alternately generate negative pressure and positive pressure, and the electroosmosis The pump alternately generates negative and positive pressure for each pulse block to inhale and discharge the drug.

Description

Drug injection device and method {DRUG INJECTION APPARATUS AND METHOD}

The present invention relates to a drug injection device and method.

Drugs can be injected into the body in various ways, such as oral, subcutaneous, or intravenous administration, depending on the type, purpose, and method of treatment. A drug injector using a drug pump can automatically inject drugs into the body at the desired speed and volume at the required time. Therefore, drug injectors using drug pumps can be used in various forms as well as those used in hospitals or patients' daily living environments.

Insulin pumps, commonly called insulin injectors, are for diabetic patients who do not secrete insulin or secrete only a small amount of insulin. It is a medical device that plays the same role as the pancreas in controlling blood sugar levels by supplying insulin from the outside into the body accurately at a set time. .

These insulin pumps are used by insulin-dependent diabetic patients, and can continuously inject medication for 24 hours while attached to the patient. In this way, since insulin injectors must periodically inject drugs into diabetic patients over a long period of time, technology for miniaturization and automation of insulin injectors is being actively developed for user convenience.

However, as insulin injectors become miniaturized and automated, there are cases where it is difficult to actually ensure the operational stability of the insulin injector. This is mostly due to back pressure caused by various reactions between the drug and biological fluid at the tip of the cannula or needle. This is the main cause of clogging. In particular, when the amount of drug injected is small or when it is injected slowly, the problem of this clogging becomes more serious.

Therefore, there is a need for a method of continuously injecting drugs into a patient, stably injecting the correct amount of drugs, and controlling the injection of drugs so that the flow path is not blocked during drug injection.

In order to solve the above-mentioned problems, the technical task of the present invention is to provide a drug injection device and method that can inject a fixed amount of drug according to injection conditions.

However, the technical challenges that this embodiment aims to achieve are not limited to the technical challenges described above, and other technical challenges may exist.

As a technical means for solving the above-described technical problem, the drug injection device according to an embodiment of the present invention electrochemically drives an electroosmotic pump to inhale the drug from the drug source and discharge the inhaled drug to the injection target. drug injector; And for the drug injector, a control unit that outputs a control signal corresponding to an injection sequence defining driving of the electro-osmotic pump, wherein the injection sequence defines a voltage pulse or current pulse to be applied to the electro-osmotic pump. Comprising at least one pulse block, each of the pulse blocks defines a pair of pulse signals including a forward pulse and a reverse pulse that are applied to the electroosmosis pump to alternately generate negative pressure and positive pressure, and the electroosmosis The pump alternately generates negative and positive pressure for each pulse block to inhale and discharge the drug.

In addition, a drug injection method according to an embodiment of the present invention includes setting an injection sequence that determines the operation of the drug injection device; Applying a control signal corresponding to the injection sequence to the electro-osmotic pump; And in response to the control signal, the electro-osmotic pump alternately generates negative pressure and positive pressure for each pulse block to inhale and discharge the drug, wherein the injection sequence includes the voltage to be applied to the electro-osmotic pump. It includes at least one pulse block defining a pulse or current pulse, each of the pulse blocks comprising a pair of pulse signals including a forward pulse and a reverse pulse that are applied to the electroosmotic pump to alternately generate negative pressure and positive pressure. It is to define.

According to the means for solving the problem of the present invention described above, the drug injector can be controlled to inject a fixed amount of drug by setting an appropriate injection sequence for the drug injector using an electroosmotic pump.

In addition, the injection sequence for drug injection can be set using various data, increasing usability depending on the user and situation.

Figure 1 is a block diagram schematically showing a drug injection device according to an embodiment of the present invention.
FIG. 2 is a block diagram schematically showing the configuration of the drug injector shown in FIG. 1.
Figure 3 is a diagram illustrating the concept of an injection sequence according to an embodiment of the present invention.
Figure 4 is an exemplary diagram showing an injection sequence according to an embodiment of the present invention.
Figure 5 is a block diagram schematically showing the configuration of the electroosmotic pump shown in Figure 2.
FIG. 6 is a block diagram schematically showing the configuration of the driving unit shown in FIG. 5.
FIG. 7 is an exemplary diagram schematically showing the configuration of the driving unit shown in FIG. 6.
Figure 8 is an application example of a drug injection device according to an embodiment of the present invention.
FIG. 9 is a block diagram schematically showing the configuration of the drug injection device shown in FIG. 8.
FIG. 10 is a block diagram schematically showing the configuration of the drug injection device shown in FIG. 8.
Figure 11a is an example of a table in which a plurality of injection sequences are stored.
Figure 11b is an example diagram showing information on a plurality of pulse blocks.
Figure 12 is a flowchart for explaining a drug injection method according to an embodiment of the present invention.

Hereinafter, the present invention will be described in detail with reference to the attached drawings. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein. In addition, the attached drawings are only intended to facilitate understanding of the embodiments disclosed in this specification, and the technical idea disclosed in this specification is not limited by the attached drawings. In order to clearly explain the present invention in the drawings, parts not related to the description are omitted, and the size, shape, and shape of each component shown in the drawings may be modified in various ways. Throughout the specification, identical/similar parts are given identical/similar reference numerals.

The suffixes "module" and "part" for components used in the following description are given or used interchangeably only for the ease of preparing the specification, and do not have distinct meanings or roles in themselves. Additionally, in describing the embodiments disclosed in this specification, if it is determined that detailed descriptions of related known technologies may obscure the gist of the embodiments disclosed in this specification, the detailed descriptions are omitted.

Throughout the specification, when a part is said to be “connected (connected, contacted, or combined)” with another part, this means not only when it is “directly connected (connected, contacted, or combined),” but also when it has other members in between. It also includes cases where they are “indirectly connected (connected, contacted, or combined).” Additionally, when a part is said to "include (equip or provide)" a certain component, this does not exclude other components, unless specifically stated to the contrary, but rather "includes (provides or provides)" other components. It means that you can.

Terms representing ordinal numbers, such as first, second, etc., used in this specification are used only for the purpose of distinguishing one component from another component and do not limit the order or relationship of the components. For example, the first component of the present invention may be named a second component, and similarly, the second component may also be named a first component.

FIG. 1 is a block diagram schematically showing the configuration of a drug injection device according to an embodiment of the present invention, and FIG. 2 is a block diagram schematically showing the configuration of the drug injector shown in FIG. 1.

When describing the drug injection device 10 according to an embodiment of the present invention with reference to FIGS. 1 and 2, the drug injection device 10 includes a drug injector 100 and a control unit 200.

The drug injector 100 electrochemically drives the electroosmotic pump 110 to inhale drug from the drug source and discharges the inhaled drug to the injection target. Then, the control unit 200 outputs a control signal corresponding to the injection sequence defining the operation of the electroosmotic pump 110 to the drug injector 100.

The control unit 200 may refer to a data processing device built into hardware that has a physically structured circuit to perform functions expressed by codes or commands included in a program. Examples of data processing devices built into hardware include a microprocessor, central processing unit (CPU), processor core, multiprocessor, and application-specific integrated (ASIC). circuit), FPGA (field programmable gate array), MCU (Micro Controller Unit), and embedded processors, but the scope of the present invention is not limited thereto.

Meanwhile, the control unit 200 is not only built into the drug injection device 10, but is also connected to the user terminal 40 through a communication module, which will be described later, and the user terminal 40 and the control unit 200 are integrated. Thus, it can be implemented in a form that controls the operation of the drug injection device 10.

FIG. 3 is a diagram illustrating the concept of an injection sequence according to an embodiment of the present invention, and FIG. 4 is an exemplary diagram showing an injection sequence according to an embodiment of the present invention. Next, the injection sequence will be described in detail with reference to FIGS. 3 and 4.

As shown in (a) of FIG. 3, the injection sequence is one in which at least one pulse block 20 to be applied to the electroosmotic pump 110 is sequentially arranged. And, as shown in (c) of FIG. 3, each pulse block 20 contains information about a pair of pulse signals including a forward pulse and a reverse pulse, and the size and pulse of each pulse are maintained. Contains information about the duration. A pair of pulse signals including a forward pulse and a reverse pulse are applied to the electroosmotic pump 110 to alternately generate negative pressure and positive pressure, thereby alternately generating negative pressure and positive pressure for each pulse block 20. The drug is inhaled and expelled.

A pair of pulse signals 21 and 22 included in the pulse block 20 are voltage pulse signals or current pulse signals. A pair of voltage pulse signals consists of a forward voltage pulse and a reverse voltage pulse, and a pair of current pulse signals consists of a forward current pulse and a reverse current pulse. Here, a pair of voltage pulse signals may include information about the size and retention time of each voltage pulse, and a pair of current pulse signals may include information about the size and retention time of each current pulse. For example, in the injection sequence shown in FIG. 4, the size of the pulse signal may be 2V and the retention time may be 10s.

Each pulse block included in the injection sequence may include voltage pulses having voltages of different magnitudes or current pulses having currents of different magnitudes. Alternatively, each pulse block may include pulses having voltages of the same magnitude or current pulses having currents of the same magnitude, but each holding time may be set differently.

In addition, the forward pulse 21 and the reverse pulse 22 included in the pulse block 20 are set to have the same size and maintenance time, so that the amount of drug inhaled and discharged by the electroosmotic pump 110 is adjusted. It can remain the same.

In addition, a pair of pulse signals 21 and 22 included in the pulse block 20 may be provided as a constant voltage or a constant current, and the maintenance time of the pulse signal provided by the constant voltage or constant current may be adjusted to control the pulse signals 21 and 22 provided by each pulse block. The amount of drug inhaled and discharged can be controlled. For example, pulse blocks 20 in Figure 4 are provided by a constant voltage of 2V.

Additionally, the size and maintenance time of the pair of pulse signals 21 and 22 can be adjusted so that the amounts of the drug inhaled and the drug discharged are the same. For example, the size of the forward voltage pulse is 2V and the retention time is 10s, and the size of the subsequent reverse voltage pulse is set to 1V and the retention time is 20s, so that the area of the forward pulse and the area of the reverse pulse are set to be the same. Thus, the amount of drug inhaled and the amount of drug discharged can be kept the same.

And, referring to FIG. 4, each pulse block 20 may further include a stabilization pulse 23, which is applied after application of the forward voltage pulse 21 and the reverse voltage pulse 22. It is a pulse that maintains 0V voltage for a certain period of time. The operation of the electro-osmotic pump 110 can be stabilized through the stabilization pulse 23. Here, if the pulse block 10 of the injection sequence consists of a pair of current pulses, the pulse block 20 further includes a stabilization pulse 23 that maintains 0A current for a predetermined time after application of the forward current pulse and the reverse current pulse. can do.

Additionally, as shown in (b) of FIG. 3, the injection sequence may further include a rest block 30. The pause block 30 is a signal that is placed after the pulse block 20 is applied or is placed between the pulse blocks 20 and maintains a 0V voltage or 0A current for a predetermined period of time. The drug injection device 100 of the present invention must slowly inject a certain amount of drug over a long period of time. Therefore, by including the rest block 30 in the injection sequence, it is possible to control the time at which the target drug injection amount is injected, and by minimizing the time during which the drug is not injected, the drug injector 100 is used during the period when the drug is not injected. It can prevent the flow path from being blocked.

The control unit 200 generates a control signal consisting of a voltage pulse or current pulse corresponding to the injection sequence based on the information of the pulse block included in the injection sequence and applies it to the drug injector 100.

When the control signal corresponding to this injection sequence is applied to the electroosmotic pump 110, the electroosmotic pump 110 alternately generates negative pressure and positive pressure for each pulse block to inhale and discharge the drug. Here, the control signal may be a signal composed of a voltage pulse pair including a forward voltage pulse and a reverse voltage pulse or a current pulse pair including a forward current pulse and a reverse current pulse in pulse block units.

Figure 5 is a block diagram schematically showing the configuration of the electroosmotic pump shown in Figure 2.

If the electro-osmotic pump 110 is described in detail with reference to FIG. 5, the electro-osmotic pump 110 includes a driving unit 111 and a chamber 112. The drive unit 111 is electrochemically driven by a control signal to generate positive and negative pressure, and discharges the drug according to the positive and negative pressure, and the chamber 112 stores the drug 120 according to the pressure of the drive unit 111. After inhaling the drug, the drug is discharged into the insertion part 130. Here, the drug is a drug that must be injected into a specific patient, for example, insulin injected into a diabetic patient.

FIG. 6 is a block diagram schematically showing the configuration of the driving unit shown in FIG. 5, and FIG. 7 is an example diagram schematically showing the configuration of the driving unit shown in FIG. 6.

6 and 7, the driving unit 111 is described in detail by the electro-osmosis phenomenon that occurs when voltage or current is applied to both ends of a porous membrane (membrane, 111a) using electrodes. It is a pump that uses fluid movement. The driving unit 111 includes a membrane 111a, a power source 111d that applies voltage or current to the first electrode 111b and the second electrode 111c disposed on both sides of the membrane 111a, and a flow path for fluid movement. It may include (111e).

Silica, glass, etc. are generally used as materials for the porous film 111a, and when these are immersed in an aqueous solution, their surface becomes negatively charged. The porous membrane 111a has paths through which numerous fluids can pass. If one of these is enlarged, the surface of the fluid path, which has a negative charge (bound anion), is a positive ion (mobile cation) with a movable (+) charge. It can be in a state where charge balance is achieved. In this state, when a positive voltage is applied to the first electrode 111b and a negative voltage is applied to the second electrode 111c, negative pressure is generated. This negative pressure causes the fluid inside the driving unit 111 to move in direction ①. is moved to At this time, the drug is inhaled through the suction passage 141 and flows into the chamber 112 through the suction valve 140. At this time, the discharge valve 150 is closed to prevent negative pressure from being transmitted to the discharge path 151.

Conversely, when a (-) voltage is applied to the first electrode 111b and a (+) voltage is applied to the second electrode 111c, a positive pressure in the opposite direction is generated by a reversible electrochemical reaction. Due to this positive pressure, the fluid inside the driving unit 111 moves in the direction ②. At this time, the drug stored in the chamber 112 flows into the subject through the discharge valve 150 and the discharge passage 151. At this time, the suction valve 140 is blocked to prevent positive pressure from being transmitted to the suction passage 141. Meanwhile, the suction valve 140 and discharge valve 150 are check valves that move fluid in one direction and prevent backflow of fluid when pressure is released.

This phenomenon is called electro-osmotic phenomenon, and a pump using this principle is the electro-osmotic pump (110). Therefore, the pressure generated by the electroosmotic pump 110 and the volume of the drug discharged can be controlled by controlling the magnitude and application time of the voltage or current applied to the first and second electrodes 111b and 111c.

According to this configuration, the polarity of voltage or current is alternately supplied to each of the first electrode 111b and the (-) second electrode 111c of the driver 111, so that electrochemical reactions in the forward and reverse directions occur reversibly. do. As electrochemical reactions in the forward and reverse directions occur repeatedly, the fluid inside the electroosmotic pump repeatedly performs a reciprocating motion. In addition, each of the first electrode 111b and the second electrode 111c is repeatedly consumed and regenerated by repeated reversible electrochemical reactions in the forward and reverse directions. When the suction valve 140 and the discharge valve 150 are respectively coupled to the chamber 112 of the electro-osmotic pump 110, the drug in the drug storage unit 120 is inhaled through the suction passage 141 during the suction operation. and is stored in the chamber 112 through the intake valve 140. Then, during the discharge operation, the drug stored in the chamber 112 is discharged to the insertion unit 130 through the discharge valve 150 and the discharge passage 151.

The electrode used in the driving unit 111 is a porous electrode made of platinum mesh (Pt mesh), porous carbon paper or fiber (carbon paper or carbon cloth), or a porous structure coated with various electrode materials to facilitate the movement of fluid. It may be prepared in the form of coating a variety of fixable materials such as drop coating or spin coating by applying it to a non-permeable base material. At this time, the non-permeable base material is a plate-shaped substrate containing at least one of a conductive material, a semiconductor material, and a non-conductive material, and the electrode material coated thereon is metal, metal oxide, conducting polymer, or metal. It may be composed of metal hexacyanoferrate, carbon nanostructure, or a composite thereof.

Figure 8 is an application example of a drug injection device according to an embodiment of the present invention, Figure 9 is a block diagram schematically showing the configuration of the drug injection device shown in Figure 8, and Figure 10 is a drug injection device shown in Figure 8. This is a block diagram schematically showing the configuration of the injection device. The operation of the drug injection device 10 will be described in detail with reference to FIGS. 8 to 10.

The drug injection device 10 receives predetermined information from the user and sets the injection sequence based on this. The process of setting the injection sequence can be divided according to the data used to set the injection sequence. Next, the process of setting up the injection sequence will be described.

Referring to FIG. 9, a process of setting an injection sequence by the drug injection device 10 according to an embodiment of the present invention will be described.

The drug injection device 10 can set an injection sequence using drug injection conditions. Here, the drug injection conditions include the drug injection amount, the drug injection period and drug injection speed, or the drug injection amount and drug injection period. For diabetic patients, drug infusion conditions can be set differently depending on basal infusion and immediate infusion. Basal infusion is an injection method to keep the blood sugar level of a diabetic patient constant by injecting the drug at a predetermined rate for a predetermined time. Immediate injection is an injection method for injecting drugs into diabetic patients without any downtime. Basal infusion and immediate infusion can be adjusted according to the user's choice.

The drug injection device 10 may further include a communication module 300 to receive drug injection conditions from the user terminal 40. Drug injection conditions are input from the user through the user terminal 40, which is connected to the drug injection device 10 through the communication module 300. Then, the control unit 200 sets an injection sequence corresponding to the drug injection conditions and transmits a control signal to the drug injector 100. Here, the injection sequence is not set using drug injection conditions, but is directly selected by the user through the user terminal 40, or is calculated and received through an external computing device based on the user's past use history of the drug injection device. It may be possible.

The user terminal 40 may be implemented as a computer or a portable terminal capable of accessing the drug injection device 10 through wireless communication. Here, the computer includes, for example, a laptop, desktop, laptop, etc. equipped with a web browser, and the portable terminal is, for example, a wireless communication device that guarantees portability and mobility. , may include all types of handheld-based wireless communication devices such as various smartphones, tablet PCs, smart watches, etc. As such, the user terminal 40 is managed by the wearer of the drug injection device 10 or a medical professional, and drug injection conditions can be set through an application running on the user terminal 40.

Additionally, the drug injection device 10 can set the injection sequence using user input data. Here, the user input data includes the user's blood sugar or the user's meal information. User input data is received from the user through the user terminal 40, which is communicated with the drug injection device 10 and the communication module 300, and the control unit 200 calculates drug injection conditions based on the received user input data. do. Then, an injection sequence corresponding to the drug injection conditions is set and a control signal corresponding to the injection sequence is transmitted to the drug injector 100.

Additionally, the drug injection device 10 may set an injection sequence using user biometric data. Here, the user biometric data includes the user's blood sugar information. User biometric data is received through an external measurement device 50 that is communicated with the drug injection device 10 and the communication module 300, and the control unit 200 sets drug injection conditions based on the received user biometric data. Calculate Then, an injection sequence corresponding to the drug injection conditions is set and a control signal corresponding to the injection sequence is transmitted to the drug injector 100. Here, the external measuring device 50 may be a device that senses the user's blood sugar level.

Next, the process by which the drug injection device sets the injection sequence will be described with reference to FIG. 10.

The drug injection device 10 can set an injection sequence using drug injection conditions. The drug injection device 10 may further include a user input/output interface module 400 and receive drug injection conditions from the user using the user input/output interface module 400. In an embodiment in which the drug injection device 10 includes the user input/output interface module 400, the user inputs drug injection conditions, etc. directly into the user input/output interface module 400 without using a separate user terminal 40. Thus, the operation of the drug injection device 10 can be controlled. In this case, the communication module 300 can be selectively excluded.

The control unit 200 sets an injection sequence corresponding to the drug injection condition input through the user input/output interface module 400 and transmits a control signal corresponding thereto to the drug injector 100. Here, the injection sequence is not set using drug injection conditions, but may be directly selected by the user through the user input/output interface module 400.

The user input/output interface module 400 includes a physical input/output button coupled to an external housing containing the drug injection device 10, and a signal processing circuit that transmits a signal generated according to manipulation of the physical input/output button to the control unit 200. can do.

Alternatively, the user input/output interface module 400 may output a UI that guides the user to input information about drug injection conditions or injection sequence through a touch screen display.

Additionally, in the process of setting the injection sequence described above, the controller 200 may refer to a table storing a plurality of injection sequences for each drug injection condition and set an injection sequence corresponding to the drug injection condition. FIG. 11A is an exemplary diagram of a portion of a table in which a plurality of injection sequences are stored, and FIG. 11B is an exemplary diagram showing information on a plurality of pulse blocks. The controller 200 can match and set the injection sequence corresponding to each drug injection condition in the table shown in FIG. 11A. That is, the injection sequence can be set according to drug injection conditions such as injection speed or injection amount.

With reference to FIGS. 11A and 11B , the process of setting an injection sequence according to drug injection conditions will be described as an example. Referring to FIG. 11A, when an injection speed (injection amount per hour) is input as a drug injection condition, the control unit 200 sets an injection sequence corresponding to the input injection speed. When 0.55 U/hr is input as the drug injection condition, the control unit 200 sets the corresponding fourth injection sequence as the injection sequence. The fourth injection sequence consists of a first pulse block, a second pulse block and a third pulse block. Referring to FIG. 11B, the first to third pulse blocks constituting the fourth injection sequence are pulse signals for injecting different amounts of drug. Accordingly, the injection sequence may consist of different pulse blocks depending on the amount of drug injected. In Figure 11b, the pulse block is shown as consisting of forward voltage pulses and reverse voltage pulses, but it is not limited thereto and may be composed of forward current pulses and reverse current pulses in some cases.

Figure 12 is a flowchart for explaining a drug injection method according to an embodiment of the present invention.

When describing the drug injection method (S100) according to an embodiment of the present invention with reference to FIGS. 1, 2, and 12, the drug injection method (S100) includes an injection sequence that determines the operation of the drug injection device 10. Set (step S110), and apply a control signal corresponding to the injection sequence to the electroosmotic pump 110 (step S120). Thereafter, in response to the control signal, the electroosmotic pump 110 alternately generates negative and positive pressure for each pulse block to inhale and discharge the drug, thereby proceeding with the process of injecting the drug into the user (step S130). Here, the injection sequence includes at least one pulse block defining a voltage pulse or current pulse to be applied to the electroosmotic pump 110, and each pulse block is applied to the electroosmotic pump to alternately generate negative pressure and positive pressure. It defines a pair of pulse signals including a pulse and a reverse pulse.

Next, each step will be described in detail.

The process of setting the injection sequence (step S110) can be divided into various embodiments depending on the data used to set the injection sequence.

First, the drug injection device 10 can set an injection sequence using drug injection conditions. Here, the drug injection conditions include the drug injection amount, the drug injection period and drug injection speed, or the drug injection amount and drug injection period. The drug injection device 10 may receive drug injection conditions from the user through the user terminal 40, which is connected to the drug injection device 10 through the communication module 300. Then, the control unit 200 sets an injection sequence corresponding to the drug injection conditions and transmits a control signal corresponding thereto to the drug injector 100. Here, the injection sequence is not set using drug injection conditions, but may be directly selected by the user through the user terminal 40.

In addition, the drug injection device 10 can receive drug injection conditions from the user using the user input/output interface module 400, and the control unit 200 sets an injection sequence corresponding to the drug injection conditions and sends a control signal to the drug. Transfer to injector 100. Here, the injection sequence is not set using drug injection conditions, but may be directly selected by the user through the user input/output interface module 400.

Additionally, the drug injection device 10 can set the injection sequence using user input data. Here, the user input data includes the user's blood sugar or the user's meal information. User input data is received from the user through the user terminal 40, which is communicated with the drug injection device 10 and the communication module 300, and the control unit 200 calculates drug injection conditions based on the received user input data. do. Then, an injection sequence corresponding to the drug injection conditions is set and a control signal corresponding to the injection sequence is transmitted to the drug injector 100.

Additionally, the drug injection device 10 may set an injection sequence using user biometric data. Here, the user biometric data includes the user's blood sugar information. User biometric data is received through an external measuring device 50 that is connected to the drug injection device 10 through communication module 300, and the control unit 200 sets drug injection conditions based on the received user biometric data. Calculate Then, an injection sequence corresponding to the drug injection conditions is set and a control signal corresponding to the injection sequence is transmitted to the drug injector 100. Here, the external measuring device 50 may be a device that senses the user's blood sugar level.

Meanwhile, in the process of setting the injection sequence, the controller 200 may refer to a table storing a plurality of injection sequences for each drug injection condition and set the injection sequence corresponding to the drug injection condition.

In addition, in the process of applying a control signal to the electroosmotic pump (step S120), the control signal corresponding to the injection sequence is a voltage pulse pair including a forward voltage pulse and a reverse voltage pulse or a forward current pulse and a reverse current pulse in pulse block units. It may include a pair of current pulses including, and through this control signal, the electroosmotic pump alternately generates negative pressure and positive pressure for each pulse block to perform the operation of suctioning and discharging the drug (step S130) to the user. Drugs can be injected.

The method according to an embodiment of the present invention may also be implemented in the form of a recording medium containing instructions that can be executed by a computer, such as a program module executed by a computer. Computer-readable media can be any available media that can be accessed by a computer and includes both volatile and non-volatile media, removable and non-removable media. Additionally, computer-readable media may include computer storage media. Computer storage media includes both volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage of information such as computer-readable instructions, data structures, program modules or other data.

Additionally, although the methods and systems of the present invention have been described with respect to specific embodiments, some or all of their components or operations may be implemented using a computer system having a general-purpose hardware architecture.

Those of ordinary skill in the technical field to which the present invention pertains will be able to understand that the present invention can be easily modified into other specific forms without changing the technical idea or essential features of the present invention based on the above description. Therefore, the embodiments described above should be understood in all respects as illustrative and not restrictive. The scope of the present invention is indicated by the patent claims described below, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be construed as being included in the scope of the present invention.

The scope of the present application is indicated by the claims described below rather than the detailed description above, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be construed as being included in the scope of the present application.

10: Drug injection device
100: Drug injector
200: control unit
300: Communication module
400: User input/output interface module

Claims (31)

In the drug injection device,
A drug injector that electrochemically drives an electroosmotic pump to inhale drugs from a drug reservoir and discharges the inhaled drugs to the injection target; and
For the drug injector, it includes a control unit that outputs a control signal corresponding to an injection sequence defining driving of the electro-osmotic pump,
The injection sequence includes at least one pulse block defining a voltage pulse or current pulse to be applied to the electroosmotic pump,
Each of the pulse blocks defines a pair of pulse signals including a forward pulse and a reverse pulse that are applied to the electroosmotic pump and generate alternating negative pressure and positive pressure,
The electro-osmotic pump is a drug injection device that alternately generates negative pressure and positive pressure for each pulse block to inhale and discharge the drug. According to paragraph 1,
The magnitude and retention time of the forward pulse and reverse pulse included in the pair of pulse signals are set to be the same, so that the amount of drug inhaled and discharged by the electroosmotic pump is the same, drug injection. Device. According to paragraph 1,
A drug injection device, wherein the information about the pair of voltage pulse signals or the pair of current pulse signals includes information about the size and maintenance time of each voltage pulse or the size and maintenance time of each current pulse. According to paragraph 1,
The size and maintenance time of a pair of voltage pulse signals supplied by the drug injection device or the size and maintenance time of a pair of current signals are adjusted, and the intake by the pair of voltage pulse signals or the pair of current pulse signals is adjusted. A drug injection device that is adjusted so that the amount of drug and the drug discharged are the same. According to paragraph 1,
The drug injection device provides constant voltage or constant current, and adjusts the maintenance time of the voltage pulse or the maintenance time of the current pulse provided by the constant voltage or constant current, so that the amount of drug inhaled and discharged by each pulse block is adjusted. Phosphorus, drug injection device. According to paragraph 1,
The pair of pulse signals consists of a pair of voltage pulses including a forward voltage pulse and a reverse voltage pulse,
A drug injection device comprising a stabilizing pulse that maintains a 0V voltage for a predetermined period of time after application of the forward voltage pulse and the reverse voltage pulse. According to claim 1,
The pair of pulse signals consists of a current pulse pair including a forward current pulse and a reverse current pulse,
A drug injection device comprising a stabilizing pulse that maintains a 0A current for a predetermined period of time after application of the forward current pulse and the reverse current pulse. According to paragraph 1,
The injection sequence includes at least one pulse block,
A drug injection device comprising a rest block that maintains 0V voltage or 0A current for a predetermined period of time after application of the pulse block or between adjacent pulse blocks. According to paragraph 1,
The drug injection device wherein the injection sequence includes a plurality of pulse blocks, and each pulse block is arranged sequentially. According to paragraph 1,
The electroosmotic pump is electrochemically driven by the control signal, and a driving unit that alternately generates positive pressure and negative pressure.
A drug injection device comprising a chamber that inhales drug from the drug source and then discharges the drug to the insertion portion according to the pressure of the driving unit. According to paragraph 1,
The drug injection device receives drug injection conditions from a user terminal or user input/output interface module,
The control unit outputs the control signal using an injection sequence corresponding to the drug injection conditions,
The drug injection condition includes a drug injection amount, a drug injection period and a drug injection speed, or a drug injection amount and a drug injection period. According to paragraph 1,
The drug injection device receives user input data from a user terminal,
The control unit calculates drug injection conditions based on the user input data and outputs the control signal using an injection sequence corresponding to the drug injection conditions,
The user input data includes the user's blood sugar, user activity information, or user's meal information,
The drug injection condition includes a drug injection amount, a drug injection period and a drug injection speed, or a drug injection amount and a drug injection period. According to paragraph 1,
The drug injection device receives user biometric data from an external measurement device,
The control unit calculates drug injection conditions based on the user biometric data and outputs the control signal using an injection sequence corresponding to the drug injection conditions,
The user biometric data includes the user's blood sugar information or user activity information,
The drug injection condition includes a drug injection amount, a drug injection period and a drug injection speed, or a drug injection amount and a drug injection period. The method according to any one of claims 11 to 13,
The control unit refers to a table storing a plurality of injection sequences for each drug injection condition and sets an injection sequence corresponding to the drug injection condition. According to paragraph 1,
The drug injection device receives an injection sequence set by a user terminal or a user input/output interface module,
The control unit outputs the control signal using the injection sequence. According to paragraph 1,
The injection sequence is calculated and received through an external computing device based on the user's past use history of the drug injection device. In a method of injecting a drug using a drug injection device including an electroosmotic pump,
setting an injection sequence that determines the operation of the drug injection device;
Applying a control signal corresponding to the injection sequence to the electro-osmotic pump; and
In response to the control signal, the electro-osmotic pump alternately generates negative pressure and positive pressure for each pulse block to inhale and discharge the drug,
The injection sequence includes at least one pulse block defining a voltage pulse or current pulse to be applied to the electroosmotic pump,
Each of the pulse blocks is applied to the electroosmotic pump and defines a pair of pulse signals including a forward pulse and a reverse pulse that alternately generate negative pressure and positive pressure. According to clause 17,
The step of setting the injection sequence is,
A drug injection device that sets the magnitude and retention time of the forward and reverse pulses included in a pair of pulse signals to be the same, so that the amounts of drug inhaled and discharged by the electroosmotic pump are the same. Method of drug injection. According to clause 17,
Each pulse block included in the injection sequence contains information about a pair of voltage pulse signals including a forward voltage pulse and a reverse voltage pulse or a pair of current pulse signals including a forward current pulse and a reverse current pulse. , drug injection method of drug injection device. According to clause 19,
The drug injection method of the drug injection device, wherein the information about the pair of voltage pulse signals or the pair of current pulse signals includes information about the size and maintenance time of each voltage pulse or the size and maintenance time of each current pulse. According to clause 19,
The step of setting the injection sequence is,
By adjusting the size and maintenance time of the pair of voltage pulse signals or the size and maintenance time of the pair of current signals, the amount of drug inhaled and the drug discharged by the pair of voltage pulse signals or the pair of current pulse signals are the same. A drug injection method of a drug injection device, which is set to be used. According to clause 19,
The step of setting the injection sequence is,
The drug is set so that the amount of drug inhaled and discharged by each pulse block is adjusted by adjusting the maintenance time of the voltage pulse or the maintenance time of the current pulse applied by the constant voltage or constant current supplied by the drug injection device. Method of drug injection using an injection device. According to clause 19,
The pair of pulse signals consists of a pair of voltage pulses including a forward voltage pulse and a reverse voltage pulse,
A drug injection method of a drug injection device comprising a stabilization pulse that maintains a 0V voltage for a predetermined time after application of the forward voltage pulse and the reverse voltage pulse. According to clause 19,
The pair of pulse signals consists of a current pulse pair including a forward current pulse and a reverse current pulse,
A drug injection method of a drug injection device, comprising a stabilizing pulse that maintains a 0A current for a predetermined period of time after application of the forward current pulse and the reverse current pulse. According to clause 17,
The injection sequence is,
A drug injection method of a drug injection device, comprising a rest block that maintains 0V voltage or 0A current for a predetermined time after application of the pulse block or between adjacent pulse blocks. According to clause 17,
The drug injection method of the drug injection device, wherein the injection sequence includes a plurality of pulse blocks, and each pulse block is arranged sequentially. According to clause 17,
The step of setting the injection sequence is,
The drug injection device sets the injection sequence based on the drug injection conditions received from the user terminal or user input/output interface module,
The drug injection conditions include a drug injection amount, a drug injection period and a drug injection speed, or include a drug injection amount and a drug injection period. According to clause 17,
The step of setting the injection sequence is,
The drug injection device calculates the drug injection conditions based on user input data received from the user terminal and sets an injection sequence corresponding to the drug injection conditions,
The user input data includes the user's blood sugar, user activity information, or user's meal information,
The drug injection condition includes a drug injection amount, a drug injection period and a drug injection speed, or includes a drug injection amount and a drug injection period. According to clause 17,
The step of setting the injection sequence is,
The drug injection device calculates the drug injection conditions based on user biometric data received from an external measurement device and sets an injection sequence corresponding to the drug injection conditions,
The user biometric data includes the user's blood sugar information or user activity information,
The drug injection condition includes a drug injection amount, a drug injection period and a drug injection speed, or includes a drug injection amount and a drug injection period. According to any one of claims 27 to 29,
The step of setting the injection sequence is,
A drug injection method of a drug injection device, wherein an injection sequence corresponding to the drug injection condition is set by referring to a table storing a plurality of injection sequences for each drug injection condition. According to clause 17,
The step of setting the injection sequence is,
A drug injection method of a drug injection device, wherein the drug injection device receives an injection sequence set by a user terminal or a user input/output interface module, and sets the received injection sequence as the injection sequence.